Ali Zarrinpar

Ali Zarrinpar, MD, PhD

Associate Professor

Department: MD-SURGERY-GEN-TRANSPLANT
Business Phone: (352) 265-0606

About Ali Zarrinpar

Ali Zarrinpar, MD, PhD, is an associate professor in the Division of Transplantation and Hepatobiliary Surgery at the University of Florida College of Medicine. Dr. Zarrinpar earned his medical degree from the University of California, San Francisco, where he also obtained a doctorate degree in biochemistry. He completed a general surgery residency and a fellowship in multivisceral transplant and hepatobiliary surgery from the University of California, Los Angeles. Dr. Zarrinpar is a diplomate in general surgery through the American Board of Surgery and a fellow of the American College of Surgeons and a fellow of the American Society of Transplantation. He is also certified in multivisceral transplantation through the American Society of Transplant Surgeons.

Board Certifications

  • ABS
    American Board of Surgery

Clinical Profile

Specialties
  • Surgery
Subspecialties
  • Transplant Hepatology
  • Transplant Surgery
Areas of Interest
  • Bile duct obstruction
  • Bile duct stricture
  • Cholangiocarcinoma
  • Choledocholithiasis
  • Chronic cholecystitis
  • Hepatic hemangioma
  • Hepatic ischemia
  • Hepatic vein obstruction (Budd-Chiari)
  • Kidney transplant
  • Laparoscopic gallbladder removal
  • Liver biopsy
  • Liver cancer – hepatocellular carcinoma
  • Liver disease
  • Liver metastases
  • Liver transplant
  • Open gallbladder removal

Research Profile

Please see: https://surgery.med.ufl.edu/research/hepatobiliary-and-transplantation-laboratory/

