Guoshuai Cai

Guoshuai Cai,

AST PROF

Department: MD-SURGERY-VASCULAR
Business Phone: (352) 273-5484

About Guoshuai Cai

Additional Positions:
Director
2023 – Current · UF Surgery Genomics Core
Related Links:

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-5331-1297

Publications

2024
CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility
Cancer Research. 84(4):616-625 [DOI] 10.1158/0008-5472.can-23-0900.
2023
CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.
Nucleic acids research. 51(14):7288-7313 [DOI] 10.1093/nar/gkad538. [PMID] 37378433.
2023
Integrated multi-omics approach to distinct molecular characterization and classification of early-onset colorectal cancer.
Cell reports. Medicine. 4(3) [DOI] 10.1016/j.xcrm.2023.100974. [PMID] 36921601.
2023
Risks of suicide in migraine, non-migraine headache, back, and neck pain: a systematic review and meta-analysis.
Frontiers in neurology. 14 [DOI] 10.3389/fneur.2023.1160204. [PMID] 37153662.
2022
A pilot study that provides evidence of epigenetic changes among mother-child pairs living proximal to mining in the US.
Environmental geochemistry and health. 44(12):4735-4746 [DOI] 10.1007/s10653-022-01217-9. [PMID] 35137284.
2022
BISC: accurate inference of transcriptional bursting kinetics from single-cell transcriptomic data.
Briefings in bioinformatics. 23(6) [DOI] 10.1093/bib/bbac464. [PMID] 36326081.
2022
BMI-CNV: a Bayesian framework for multiple genotyping platforms detection of copy number variants
Genetics. 222(4) [DOI] 10.1093/genetics/iyac147. [PMID] 36171678.
2022
Breast cancer cell-derived microRNA-155 suppresses tumor progression via enhancing immune cell recruitment and antitumor function.
The Journal of clinical investigation. 132(19) [DOI] 10.1172/JCI157248. [PMID] 35925680.
2022
Editorial: High-Throughput Sequencing-Based Investigation of Chronic Disease Markers and Mechanisms.
Frontiers in genetics. 13 [DOI] 10.3389/fgene.2022.922206. [PMID] 35801080.
2022
Relationship Between Headache Characteristics and a Remote History of TBI in Veterans: A 10-Year Retrospective Chart Review.
Neurology. 99(2):e187-e198 [DOI] 10.1212/WNL.0000000000200518. [PMID] 35470141.
2022
SCANNER: a web platform for annotation, visualization and sharing of single cell RNA-seq data.
Database : the journal of biological databases and curation. 2022 [DOI] 10.1093/database/baab086. [PMID] 35134150.
2022
SCRIP: an accurate simulator for single-cell RNA sequencing data.
Bioinformatics (Oxford, England). 38(5):1304-1311 [DOI] 10.1093/bioinformatics/btab824. [PMID] 34874992.
2022
Vibrio parahaemolyticus and Vibrio vulnificus in vitro colonization on plastics influenced by temperature and strain variability.
Frontiers in microbiology. 13 [DOI] 10.3389/fmicb.2022.1099502. [PMID] 36704570.
2021
A Cluster-Based Approach for Identifying Prognostic microRNA Signatures in Digestive System Cancers.
International journal of molecular sciences. 22(4) [DOI] 10.3390/ijms22041529. [PMID] 33546390.
2021
A Systematic Review and Meta-Analysis on the Efficacy of Repeated Transcranial Direct Current Stimulation for Migraine.
Journal of pain research. 14:1171-1183 [DOI] 10.2147/JPR.S295704. [PMID] 33953607.
2021
Cannabinoid Receptor Activation on Haematopoietic Cells and Enterocytes Protects against Colitis.
Journal of Crohn's & colitis. 15(6):1032-1048 [DOI] 10.1093/ecco-jcc/jjaa253. [PMID] 33331878.
2021
Integrating genomic correlation structure improves copy number variations detection.
Bioinformatics (Oxford, England). 37(3):312-317 [DOI] 10.1093/bioinformatics/btaa737. [PMID] 32805016.
2021
Integrative omics provide biological and clinical insights into acute respiratory distress syndrome.
Intensive care medicine. 47(7):761-771 [DOI] 10.1007/s00134-021-06410-5. [PMID] 34032881.
2021
Post-traumatic Headache and Mild Traumatic Brain Injury: Brain Networks and Connectivity.
Current pain and headache reports. 25(3) [DOI] 10.1007/s11916-020-00935-y. [PMID] 33674899.
2021
SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues.
International journal of molecular sciences. 22(17) [DOI] 10.3390/ijms22179228. [PMID] 34502134.
2021
SCISSOR™: a single-cell inferred site-specific omics resource for tumor microenvironment association study.
NAR cancer. 3(3) [DOI] 10.1093/narcan/zcab037. [PMID] 34514416.
2021
Shall genomic correlation structure be considered in copy number variants detection?
Briefings in bioinformatics. 22(6) [DOI] 10.1093/bib/bbab215. [PMID] 34114005.
2020
A gene expression-based immune signature for lung adenocarcinoma prognosis.
Cancer immunology, immunotherapy : CII. 69(9):1881-1890 [DOI] 10.1007/s00262-020-02595-8. [PMID] 32372138.
2020
Activation of Cannabinoid Receptor 2 Prevents Colitis-Associated Colon Cancer through Myeloid Cell De-activation Upstream of IL-22 Production.
iScience. 23(9) [DOI] 10.1016/j.isci.2020.101504. [PMID] 32942172.
2020
Mature Vascular Smooth Muscle Cells, but Not Endothelial Cells, Serve as the Major Cellular Source of Intimal Hyperplasia in Vein Grafts.
Arteriosclerosis, thrombosis, and vascular biology. 40(8):1870-1890 [DOI] 10.1161/ATVBAHA.120.314465. [PMID] 32493169.
2020
Multiomics Evaluation of Gastrointestinal and Other Clinical Characteristics of COVID-19.
Gastroenterology. 158(8):2298-2301.e7 [DOI] 10.1053/j.gastro.2020.03.045. [PMID] 32234303.
2020
Reply to Polverino: Cigarette Smoking and COVID-19: A Complex Interaction.
American journal of respiratory and critical care medicine. 202(3):472-474 [DOI] 10.1164/rccm.202005-1807LE. [PMID] 32530707.
2020
Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase-like 4: New Evidence From Three-Dimensional Skin-like Tissues.
Arthritis & rheumatology (Hoboken, N.J.). 72(5):791-801 [DOI] 10.1002/art.41163. [PMID] 31705627.
2020
Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2.
American journal of respiratory and critical care medicine. 201(12):1557-1559 [DOI] 10.1164/rccm.202003-0693LE. [PMID] 32329629.
2020
Δ9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression.
International journal of molecular sciences. 21(17) [DOI] 10.3390/ijms21176244. [PMID] 32872332.
2019
A Machine Learning Classifier for Assigning Individual Patients With Systemic Sclerosis to Intrinsic Molecular Subsets.
Arthritis & rheumatology (Hoboken, N.J.). 71(10):1701-1710 [DOI] 10.1002/art.40898. [PMID] 30920766.
2019
An accurate and powerful method for copy number variation detection.
Bioinformatics (Oxford, England). 35(17):2891-2898 [DOI] 10.1093/bioinformatics/bty1041. [PMID] 30649252.
2019
Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin
Arthritis Research & Therapy. 21(1) [DOI] 10.1186/s13075-019-1816-z. [PMID] 30728065.
2018
A P53-Deficiency Gene Signature Predicts Recurrence Risk of Patients with Early-Stage Lung Adenocarcinoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 27(1):86-95 [DOI] 10.1158/1055-9965.EPI-17-0478. [PMID] 29141854.
2018
Antisense Long Non-Coding RNAs Are Deregulated in Skin Tissue of Patients with Systemic Sclerosis.
The Journal of investigative dermatology. 138(4):826-835 [DOI] 10.1016/j.jid.2017.09.053. [PMID] 29179949.
2018
Feature specific quantile normalization enables cross-platform classification of molecular subtypes using gene expression data.
Bioinformatics (Oxford, England). 34(11):1868-1874 [DOI] 10.1093/bioinformatics/bty026. [PMID] 29360996.
2017
Local sequence and sequencing depth dependent accuracy of RNA-seq reads.
BMC bioinformatics. 18(1) [DOI] 10.1186/s12859-017-1780-z. [PMID] 28793860.
2017
Population effect model identifies gene expression predictors of survival outcomes in lung adenocarcinoma for both Caucasian and Asian patients.
PloS one. 12(4) [DOI] 10.1371/journal.pone.0175850. [PMID] 28426704.
2016
FastPop: a rapid principal component derived method to infer intercontinental ancestry using genetic data.
BMC bioinformatics. 17 [DOI] 10.1186/s12859-016-0965-1. [PMID] 26961892.
2016
Segregation Analysis Suggests That a Genetic Reason May Contribute to “the Dress” Colour Perception.
PloS one. 11(10) [DOI] 10.1371/journal.pone.0165095. [PMID] 27768729.
2016
Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance.
Cancer letters. 383(2):261-271 [DOI] 10.1016/j.canlet.2016.10.006. [PMID] 27721021.
2015
Bayesian Hierarchical Model for Differential Gene Expression Using RNA-seq Data.
Statistics in biosciences. 7(1):48-67 [PMID] 26191087.
2015
Long Non Coding RNA MALAT1 Promotes Tumor Growth and Metastasis by inducing Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma.
Scientific reports. 5 [DOI] 10.1038/srep15972. [PMID] 26522444.
2015
Mitochondrial Ca²⁺ uniporter is critical for store-operated Ca²⁺ entry-dependent breast cancer cell migration.
Biochemical and biophysical research communications. 458(1):186-93 [DOI] 10.1016/j.bbrc.2015.01.092. [PMID] 25640838.
2015
PAND: A Distribution to Identify Functional Linkage from Networks with Preferential Attachment Property.
PloS one. 10(7) [DOI] 10.1371/journal.pone.0127968. [PMID] 26158709.
2015
Targeting EZH2 regulates tumor growth and apoptosis through modulating mitochondria dependent cell-death pathway in HNSCC.
Oncotarget. 6(32):33720-32 [DOI] 10.18632/oncotarget.5606. [PMID] 26378043.
2014
Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3).
European journal of medicinal chemistry. 82:195-203 [DOI] 10.1016/j.ejmech.2014.05.049. [PMID] 24904966.
2014
Natural and orthogonal model for estimating gene-gene interactions applied to cutaneous melanoma.
Human genetics. 133(5):559-74 [DOI] 10.1007/s00439-013-1392-2. [PMID] 24241239.
2012
Accuracy of RNA-Seq and its dependence on sequencing depth.
BMC bioinformatics. 13 Suppl 13(Suppl 13) [DOI] 10.1186/1471-2105-13-S13-S5. [PMID] 23320920.
2011
On differential gene expression using RNA-Seq data.
Cancer informatics. 10:205-15 [DOI] 10.4137/CIN.S7473. [PMID] 21863128.
2009
miRecords: an integrated resource for microRNA-target interactions.
Nucleic acids research. 37(Database issue):D105-10 [DOI] 10.1093/nar/gkn851. [PMID] 18996891.
2007
Identification and functional analysis of LsMNPV anti-apoptosis genes.
Journal of biochemistry and molecular biology. 40(4):571-6 [PMID] 17669274.

Grants

Aug 2023 ACTIVE
Metabolic control of vascular smooth muscle cell plasticity
Role: Principal Investigator
Funding: UNIV OF MISSOURI via NATL INST OF HLTH NHLBI

Education

PhD
2013 · University of Texas Health Science Center & MD Anderson Cancer Center
MS
2009 · Wuhan University
BS
2002 · Wuhan University

Contact Details

Phones:
Business:
(352) 273-5484
Emails:
Addresses:
Business Mailing:
P O Box 117450
GAINESVILLE FL 32611
Business Street:
1600 SW ARCHER RD
GAINESVILLE FL 32610