References

PPM

• Making N-of-1 Medicine a Reality. Ho D, Zarrinpar A. SLAS Technol. 2017 Jun;22(3):231-232 
• Diamonds, Digital Health, and Drug Development: Optimizing Combinatorial Nanomedicine. Ho D, Zarrinpar A, Chow EK. ACS Nano. 2016 Sep 28

PPM Applications

Hepatocellular Carcinoma

• Aminoacylase 3 Is a New Potential Marker and Therapeutic Target in Hepatocellular Carcinoma. Tsirulnikov K, Duarte S, Ray A, Datta N, Zarrinpar A, Hwang L, Faull K, Pushkin A, Kurtz I. J Cancer. 2018 Jan 1;9(1):1-12

• Metabolic Pathway Inhibition in Liver Cancer. Zarrinpar A. SLAS Technol. 2017 Jun;22(3):237-244

Transplant Immunosuppression

• Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform. Zarrinpar A, Lee DK, Silva A, Datta N, Kee T, Eriksen C, Weigle K, Agopian V, Kaldas F, Farmer D, Wang SE, Busuttil R, Ho CM, Ho D. Sci Transl Med. 2016 Apr 6;8(333):333ra49

Immune metabolism

• The Therapeutic Potential of T Cell Metabolism. Zarrinpar A, Bensinger SJ. Am J Transplant. 2017 Jul;17(7):1705-1712

Immunology of Injury

• Recombinant Relaxin Protects Liver Transplants from Ischemia Damage via Hepatocyte Glucocorticoid Receptor: From Bench-to-Bedside. Kageyama S, Nakamura K, Fujii T, Ke B, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. Hepatology. 2018 Jan 19

• Heme oxygenase-1 regulates sirtuin-1-autophagy pathway in liver transplantation: From mouse to human. Nakamura K, Kageyama S, Yue S, Huang J, Fujii T, Ke B, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. Am J Transplant. 2018 May;18(5):1110-1121

• Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury. Nakamura K, Zhang M, Kageyama S, Ke B, Fujii T, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Araujo JA, Kupiec-Weglinski JW. J Hepatol. 2017 Dec;67(6):1232-1242

• Sirtuin 1 attenuates inflammation and hepatocellular damage in liver transplant ischemia/Reperfusion: From mouse to human.  Nakamura K, Kageyama S, Ke B, Fujii T, Sosa RA, Reed EF, Datta N, Zarrinpar A, Busuttil RW, Kupiec-Weglinski JW. Liver Transpl. 2017 Oct;23(10):1282-1293

• Early cytokine signatures of ischemia/reperfusion injury in human orthotopic liver transplantation. Sosa RA, Zarrinpar A, Rossetti M, Lassman CR, Naini BV, Datta N, Rao P, Harre N, Zheng Y, Spreafico R, Hoffmann A, Busuttil RW, Gjertson DW, Zhai Y, Kupiec-Weglinski JW, Reed EF. JCI Insight. 2016 Dec 8;1(20):e89679

Technology

• Intraoperative Laparoscopic Near-Infrared Fluorescence Cholangiography to Facilitate Anatomical Identification: When to Give Indocyanine Green and How Much. Zarrinpar A, Dutson EP, Mobley C, Busuttil RW, Lewis CE, Tillou A, Cheaito A, Hines OJ, Agopian VG, Hiyama DT. Surg Innov. 2016 Aug;23(4):360-5

• A rapid, reproducible, noninvasive predictor of liver graft survival. Zarrinpar A, Lee C, Noguchi E, Yersiz H, Agopian VG, Kaldas FM, Farmer DG, Busuttil RW. J Surg Res. 2015 Jul;197(1):183-90