Areas of Interest
  • Multivisceral Transplantation

Publications

2021
Inhibin-positive hepatic carcinoma: proposal for a solid-tubulocystic variant of intrahepatic cholangiocarcinoma.
Human pathology. 116:82-93 [DOI] 10.1016/j.humpath.2021.07.004. [PMID] 34298064.
2021
Racial Disparity in Liver Transplantation Listing.
Journal of the American College of Surgeons. 232(4):526-534 [DOI] 10.1016/j.jamcollsurg.2020.12.021. [PMID] 33444709.
2021
The Sobering Complexities of Alcoholic Liver Disease and Decisions for Transplant.
JAMA surgery. [DOI] 10.1001/jamasurg.2021.3749. [PMID] 34379089.
2020
Delayed Implantation of Pumped Kidneys Decreases Renal Allograft Futility in Combined Liver-Kidney Transplantation.
Transplantation. 104(8):1591-1603 [DOI] 10.1097/TP.0000000000003040. [PMID] 32732836.
2020
Enabling Technologies for Personalized and Precision Medicine.
Trends in biotechnology. 38(5):497-518 [DOI] 10.1016/j.tibtech.2019.12.021. [PMID] 31980301.
2020
Liver-on-a-Chip Models of Fatty Liver Disease.
Hepatology (Baltimore, Md.). 71(2):733-740 [DOI] 10.1002/hep.31106. [PMID] 31909504.
2020
Recent advances in precision medicine for individualized immunosuppression.
Current opinion in organ transplantation. 25(4):420-425 [DOI] 10.1097/MOT.0000000000000771. [PMID] 32520785.
2020
What Can We Learn About Drug Safety and Other Effects in the Era of Electronic Health Records and Big Data That We Would Not Be Able to Learn From Classic Epidemiology?
The Journal of surgical research. 246:599-604 [DOI] 10.1016/j.jss.2019.09.053. [PMID] 31653413.
2019
A Targeted Swallow Screen for the Detection of Postoperative Dysphagia in Liver Transplant Patients.
Progress in transplantation (Aliso Viejo, Calif.). 29(1):4-10 [DOI] 10.1177/1526924818817035. [PMID] 30514164.
2019
Factors predicting kidney delayed graft function among recipients of simultaneous liver-kidney transplantation: A single-center experience.
Clinical transplantation. 33(6) [DOI] 10.1111/ctr.13569. [PMID] 31006141.
2019
Metabolic factors affecting hepatocellular carcinoma in steatohepatitis.
Liver international : official journal of the International Association for the Study of the Liver. 39(3):531-539 [DOI] 10.1111/liv.14002. [PMID] 30427105.
2019
Quantitative Measure of Intestinal Permeability Using Blue Food Coloring.
The Journal of surgical research. 233:20-25 [DOI] 10.1016/j.jss.2018.07.005. [PMID] 30502249.
2018
Aminoacylase 3 Is a New Potential Marker and Therapeutic Target in Hepatocellular Carcinoma.
Journal of Cancer. 9(1):1-12 [DOI] 10.7150/jca.21747. [PMID] 29290764.
2018
Evaluation Of Early Allograft Function Using The Liver Graft Assessment Following Transplantation Risk Score Model.
Jama Surgery. 153(5):436-444 [DOI] 10.1001/jamasurg.2017.5040. [PMID] 29261831.
2018
Heme Oxygenase-1 Regulates Sirtuin-1-Autophagy Pathway in Liver Transplantation: From Mouse to Human
American Journal of Transplantation. 18(5):1110-1121 [DOI] 10.1111/ajt.14586. [PMID] 29136322.
2018
Hepatocyte transplantation: past efforts, current technology, and future expansion of therapeutic potential.
The Journal of surgical research. 226:48-55 [DOI] 10.1016/j.jss.2018.01.031. [PMID] 29661288.
2018
Recombinant Relaxin Protects Liver Transplants From Ischemia Damage By Hepatocyte Glucocorticoid Receptor: From Bench-To-Bedside.
Hepatology. 68(1):258-273 [DOI] 10.1002/hep.29787. [PMID] 29350771.
2017
Avoiding Futility in Simultaneous Liver-kidney Transplantation: Analysis of 331 Consecutive Patients Listed for Dual Organ Replacement.
Annals of surgery. 265(5):1016-1024 [DOI] 10.1097/SLA.0000000000001801. [PMID] 27232249.
2017
Bruton Tyrosine Kinase Inhibition Attenuates Liver Damage in a Mouse Warm Ischemia and Reperfusion Model.
Transplantation. 101(2):322-331 [DOI] 10.1097/TP.0000000000001552. [PMID] 27820779.
2017
Determination of hepatocellular carcinoma grade by needle biopsy is unreliable for liver transplant candidate selection.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 23(9):1123-1132 [DOI] 10.1002/lt.24811. [PMID] 28688158.
2017
Evaluation of Patients With Hepatocellular Carcinomas That Do Not Produce α-Fetoprotein.
JAMA surgery. 152(1):55-64 [DOI] 10.1001/jamasurg.2016.3310. [PMID] 27706479.
2017
Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury.
Journal of hepatology. 67(6):1232-1242 [DOI] 10.1016/j.jhep.2017.08.010. [PMID] 28842295.
2017
Making N-of-1 Medicine a Reality.
SLAS technology. 22(3):231-232 [DOI] 10.1177/2472630317702449. [PMID] 28520523.
2017
Metabolic Pathway Inhibition in Liver Cancer.
SLAS technology. 22(3):237-244 [DOI] 10.1177/2472630317698683. [PMID] 28314110.
2017
Peritransplant pancreatitis: A marker of high mortality and graft failure in liver transplant patients.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 23(7):925-932 [DOI] 10.1002/lt.24760. [PMID] 28294516.
2017
Safety and Efficacy of Electromagnetic-Guided Bedside Placement of Nasoenteral Feeding Tubes versus Standard Placement.
The American surgeon. 83(10):1184-1187 [PMID] 29391121.
View on: PubMed
2017
Sirtuin 1 attenuates inflammation and hepatocellular damage in liver transplant ischemia/Reperfusion: From mouse to human.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 23(10):1282-1293 [DOI] 10.1002/lt.24821. [PMID] 28719070.
2017
The Therapeutic Potential of T Cell Metabolism.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 17(7):1705-1712 [DOI] 10.1111/ajt.14149. [PMID] 27931083.
2016
Diamonds, Digital Health, and Drug Development: Optimizing Combinatorial Nanomedicine.
ACS nano. 10(10):9087-9092 [DOI] 10.1021/acsnano.6b06174. [PMID] 27682869.
2016
Early cytokine signatures of ischemia/reperfusion injury in human orthotopic liver transplantation.
JCI insight. 1(20) [DOI] 10.1172/jci.insight.89679. [PMID] 27942590.
2016
Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform.
Science translational medicine. 8(333) [DOI] 10.1126/scitranslmed.aac5954. [PMID] 27053773.
2016
Intraoperative Laparoscopic Near-Infrared Fluorescence Cholangiography to Facilitate Anatomical Identification: When to Give Indocyanine Green and How Much.
Surgical innovation. 23(4):360-5 [DOI] 10.1177/1553350616637671. [PMID] 26964557.
2016
Mind MELD or Ignore It at Your Peril.
JAMA surgery. 151(7) [DOI] 10.1001/jamasurg.2016.0839. [PMID] 27191733.
2016
Portable device for the analysis of liver function: a boon to liver surgery and critical care.
Expert review of medical devices. 13(1):1-4 [DOI] 10.1586/17434440.2016.1126178. [PMID] 26613130.
2016
Quantification of hepatic functional capacity: a call for standardization.
Expert review of gastroenterology & hepatology. 10(1):9-11 [DOI] 10.1586/17474124.2016.1116938. [PMID] 26561002.
2016
TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice.
Gastroenterology. 150(3):707-19 [DOI] 10.1053/j.gastro.2015.11.002. [PMID] 26582088.
2015
A novel prognostic nomogram accurately predicts hepatocellular carcinoma recurrence after liver transplantation: analysis of 865 consecutive liver transplant recipients.
Journal of the American College of Surgeons. 220(4):416-27 [DOI] 10.1016/j.jamcollsurg.2014.12.025. [PMID] 25690672.
2015
A rapid, reproducible, noninvasive predictor of liver graft survival.
The Journal of surgical research. 197(1):183-90 [DOI] 10.1016/j.jss.2015.03.093. [PMID] 25940156.
2015
A Surgical Perspective on Targeted Therapy of Hepatocellular Carcinoma.
Diseases (Basel, Switzerland). 3(4):221-252 [DOI] 10.3390/diseases3040221. [PMID] 28943622.
2015
Acetaminophen hepatotoxicity: an updated review.
Archives of toxicology. 89(2):193-9 [DOI] 10.1007/s00204-014-1432-2. [PMID] 25537186.
2015
Complete pathologic response to pretransplant locoregional therapy for hepatocellular carcinoma defines cancer cure after liver transplantation: analysis of 501 consecutively treated patients.
Annals of surgery. 262(3):536-45; discussion 543 [DOI] 10.1097/SLA.0000000000001384. [PMID] 26258323.
2015
Damage Control as a Strategy to Manage Postreperfusion Hemodynamic Instability and Coagulopathy in Liver Transplant.
JAMA surgery. 150(11):1066-72 [DOI] 10.1001/jamasurg.2015.1853. [PMID] 26308380.
2015
Liver transplantation: Evading antigens-ABO-incompatible liver transplantation.
Nature reviews. Gastroenterology & hepatology. 12(12):676-8 [DOI] 10.1038/nrgastro.2015.193. [PMID] 26577350.
2015
RE: Anesthetic Management for Resection of Hepatic Paraganglioma Metastatic From the Donor Organ in an Orthotopic Liver Transplant Recipient: A Case Report.
Transplantation proceedings. 47(6):2072-3 [DOI] 10.1016/j.transproceed.2015.07.012. [PMID] 26293099.
2014
