Zhihua Jiang

Zhihua Jiang, PhD

Associate Professor

Department: MD-SURGERY-VASCULAR
Business Phone: (352) 294-5689
Business Email: jiangzh@surgery.ufl.edu

About Zhihua Jiang

2012-present: Assistant professor (tenure-track) of surgery, UF College of Medicine, Department of Surgery

2012-present: Faculty, UF Graduate School

2012-present: Assistant professor, UF College of Medicine, Department of Physiology and Functional Genomics

2006-2011: Research assistant professor, UF College of Medicine, Department of Surgery

Publications

2021
Maresin 1 activates LGR6 signaling to inhibit smooth muscle cell activation and attenuate murine abdominal aortic aneurysm formation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35(8) [DOI] 10.1096/fj.202100484R. [PMID] 34320253.
2019
Cyclophilin A contributes to aortopathy induced by postnatal loss of smooth muscle TGFBR1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(10):11396-11410 [DOI] 10.1096/fj.201900601RR. [PMID] 31311317.
2017
Hemodynamic Influence on Smooth Muscle Cell Kinetics and Phenotype During Early Vein Graft Adaptation.
Annals of biomedical engineering. 45(3):644-655 [DOI] 10.1007/s10439-016-1725-0. [PMID] 27624660.
2016
Preexisting smooth muscle cells contribute to neointimal cell repopulation at an incidence varying widely among individual lesions.
Surgery. 159(2):602-12 [DOI] 10.1016/j.surg.2015.08.015. [PMID] 26387788.
2016
Smooth muscle cell-specific Tgfbr1 deficiency attenuates neointimal hyperplasia but promotes an undesired vascular phenotype for injured arteries.
Physiological reports. 4(23) [PMID] 27923978.
View on: PubMed
2016
Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events.
Scientific reports. 6 [DOI] 10.1038/srep35444. [PMID] 27739498.
2015
Hypertension overrides the protective effect of female hormones on the development of aortic aneurysm secondary to Alk5 deficiency via ERK activation.
American journal of physiology. Heart and circulatory physiology. 308(2):H115-25 [DOI] 10.1152/ajpheart.00521.2014. [PMID] 25398982.
2015
Time and flow-dependent changes in the p27(kip1) gene network drive maladaptive vascular remodeling.
Journal of vascular surgery. 62(5):1296-302.e2 [DOI] 10.1016/j.jvs.2014.05.015. [PMID] 24953896.
2014
Common and distinctive pathogenetic features of arteriovenous malformations in hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 animal models–brief report.
Arteriosclerosis, thrombosis, and vascular biology. 34(10):2232-6 [DOI] 10.1161/ATVBAHA.114.303984. [PMID] 25082229.
2014
Flow reversal promotes intimal thickening in vein grafts.
Journal of vascular surgery. 60(2):471-478.e1 [DOI] 10.1016/j.jvs.2013.06.081. [PMID] 24342069.
2013
Rule-based model of vein graft remodeling.
PloS one. 8(3) [DOI] 10.1371/journal.pone.0057822. [PMID] 23533576.
2012
Monocyte chemoattractant protein-1/CCR2 axis promotes vein graft neointimal hyperplasia through its signaling in graft-extrinsic cell populations.
Arteriosclerosis, thrombosis, and vascular biology. 32(10):2418-26 [DOI] 10.1161/ATVBAHA.112.255786. [PMID] 22904274.
2010
The Mismatch Repair System Modulates Curcumin Sensitivity Through Induction of Dna Strand Breaks and Activation of G(2)-M Checkpoint
Molecular Cancer Therapeutics. 9(3):558-568 [DOI] 10.1158/1535-7163.MCT-09-0627. [PMID] 20145018.
2009
Established neointimal hyperplasia in vein grafts expands via TGF-beta-mediated progressive fibrosis.
American journal of physiology. Heart and circulatory physiology. 297(4):H1200-7 [DOI] 10.1152/ajpheart.00268.2009. [PMID] 19617405.
2009
Hemodynamically driven vein graft remodeling: a systems biology approach.
Vascular. 17 Suppl 1:S2-9 [PMID] 19426605.
View on: PubMed
2009
Interplay of CCR2 signaling and local shear force determines vein graft neointimal hyperplasia in vivo.
FEBS letters. 583(21):3536-40 [DOI] 10.1016/j.febslet.2009.10.015. [PMID] 19822149.
2008
An experiment-based model of vein graft remodeling induced by shear stress.
Annals of biomedical engineering. 36(7):1083-91 [DOI] 10.1007/s10439-008-9495-y. [PMID] 18415018.
2008
Danger Signaling Dependent Mechanisms in Flow-Induced Arterial Remodeling
Arteriosclerosis Thrombosis and Vascular Biology. 28
2008
Myd88-Dependent Pathway Initiates Neointimal Hyperplasia Development Independently of Tlr4
Circulation. 118
2007
TGF-beta- and CTGF-mediated fibroblast recruitment influences early outward vein graft remodeling.
American journal of physiology. Heart and circulatory physiology. 293(1):H482-8 [PMID] 17369455.
View on: PubMed
2007
TNF-alpha and shear stress-induced large artery adaptations.
The Journal of surgical research. 141(2):299-305 [PMID] 17574273.
View on: PubMed
2007
Tumor necrosis factor-alpha and the early vein graft.
Journal of vascular surgery. 45(1):169-76 [PMID] 17210403.
View on: PubMed
2006
Early differential MMP-2 and -9 dynamics during flow-induced arterial and vein graft adaptations.
The Journal of surgical research. 134(2):327-34 [PMID] 16488440.
View on: PubMed
2004
A novel vein graft model: adaptation to differential flow environments.
American journal of physiology. Heart and circulatory physiology. 286(1):H240-5 [PMID] 14500133.
View on: PubMed
2004
Differential expression and activity of matrix metalloproteinases during flow-modulated vein graft remodeling.
Journal of vascular surgery. 39(5):1084-90 [PMID] 15111865.
View on: PubMed
2004
Impact of IL-1beta on flow-induced outward arterial remodeling.
Surgery. 136(2):478-82 [PMID] 15300218.
View on: PubMed
2004
Impact of shear stress on early vein graft remodeling: a biomechanical analysis.
Annals of biomedical engineering. 32(11):1484-93 [PMID] 15636109.
View on: PubMed
2004
Wall shear modulation of cytokines in early vein grafts.
Journal of vascular surgery. 40(2):345-50 [PMID] 15297832.
View on: PubMed

Grants

Jul 2020 ACTIVE
Immune injury as a driver for the development of ascending aortic aneurysms and dissections
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2020 ACTIVE
Novel specialized pro-resolving lipid mediators in resolution of aortic aneurysms and rupture
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Aug 2019 ACTIVE
Role of RNA-mediated danger signals in regulating TAAD development
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Mar 2017 – Feb 2021
Mechanisms for tobacco smoke to modulate aortic aneurysm development
Role: Principal Investigator
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
Jul 2011 – May 2017
The Dichotomy of Akl1 and Alk5 Signaling Pathways in Vascular Response to Injury.
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI

Teaching Profile

Courses Taught
2015,2020
GMS6683 Fundamentals of Vascular Physiology and Pathology
2018
BME7980 Research for Doctoral Dissertation
2010
IDH4917 Undergrad Research

Contact Details

Phones:
Business:
(352) 294-5689
Emails: