Guoshuai Cai,
AST PROF
Department:
MD-SURGERY-VASCULAR
Business Phone:
(352) 273-5484
Business Email:
guoshuai.cai@surgery.ufl.edu
About Guoshuai Cai
Publications
Academic Articles
2024
A statistical learning method for simultaneous copy number estimation and subclone clustering with single-cell sequencing data.
Genome research.
34(1):85-93
[DOI] 10.1101/gr.278098.123.
[PMID] 38290978.
2024
CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility
Cancer Research.
84(4):616-625
[DOI] 10.1158/0008-5472.can-23-0900.
2024
Multimodal functional deep learning for multiomics data.
Briefings in bioinformatics.
25(5)
[DOI] 10.1093/bib/bbae448.
[PMID] 39285512.
2024
OSCAA: A two-dimensional Gaussian mixture model for copy number variation association analysis.
Genetic epidemiology.
[DOI] 10.1002/gepi.22558.
[PMID] 38533840.
2024
Short-Term Dietary Restriction Potentiates an Anti-Inflammatory Circulating Mucosal-Associated Invariant T-Cell Response.
Nutrients.
16(8)
[DOI] 10.3390/nu16081245.
[PMID] 38674935.
2024
SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages.
Molecular therapy : the journal of the American Society of Gene Therapy.
32(5):1425-1444
[DOI] 10.1016/j.ymthe.2024.03.025.
[PMID] 38504518.
2024
Transcriptomic Differences in Peripheral Monocyte Populations in Septic Patients Based on Outcome.
Shock (Augusta, Ga.).
62(2):208-216
[DOI] 10.1097/SHK.0000000000002379.
[PMID] 38713581.
2023
CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.
Nucleic acids research.
51(14):7288-7313
[DOI] 10.1093/nar/gkad538.
[PMID] 37378433.
2023
Integrated multi-omics approach to distinct molecular characterization and classification of early-onset colorectal cancer.
Cell reports. Medicine.
4(3)
[DOI] 10.1016/j.xcrm.2023.100974.
[PMID] 36921601.
2023
Migraine and major depression: localizing shared genetic susceptibility in different cell types of the nervous systems.
Frontiers in neurology.
14
[DOI] 10.3389/fneur.2023.1254290.
[PMID] 38033772.
2023
Risks of suicide in migraine, non-migraine headache, back, and neck pain: a systematic review and meta-analysis.
Frontiers in neurology.
14
[DOI] 10.3389/fneur.2023.1160204.
[PMID] 37153662.
2023
Vibrio parahaemolyticus and Vibrio vulnificus in vitro biofilm dispersal from microplastics influenced by simulated human environment.
Frontiers in microbiology.
14
[DOI] 10.3389/fmicb.2023.1236471.
[PMID] 37854331.
2022
A pilot study that provides evidence of epigenetic changes among mother-child pairs living proximal to mining in the US.
Environmental geochemistry and health.
44(12):4735-4746
[DOI] 10.1007/s10653-022-01217-9.
[PMID] 35137284.
2022
BISC: accurate inference of transcriptional bursting kinetics from single-cell transcriptomic data.
Briefings in bioinformatics.
23(6)
[DOI] 10.1093/bib/bbac464.
[PMID] 36326081.
2022
BMI-CNV: a Bayesian framework for multiple genotyping platforms detection of copy number variants
Genetics.
222(4)
[DOI] 10.1093/genetics/iyac147.
[PMID] 36171678.
2022
Breast cancer cell-derived microRNA-155 suppresses tumor progression via enhancing immune cell recruitment and antitumor function.
The Journal of clinical investigation.
132(19)
[DOI] 10.1172/JCI157248.
[PMID] 35925680.
2022
Editorial: High-Throughput Sequencing-Based Investigation of Chronic Disease Markers and Mechanisms.
Frontiers in genetics.
13
[DOI] 10.3389/fgene.2022.922206.
[PMID] 35801080.
2022
Relationship Between Headache Characteristics and a Remote History of TBI in Veterans: A 10-Year Retrospective Chart Review.
Neurology.
99(2):e187-e198
[DOI] 10.1212/WNL.0000000000200518.
[PMID] 35470141.
2022
SCANNER: a web platform for annotation, visualization and sharing of single cell RNA-seq data.
Database : the journal of biological databases and curation.
2022
[DOI] 10.1093/database/baab086.
[PMID] 35134150.
2022
SCRIP: an accurate simulator for single-cell RNA sequencing data.
Bioinformatics (Oxford, England).
38(5):1304-1311
[DOI] 10.1093/bioinformatics/btab824.
[PMID] 34874992.
2022
Vibrio parahaemolyticus and Vibrio vulnificus in vitro colonization on plastics influenced by temperature and strain variability.
Frontiers in microbiology.
13
[DOI] 10.3389/fmicb.2022.1099502.
[PMID] 36704570.
2021
A Cluster-Based Approach for Identifying Prognostic microRNA Signatures in Digestive System Cancers.
International journal of molecular sciences.
22(4)
[DOI] 10.3390/ijms22041529.
[PMID] 33546390.
2021
A Systematic Review and Meta-Analysis on the Efficacy of Repeated Transcranial Direct Current Stimulation for Migraine.
Journal of pain research.
14:1171-1183
[DOI] 10.2147/JPR.S295704.
[PMID] 33953607.
2021
Cannabinoid Receptor Activation on Haematopoietic Cells and Enterocytes Protects against Colitis.
Journal of Crohn's & colitis.
15(6):1032-1048
[DOI] 10.1093/ecco-jcc/jjaa253.
[PMID] 33331878.
2021
Integrating genomic correlation structure improves copy number variations detection.
Bioinformatics (Oxford, England).
37(3):312-317
[DOI] 10.1093/bioinformatics/btaa737.
[PMID] 32805016.
2021
Integrative omics provide biological and clinical insights into acute respiratory distress syndrome.
Intensive care medicine.
47(7):761-771
[DOI] 10.1007/s00134-021-06410-5.
[PMID] 34032881.
2021
Post-traumatic Headache and Mild Traumatic Brain Injury: Brain Networks and Connectivity.
Current pain and headache reports.
25(3)
[DOI] 10.1007/s11916-020-00935-y.
[PMID] 33674899.
2021
SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues.
International journal of molecular sciences.
22(17)
[DOI] 10.3390/ijms22179228.
[PMID] 34502134.
2021
SCISSOR™: a single-cell inferred site-specific omics resource for tumor microenvironment association study.
NAR cancer.
3(3)
[DOI] 10.1093/narcan/zcab037.
[PMID] 34514416.
2021
Shall genomic correlation structure be considered in copy number variants detection?
Briefings in bioinformatics.
22(6)
[DOI] 10.1093/bib/bbab215.
[PMID] 34114005.
2020
A gene expression-based immune signature for lung adenocarcinoma prognosis.
Cancer immunology, immunotherapy : CII.
69(9):1881-1890
[DOI] 10.1007/s00262-020-02595-8.
[PMID] 32372138.
2020
Activation of Cannabinoid Receptor 2 Prevents Colitis-Associated Colon Cancer through Myeloid Cell De-activation Upstream of IL-22 Production.
iScience.
23(9)
[DOI] 10.1016/j.isci.2020.101504.
[PMID] 32942172.
2020
Mature Vascular Smooth Muscle Cells, but Not Endothelial Cells, Serve as the Major Cellular Source of Intimal Hyperplasia in Vein Grafts.
Arteriosclerosis, thrombosis, and vascular biology.
40(8):1870-1890
[DOI] 10.1161/ATVBAHA.120.314465.
[PMID] 32493169.
2020
Multiomics Evaluation of Gastrointestinal and Other Clinical Characteristics of COVID-19.
Gastroenterology.
158(8):2298-2301.e7
[DOI] 10.1053/j.gastro.2020.03.045.
[PMID] 32234303.
2020
Reply to Polverino: Cigarette Smoking and COVID-19: A Complex Interaction.
American journal of respiratory and critical care medicine.
202(3):472-474
[DOI] 10.1164/rccm.202005-1807LE.
[PMID] 32530707.
2020
Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase-like 4: New Evidence From Three-Dimensional Skin-like Tissues.
Arthritis & rheumatology (Hoboken, N.J.).
72(5):791-801
[DOI] 10.1002/art.41163.
[PMID] 31705627.
2020
Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2.
American journal of respiratory and critical care medicine.
201(12):1557-1559
[DOI] 10.1164/rccm.202003-0693LE.
[PMID] 32329629.
2020
Δ9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression.
International journal of molecular sciences.
21(17)
[DOI] 10.3390/ijms21176244.
[PMID] 32872332.
2019
A Machine Learning Classifier for Assigning Individual Patients With Systemic Sclerosis to Intrinsic Molecular Subsets.
Arthritis & rheumatology (Hoboken, N.J.).
71(10):1701-1710
[DOI] 10.1002/art.40898.
[PMID] 30920766.
2019
An accurate and powerful method for copy number variation detection.
Bioinformatics (Oxford, England).
35(17):2891-2898
[DOI] 10.1093/bioinformatics/bty1041.
[PMID] 30649252.
2019
Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin
Arthritis Research & Therapy.
21(1)
[DOI] 10.1186/s13075-019-1816-z.
[PMID] 30728065.
2018
A P53-Deficiency Gene Signature Predicts Recurrence Risk of Patients with Early-Stage Lung Adenocarcinoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
27(1):86-95
[DOI] 10.1158/1055-9965.EPI-17-0478.
[PMID] 29141854.