Digital quantitation of HCC-associated stem cell markers and protein quality control factors using tissue arrays of human liver sections.
Experimental and molecular pathology. 97(3):399-410 [DOI] 10.1016/j.yexmp.2014.09.002. [PMID] 25218810.
2014
Liver transplantation in recipients receiving renal replacement therapy: outcomes analysis and the role of intraoperative hemodialysis.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 14(7):1638-47 [DOI] 10.1111/ajt.12759. [PMID] 24854341.
2014
Reoperative complications after primary orthotopic liver transplantation: a contemporary single-center experience in the post-model for end-stage liver disease era.
Journal of the American College of Surgeons. 219(5):993-1000 [DOI] 10.1016/j.jamcollsurg.2014.07.005. [PMID] 25127506.
2013
Assessment of hepatic steatosis by transplant surgeon and expert pathologist: a prospective, double-blind evaluation of 201 donor livers.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 19(4):437-49 [DOI] 10.1002/lt.23615. [PMID] 23408461.
2013
Liver transplantation for lethal genetic syndromes: a novel model of personalized genomic medicine.
Journal of the American College of Surgeons. 216(4):534-43; discussion 543 [DOI] 10.1016/j.jamcollsurg.2012.12.050. [PMID] 23521929.
2013
Liver transplantation: past, present and future.
Nature reviews. Gastroenterology & hepatology. 10(7):434-40 [DOI] 10.1038/nrgastro.2013.88. [PMID] 23752825.
2013
The evolution of liver transplantation during 3 decades: analysis of 5347 consecutive liver transplants at a single center.
Annals of surgery. 258(3):409-21 [DOI] 10.1097/SLA.0b013e3182a15db4. [PMID] 24022434.
2012
Immunomodulating options for liver transplant patients.
Expert review of clinical immunology. 8(6):565-78; quiz 578 [PMID] 22992151.
View on: PubMed
2012
Liver transplantation for nonalcoholic steatohepatitis: the new epidemic.
Annals of surgery. 256(4):624-33 [DOI] 10.1097/SLA.0b013e31826b4b7e. [PMID] 22964732.
2012
Pneumothorax ex-vacuo or “trapped lung” in the setting of hepatic hydrothorax.
BMC pulmonary medicine. 12 [DOI] 10.1186/1471-2466-12-78. [PMID] 23244504.
2012
Review article: the emerging interplay among the gastrointestinal tract, bile acids and incretins in the pathogenesis of diabetes and non-alcoholic fatty liver disease.
Alimentary pharmacology & therapeutics. 36(10):909-21 [DOI] 10.1111/apt.12084. [PMID] 23057494.
2012
What is the prognosis after retransplantation of the liver?
Advances in surgery. 46:87-100 [PMID] 22873034.
View on: PubMed
2011
Liver transplantation for hepatocellular carcinoma: an update.
Hepatobiliary & pancreatic diseases international : HBPD INT. 10(3):234-42 [PMID] 21669564.
View on: PubMed
2011
Liver transplantation: Toward a unified allocation system.
Nature reviews. Gastroenterology & hepatology. 8(10):542-3 [DOI] 10.1038/nrgastro.2011.163. [PMID] 21970965.
2010
Functional cortical neoplasms.
Cancer treatment and research. 153:163-86 [DOI] 10.1007/978-1-4419-0857-5_10. [PMID] 19957225.
2007
Liver transplantation for HELLP syndrome.
The American surgeon. 73(10):1013-6 [PMID] 17983071.
View on: PubMed
2006
Sharp recanalization of a short esophageal occluding stricture in a patient with epidermolysis bullosa.
Gastrointestinal endoscopy. 64(5):793-6 [PMID] 17055877.
View on: PubMed
2005
A guide to antibiotics for the interventional radiologist.
Seminars in interventional radiology. 22(2):69-79 [DOI] 10.1055/s-2005-871861. [PMID] 21326676.
2004
Sho1 and Pbs2 act as coscaffolds linking components in the yeast high osmolarity MAP kinase pathway.
Molecular cell. 14(6):825-32 [PMID] 15200959.
View on: PubMed
2003
Optimization of specificity in a cellular protein interaction network by negative selection.
Nature. 426(6967):676-80 [PMID] 14668868.
View on: PubMed
2003
Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms.
Science (New York, N.Y.). 299(5609):1061-4 [PMID] 12511654.
View on: PubMed
2003
The structure and function of proline recognition domains.
Science's STKE : signal transduction knowledge environment. 2003(179) [PMID] 12709533.
View on: PubMed
2000
Converging on proline: the mechanism of WW domain peptide recognition.
Nature structural biology. 7(8):611-3 [PMID] 10932238.
View on: PubMed
1999
NMR structure of the mature dimer initiation complex of HIV-1 genomic RNA.
FEBS letters. 458(3):387-92 [PMID] 10570946.
View on: PubMed

