Selected Publications

Learn more about our lab’s research highlights below.

  1. Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation. Filiberto A, Spinosa M, Elder C, Leroy V, Mehaffey JH, Salmon MD, Ravichandran KS, Isakson BE, Upchurch, Jr., G.R., and Sharma AK. Nature Communications; PMID: 35315432; 2022.
  2. Maresin-1 activates LGR6 signaling to inhibit smooth muscle cell activation and attenuate abdominal aortic aneurysm formation. Elder C, Filiberto A, Su G, Ladd Z, Leroy V, Pruitt E, Lu G, Jiang Z, Sharma AK, Upchurch GR, Jr. FASEB, 2021 Aug;35(8):e21780.
  3. Pharmacologic inhibition of transient receptor channel vanilloid 4 attenuates abdominal aortic aneurysm formation. Shannon AH, Elder CT, Lu G, Su G, Mast A, Salmon MD, Montgomery WG, Spinosa MD, Upchurch Jr., GR, Sharma AK. FASEB; 2020 Jul;34(7):9787-9801
  4. Single-photon emission computed tomography imaging using formyl peptide receptor 1 ligand can diagnose aortic aneurysms in a mouse model. Shannon AH, Chordia MD, Spinosa MD, Su G, Ladd Z, Pan D, Upchurch Jr. GR, Sharma AK. J Surg Res., 2020 Jul;251:239-247.
  5. Resolvin D1 decreases abdominal aortic aneurysm formation by inhibiting NETosis in a mouse model. Spinosa MD, Su G, Salmon MD, Lu G, Cullen JM, Fashandi AZ, Hawkins RB, Montgomery W, Meher AK, Conte MS, Sharma AK, Ailawadi G, Upchurch Jr. GR. J Vasc Surg., 2018 Dec;68(6S):93S-103S.
  6. Tamsulosin attenuates abdominal aortic aneurysm growth. Montgomery WG, Spinosa MD, Cullen JM, Salmon MD, Su G, Hassinger T, Sharma AK, Lu G, Fashandi A, Ailawadi G, Upchurch GR Jr. Surgery. 2018;164(5):1087-1092
  7. Human mesenchymal stromal cell-derived extracellular vesicles attenuate aortic aneurysm formation and macrophage activation via microRNA-147. Spinosa M, Lu G, Su G, Bontha SV, Gehrau R, Salmon MD, Smith JR, Weiss ML, Mas VR, Upchurch GR Jr, Sharma AK. FASEB J. 2018 May 29 [Epub ahead of print]
  8. Novel Role of IL (Interleukin)-1β in Neutrophil Extracellular Trap Formation and Abdominal Aortic Aneurysms. Meher AK, Spinosa M, Davis JP, Pope N, Laubach VE, Su G, Serbulea V, Leitinger N, Ailawadi G, Upchurch GR Jr. Arterioscler Thromb Vasc Biol. 2018;38(4):843-853
  9. A novel reproducible model of aortic aneurysm rupture. Fashandi AZ, Hawkins RB, Salmon MD, Spinosa MD, Montgomery WG, Cullen JM, Lu G, Su G, Ailawadi G, Upchurch GR Jr. Surgery. 2018;163(2):397-403
  10. A novel chronic advanced staged abdominal aortic aneurysm murine model. Lu G, Su G, Davis JP, Schaheen B, Downs E, Roy RJ, Ailawadi G, Upchurch GR Jr. J Vas Surg. 2017;66(1):232-242.
  11. D-series resolvins inhibit murine abdominal aortic aneurysm formation and increase M2 macrophage polarization. Pope NH, Salmon M, Davis JP, Chatterjee A, Su G, Conte MS, Ailawadi G, Upchurch GR Jr. FASEB J. 2016;30(12):4192-4201
  12. B-Cell Depletion Promotes Aortic Infiltration of Immunosuppressive Cells and Is Protective of Experimental Aortic Aneurysm. Schaheen B, Downs EA, Serbulea V, Almenara CC, Spinosa M, Su G, Zhao Y, Srikakulapu P, Butts C, McNamara CA, Leitinger N, Upchurch GR Jr, Meher AK, Ailawadi G. Arterioscler Thromb Vasc Biol. 2016;36(11):2191-2202
  13. Mesenchymal Stem Cells Attenuate NADPH Oxidase-Dependent High Mobility Group Box 1 Production and Inhibit Abdominal Aortic Aneurysms. Sharma AK, Salmon MD, Lu G, Su G, Pope NH, Smith JR, Weiss ML, Upchurch GR Jr. Arterioscler Thromb Vasc Biol. 2016;36(5):908-18.
  14. Pharmacologic blockade and genetic deletion of androgen receptor attenuates aortic aneurysm formation. Davis JP, Salmon M, Pope NH, Lu G, Su G, Meher A, Ailawadi G, Upchurch GR Jr. J Vasc Surg. 2016;63(6):1602-1612.
  15. Utility of (18) F-FDG and (11)C-PBR28 microPET for the assessment of rat aortic aneurysm inflammation. English SJ, Diaz JA, Shao X, Gordon D, Bevard M, Su G, Henke PK, Rogers VE, Upchurch GR, Piert M. EJNMMI Res. 2014;4(1):20.
  16. Interleukin-6 Receptor Inhibition Prevents Descending Thoracic Aortic Aneurysm Formation. Pope NH, Salmon M, Johnston WF, Lu G, Lau CL, Upchurch GR Jr, Ailawadi G. Ann Thorac Surg. 2015;100(5):1620-6.
  17. Attenuation of aortic aneurysms with stem cells from different genders. Davis JP, Salmon M, Pope NH, Lu G, Su G, Sharma AK, Ailawadi G, Upchurch GR Jr. J Surg Res. 2015;199(1):249-58.
  18. Increased 18F-FDG Uptake Is Predictive of Rupture in a Novel Rat Abdominal Aortic Aneurysm Rupture Model. English SJ, Piert MR, Diaz JA, Gordon D, Ghosh A, Dʼalecy LG, Whitesall SE, Sharma AK, Deroo EP, Watt T, Su G, Henke PK, Eliason JL, Ailawadi G, Upchurch GR Jr. Ann Surg. 2015;261(2):395-404
  19. Phosphorylation of AKT and abdominal aortic aneurysm formation. Ghosh A, Lu G, Su G, McEvoy B, Sadiq O, Dimusto PD, Laser A, Futchko JS, Henke PK, Eliason JL, Upchurch GR Jr. Am J Pathol. 2014;184 (1):148-58.
  20. KLF4 regulates abdominal aortic aneurysm morphology and deletion attenuates aneurysm formation. Salmon M, Johnston WF, Woo A, Pope NH, Su G, Upchurch GR Jr, Owens GK, Ailawadi G. Circulation. 2013;128(11 Suppl 1):S163-74.
  21. Increased estrogen receptor alpha in experimental aortic aneurysms in females compared with males.Laser A, Ghosh A, Roelofs K, Sadiq O, McEvoy B, Dimusto P, Eliason J, Upchurch GR Jr. J Surg Res. 2014;186(1):467-74.
  22. Adenosine 2A receptor modulates inflammation and phenotype in experimental abdominal aortic aneurysms. Bhamidipati CM, Mehta GS, Moehle CW, Meher AK, Su G, Vigneshwar NG, Barbery C, Sharma AK, Kron IL, Laubach VE, Owens GK, Upchurch GR Jr, Ailawadi G. FASEB J. 2013;27(6):2122-31.
  23. Genetic and pharmacologic disruption of interleukin-1β signaling inhibits experimental aortic aneurysm formation. Johnston WF, Salmon M, Su G, Lu G, Stone ML, Zhao Y, Owens GK, Upchurch GR Jr, Ailawadi G. Arterioscler Thromb Vasc Biol. 2013;33(2):294-304.
  24. Experimental abdominal aortic aneurysm formation is mediated by IL-17 and attenuated by  mesenchymal stem cell treatment.  Sharma AK, Lu G, Jester A, Johnston WF, Zhao Y, Hajzus VA, Saadatzadeh MR, Su G, Bhamidipati    CM, Mehta GS, Kron IL, Laubach VE, Murphy MP, Ailawadi G, Upchurch GR Jr. Circulation. 2012;126(11 Suppl 1):S38-45.