2018
Antisense Long Non-Coding RNAs Are Deregulated in Skin Tissue of Patients with Systemic Sclerosis.
The Journal of investigative dermatology.
138(4):826-835
[DOI] 10.1016/j.jid.2017.09.053.
[PMID] 29179949.
2018
Feature specific quantile normalization enables cross-platform classification of molecular subtypes using gene expression data.
Bioinformatics (Oxford, England).
34(11):1868-1874
[DOI] 10.1093/bioinformatics/bty026.
[PMID] 29360996.
2017
Local sequence and sequencing depth dependent accuracy of RNA-seq reads.
BMC bioinformatics.
18(1)
[DOI] 10.1186/s12859-017-1780-z.
[PMID] 28793860.
2017
Population effect model identifies gene expression predictors of survival outcomes in lung adenocarcinoma for both Caucasian and Asian patients.
PloS one.
12(4)
[DOI] 10.1371/journal.pone.0175850.
[PMID] 28426704.
2016
FastPop: a rapid principal component derived method to infer intercontinental ancestry using genetic data.
BMC bioinformatics.
17
[DOI] 10.1186/s12859-016-0965-1.
[PMID] 26961892.
2016
Segregation Analysis Suggests That a Genetic Reason May Contribute to “the Dress” Colour Perception.
PloS one.
11(10)
[DOI] 10.1371/journal.pone.0165095.
[PMID] 27768729.
2016
Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance.
Cancer letters.
383(2):261-271
[DOI] 10.1016/j.canlet.2016.10.006.
[PMID] 27721021.
2015
Bayesian Hierarchical Model for Differential Gene Expression Using RNA-seq Data.
Statistics in biosciences.
7(1):48-67
[PMID] 26191087.
2015
Long Non Coding RNA MALAT1 Promotes Tumor Growth and Metastasis by inducing Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma.
Scientific reports.
5
[DOI] 10.1038/srep15972.
[PMID] 26522444.
2015
Mitochondrial Ca²⁺ uniporter is critical for store-operated Ca²⁺ entry-dependent breast cancer cell migration.
Biochemical and biophysical research communications.
458(1):186-93
[DOI] 10.1016/j.bbrc.2015.01.092.
[PMID] 25640838.
2015
PAND: A Distribution to Identify Functional Linkage from Networks with Preferential Attachment Property.
PloS one.
10(7)
[DOI] 10.1371/journal.pone.0127968.
[PMID] 26158709.
2015
Targeting EZH2 regulates tumor growth and apoptosis through modulating mitochondria dependent cell-death pathway in HNSCC.
Oncotarget.
6(32):33720-32
[DOI] 10.18632/oncotarget.5606.
[PMID] 26378043.
2014
Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3).
European journal of medicinal chemistry.
82:195-203
[DOI] 10.1016/j.ejmech.2014.05.049.
[PMID] 24904966.
2014
Natural and orthogonal model for estimating gene-gene interactions applied to cutaneous melanoma.
Human genetics.
133(5):559-74
[DOI] 10.1007/s00439-013-1392-2.
[PMID] 24241239.
2012
Accuracy of RNA-Seq and its dependence on sequencing depth.
BMC bioinformatics.
13 Suppl 13(Suppl 13)
[DOI] 10.1186/1471-2105-13-S13-S5.
[PMID] 23320920.
2011
On differential gene expression using RNA-Seq data.
Cancer informatics.
10:205-15
[DOI] 10.4137/CIN.S7473.
[PMID] 21863128.
2009
miRecords: an integrated resource for microRNA-target interactions.
Nucleic acids research.
37(Database issue):D105-10
[DOI] 10.1093/nar/gkn851.
[PMID] 18996891.
2007
Identification and functional analysis of LsMNPV anti-apoptosis genes.
Journal of biochemistry and molecular biology.
40(4):571-6
[PMID] 17669274.
Grants
Nov 2023
– Oct 2024
Innovative Approach to Assess the Effect of Metal Mixtures from Infant Meconium Associated with Adverse Infant Outcomes by Identifying Methylation Loci in Mothers and Infants
Role: Principal Investigator
Funding: CITY UNIVERSITY OF NEW YORK
via US ENVIRONMENTAL PRO AGCY
Aug 2023
– Nov 2024
Metabolic control of vascular smooth muscle cell plasticity
Role: Principal Investigator
Funding: UNIV OF MISSOURI
via NATL INST OF HLTH NHLBI
Education
PhD
2013
·
University of Texas Health Science Center & MD Anderson Cancer Center
MS
2009
·
Wuhan University
BS
2002
·
Wuhan University
Contact Details
Phones:
- Business:
- (352) 273-5484
Emails:
- Business:
- guoshuai.cai@surgery.ufl.edu
Addresses:
- Business Mailing:
-
P O Box 117450
GAINESVILLE FL 32611 - Business Street:
-
1600 SW ARCHER RD
GAINESVILLE FL 32610