Grants

Sep 2020 – Aug 2021
Utilization of Phenotypic Precision Medicine to Identify Optimal Drug Combinations for the Treatment of Hepatocellular Carcinoma
Role: Principal Investigator
Funding: NATL INST OF HLTH NCATS
Jul 2020 ACTIVE
2020 ASTA-Natera Research Grant: Using Phenotypic Precision Medicine to Individualize Immunosuppression Based on Quantifiable Markers of Immune Response and Allograft Injury
Role: Principal Investigator
Funding: AMER SOC OF TRANSPLANT PHYS
Jul 2020 ACTIVE
Innovative techniques for organ preservation, repair and reconditioning
Role: Principal Investigator
Funding: American Society of Transplant Surgeons
Jul 2020 – Jun 2021
Microbial DNA as Diagnostic Marker for Hepatocellular Carcinoma
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN DIEGO via Prevent Cancer Foundation
Sep 2019 ACTIVE
Diversity Supplement: Novel Pathways in the Pathogenesis and Pathophysiology of NAFLD in Hispanics
Role: Other
Funding: OHIO UNIV via NATL INST OF HLTH NIMHD
Aug 2019 ACTIVE
Duggan Fund – Research Project
Role: Principal Investigator
Funding: UF FOU via DUGGAN LIVER CANCER AND TRANSPLANT FUND
Mar 2019 ACTIVE
Novel pathways in the pathogenesis and pathophysiology of NAFLD in Hispanics
Role: Principal Investigator
Funding: OHIO UNIV via NATL INST OF HLTH NIMHD
Sep 2018 – Aug 2021
Optimizing Immunosuppression Drug Dosing via Phenotypic Precision Medicine
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2017 – Aug 2020
Utilization of Phenotypic Precision Medicine to Identify Optimal Drug Combinations for the Treatment of Hepatocellular Carcinoma
Role: Principal Investigator
Funding: NATL INST OF HLTH NCATS
Sep 2017 ACTIVE
Ischemia-reperfusion injury in liver transplantation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2017 – Aug 2017
Quantitative Evaluation of Donor Liver Grafts
Role: Principal Investigator
Funding: ONELEGACY FOUNDATION
Jun 2017 – Jun 2019
2016 ASTS-Astellas Faculty Development Grant: Role of Neutrophil Activation in Ischemia Reperfusion Injury
Role: Principal Investigator
Funding: American Society of Transplant Surgeons

Education

MD
2005 · UCSF
PhD
2003 · UCSF

Teaching Profile

Courses Taught
2020
BCH6208 Advanced Metabolism: Regulation of Key Reactions in Carbohydrate and Lipid Metabolism
2020
BCH6207 Advanced Metabolism: Role of Membranes in Signal Transduction and Metabolic Control
2020-2021
BCH6206 Advanced Metabolism
2020-2021
GMS6905 Independent Studies in Medical Sciences
2018
MDC7600 Surgery Clerkship
2021
BCH4905 Biochemistry Senior Research

Contact Details

Phones:
Business:
(352) 265-0606
Emails:
Office Manager: