Lyle L Moldawer

Lyle L Moldawer, PhD

Professor

Department: MD-SURGERY-TRAUMA
Business Phone: (352) 265-0494
Business Email: moldawer@surgery.ufl.edu

About Lyle L Moldawer

Dr. Moldawer is currently a professor in the department of surgery at the University of Florida College of Medicine. He is the former Robert H and Kathleen M Axline Endowed Research Professor in the UF College of Medicine. He is currently the Director of the Sepsis and Critical Illness Research Center, and emeritus director of the Laboratory of Inflammation Biology and Surgical Science. He has been on the UF College of Medicine faculty since 1993. Prior to that, he was on the faculty of the Weil College of Medicine at Cornell University where he joined the faculty in 1987, rising to the rank of Associate Professor of Surgery, and Cell Biology. He completed his Ph.D. degree from the Medical Faculty of Gotesborgs Universitet, Gotesborg, SWEDEN in 1986 (academic year 1987).

Accomplishments

University of Florida Research Foundation Professor
2019-2021 · University of Florida
Robert H and Kathleen M Axline Endowed Research Professor
2014-2019 · University of Florida College of Medicine
University of Florida Research Foundation Professor
2014-2016 · University of Florida
University of Florida Research Foundation Professor
2009-2011 · University of Florida
Scientific Achievement Award
2009 · Shock SOciety
President Machen Faculty Achievement Recognition
2007 · University of Florida
College of Medicine Faculty Research Prize
2004 · University of Florida
NIGMS MERIT AWARD
1998-2007 · National Institute of General Medical Sciences
Distinguished Faculty Award
1998 · Blue Key
Lester Dragsted Scientist-Physician Award
1998 · Department of Surgery, University of Florida College of Medicine

Teaching Profile

Teaching Philosophy
Dr. Moldawer served for 23 years as the Program Director for a post-doctoral training grant from the NIGMS. The program provides M.D.’s from accredited programs in General Surgery or other intensive care disciplines with a 2-4 year research experience in the laboratory of an established research mentor. Past trainees have had the opportunity to complete an M.S., M.P.H and Ph.D. during their training period.

Research Profile

For the past 30 years, Dr. Moldawer has been conducting inflammation research, and exploring the inflammatory response to trauma, sepsis and burn injury. Funded continuously by the NIH (R01) since 1988, Dr. Moldawer is a past NIH MERIT Award recipient, and has been the past chairman of the Surgery, Anesthesiology and Trauma Study Section at CSR/NIH. Since 1986, Dr. Moldawer was one of the first to describe the “cytokine storm” and first report the plasma appearance of several inflammatory mediators in human disease, including IL-6, sTNFRI, sTNFRII, IL-1ra and sIL1RII. In 2011, as a member of the Glue Grant, he was one of the first to describe the human host response to severe trauma and burns as a “genomic storm”, demonstrating in the blood leukocyte that 70% of the leukocyte transcriptome changed in response to trauma. Over the past ten years, he has branched out examining the communication between innate and adaptive immunity in the septic and traumatized young adult and the aged.

Dr. Moldawer was one of the first to argue that dysregulated ‘emergency myelopoiesis’ contributes to the loss of protective immunity in these at-risk populations. In 2007, he was the first to demonstrate the expansion of an immature myeloid population, designated myeloid-derived suppressor cells (MDSC), in severe sepsis, and postulated that they contributed to post-sepsis, post-trauma immune suppression. He and Dr. Efron confirmed these findings in humans in 2016.

In 2012, Dr. Moldawer, in collaboration with Dr. Frederick Moore, described a new syndrome, entitled PICS (a persistent inflammatory/immune-suppressive catabolic state) in severe sepsis and trauma. The syndrome has become the predominant phenotype of severely traumatized sepsis and trauma patients who survive their initial event. Dr. Moldawer’s current research interest is focused on the underlying mechanisms that drive chronic critical illness in patients who have severe trauma or sepsis. Specifically, he is focused on the myelopoietic dyscrasia that results in a preferential myelopoiesis and the dramatic increase in “pathologically-activated myeloid cells”, myeloid-derived suppressor cells (MDSC).

In 2016, Dr. Moldawer and Dr. Frederick A. Moore established the University-recognized “Sepsis and Critical Illness Research Center” (SCIRC). SCIRC is focused on the mechanisms of chronic inflammation and immunosuppression that result from severe sepsis and trauma, especially in the aged. It is focused on ‘induced-frailty’ as a long-term outcome in patients with severe sepsis and trauma.

In July, 2019, Dr. Moldawer voluntarily resigned his endowed chair, his vice chair of the department of surgery, and his vice chair of the UF IACUC (as well as all other college of medicine responsibilities). He turned over the directorship of the Laboratory of Inflammation Biology and Surgical Science to Dr. Efron. His only University responsibility (0.9 FTE) is research and T32 training, and his primary focus is the mechanistic clinical studies in severe sepsis and trauma. He continues to oversee his T32 that he has had for 24 years (T32 GM008721, Molecular Biology and Gene Therapy in Burns and Trauma), the training of surgical residents in research. In addition, Dr. Moldawer serves on the executive committee and internal advisory committee for a new T32 (PARADIGM T32 HG008958-01A1) training program in genomics and genetics. The program is focused on providing clinical doctorates (M.D., Pharm.D.) with an intense two year training into the future of genetic and genomic analyses in the diagnosis and therapeutic interventions in hospitalized patients. To date, three surgical residents have enrolled in the program, and one has completed his tenure.

In 2021, Dr. Moldawer was awarded a new 5 year RM1 Program award focused on the pathological activation of myelopoiesis in severe trauma and sepsis (RM1 GM139690,Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology). The study is focused on understanding the immunological endotype that drives the clinical phenotype of ‘chronic critical illness’ in survivors of severe blunt trauma and sepsis. The overarching hypothesis is that dyscratic myelopoiesis and dysfunctional myeloid pathological activation drives this immunological endotype of persistent inflammation, immunosuppression and protein catabolism (PICS) similar to that seen in advanced cancers, autoimmune disease and chronic organ dysfunction, including chronic renal and obstructive pulmonary disease and congestive heart failure.

Areas of Interest
  • Critical care monitoring
  • Inflammation biology
  • Innate immunity
  • Neonatal Sepsis
  • Sepsis
  • Trauma and Shock
Open Researcher and Contributor ID (ORCID)

0000-0002-9041-9838

Publications

2022
Chronic Critical Illness in Patients With Sepsis is Associated With Persistent Anemia, Inflammation, and Impaired Functional Outcomes.
The American surgeon. [DOI] 10.1177/00031348221104252. [PMID] 35593749.
2022
Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study.
Annals of surgery. 275(6):1184-1193 [DOI] 10.1097/SLA.0000000000004360. [PMID] 33196489.
2022
Correction to: Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications.
BMC infectious diseases. 22(1) [DOI] 10.1186/s12879-022-07563-4. [PMID] 35799137.
2022
Evaluation of a Multivalent Transcriptomic Metric for Diagnosing Surgical Sepsis and Estimating Mortality Among Critically Ill Patients.
JAMA network open. 5(7) [DOI] 10.1001/jamanetworkopen.2022.21520. [PMID] 35819783.
2022
Ineffective Erythropoietin Response to Anemia in Sepsis.
Surgical infections. 23(2):142-149 [DOI] 10.1089/sur.2021.152. [PMID] 34958257.
2022
Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis.
Aging. 14(2):728-746 [DOI] 10.18632/aging.203868. [PMID] 35094981.
2022
Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications.
BMC infectious diseases. 22(1) [DOI] 10.1186/s12879-022-07526-9. [PMID] 35725405.
2022
Older Adults Demonstrate Biomarker Evidence of the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) After Sepsis.
The journals of gerontology. Series A, Biological sciences and medical sciences. 77(1):188-196 [DOI] 10.1093/gerona/glab080. [PMID] 33721883.
2022
Redefining critical illness.
Nature medicine. 28(6):1141-1148 [DOI] 10.1038/s41591-022-01843-x. [PMID] 35715504.
2022
Sex differences associate with late microbiome alterations after murine surgical sepsis.
The journal of trauma and acute care surgery. 93(2):137-146 [DOI] 10.1097/TA.0000000000003599. [PMID] 35324554.
2021
A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes.
Critical care (London, England). 25(1) [DOI] 10.1186/s13054-021-03757-5. [PMID] 34535154.
2021
A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis.
Frontiers in immunology. 12 [DOI] 10.3389/fimmu.2021.696536. [PMID] 34484194.
2021
A road map from single-cell transcriptome to patient classification for the immune response to trauma
JCI Insight. 6(2) [DOI] 10.1172/jci.insight.145108. [PMID] 33320841.
2021
A Transcriptomic Severity Metric That Predicts Clinical Outcomes in Critically Ill Surgical Sepsis Patients.
Critical care explorations. 3(10) [DOI] 10.1097/CCE.0000000000000554. [PMID] 34671746.
2021
A Whole Blood Enzyme-Linked Immunospot Assay for Functional Immune Endotyping of Septic Patients
The Journal of Immunology. 206(1):23-36 [DOI] 10.4049/jimmunol.2001088. [PMID] 33239423.
2021
Aluminum Adjuvant Improves Survival Via NLRP3 Inflammasome and Myeloid Non-Granulocytic Cells in a Murine Model of Neonatal Sepsis.
Shock (Augusta, Ga.). 55(2):274-282 [DOI] 10.1097/SHK.0000000000001623. [PMID] 32769820.
2021
Biomarker Evidence of the Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) in Chronic Critical Illness (CCI) After Surgical Sepsis.
Annals of surgery. 274(4):664-673 [DOI] 10.1097/SLA.0000000000005067. [PMID] 34506322.
2021
Cecal Slurry Injection in Neonatal and Adult Mice.
Methods in molecular biology (Clifton, N.J.). 2321:27-41 [DOI] 10.1007/978-1-0716-1488-4_4. [PMID] 34048005.
2021
Chronic critical illness after hypothermia in trauma patients.
Trauma surgery & acute care open. 6(1) [DOI] 10.1136/tsaco-2021-000747. [PMID] 34423134.
2021
Chronic Critical Illness Elicits a Unique Circulating Leukocyte Transcriptome in Sepsis Survivors.
Journal of clinical medicine. 10(15) [DOI] 10.3390/jcm10153211. [PMID] 34361995.
2021
Distinct immunologic endotypes are associated with clinical trajectory after severe blunt trauma and hemorrhagic shock.
The journal of trauma and acute care surgery. 90(2):257-267 [DOI] 10.1097/TA.0000000000003029. [PMID] 33214489.
2021
Dysregulated Immunity and Immunotherapy after Sepsis.
Journal of clinical medicine. 10(8) [DOI] 10.3390/jcm10081742. [PMID] 33920518.
2021
Identification of unique microRNA expression patterns in bone marrow hematopoietic stem and progenitor cells after hemorrhagic shock and multiple injuries in young and old adult mice.
The journal of trauma and acute care surgery. 91(4):692-699 [DOI] 10.1097/TA.0000000000003350. [PMID] 34252063.
2021
Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case Report.
Critical care explorations. 3(7) [DOI] 10.1097/CCE.0000000000000500. [PMID] 34345826.
2021
Lipid and Lipoprotein Dysregulation in Sepsis: Clinical and Mechanistic Insights into Chronic Critical Illness.
Journal of clinical medicine. 10(8) [DOI] 10.3390/jcm10081693. [PMID] 33920038.
2021
Lipid and lipoprotein predictors of functional outcomes and long-term mortality after surgical sepsis.
Annals of intensive care. 11(1) [DOI] 10.1186/s13613-021-00865-x. [PMID] 34018068.
2021
Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course Analysis.
Frontiers in immunology. 12 [DOI] 10.3389/fimmu.2021.792448. [PMID] 34956225.
2021
Reply to “Do Not Blame the Rodent for the Failure of Developing Sepsis Therapies”.
Shock (Augusta, Ga.). 56(1):152-153 [DOI] 10.1097/SHK.0000000000001688. [PMID] 33156239.
2021
Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice.
Shock (Augusta, Ga.). 55(4):519-525 [DOI] 10.1097/SHK.0000000000001648. [PMID] 32826817.
2021
Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research.
Critical care explorations. 3(3) [DOI] 10.1097/CCE.0000000000000374. [PMID] 33786450.
2021
Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study.
Shock (Augusta, Ga.). 55(5):587-595 [DOI] 10.1097/SHK.0000000000001671. [PMID] 33021571.
2021
The Effect of Aging Physiology on Critical Care.
Critical care clinics. 37(1):135-150 [DOI] 10.1016/j.ccc.2020.08.006. [PMID] 33190766.
2021
The impact of sarcopenia and acute muscle mass loss on long-term outcomes in critically ill patients with intra-abdominal sepsis.
Journal of cachexia, sarcopenia and muscle. 12(5):1203-1213 [DOI] 10.1002/jcsm.12752. [PMID] 34196134.
2021
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35(2) [DOI] 10.1096/fj.202002150R. [PMID] 33140449.
2020
Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes.
American journal of surgery. 220(6):1467-1474 [DOI] 10.1016/j.amjsurg.2020.07.016. [PMID] 32807383.
2020
Effect of Beta-Blockade on the Expression of Regulatory MicroRNA after Severe Trauma and Chronic Stress.
Journal of the American College of Surgeons. 230(1):121-129 [DOI] 10.1016/j.jamcollsurg.2019.09.011. [PMID] 31672639.
2020
Immunological Endotyping of Chronic Critical Illness After Severe Sepsis.
Frontiers in medicine. 7 [DOI] 10.3389/fmed.2020.616694. [PMID] 33659259.
2020
Immunotherapies for COVID-19: lessons learned from sepsis.
The Lancet. Respiratory medicine. 8(10):946-949 [DOI] 10.1016/S2213-2600(20)30217-4. [PMID] 32444269.
2020
Lipid intensive drug therapy for sepsis pilot: A Bayesian phase I clinical trial.
Journal of the American College of Emergency Physicians open. 1(6):1332-1340 [DOI] 10.1002/emp2.12237. [PMID] 33392541.
2020
Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.
Journal of the American Geriatrics Society. 68(9):1962-1969 [DOI] 10.1111/jgs.16435. [PMID] 32294254.
2020
Persistently increased cell-free DNA concentrations only modestly contribute to outcome and host response in sepsis survivors with chronic critical illness.
Surgery. 167(3):646-652 [DOI] 10.1016/j.surg.2019.11.018. [PMID] 31898953.
2020
Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study.
Critical care (London, England). 24(1) [DOI] 10.1186/s13054-020-02917-3. [PMID] 32381107.
2020
Prospective Validation of a Transcriptomic Metric in Severe Trauma.
Annals of surgery. 271(5):802-810 [DOI] 10.1097/SLA.0000000000003204. [PMID] 30688688.
2020
Severe immunosuppression and not a cytokine storm characterize COVID-19 infections
JCI Insight. 5(17) [DOI] 10.1172/jci.insight.140329. [PMID] 32687484.
2019
A checkpoint on innate myeloid cells in pulmonary arterial hypertension.
Pulmonary circulation. 9(1) [DOI] 10.1177/2045894018823528. [PMID] 30562157.
2019
Age and Sex Influence the Hippocampal Response and Recovery Following Sepsis.
Molecular neurobiology. 56(12):8557-8572 [DOI] 10.1007/s12035-019-01681-y. [PMID] 31278440.
2019
Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma.
Scientific reports. 9(1) [DOI] 10.1038/s41598-019-50044-z. [PMID] 31541163.
2019
Current Epidemiology of Surgical Sepsis: Discordance Between Inpatient Mortality and 1-year Outcomes.
Annals of surgery. 270(3):502-510 [DOI] 10.1097/SLA.0000000000003458. [PMID] 31356275.
2019
Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab.
Intensive care medicine. 45(10):1360-1371 [DOI] 10.1007/s00134-019-05704-z. [PMID] 31576433.
2019
Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559).
Critical care medicine. 47(5):632-642 [DOI] 10.1097/CCM.0000000000003685. [PMID] 30747773.
2019
LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock.
BMJ open. 9(9) [DOI] 10.1136/bmjopen-2019-029348. [PMID] 31537565.
2019
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.
Critical care (London, England). 23(1) [DOI] 10.1186/s13054-019-2628-x. [PMID] 31722736.
2019
Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.
Critical care medicine. 47(11):e919-e929 [DOI] 10.1097/CCM.0000000000003926. [PMID] 31389840.
2019
Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints.
Shock (Augusta, Ga.). 51(1):10-22 [DOI] 10.1097/SHK.0000000000001243. [PMID] 30106874.
2019
Persistent inflammation and anemia among critically ill septic patients.
The journal of trauma and acute care surgery. 86(2):260-267 [DOI] 10.1097/TA.0000000000002147. [PMID] 30489504.
2019
Persistently Elevated Glucagon-Like Peptide-1 Levels among Critically Ill Surgical Patients after Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes.
Journal of the American College of Surgeons. 229(1):58-67.e1 [DOI] 10.1016/j.jamcollsurg.2019.04.014. [PMID] 30991107.
2019
Premise for Standardized Sepsis Models.
Shock (Augusta, Ga.). 51(1):4-9 [DOI] 10.1097/SHK.0000000000001164. [PMID] 29877959.
2019
Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors.
Critical care (London, England). 23(1) [DOI] 10.1186/s13054-019-2505-7. [PMID] 31234943.
2019
The authors reply.
Critical care medicine. 47(9):e788-e789 [DOI] 10.1097/CCM.0000000000003887. [PMID] 31415323.
2019
What’s New in Shock, February 2019?
Shock (Augusta, Ga.). 51(2):143-146 [DOI] 10.1097/SHK.0000000000001292. [PMID] 30640890.
2018
A community approach to mortality prediction in sepsis via gene expression analysis.
Nature communications. 9(1) [DOI] 10.1038/s41467-018-03078-2. [PMID] 29449546.
2018
Adjuvant pretreatment with alum protects neonatal mice in sepsis through myeloid cell activation.
Clinical and experimental immunology. 191(3):268-278 [DOI] 10.1111/cei.13072. [PMID] 29052227.
2018
Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.
The journal of trauma and acute care surgery. 84(2):342-349 [DOI] 10.1097/TA.0000000000001758. [PMID] 29251709.
2018
Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.01511. [PMID] 30013565.
2018
Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.
Infection. 46(5):745-747 [DOI] 10.1007/s15010-018-1197-2. [PMID] 30225655.
2018
Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult.
Current opinion in hematology. 25(1):37-43 [DOI] 10.1097/MOH.0000000000000395. [PMID] 29035909.
2018
Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis.
Shock (Augusta, Ga.). 49(3):249-258 [DOI] 10.1097/SHK.0000000000000981. [PMID] 28885387.
2018
HDL Cholesterol Efflux is Impaired in Older Patients with Early Sepsis: A Subanalysis of a Prospective Pilot Study.
Shock (Augusta, Ga.). 50(1):66-70 [DOI] 10.1097/SHK.0000000000001030. [PMID] 29049133.
2018
HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock.
PloS one. 13(9) [DOI] 10.1371/journal.pone.0203813. [PMID] 30216360.
2018
Hyperacute Monocyte Gene Response Patterns Are Associated With Lower Extremity Vein Bypass Graft Failure.
Circulation. Genomic and precision medicine. 11(3) [DOI] 10.1161/CIRCGEN.117.001970. [PMID] 29530886.
2018
Immunotherapy: It is not just for cancer anymore.
Journal of leukocyte biology. 103(1):9-11 [DOI] 10.1002/JLB.4CE1117-447. [PMID] 29345063.
2018
Impact of toll-like receptor 4 stimulation on human neonatal neutrophil spontaneous migration, transcriptomics, and cytokine production.
Journal of molecular medicine (Berlin, Germany). 96(7):673-684 [DOI] 10.1007/s00109-018-1646-5. [PMID] 29808244.
2018
Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.00595. [PMID] 29670613.
2018
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis.
Shock (Augusta, Ga.). 50(4):377-380 [DOI] 10.1097/SHK.0000000000001212. [PMID] 30106875.
2018
Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.
Intensive care medicine experimental. 6(1) [DOI] 10.1186/s40635-018-0189-y. [PMID] 30112605.
2018
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.
Infection. 46(5):687-691 [DOI] 10.1007/s15010-018-1183-8. [PMID] 30105433.
2018
Mouse Injury Model of Polytrauma and Shock.
Methods in molecular biology (Clifton, N.J.). 1717:1-15 [DOI] 10.1007/978-1-4939-7526-6_1. [PMID] 29468579.
2018
Myeloid-Derived Suppressor Cells and Pulmonary Hypertension.
International journal of molecular sciences. 19(8) [DOI] 10.3390/ijms19082277. [PMID] 30081463.
2018
Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.
Surgery. 164(2):178-184 [DOI] 10.1016/j.surg.2018.04.011. [PMID] 29807651.
2018
Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults
PLOS ONE. 13(10) [DOI] 10.1371/journal.pone.0205327. [PMID] 30300408.
2018
The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients.
The journal of trauma and acute care surgery. 85(2):247-255 [DOI] 10.1097/TA.0000000000001921. [PMID] 29613958.
2018
The Post-injury Inflammatory State and the Bone Marrow Response to Anemia.
American Journal of Respiratory and Critical Care Medicine. 198(5):629-638 [DOI] 10.1164/rccm.201712-2536OC. [PMID] 29768025.
2017
Exploring the Predictive Ability of Dysfunctional High-Density Lipoprotein for Adverse Outcomes in Emergency Department Patients with Sepsis: A Preliminary Investigation.
Shock (Augusta, Ga.). 48(5):539-544 [DOI] 10.1097/SHK.0000000000000887. [PMID] 28452909.
2017
Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock.
Annals of surgery. 265(4):827-834 [DOI] 10.1097/SLA.0000000000001783. [PMID] 27163951.
2017
Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.
Cancer research. 77(3):672-683 [DOI] 10.1158/0008-5472.CAN-16-1765. [PMID] 27864347.
2017
ICU-Acquired Weakness, Chronic Critical Illness, and the Persistent Inflammation-Immunosuppression and Catabolism Syndrome.
Critical care medicine. 45(11) [DOI] 10.1097/CCM.0000000000002576. [PMID] 29028707.
2017
Immunological Defects in Neonatal Sepsis and Potential Therapeutic Approaches.
Frontiers in pediatrics. 5 [DOI] 10.3389/fped.2017.00014. [PMID] 28224121.
2017
Impact of Early-Life Exposures to Infections, Antibiotics, and Vaccines on Perinatal and Long-term Health and Disease.
Frontiers in immunology. 8 [DOI] 10.3389/fimmu.2017.00729. [PMID] 28690615.
2017
LPS Stimulation of Cord Blood Reveals a Newborn-Specific Neutrophil Transcriptomic Response and Cytokine Production.
Shock (Augusta, Ga.). 47(5):606-614 [DOI] 10.1097/SHK.0000000000000800. [PMID] 28410545.
2017
Microbial recognition and danger signals in sepsis and trauma.
Biochimica et biophysica acta. Molecular basis of disease. 1863(10 Pt B):2564-2573 [DOI] 10.1016/j.bbadis.2017.01.013. [PMID] 28115287.
2017
Murine Models of Sepsis and Trauma: Can We Bridge the Gap?
ILAR journal. 58(1):90-105 [DOI] 10.1093/ilar/ilx007. [PMID] 28444204.
2017
Neutrophil chemotaxis and transcriptomics in term and preterm neonates.
Translational research : the journal of laboratory and clinical medicine. 190:4-15 [DOI] 10.1016/j.trsl.2017.08.003. [PMID] 28873345.
2017
Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus.
Arthritis & rheumatology (Hoboken, N.J.). 69(6):1280-1293 [DOI] 10.1002/art.40077. [PMID] 28217966.
2017
Persistent Inflammation, Immunosuppression and Catabolism Syndrome.
Critical care clinics. 33(2):245-258 [DOI] 10.1016/j.ccc.2016.12.001. [PMID] 28284293.
2017
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.
BMJ open. 7(7) [DOI] 10.1136/bmjopen-2016-015136. [PMID] 28765125.
2017
Sepsis Diagnostics: From Discovery to Application.
Critical care medicine. 45(1):129-130 [PMID] 27984279.
2017
Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome.
Critical care medicine. 45(2):253-262 [DOI] 10.1097/CCM.0000000000002074. [PMID] 27632674.
2017
The authors reply.
Critical care medicine. 45(7):e740-e741 [DOI] 10.1097/CCM.0000000000002469. [PMID] 28622238.
2017
The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two Level-One Trauma Centers.
Critical care medicine. 45(12):1989-1996 [DOI] 10.1097/CCM.0000000000002697. [PMID] 28837430.
2017
The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure.
The journal of trauma and acute care surgery. 83(3):520-531 [DOI] 10.1097/TA.0000000000001587. [PMID] 28538636.
2017
Unique transcriptomic response to sepsis is observed among patients of different age groups.
PloS one. 12(9) [DOI] 10.1371/journal.pone.0184159. [PMID] 28886074.
2016
Gene Expression Patterns in Peripheral Blood Leukocytes in Patients with Recurrent Ciguatera Fish Poisoning: Preliminary Studies.
Harmful algae. 57(B):35-38 [PMID] 27594814.
2016
Gene expression patterns in peripheral blood leukocytes in patients with recurrent ciguatera fish poisoning: Preliminary studies.
Harmful algae. 57(Pt B):35-38 [DOI] 10.1016/j.hal.2016.03.009. [PMID] 28918889.
2016
Histological chorioamnionitis shapes the neonatal transcriptomic immune response.
Early human development. 98:1-6 [DOI] 10.1016/j.earlhumdev.2016.06.001. [PMID] 27318328.
2016
Integrating “big data” into surgical practice
Surgery. 159(2):371-374 [DOI] 10.1016/j.surg.2015.08.043. [PMID] 26603852.
2016
Patterns of gene expression among murine models of hemorrhagic shock/trauma and sepsis.
Physiological genomics. 48(2):135-44 [DOI] 10.1152/physiolgenomics.00072.2015. [PMID] 26578697.
2016
Sepsis and septic shock.
Nature reviews. Disease primers. 2 [DOI] 10.1038/nrdp.2016.45. [PMID] 28117397.
2016
Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock.
The journal of trauma and acute care surgery. 81(3):478-85 [DOI] 10.1097/TA.0000000000001113. [PMID] 27306446.
2016
Systemic inflammation as a predictor of clinical outcomes after lower extremity angioplasty/stenting.
Journal of vascular surgery. 64(3):766-778.e5 [DOI] 10.1016/j.jvs.2015.04.399. [PMID] 26054584.
2016
Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.
Proceedings of the National Academy of Sciences of the United States of America. 113(19):E2627-35 [DOI] 10.1073/pnas.1515793113. [PMID] 27114524.
2016
What’s New in Shock, January 2016?
Shock (Augusta, Ga.). 45(1):1-3 [DOI] 10.1097/SHK.0000000000000527. [PMID] 26674448.
2016
What’s New in Shock, September 2016?
Shock (Augusta, Ga.). 46(3):227-9 [DOI] 10.1097/SHK.0000000000000674. [PMID] 27525376.
2016
β-Blockade use for Traumatic Injuries and Immunomodulation: A Review of Proposed Mechanisms and Clinical Evidence.
Shock (Augusta, Ga.). 46(4):341-51 [DOI] 10.1097/SHK.0000000000000636. [PMID] 27172161.
2015
A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged.
Journal of immunology (Baltimore, Md. : 1950). 195(5):2396-407 [DOI] 10.4049/jimmunol.1500984. [PMID] 26246141.
2015
A Review of GM-CSF Therapy in Sepsis.
Medicine. 94(50) [DOI] 10.1097/MD.0000000000002044. [PMID] 26683913.
2015
Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.
Critical care (London, England). 19(1) [DOI] 10.1186/s13054-015-0788-x. [PMID] 25880307.
2015
Alum as a Preventative Therapy Abolishes Mortality in Murine Neonatal Sepsis By Improving Effector Cell Function and Bacterial Clearance
Shock. 43(6, 1)
2015
Blunt Trauma Releases Cell Free Nucleic Acids, But Its Prognostic Relevance Does Not Surface Until the Following Day.
Shock. 43(6, 1)
2015
Cost and Mortality Associated With Postoperative Acute Kidney Injury.
Annals of surgery. 261(6):1207-14 [DOI] 10.1097/SLA.0000000000000732. [PMID] 24887982.
2015
Delayed emergency myelopoiesis following polymicrobial sepsis in neonates.
Innate immunity. 21(4):386-91 [DOI] 10.1177/1753425914542445. [PMID] 25106654.
2015
Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer.
Cancer immunology, immunotherapy : CII. 64(12):1553-63 [DOI] 10.1007/s00262-015-1760-y. [PMID] 26423423.
2015
Early Angiogenic Balance and Adverse Long-Term Outcomes in Sepsis
Shock. 43(6, 1)
2015
Human Myeloid Derived Suppressor Cells Induce Immune Suppression After Severe Sepsis
Shock. 43(6, 1)
2015
Il-18 Increases Murine Neonatal Sepsis Mortality Via Il-17a
Shock. 43(6, 1):89-90
2015
Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation.
Immunology. 145(2):300-11 [DOI] 10.1111/imm.12450. [PMID] 25684123.
2015
Mice are not men.
Proceedings of the National Academy of Sciences of the United States of America. 112(4) [DOI] 10.1073/pnas.1414857111. [PMID] 25540422.
2015
Patterns of Gene Expression Among Murine Models of Hemorrhagic Shock Trauma and Sepsis
Shock. 43(6, 1):111-112
2015
Postnatal Age Is a Critical Determinant of the Neonatal Host Response to Sepsis.
Molecular medicine (Cambridge, Mass.). 21(1):496-504 [DOI] 10.2119/molmed.2015.00064. [PMID] 26052715.
2015
Sepsis Enhances Myeloid Cell Function and Immune Protection From Secondary Listeria Infection Through Tnf Alpha Signaling
Shock. 43(6, 1)
2015
The future of murine sepsis and trauma research models.
Journal of leukocyte biology. 98(6):945-52 [DOI] 10.1189/jlb.5MR0315-127R. [PMID] 26034205.
2015
The Genomic Response After Burn Injury Predicts Organ Dysfunction and Mortality
Shock. 43(6, 1)
2015
The Inflammatory Milieu Within the Pancreatic Cancer Microenvironment Correlates With Clinicopathologic Parameters, Chemoresistance and Survival
Bmc Cancer. 15 [DOI] 10.1186/s12885-015-1820-x. [PMID] 26498838.
2015
TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis.
Journal of immunology (Baltimore, Md. : 1950). 194(3):1169-77 [DOI] 10.4049/jimmunol.1302676. [PMID] 25548220.
2014
A better understanding of why murine models of trauma do not recapitulate the human syndrome.
Critical care medicine. 42(6):1406-13 [DOI] 10.1097/CCM.0000000000000222. [PMID] 24413577.
2014
A Comparison of the Leukocyte Genomic Responses To Sterile Or Infectious Inflammation
Shock. 41(2)
2014
A Novel Drug for Treatment of Necrotizing Soft-Tissue Infections: A Randomized Clinical Trial.
JAMA surgery. 149(6):528-36 [DOI] 10.1001/jamasurg.2013.4841. [PMID] 24740134.
2014
Aged mice are unable to mount an effective myeloid response to sepsis.
Journal of immunology (Baltimore, Md. : 1950). 192(2):612-22 [DOI] 10.4049/jimmunol.1302109. [PMID] 24337739.
2014
HMGB1 as a therapeutic target for sepsis: it’s all in the timing!
Expert opinion on therapeutic targets. 18(3):243-5 [DOI] 10.1517/14728222.2014.883380. [PMID] 24479494.
2014
Host responses to sepsis vary in different low-lethality murine models.
PloS one. 9(5) [DOI] 10.1371/journal.pone.0094404. [PMID] 24788351.
2014
Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia.
Journal of immunology (Baltimore, Md. : 1950). 192(12):6111-9 [DOI] 10.4049/jimmunol.1302895. [PMID] 24829407.
2014
Parallels between cancer and infectious disease.
The New England journal of medicine. 371(4):380-3 [DOI] 10.1056/NEJMcibr1404664. [PMID] 25054723.
2014
Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma.
The journal of trauma and acute care surgery. 76(1):21-9; discussion 29 [DOI] 10.1097/TA.0b013e3182ab1ab5. [PMID] 24368353.
2014
Protective immunity and defects in the neonatal and elderly immune response to sepsis.
Journal of immunology (Baltimore, Md. : 1950). 192(7):3156-65 [DOI] 10.4049/jimmunol.1301726. [PMID] 24591376.
2014
What’s new in Shock, October 2014?
Shock (Augusta, Ga.). 42(4):283-5 [DOI] 10.1097/SHK.0000000000000246. [PMID] 25225834.
2013
A genomic analysis of Clostridium difficile infections in blunt trauma patients.
The journal of trauma and acute care surgery. 74(1):334-8 [DOI] 10.1097/TA.0b013e3182789426. [PMID] 23271108.
2013
Acute kidney injury is associated with early cytokine changes after trauma.
The journal of trauma and acute care surgery. 74(4):1005-13 [DOI] 10.1097/TA.0b013e31828586ec. [PMID] 23511138.
2013
DAMPs, PAMPs, and the origins of SIRS in bacterial sepsis.
Shock (Augusta, Ga.). 39(1):113-4 [DOI] 10.1097/SHK.0b013e318277109c. [PMID] 23247128.
2013
Determination of burn patient outcome by large-scale quantitative discovery proteomics.
Critical care medicine. 41(6):1421-34 [DOI] 10.1097/CCM.0b013e31827c072e. [PMID] 23507713.
2013
Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients.
Critical care medicine. 41(5):1175-85 [DOI] 10.1097/CCM.0b013e318277131c. [PMID] 23388514.
2013
Genomic responses in mouse models poorly mimic human inflammatory diseases.
Proceedings of the National Academy of Sciences of the United States of America. 110(9):3507-12 [DOI] 10.1073/pnas.1222878110. [PMID] 23401516.
2013
Is there value in plasma cytokine measurements in patients with severe trauma and sepsis?
Methods (San Diego, Calif.). 61(1):3-9 [DOI] 10.1016/j.ymeth.2013.04.024. [PMID] 23669589.
2013
Maintenance of anti-Sm/RNP autoantibody production by plasma cells residing in ectopic lymphoid tissue and bone marrow memory B cells.
Journal of immunology (Baltimore, Md. : 1950). 190(8):3916-27 [DOI] 10.4049/jimmunol.1201880. [PMID] 23509349.
2013
Role of innate immunity in neonatal infection.
American journal of perinatology. 30(2):105-12 [DOI] 10.1055/s-0032-1333412. [PMID] 23297181.
2013
Soybean oil: a potentially new intravascular perfusate.
Perfusion. 28(2):160-6 [DOI] 10.1177/0267659112469643. [PMID] 23257679.
2013
What’s New in Shock? February 2013.
Shock (Augusta, Ga.). 39(2):117-20 [DOI] 10.1097/SHK.0b013e318283f6a9. [PMID] 23324880.
2012
A Novel Role for Tumor-Induced Expansion of Myeloid Derived Cells in Host Resistance and Cancer Cachexia
Shock. 37
2012
A regionalised strategy for improving motor vehicle-related highway driver deaths using a weighted averages method.
Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention. 18(1):16-21 [DOI] 10.1136/ip.2010.030759. [PMID] 21685144.
2012
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures.
Annals of surgery. 255(5):993-9 [DOI] 10.1097/SLA.0b013e31824f1ebc. [PMID] 22470077.
2012
CXCR3 blockade: a novel anti-sepsis approach?
Critical care (London, England). 16(6) [DOI] 10.1186/cc11818. [PMID] 23171733.
2012
Gram Stain Can Be Used To Safely Discontinue Vancomycin Therapy for Early Pneumonia in the Trauma Icu
Critical Care Medicine. 40:U114-U115
2012
Hypdxia-Induced Angiogenic Factors, Progenitor Endothelial Cells and Urinary Hypdxic Markers as Early Markers of Endothelial Injury in Hemorrhagic Shock (Hypper)
Shock. 37:59-60
2012
Identification and Description of a Novel Murine Model for Polytrauma and Shock
Shock. 37
2012
Identification of Soluble Immunophilin Fkbp52 as a Potent Macrophage (M Phi) Activating Factor
Journal of Investigative Dermatology. 132
2012
Immediate postoperative inflammatory response predicts long-term outcome in lung-transplant recipients.
Interactive cardiovascular and thoracic surgery. 15(4):603-7 [PMID] 22815323.
2012
Loss of Myd88 Or Trif Does Not Impact Survival To Neonatal Polymicrobial Sepsis
Shock. 37:29-30
2012
Monocyte chemoattractant protein-1/CCR2 axis promotes vein graft neointimal hyperplasia through its signaling in graft-extrinsic cell populations.
Arteriosclerosis, thrombosis, and vascular biology. 32(10):2418-26 [DOI] 10.1161/ATVBAHA.112.255786. [PMID] 22904274.
2012
Myeloid-Derived Suppressor Cells in Sepsis: Friend Or Foe?
Intensive Care Medicine. 38(6):928-930 [DOI] 10.1007/s00134-012-2575-3. [PMID] 22552587.
2012
Obese patients show a depressed cytokine profile following severe blunt injury.
Shock (Augusta, Ga.). 37(3):253-6 [DOI] 10.1097/SHK.0b013e3182449c0e. [PMID] 22266966.
2012
Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care.
The journal of trauma and acute care surgery. 72(6):1491-501 [DOI] 10.1097/TA.0b013e318256e000. [PMID] 22695412.
2012
Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus.
Journal of immunology (Baltimore, Md. : 1950). 188(8):4113-21 [DOI] 10.4049/jimmunol.1103113. [PMID] 22422888.
2012
Profibrotic Effect of Interleukin-18 in Hk-2 Cells Is Dependent On Stimulation of the Toll-Like Receptor 4 (Tlr4) Promoter and Increased Tlr4 Expression
Journal of Biological Chemistry. 287(48):40391-40399 [DOI] 10.1074/jbc.M112.402420. [PMID] 23027874.
2012
Successful Implementation of a Packed Red Blood Cell and Fresh Frozen Plasma Transfusion Protocol in the Surgical Intensive Care Unit
Critical Care Medicine. 40
2012
The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock.
Critical care medicine. 40(4):1129-35 [DOI] 10.1097/CCM.0b013e3182376e9f. [PMID] 22020243.
2012
What is the role for the inflammasome in burn injury and sepsis?
Shock (Augusta, Ga.). 37(1):124-5 [DOI] 10.1097/SHK.0b013e31823b7643. [PMID] 22157943.
2011
A genomic storm in critically injured humans.
The Journal of experimental medicine. 208(13):2581-90 [DOI] 10.1084/jem.20111354. [PMID] 22110166.
2011
A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma.
Molecular medicine (Cambridge, Mass.). 17(3-4):281-92 [DOI] 10.2119/molmed.2010.00178. [PMID] 21085745.
2011
B cells enhance early innate immune responses during bacterial sepsis.
The Journal of experimental medicine. 208(8):1673-82 [DOI] 10.1084/jem.20101715. [PMID] 21746813.
2011
Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.
Infection and immunity. 79(7):2746-54 [DOI] 10.1128/IAI.01291-10. [PMID] 21518789.
2011
Early blood biomarkers predict organ injury and resource utilization following complex cardiac surgery.
The Journal of surgical research. 168(2):168-72 [DOI] 10.1016/j.jss.2009.09.023. [PMID] 20031165.
2011
Human Transcriptome Array for High-Throughput Clinical Studies
Proceedings of the National Academy of Sciences. 108(9):3707-3712 [DOI] 10.1073/pnas.1019753108. [PMID] 21317363.
2011
Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage.
Laboratory investigation; a journal of technical methods and pathology. 91(12):1787-95 [DOI] 10.1038/labinvest.2011.94. [PMID] 21931299.
2011
Mopeds and scooters: crash outcomes in a high traffic state.
The Journal of trauma. 71(1):217-22 [DOI] 10.1097/TA.0b013e318208f874. [PMID] 21399547.
2011
Murine Blood Transfusion Induces Immune Dysregulation During Sepsis
Shock. 35
2011
Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling.
Journal of immunology (Baltimore, Md. : 1950). 187(2):911-8 [DOI] 10.4049/jimmunol.1100588. [PMID] 21690321.
2011
Roles of vaccinia virus genes E3L and K3L and host genes PKR and RNase L during intratracheal infection of C57BL/6 mice.
Journal of virology. 85(1):550-67 [DOI] 10.1128/JVI.00254-10. [PMID] 20943971.
2011
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.
Journal of immunology (Baltimore, Md. : 1950). 186(1):195-202 [DOI] 10.4049/jimmunol.1002104. [PMID] 21106855.
2011
Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes.
Diabetes. 60(8):2144-51 [DOI] 10.2337/db10-1222. [PMID] 21715554.
2011
The Glue Grant experience: characterizing the post injury genomic response.
European journal of trauma and emergency surgery : official publication of the European Trauma Society. 37(6):549-58 [DOI] 10.1007/s00068-011-0148-8. [PMID] 26815465.
2011
The potential influence of common viral infections diagnosed during hospitalization among critically ill patients in the United States.
PloS one. 6(4) [DOI] 10.1371/journal.pone.0018890. [PMID] 21573031.
2010
Alternative Modes of Transportation and Their Crash Oucomes
Shock. 33
2010
Analysis of factorial time-course microarrays with application to a clinical study of burn injury.
Proceedings of the National Academy of Sciences of the United States of America. 107(22):9923-8 [DOI] 10.1073/pnas.1002757107. [PMID] 20479259.
2010
Cd11C(+) Dendritic Cells Modulate the Local Inflammatory Response and Host Defense To Cutaneous Staphylococcus Aureus Infection
Shock. 33
2010
Cecal ligation and puncture.
Current protocols in immunology. Chapter 19 [DOI] 10.1002/0471142735.im1913s91. [PMID] 21053304.
2010
Clinical microfluidics for neutrophil genomics and proteomics.
Nature medicine. 16(9):1042-7 [DOI] 10.1038/nm.2205. [PMID] 20802500.
2010
Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling.
Journal of immunology (Baltimore, Md. : 1950). 184(5):2247-51 [DOI] 10.4049/jimmunol.0903652. [PMID] 20130216.
2010
Differences in outcome between obese and nonobese patients following severe blunt trauma are not consistent with an early inflammatory genomic response.
Critical care medicine. 38(1):51-8 [DOI] 10.1097/CCM.0b013e3181b08089. [PMID] 19661803.
2010
Do Tregs link sepsis to tumor growth?
Blood. 115(22):4324-5 [DOI] 10.1182/blood-2010-03-271379. [PMID] 20522717.
2010
Identification and interpretation of longitudinal gene expression changes in trauma.
PloS one. 5(12) [DOI] 10.1371/journal.pone.0014380. [PMID] 21187951.
2010
Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients.
Annals of surgery. 252(1):158-65 [DOI] 10.1097/SLA.0b013e3181deb6bc. [PMID] 20562612.
2010
Plasma proteome response to severe burn injury revealed by 18O-labeled “universal” reference-based quantitative proteomics.
Journal of proteome research. 9(9):4779-89 [DOI] 10.1021/pr1005026. [PMID] 20698492.
2010
The Role of Ip-10/Cxcr3 in the Neonatal Immune Response To a Septic Insult
Shock. 33
2010
Traditional resuscitative practices fail to resolve metabolic acidosis in morbidly obese patients after severe blunt trauma.
The Journal of trauma. 68(2):317-30 [DOI] 10.1097/TA.0b013e3181caab6c. [PMID] 20154544.
2010
Transfusion-Induced Immunosuppression Varies With Blood Age
Shock. 33
2010
Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10.
The Journal of experimental medicine. 207(2):319-26 [DOI] 10.1084/jem.20091959. [PMID] 20071504.
2009
A dynamic network of transcription in LPS-treated human subjects.
BMC systems biology. 3 [DOI] 10.1186/1752-0509-3-78. [PMID] 19638230.
2009
A genomic score prognostic of outcome in trauma patients.
Molecular medicine (Cambridge, Mass.). 15(7-8):220-7 [DOI] 10.2119/molmed.2009.00027. [PMID] 19593405.
2009
Blockade of Ip-10 Inhibits Adjuvant-Induced Protection During Neonatal Sepsis
Shock. 31:9-10
2009
Cancer-induced expansion and activation of CD11b+ Gr-1+ cells predispose mice to adenoviral-triggered anaphylactoid-type reactions.
Molecular therapy : the journal of the American Society of Gene Therapy. 17(3):508-15 [DOI] 10.1038/mt.2008.280. [PMID] 19127252.
2009
Characterization of the Prolonged Genomic Changes Induced By a Severe Burn Injury
Critical Care Medicine. 37
2009
Hemorrhage and subsequent allogenic red blood cell transfusion are associated with characteristic monocyte messenger RNA expression patterns in patients after multiple injury-a genome wide view.
The Journal of trauma. 67(4):792-801 [DOI] 10.1097/TA.0b013e31819d9c04. [PMID] 19820587.
2009
Large-scale multiplexed quantitative discovery proteomics enabled by the use of an (18)O-labeled “universal” reference sample.
Journal of proteome research. 8(1):290-9 [DOI] 10.1021/pr800467r. [PMID] 19053531.
2009
Magic bullets and surrogate biomarkers circa 2009.
Critical care medicine. 37(5):1796-8 [DOI] 10.1097/CCM.0b013e3181a09440. [PMID] 19373047.
2009
Major hepatectomy induces phenotypic changes in circulating dendritic cells and monocytes.
Journal of clinical immunology. 29(5):568-81 [DOI] 10.1007/s10875-009-9291-y. [PMID] 19387804.
2009
Myeloid-Derived Suppressor Cell Expansion Requires Cxcl12-Induced Progenitor Cell Development and Is Necessary for Survival
Shock. 31
2009
Polymicrobial Sepsis Activates Th1 and Protects Against Listeria Infection
Shock. 31
2009
Potential of Immunomodulatory Agents for Prevention and Treatment of Neonatal Sepsis
Journal of Perinatology. 29(2):79-88 [DOI] 10.1038/jp.2008.132. [PMID] 18769381.
2009
Pseudomonas Eradication After Sepsis Depends On Adequate Neutrophil Function
Shock. 31
2009
The role of the cowpox virus crmA gene during intratracheal and intradermal infection of C57BL/6 mice.
Virology. 384(1):151-60 [DOI] 10.1016/j.virol.2008.10.041. [PMID] 19056101.
2009
Type I Interferon in the Hematopoietic System Is Necessary for Host Defense During Sepsis
Shock. 31
2008
A novel type I IFN-producing cell subset in murine lupus.
Journal of immunology (Baltimore, Md. : 1950). 180(7):5101-8 [PMID] 18354236.
2008
Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists.
Blood. 112(5):1750-8 [DOI] 10.1182/blood-2008-01-130500. [PMID] 18591384.
2008
Defective Neonatal Innate Immunity Causes Poor Sepsis Outcome, But Is Overcome By Select Toll-Like Receptor Agonists
Shock. 29:96-97
2008
Early Blood Biomarkers Predict Organ Injury and Resource Utilization Following Complex Cardiac Surgery
Journal of the American College of Surgeons. 207(3) [DOI] 10.1016/j.jamcollsurg.2008.06.042.
2008
Endogenous IL-10 regulates sepsis-induced thymic apoptosis and improves survival in septic IL-10 null mice.
Scandinavian journal of immunology. 68(6):565-71 [DOI] 10.1111/j.1365-3083.2008.02176.x. [PMID] 18959626.
2008
Immunohistochemical Analysis of Tgf-Beta and Ctgf in Thermal Burn Injury Tissue and Normal Skin
Wound repair and regeneration. 16
2008
Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes.
Hepatology (Baltimore, Md.). 47(5):1725-36 [DOI] 10.1002/hep.22187. [PMID] 18311843.
2008
Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients.
Clinical chemistry. 54(5):891-900 [DOI] 10.1373/clinchem.2007.099150. [PMID] 18375483.
2008
Myd88-Dependent Pathway Initiates Neointimal Hyperplasia Development Independently of Tlr4
Circulation. 118
2008
Myeloid-derived suppressor cells in cancer cachexia syndrome: a new explanation for an old problem.
JPEN. Journal of parenteral and enteral nutrition. 32(6):651-5 [DOI] 10.1177/0148607108325075. [PMID] 18974247.
2008
Polymicrobial Sepsis Activates B Cells Through a Type I Interferon Dependent But Myd88 Independent Pathway
Shock. 29
2008
Role of Toll-like receptors in the development of sepsis.
Shock (Augusta, Ga.). 29(3):315-21 [DOI] 10.1097/SHK.0b013e318157ee55. [PMID] 18277854.
2008
Stromal Cell Derived Factor-1 Mediates Myeloid Derived Suppressor Cell Expansion During Polymicrobial Sepsis
Shock. 29
2008
Systemic Inflammatory Response To Lower Extremity Revascularization
Arteriosclerosis Thrombosis and Vascular Biology. 28
2008
Using innate immunity to characterize the host response to microbial invasion in severe sepsis.
Future microbiology. 3(2):177-89 [DOI] 10.2217/17460913.3.2.177. [PMID] 18366338.
2007
Gene expression profiles are influenced by ISS, MOF, and clinical outcome in multiple injured patients: a genome-wide comparative analysis.
Langenbeck's archives of surgery. 392(3):255-65 [PMID] 17404753.
2007
Genomic and proteomic determinants of lower extremity revascularization failure: rationale and study design.
Journal of vascular surgery. 45 Suppl A(Suppl A):A82-91 [PMID] 17544028.
2007
In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen.
Arthritis and rheumatism. 56(10):3379-86 [PMID] 17907192.
2007
Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis.
Shock (Augusta, Ga.). 28(6):675-683 [PMID] 17621256.
2007
Longitudinal studies of inter-alpha inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis.
Critical care medicine. 35(2):387-92 [PMID] 17205024.
2007
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.
The Journal of experimental medicine. 204(6):1463-74 [PMID] 17548519.
2007
Stored packed red blood cell transfusion up-regulates inflammatory gene expression in circulating leukocytes.
Annals of surgery. 246(1):129-34 [PMID] 17592301.
2007
Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis.
Blood. 110(10):3673-81 [PMID] 17690255.
2007
Variable requirement of dendritic cells for recruitment of NK and T cells to different TLR agonists.
Journal of immunology (Baltimore, Md. : 1950). 178(6):3886-92 [PMID] 17339488.
2006
A critical role of CpG motifs in a murine peritonitis model by their binding to highly expressed toll-like receptor-9 on liver NKT cells.
Journal of hepatology. 45(6):836-43 [PMID] 17030073.
2006
Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways.
Proceedings of the National Academy of Sciences of the United States of America. 103(42):15564-9 [PMID] 17032758.
2006
Cytokine profile after lung transplantation: correlation with allograft injury.
The Annals of thoracic surgery. 81(5):1844-9; discussion 1849 [PMID] 16631683.
2006
Differential toll-like receptor expression after ex vivo lipopolysaccharide exposure in patients with sepsis and following surgical stress.
Clinical immunology (Orlando, Fla.). 119(2):180-7 [PMID] 16517212.
2006
Dose-dependent improvements in outcome with adenoviral expression of interleukin-10 in a murine model of multisystem organ failure.
Gene therapy. 13(3):276-82 [PMID] 16251998.
2006
High dynamic range characterization of the trauma patient plasma proteome.
Molecular & cellular proteomics : MCP. 5(10):1899-913 [PMID] 16684767.
2006
Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950). 177(11):7943-9 [PMID] 17114466.
2006
Interleukin-18: a novel prognostic cytokine in bacteria-induced sepsis.
Critical care medicine. 34(4):1225-33 [PMID] 16540967.
2006
Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning.
Surgery. 140(5):793-802 [PMID] 17084723.
2006
Local thymic caspase-9 inhibition improves survival during polymicrobial sepsis in mice.
Journal of molecular medicine (Berlin, Germany). 84(5):389-95 [PMID] 16453149.
2006
Maturation of murine bone marrow-derived dendritic cells with poly(I:C) produces altered TLR-9 expression and response to CpG DNA.
Immunology letters. 107(2):155-62 [PMID] 17011046.
2006
Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis.
Analytical chemistry. 78(15):5453-61 [PMID] 16878882.
2006
Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha.
Arthritis and rheumatism. 54(9):2872-85 [PMID] 16947419.
2006
The origins of cachexia in acute and chronic inflammatory diseases.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. 21(1):68-81 [PMID] 16439772.
2006
What’s new in Shock, June 2006?
Shock (Augusta, Ga.). 25(6):555-6 [PMID] 16721261.
2005
A network-based analysis of systemic inflammation in humans.
Nature. 437(7061):1032-7 [PMID] 16136080.
2005
A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation.
Chembiochem : a European journal of chemical biology. 6(1):133-44 [PMID] 15540220.
2005
Adenoviral gene transfer of an NF-kappaB super-repressor increases collagen deposition in rodent cutaneous wound healing.
Surgery. 138(5):940-6 [PMID] 16291396.
2005
Application of genome-wide expression analysis to human health and disease.
Proceedings of the National Academy of Sciences of the United States of America. 102(13):4801-6 [PMID] 15781863.
2005
Biology of interleukin-10 and its regulatory roles in sepsis syndromes.
Critical care medicine. 33(12 Suppl):S468-71 [PMID] 16340424.
2005
CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950). 175(5):3282-6 [PMID] 16116220.
2005
Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry.
Proteomics. 5(2):572-84 [PMID] 15627965.
2005
Delayed neutralization of interferon-gamma prevents lethality in primate Gram-negative bacteremic shock.
Critical care medicine. 33(4):797-805 [PMID] 15818108.
2005
Differential maturation of murine bone-marrow derived dendritic cells with lipopolysaccharide and tumor necrosis factor-alpha.
Journal of endotoxin research. 11(3):145-60 [PMID] 15949143.
2005
Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions.
Journal of leukocyte biology. 78(4):888-97 [PMID] 16033815.
2005
Functional genomics and gene expression profiling in sepsis: beyond class prediction.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 41 Suppl 7:S427-35 [PMID] 16237642.
2005
Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis.
Shock (Augusta, Ga.). 23(6):507-15 [PMID] 15897802.
2005
Genome-wide monocytic mRNA expression in polytrauma patients for identification of clinical outcome.
Shock (Augusta, Ga.). 24(1):11-9 [PMID] 15988315.
2005
Human leukocyte antigen expression in sepsis: what have we learned?
Critical care medicine. 33(1):236-7 [PMID] 15644679.
2005
In vivo transduction of thymic dendritic cells with adenovirus and its potential use in acute inflammatory diseases.
Scandinavian journal of immunology. 61(4):309-15 [PMID] 15853912.
2005
Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis.
Shock (Augusta, Ga.). 23(1):39-44 [PMID] 15614130.
2005
Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis.
Shock (Augusta, Ga.). 23(6):488-93 [PMID] 15897799.
2005
Preclinical models of shock and sepsis: what can they tell us?
Shock (Augusta, Ga.). 24 Suppl 1:1-6 [PMID] 16374365.
2005
Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach.
Molecular & cellular proteomics : MCP. 4(5):700-9 [PMID] 15753121.
2005
Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation.
Journal of immunology (Baltimore, Md. : 1950). 175(9):6155-62 [PMID] 16237112.
2005
Signal transduction activator of transcription 5 (STAT5) dysfunction in autoimmune monocytes and macrophages.
Journal of autoimmunity. 24(4):297-310 [PMID] 15927792.
2005
Splenic transposition is superior to caudal shunt as a model of murine total hepatic ischemia.
Laboratory investigation; a journal of technical methods and pathology. 85(1):90-8 [PMID] 15558060.
2005
Varying blood monocyte and dendritic cell responses after laparoscopic versus open gastric bypass surgery.
Obesity surgery. 15(10):1424-31 [PMID] 16354522.
2004
Aberrant signaling in the TNFalpha/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse.
Clinical immunology (Orlando, Fla.). 110(2):124-33 [PMID] 15003809.
2004
Anti-cytokine and anti-inflammatory therapies for the treatment of severe sepsis: progress and pitfalls.
The Proceedings of the Nutrition Society. 63(3):437-41 [PMID] 15373955.
2004
Aortic aneurysm repair is associated with a lower inflammatory response compared with surgery for inflammatory bowel disease.
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. 36(5):266-73 [PMID] 15359089.
2004
Biology of tumor necrosis factor-alpha- implications for psoriasis.
Experimental dermatology. 13(4):193-222 [PMID] 15086336.
2004
CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14).
Critical care medicine. 32(5):1100-8 [PMID] 15190957.
2004
Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950). 173(5):3035-43 [PMID] 15322163.
2004
Continuous flow microfluidic device for rapid erythrocyte lysis.
Analytical chemistry. 76(21):6247-53 [PMID] 15516115.
2004
Cytokines and wound healing: the role of cytokine and anticytokine therapy in the repair response.
The Journal of burn care & rehabilitation. 25(2):149-60 [PMID] 15091141.
2004
Genomic and proteomic determinants of outcome in patients undergoing thoracoabdominal aortic aneurysm repair.
Journal of immunology (Baltimore, Md. : 1950). 172(11):7103-9 [PMID] 15153533.
2004
IL10 resistant PGS2 expression in at-risk/Type 1 diabetic human monocytes.
Journal of autoimmunity. 22(3):227-33 [PMID] 15041043.
2004
Increased lymphoid tissue apoptosis in baboons with bacteremic shock.
Shock (Augusta, Ga.). 21(6):566-71 [PMID] 15167687.
2004
Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer.
Journal of the American College of Surgeons. 199(2):249-58 [PMID] 15275881.
2004
Influence of recombinant adenovirus on liver injury in endotoxicosis and its modulation by IL-10 expression.
Journal of endotoxin research. 10(6):393-401 [PMID] 15588421.
2004
Inhibition of NF-kappa B augments sensitivity to 5-fluorouracil/folinic acid in colon cancer.
The Journal of surgical research. 120(2):178-88 [PMID] 15234211.
2004
Temporal patterns of gene expression in murine cutaneous burn wound healing.
Physiological genomics. 16(3):341-8 [PMID] 14966252.
2004
Whole blood and leukocyte RNA isolation for gene expression analyses.
Physiological genomics. 19(3):247-54 [PMID] 15548831.
2003
A locus on mouse chromosome 6 that determines resistance to herpes simplex virus also influences reactivation, while an unlinked locus augments resistance of female mice.
Journal of virology. 77(21):11661-73 [PMID] 14557652.
2003
Analysis of gene expression patterns in human postburn hypertrophic scars.
The Journal of burn care & rehabilitation. 24(6):371-7 [PMID] 14610421.
2003
Anti-TNF-alpha therapies: the next generation.
Nature reviews. Drug discovery. 2(9):736-46 [PMID] 12951580.
2003
Antineoplastic therapy in colorectal cancer through proteasome inhibition.
The American surgeon. 69(1):15-23 [PMID] 12575774.
2003
Blocking interleukin-18: a tumor necrosis factor-alpha lesson already learned.
Critical care medicine. 31(8):2241-2 [PMID] 12973187.
2003
Genetic polymorphisms, functional genomics and the host inflammatory response to injury and inflammation.
Nestle Nutrition workshop series. Clinical & performance programme. 8:15-32; discussion 32 [PMID] 12968446.
2003
Hypothermia induces interleukin-10 and attenuates injury in the lungs of endotoxemic rats.
Shock (Augusta, Ga.). 20(1):41-5 [PMID] 12813367.
2003
Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria.
Infection and immunity. 71(10):5803-13 [PMID] 14500502.
2003
Role of endogenous interleukin-10 in local and distant organ injury after visceral ischemia-reperfusion.
Shock (Augusta, Ga.). 20(1):35-40 [PMID] 12813366.
2003
Sepsis and the dendritic cell.
Shock (Augusta, Ga.). 20(5):386-401 [PMID] 14560102.
2003
Structural basis for the proinflammatory cytokine activity of high mobility group box 1.
Molecular medicine (Cambridge, Mass.). 9(1-2):37-45 [PMID] 12765338.
2003
Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents.
Bioorganic & medicinal chemistry letters. 13(19):3217-21 [PMID] 12951096.
2002
Bioglass attenuates a proinflammatory response in mouse peritoneal endotoxicosis.
Shock (Augusta, Ga.). 17(2):135-8 [PMID] 11837789.
2002
Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis.
Circulation. 105(14):1639-41 [PMID] 11940540.
2002
Effects of megestrol acetate on weight gain, body composition, and pulmonary function in patients with cystic fibrosis.
The Journal of pediatrics. 140(4):439-44 [PMID] 12006958.
2002
Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950). 168(7):3412-8 [PMID] 11907099.
2002
Interleukin-10 fails to modulate low shear stress-induced neointimal hyperplasia.
The Journal of surgical research. 102(2):110-8 [PMID] 11796006.
2002
Interleukin-10: a complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug.
Critical care medicine. 30(1 Suppl):S58-63 [PMID] 11782562.
2002
Interleukin-10: A complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug.
Critical care medicine. 30(1 Supp):S58-S63 [PMID] 11839946.
2002
Peaks of endogenous G-CSF serum concentrations are followed by an increase in respiratory burst activity of granulocytes in patients with septic shock.
Cytokine. 17(5):275-84 [PMID] 12027409.
2002
Pro- and antiinflammatory cytokine production after radiofrequency ablation of unresectable hepatic tumors.
Journal of the American College of Surgeons. 195(6):774-81 [PMID] 12495309.
2001
Adenoviral delivery of human and viral IL-10 in murine sepsis.
Journal of immunology (Baltimore, Md. : 1950). 167(2):1053-9 [PMID] 11441115.
2001
Apoptosis in sepsis: a new target for therapeutic exploration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(6):879-92 [PMID] 11292647.
2001
Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study.
Regulatory peptides. 99(2-3):69-77 [PMID] 11384767.
2001
Considering immunomodulatory therapies in the septic patient: should apoptosis be a potential therapeutic target?
Immunology letters. 75(3):221-4 [PMID] 11166379.
2001
Development of a novel, nonimmunogenic, soluble human TNF receptor type I (sTNFR-I) construct in the baboon.
Journal of applied physiology (Bethesda, Md. : 1985). 91(5):2213-23 [PMID] 11641364.
2001
Extended lung expression and increased tissue localization of viral IL-10 with adenoviral gene therapy.
Proceedings of the National Academy of Sciences of the United States of America. 98(1):277-82 [PMID] 11134537.
2001
Genetic determinants of lipopolysaccharide and D-galactosamine-mediated hepatocellular apoptosis and lethality.
Journal of endotoxin research. 7(5):375-80 [PMID] 11753206.
2001
Nuclear factor-kappa B is upregulated in colorectal cancer.
Surgery. 130(2):363-9 [PMID] 11490372.
2001
Sepsis syndromes: understanding the role of innate and acquired immunity.
Shock (Augusta, Ga.). 16(2):83-96 [PMID] 11508871.
2001
Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis.
Proceedings of the National Academy of Sciences of the United States of America. 98(20):11503-8 [PMID] 11553765.
2001
Urinary cytokines for assessing inflammation in HIV-associated wasting.
Cytokine. 13(5):305-13 [PMID] 11243709.
2000
Anticytokine therapies for acute inflammation and the systemic inflammatory response syndrome: IL-10 and ischemia/reperfusion injury as a new paradigm.
Shock (Augusta, Ga.). 13(6):425-34 [PMID] 10847628.
2000
Autoregulation of human monocyte-derived dendritic cell maturation and IL-12 production by cyclooxygenase-2-mediated prostanoid production.
Journal of immunology (Baltimore, Md. : 1950). 165(8):4298-304 [PMID] 11035064.
2000
Cytokine signaling–regulation of the immune response in normal and critically ill states.
Critical care medicine. 28(4 Suppl):N3-12 [PMID] 10807312.
2000
Direct evidence for cytokine involvement in neointimal hyperplasia.
Circulation. 102(14):1697-702 [PMID] 11015350.
2000
Glucocorticoid and Fas ligand induced mucosal lymphocyte apoptosis after burn injury.
The Journal of trauma. 49(4):710-6 [PMID] 11038090.
2000
Glucocorticoid-induced, caspase-dependent organ apoptosis early after burn injury.
American journal of physiology. Regulatory, integrative and comparative physiology. 278(4):R1005-18 [PMID] 10749790.
2000
Inhibition of tumor necrosis factor-alpha attenuates wound breaking strength in rats.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 8(6):547-53 [PMID] 11208182.
2000
Interleukin-10 appearance following thoraco-abdominal and abdominal aortic aneurysm repair is associated with the duration of visceral ischaemia.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 20(2):169-72 [PMID] 10942689.
2000
Laparotomy prevents lethal endotoxemia in a murine sequential insult model by an IL-10-dependent mechanism.
Shock (Augusta, Ga.). 14(2):157-62 [PMID] 10947160.
2000
Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand.
American journal of physiology. Regulatory, integrative and comparative physiology. 278(5):R1196-201 [PMID] 10801287.
2000
Liposome-mediated, nonviral gene transfer induces a systemic inflammatory response which can exacerbate pre-existing inflammation.
Gene therapy. 7(16):1425-30 [PMID] 10981671.
2000
Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change.
Regulatory peptides. 92(1-3):97-105 [PMID] 11024571.
2000
LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor.
American journal of physiology. Regulatory, integrative and comparative physiology. 278(5):R1202-9 [PMID] 10801288.
2000
Modulation of the acute phase response by altered expression of the IL-1 type 1 receptor or IL-1ra.
American journal of physiology. Regulatory, integrative and comparative physiology. 278(4):R824-30 [PMID] 10749768.
2000
Neither Fas ligand nor endotoxin is responsible for inducible peritoneal phagocyte apoptosis during sepsis/peritonitis.
The Journal of surgical research. 91(2):147-53 [PMID] 10839964.
2000
Neuropeptide Y counteracts the anorectic and weight reducing effects of ciliary neurotropic factor.
Journal of neuroendocrinology. 12(9):827-32 [PMID] 10971807.
2000
Nutritional modulation of the sepsis response: fish oils and innate immunity.
Nutrition (Burbank, Los Angeles County, Calif.). 16(4):308-9 [PMID] 10758371.
2000
Reduced susceptibility of nonobese diabetic mice to TNF-alpha and D-galactosamine-mediated hepatocellular apoptosis and lethality.
Journal of immunology (Baltimore, Md. : 1950). 165(11):6559-67 [PMID] 11086099.
2000
The induction of EAE is only partially dependent on TNF receptor signaling but requires the IL-1 type I receptor.
Clinical immunology (Orlando, Fla.). 95(2):117-23 [PMID] 10779405.
2000
The relationship between visceral ischemia, proinflammatory cytokines, and organ injury in patients undergoing thoracoabdominal aortic aneurysm repair.
Critical care medicine. 28(9):3191-7 [PMID] 11008981.
2000
TNF-alpha receptor signaling and IL-10 gene therapy regulate the innate and humoral immune responses to recombinant adenovirus in the lung.
Journal of immunology (Baltimore, Md. : 1950). 164(1):443-51 [PMID] 10605041.
2000
Tumor necrosis factor-alpha and the development of multiple organ failure.
Critical care medicine. 28(6):2158-9 [PMID] 10890694.
1999
Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus.
The Journal of clinical investigation. 104(4):515-23 [PMID] 10449443.
1999
Application of gene therapy to acute inflammatory diseases.
Shock (Augusta, Ga.). 12(2):83-101 [PMID] 10446888.
1999
Attenuation of skeletal muscle ischemia/reperfusion injury by inhibition of tumor necrosis factor.
Journal of vascular surgery. 29(2):370-6 [PMID] 9950995.
1999
Caspase-3-dependent organ apoptosis early after burn injury.
Annals of surgery. 229(6):851-8; discussion 858 [PMID] 10363899.
1999
Characterization in vitro and in vivo of hammerhead ribozymes directed against murine tumor necrosis factoralpha.
Biochemical and biophysical research communications. 260(2):390-7 [PMID] 10403780.
1999
Discordant tumor necrosis factor-alpha superfamily gene expression in bacterial peritonitis and endotoxemic shock.
Surgery. 126(2):349-57 [PMID] 10455905.
1999
Granulocyte colony-stimulating factor to prevent the progression of systemic nonresponsiveness in systemic inflammatory response syndrome and sepsis.
Blood. 93(2):425-39 [PMID] 9885204.
1999
Interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF alpha) regulate insulin-like growth factor binding protein-1 (IGFBP-1) levels and mRNA abundance in vivo and in vitro.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 31(2-3):209-15 [PMID] 10226804.
1999
Organ apoptosis in the septic patient: a potential therapeutic target?
Critical care medicine. 27(7):1381-2 [PMID] 10446836.
1999
Products of cyclooxygenase-2 catalysis regulate postoperative bowel motility.
The Journal of surgical research. 86(1):50-4 [PMID] 10452868.
1999
Role of the type 5 adenovirus gene encoding the early region 1B 55-kDa protein in pulmonary pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America. 96(18):10409-11 [PMID] 10468621.
1999
Use of recombinant human soluble TNF receptor in anorectic tumor-bearing rats.
The American journal of physiology. 277(3):R850-5 [DOI] 10.1152/ajpregu.1999.277.3.R850. [PMID] 10484503.
1998
Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin.
Endocrinology. 139(2):466-73 [PMID] 9449612.
1998
Cationic liposome-mediated gene transfer during acute pancreatitis: tissue specificity, duration, and effects of acute inflammation.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2(1):95-101 [PMID] 9841974.
1998
Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis.
Journal of immunology (Baltimore, Md. : 1950). 160(8):4082-9 [PMID] 9558119.
1998
Enhanced collagen accumulation following direct transfection of the inducible nitric oxide synthase gene in cutaneous wounds.
Biochemical and biophysical research communications. 246(3):654-9 [PMID] 9618268.
1998
Human immunodeficiency virus-associated wasting and mechanisms of cachexia associated with inflammation.
Seminars in oncology. 25(1 Suppl 1):73-81 [PMID] 9482543.
1998
Human interleukin 10 suppresses production of inflammatory mediators by LPS-stimulated equine peritoneal macrophages.
Veterinary immunology and immunopathology. 66(1):1-10 [PMID] 9847016.
1998
Increased appetite augments hypothalamic NPY Y1 receptor gene expression: effects of anorexigenic ciliary neurotropic factor.
Regulatory peptides. 75-76:391-5 [PMID] 9802434.
1998
Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha.
Infection and immunity. 66(4):1800-2 [PMID] 9529118.
1998
Increased tumor necrosis factor-alpha (TNF-alpha) gene expression in parainfluenza type 1 (Sendai) virus-induced bronchiolar fibrosis.
The American journal of pathology. 152(2):513-22 [PMID] 9466578.
1998
Interleukin 6, but not ciliary neurotrophic factor or leukaemia inhibitory factor, is responsible for the acute phase response to turpentine-induced myositis.
Cytokine. 10(6):452-6 [PMID] 9632532.
1998
Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of luteinizing hormone release in rats: role of neuropeptide Y.
Neuroscience letters. 240(1):45-9 [PMID] 9488171.
1998
Leptin produces anorexia and weight loss without inducing an acute phase response or protein wasting.
The American journal of physiology. 274(6):R1518-25 [DOI] 10.1152/ajpregu.1998.274.6.R1518. [PMID] 9608004.
1998
Metalloproteinase inhibitors and wound healing: a novel enhancer of wound strength.
Surgery. 124(2):464-70 [PMID] 9706172.
1998
Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon.
Journal of applied physiology (Bethesda, Md. : 1985). 84(4):1119-30 [PMID] 9516174.
1998
Revisiting the role of tumor necrosis factor alpha and the response to surgical injury and inflammation.
Archives of surgery (Chicago, Ill. : 1960). 133(5):558-67 [PMID] 9605921.
1998
Role of cytokines in the metabolic response to stress.
Current opinion in clinical nutrition and metabolic care. 1(2):187-90 [PMID] 10565346.
1998
Transfection of the type II TGF-beta receptor into colon cancer cells increases receptor expression, inhibits cell growth, and reduces the malignant phenotype.
Annals of surgery. 227(6):781-9 [PMID] 9637541.
1998
Transient human gene therapy: a novel cytokine regulatory strategy for experimental pancreatitis.
Annals of surgery. 227(6):812-20 [PMID] 9637544.
1997
A matrix metalloproteinase inhibitor prevents processing of tumor necrosis factor alpha (TNF alpha) and abrogates endotoxin-induced lethality.
Shock (Augusta, Ga.). 7(6):427-31 [PMID] 9185243.
1997
Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice.
Journal of immunology (Baltimore, Md. : 1950). 159(5):2452-61 [PMID] 9278338.
1997
Arginine-enhanced enteral nutrition augments the growth of a nitric oxide-producing tumor.
JPEN. Journal of parenteral and enteral nutrition. 21(4):215-9 [PMID] 9252947.
1997
Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia.
Journal of immunology (Baltimore, Md. : 1950). 158(4):1971-5 [PMID] 9029140.
1997
Evidence that brief stress may induce the acute phase response in rats.
The American journal of physiology. 273(6):R1998-2004 [DOI] 10.1152/ajpregu.1997.273.6.R1998. [PMID] 9435654.
1997
Exogenous human recombinant interleukin-10 attenuates hindlimb ischemia-reperfusion injury.
The Journal of surgical research. 69(2):425-8 [PMID] 9224418.
1997
Exogenously administered interleukin-10 decreases pulmonary neutrophil infiltration in a tumor necrosis factor-dependent murine model of acute visceral ischemia.
Journal of vascular surgery. 26(1):113-8 [PMID] 9240329.
1997
Inhibition of transforming growth factor alpha stimulation of human squamous cell carcinoma of the head and neck with anti-TGF-alpha antibodies and tyrphostin.
Annals of surgical oncology. 4(8):670-84 [PMID] 9416416.
1997
Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor.
Journal of immunology (Baltimore, Md. : 1950). 158(1):414-9 [PMID] 8977217.
1997
Nitric oxide contributes to adriamycin’s antitumor effect.
The Journal of surgical research. 69(2):283-7 [PMID] 9224394.
1997
Pretreatment with a 55-kDa tumor necrosis factor receptor-immunoglobulin fusion protein attenuates activation of coagulation, but not of fibrinolysis, during lethal bacteremia in baboons.
The Journal of infectious diseases. 176(1):296-9 [PMID] 9207387.
1997
Proinflammatory cytokines, nutritional support, and the cachexia syndrome: interactions and therapeutic options.
Cancer. 79(9):1828-39 [PMID] 9129003.
1996
A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon.
The Journal of experimental medicine. 184(1):165-71 [PMID] 8691130.
1996
A role for tumor necrosis factor-alpha in the increased mortality associated with Vibrio vulnificus infection in the presence of hepatic dysfunction.
Annals of surgery. 223(4):428-33 [PMID] 8633922.
1996
Changes in endotoxin-induced cytokine production by whole blood after in vivo exposure of normal humans to endotoxin.
The Journal of infectious diseases. 174(6):1356-60 [PMID] 8940234.
1996
Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response.
The American journal of physiology. 271(1 Pt 2):R185-90 [PMID] 8760219.
1996
Correlation between Acute Physiology and Chronic Health Evaluation (APACHE) III score and immunological parameters in critically ill patients with sepsis.
The British journal of surgery. 83(3):396-400 [PMID] 8665205.
1996
Hepatic tumor necrosis factor-alpha production and distant organ dysfunction in a murine model of obstructive jaundice.
American journal of surgery. 171(1):202-6 [PMID] 8554142.
1996
Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome.
Blood. 87(8):3282-8 [PMID] 8605344.
1996
Monocyte tumor necrosis factor receptor levels as a predictor of risk in human sepsis.
Archives of surgery (Chicago, Ill. : 1960). 131(4):434-7 [PMID] 8615732.
1996
Protection against lethal Escherichia coli bacteremia in baboons (Papio anubis) by pretreatment with a 55-kDa TNF receptor (CD120a)-Ig fusion protein, Ro 45-2081.
Journal of immunology (Baltimore, Md. : 1950). 156(6):2221-30 [PMID] 8690912.
1996
Tumor cell nitric oxide inhibits cell growth in vitro, but stimulates tumorigenesis and experimental lung metastasis in vivo.
The Journal of surgical research. 63(1):49-52 [PMID] 8661171.
1996
Tumor necrosis factor-alpha induces activation of coagulation and fibrinolysis in baboons through an exclusive effect on the p55 receptor.
Blood. 88(3):922-7 [PMID] 8704250.
1996
Visceral ischemia and organ dysfunction after thoracoabdominal aortic aneurysm repair. A clinical and cost analysis.
Annals of surgery. 223(6):729-34; discussion 734 [PMID] 8645046.
1996
Visceral ischemia-reperfusion injury promotes tumor necrosis factor (TNF) and interleukin-1 (IL-1) dependent organ injury in the mouse.
Shock (Augusta, Ga.). 6(3):171-6 [PMID] 8885081.
1995
Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture.
Shock (Augusta, Ga.). 4(2):89-95 [PMID] 7496903.
1995
Colon cancer cells that are not growth inhibited by TGF-beta lack functional type I and type II TGF-beta receptors.
Annals of surgery. 221(6):767-76; discussion 776 [PMID] 7794080.
1995
Contribution of interleukin-1 to activation of coagulation and fibrinolysis, neutrophil degranulation, and the release of secretory-type phospholipase A2 in sepsis: studies in nonhuman primates after interleukin-1 alpha administration and during lethal bacteremia.
Blood. 86(3):1027-34 [PMID] 7620156.
1995
Cytokine-mediated alterations in host metabolism prevent nutritional repletion in cachectic cancer patients.
Journal of surgical oncology. 58(2):77-82 [PMID] 7844987.
1995
Endogenous IL-10 protects mice from death during septic peritonitis.
Journal of immunology (Baltimore, Md. : 1950). 155(11):5397-401 [PMID] 7594556.
1995
Endotoxin induces downregulation of tumor necrosis factor receptors on circulating monocytes and granulocytes in humans.
Blood. 86(7):2754-9 [PMID] 7670115.
1995
Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses.
The Journal of experimental medicine. 181(6):2289-93 [PMID] 7760015.
1995
Influence of IL-1 receptor blockade on the human response to endotoxemia.
Journal of immunology (Baltimore, Md. : 1950). 154(3):1499-507 [PMID] 7822813.
1995
Interleukin 1 binding to its type I, but not type II receptor, modulates the in vivo acute phase response.
Cytokine. 7(6):510-6 [PMID] 8580366.
1995
Interleukin-1 and interleukin-1 antagonism in sepsis, systemic inflammatory response syndrome, and septic shock.
Shock (Augusta, Ga.). 3(4):235-51 [PMID] 7600191.
1995
Interleukin-1 contributes to increased concentrations of soluble tumor necrosis factor receptor type I in sepsis.
The Journal of infectious diseases. 172(2):577-80 [PMID] 7622910.
1995
Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man.
The Journal of clinical endocrinology and metabolism. 80(4):1341-6 [PMID] 7714108.
1994
Anti-endotoxin therapy in primate bacteremia with HA-1A and BPI.
Annals of surgery. 220(1):77-85 [PMID] 8024362.
1994
Assessment of the cytokine response in liver donors at the time of organ procurement and association with allograft function after orthotopic transplantation.
Journal of the American College of Surgeons. 179(2):209-19 [PMID] 7519108.
1994
Biology of proinflammatory cytokines and their antagonists.
Critical care medicine. 22(7):S3-7 [PMID] 8026189.
1994
Changes in polymorphonuclear leukocyte surface and plasma bactericidal/permeability-increasing protein and plasma lipopolysaccharide binding protein during endotoxemia or sepsis.
Archives of surgery (Chicago, Ill. : 1960). 129(2):220-6 [PMID] 7508221.
1994
CMNSG Guest Lecture. Interleukin-1, interleukin-1 receptor, and interleukin-1 receptor antagonist.
The Proceedings of the Nutrition Society. 53(2):393-400 [PMID] 7972153.
1994
Endotoxin-induced nitric oxide production in pulmonary artery endothelial cells is regulated by cytokines.
Archives of surgery (Chicago, Ill. : 1960). 129(12):1296-300 [PMID] 7986159.
1994
Persistently elevated soluble tumor necrosis factor receptor and interleukin-1 receptor antagonist levels in critically ill patients.
Journal of the American College of Surgeons. 178(2):132-8 [PMID] 8173722.
1994
Role and effect of TNF-alpha in experimental visceral leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950). 153(2):768-75 [PMID] 8021511.
1994
The metabolic effects of platelet-activating factor antagonism in endotoxemic man.
Archives of surgery (Chicago, Ill. : 1960). 129(1):72-9 [PMID] 8279943.
1994
The role of bactericidal/permeability-increasing protein in the treatment of primate bacteremia and septic shock.
Journal of clinical immunology. 14(2):120-33 [PMID] 8195314.
1994
Tumor necrosis factor and cachexia: a current perspective.
Surgical oncology. 3(5):255-62 [PMID] 7889218.
1993
Antibodies chaperone circulating IL-6. Paradoxical effects of anti-IL-6 “neutralizing” antibodies in vivo.
Journal of immunology (Baltimore, Md. : 1950). 151(6):3225-36 [PMID] 8376777.