Shawn D Larson

Shawn D Larson, MD, FACS

Associate Professor

Department: MD-SURGERY-PEDIATRIC
Business Phone: (352) 273-8761

About Shawn D Larson

Dr. Shawn Larson, an associate professor of Pediatric Surgery, focuses on all aspects of the field, with special interest in pediatric trauma, pediatric burn care, neonatal surgery, and gastrointestinal surgery (including minimally invasive pediatric surgery). Dr. Larson serves as the medical director for the UF Health/Shands Children’s Hospital Pediatric Trauma & Burn Program.

His research interests include gastrointestinal physiology and immunology focusing on necrotizing enterocolitis (NEC), neonatal and pediatric response to sepsis, pediatric trauma and pediatric burn care.

Dr. Larson joined the UF College of Medicine in 2011. He completed his Pediatric Surgical fellowship at St. Louis Children’s Hospital/Washington University, his general surgery residency at the University of South Florida, and a surgical research fellowship at the University of Texas Medical Branch. He earned his medical degree from the University of Sheffield School of Medicine in Sheffield, England. Dr. Larson earned a Bachelor of Science in Zoology from the University of Florida.

Accomplishments

Research Career Development Award
2013 · University of Florida Department of Surgery
Scholar
2013 · American Pediatric Surgery Foundation
Resident of the Month
2008 · Tampa General Hospital
Best Clinical Paper
2007 · Singleton Surgical Society
Poster of Distinction
2007 · American Pediatric Surgical Association

Board Certifications

  • Pediatric Surgery
    American Board of Surgery
  • Surgery
    American Board of Surgery

Clinical Profile

Specialties
  • Surgery
Subspecialties
  • Pediatric Surgery
Areas of Interest
  • Appendicitis
  • Burns
  • Burns – resources
  • Cellulitis
  • Constipation in infants and children
  • Crohn disease
  • Esophageal atresia
  • Esophageal stricture – benign
  • Failure to thrive
  • Fistula
  • Gastroesophageal reflux disease
  • Gastroesophageal reflux in infants
  • Gastroschisis repair
  • Hirschsprung disease
  • Imperforate anus repair
  • Inguinal hernia repair
  • Neonatal hypothyroidism
  • Neonatal sepsis
  • Neuroblastoma
  • Pectus excavatum repair
  • Peritonitis
  • Pyloric stenosis in infants
  • Spleen removal
  • Testicular torsion
  • Thyroid diseases
  • Ulcerative colitis
  • Umbilical hernia
  • Umbilical hernia repair
  • Volvulus – childhood

Research Profile

Dr. Larson is a Fellow of the American College of Surgeons (FACS) and the American Academy of Pediatrics (FAAP). Additionally, he is a member of the following organizations: American Pediatric Surgical Association (APSA), Society of University Surgeons (SUS; elected), Association for Academic Surgery (AAS), Pediatric Trauma Society (PTS), The Shock Society, and the Florida Chapters of the American College of Surgeons & American Academy of Pediatrics

Open Researcher and Contributor ID (ORCID)

0000-0002-8564-0140

Areas of Interest
  • Gastrointestinal physiology and immunology (necrotizing enterocolitis)
  • Neonatal Sepsis
  • Pediatric Trauma
  • Thyroid Tumors

Publications

2021
Aluminum Adjuvant Improves Survival Via NLRP3 Inflammasome and Myeloid Non-Granulocytic Cells in a Murine Model of Neonatal Sepsis.
Shock (Augusta, Ga.). 55(2):274-282 [DOI] 10.1097/SHK.0000000000001623. [PMID] 32769820.
2021
Analysis of Outcomes in Adolescents and Young Adults With Pilonidal Disease.
Frontiers in surgery. 8 [DOI] 10.3389/fsurg.2021.613605. [PMID] 33718427.
2021
Cecal Slurry Injection in Neonatal and Adult Mice.
Methods in molecular biology (Clifton, N.J.). 2321:27-41 [DOI] 10.1007/978-1-0716-1488-4_4. [PMID] 34048005.
2021
Chronic “sepsis brain” and regulatory T cells – A promising therapeutic target.
Brain, behavior, and immunity. 93:10-11 [DOI] 10.1016/j.bbi.2021.01.017. [PMID] 33516922.
2021
Prehospital personnel discretion pediatric trauma team activations: Too much of a good thing?
Journal of pediatric surgery. [DOI] 10.1016/j.jpedsurg.2021.03.002. [PMID] 33814181.
2020
Commentary: Letter to the Editor “Austere Environments Consortium for Enhanced Sepsis Outcomes (ACESO)”.
Shock (Augusta, Ga.). 53(3) [DOI] 10.1097/SHK.0000000000001455. [PMID] 32044850.
2020
Immunological Endotyping of Chronic Critical Illness After Severe Sepsis.
Frontiers in medicine. 7 [DOI] 10.3389/fmed.2020.616694. [PMID] 33659259.
2020
Outcomes After Prehospital Endotracheal Intubation in Suburban/Rural Pediatric Trauma.
The Journal of surgical research. 249:138-144 [DOI] 10.1016/j.jss.2019.11.034. [PMID] 31954974.
2020
Pediatric earlobe keloids: Outcomes and patterns of recurrence.
Journal of pediatric surgery. 55(3):461-464 [DOI] 10.1016/j.jpedsurg.2019.07.006. [PMID] 31383580.
2020
The Clinical Presentation and Immunology of Viral Pneumonia and Implications for Management of Coronavirus Disease 2019.
Critical care explorations. 2(4) [DOI] 10.1097/CCE.0000000000000109. [PMID] 32426751.
2019
Long-term outcomes of antegrade continence enema in children with chronic encopresis and incontinence: what is the optimal flush to use?
Pediatric surgery international. 35(4):431-438 [DOI] 10.1007/s00383-018-4416-0. [PMID] 30426223.
2019
What’s New in Shock, December 2019?
Shock (Augusta, Ga.). 52(6):566-567 [DOI] 10.1097/SHK.0000000000001438. [PMID] 31725108.
2018
Adjuvant pretreatment with alum protects neonatal mice in sepsis through myeloid cell activation.
Clinical and experimental immunology. 191(3):268-278 [DOI] 10.1111/cei.13072. [PMID] 29052227.
2018
Delayed Healing Associated with Silver Sulfadiazine Use for Partial Thickness Scald Burns in Children.
The American surgeon. 84(6):836-840 [PMID] 29981611.
View on: PubMed
2018
Duodenal web presenting outside the neonatal period concurrently with malrotation and mid-gut volvulus
Journal of Pediatric Surgery Case Reports. 39:35-37 [DOI] 10.1016/j.epsc.2018.09.005.
2018
Impact of toll-like receptor 4 stimulation on human neonatal neutrophil spontaneous migration, transcriptomics, and cytokine production.
Journal of molecular medicine (Berlin, Germany). 96(7):673-684 [DOI] 10.1007/s00109-018-1646-5. [PMID] 29808244.
2018
Inguinal hernias in premature neonates: exploring optimal timing for repair.
Pediatric surgery international. 34(11):1157-1161 [DOI] 10.1007/s00383-018-4356-8. [PMID] 30255352.
2018
Initial primary spontaneous pneumothorax in children and adolescents: Operate or wait?
Journal of pediatric surgery. 53(10):1960-1963 [DOI] 10.1016/j.jpedsurg.2017.12.014. [PMID] 29361279.
2018
Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.00595. [PMID] 29670613.
2018
Review: The Perioperative Use of Thromboelastography for Liver Transplant Patients.
Transplantation proceedings. 50(10):3552-3558 [DOI] 10.1016/j.transproceed.2018.07.032. [PMID] 30577236.
2018
Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults.
PloS one. 13(10) [DOI] 10.1371/journal.pone.0205327. [PMID] 30300408.
2017
Immunological Defects in Neonatal Sepsis and Potential Therapeutic Approaches.
Frontiers in pediatrics. 5 [DOI] 10.3389/fped.2017.00014. [PMID] 28224121.
2017
Impact of Early-Life Exposures to Infections, Antibiotics, and Vaccines on Perinatal and Long-term Health and Disease.
Frontiers in immunology. 8 [DOI] 10.3389/fimmu.2017.00729. [PMID] 28690615.
2017
LPS Stimulation of Cord Blood Reveals a Newborn-Specific Neutrophil Transcriptomic Response and Cytokine Production.
Shock (Augusta, Ga.). 47(5):606-614 [DOI] 10.1097/SHK.0000000000000800. [PMID] 28410545.
2017
Microbial recognition and danger signals in sepsis and trauma.
Biochimica et biophysica acta. Molecular basis of disease. 1863(10 Pt B):2564-2573 [DOI] 10.1016/j.bbadis.2017.01.013. [PMID] 28115287.
2017
Neutrophil chemotaxis and transcriptomics in term and preterm neonates.
Translational research : the journal of laboratory and clinical medicine. 190:4-15 [DOI] 10.1016/j.trsl.2017.08.003. [PMID] 28873345.
2017
Severe Neonatal Purpura Fulminans Caused By Staphylococcus Aureus
Clinical Pediatrics. 56(8):776-780 [DOI] 10.1177/0009922816660693.
2017
Unique transcriptomic response to sepsis is observed among patients of different age groups.
PloS one. 12(9) [DOI] 10.1371/journal.pone.0184159. [PMID] 28886074.
2016
Improved Survival in Left Liver-Up Congenital Diaphragmatic Hernia by Early Repair Before Extracorporeal Membrane Oxygenation: Optimization of Patient Selection by Multivariate Risk Modeling.
Journal of the American College of Surgeons. 222(4):459-70 [DOI] 10.1016/j.jamcollsurg.2015.12.059. [PMID] 27016974.
2016
Patterns of gene expression among murine models of hemorrhagic shock/trauma and sepsis.
Physiological genomics. 48(2):135-44 [DOI] 10.1152/physiolgenomics.00072.2015. [PMID] 26578697.
2016
Pediatric sepsis.
Current opinion in pediatrics. 28(3):380-7 [DOI] 10.1097/MOP.0000000000000337. [PMID] 26983000.
2015
Alum as a Preventative Therapy Abolishes Mortality in Murine Neonatal Sepsis By Improving Effector Cell Function and Bacterial Clearance
Shock. 43(6, 1)
2015
Delayed emergency myelopoiesis following polymicrobial sepsis in neonates.
Innate immunity. 21(4):386-91 [DOI] 10.1177/1753425914542445. [PMID] 25106654.
2015
Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation.
Immunology. 145(2):300-11 [DOI] 10.1111/imm.12450. [PMID] 25684123.
2015
Outcomes in the physiologically most severe congenital diaphragmatic hernia (CDH) patients: Whom should we treat?
Journal of pediatric surgery. 50(6):893-7 [DOI] 10.1016/j.jpedsurg.2015.03.005. [PMID] 25933923.
2014
Appendiceal carcinoids in children–management and outcomes.
The Journal of surgical research. 192(2):250-3 [DOI] 10.1016/j.jss.2014.06.031. [PMID] 25039014.
2014
Enhanced Protective Immunity and Extramedullary Myelopoiesis in Neonatal Sepsis By Ablation of Caspase-1 Signaling
Shock. 41(2)
2014
Extracorporeal life support in patients with congenital diaphragmatic hernia: how long should we treat?
Journal of the American College of Surgeons. 218(4):808-17 [DOI] 10.1016/j.jamcollsurg.2013.12.047. [PMID] 24655875.
2014
Feasibility of Laparoscopic Pyloromyotomy Under Spinal Anesthesia
Journal of Pediatric Surgery. 49(10):1485-1487 [DOI] 10.1016/j.jpedsurg.2014.02.083. [PMID] 25280651.
2014
Ogilvie’s syndrome after pediatric spinal deformity surgery: successful treatment with neostigmine.
Journal of neurosurgery. Pediatrics. 14(3):255-8 [DOI] 10.3171/2014.6.PEDS13636. [PMID] 25036854.
2014
Protective immunity and defects in the neonatal and elderly immune response to sepsis.
Journal of immunology (Baltimore, Md. : 1950). 192(7):3156-65 [DOI] 10.4049/jimmunol.1301726. [PMID] 24591376.
2013
Long-term maturation of congenital diaphragmatic hernia treatment results: toward development of a severity-specific treatment algorithm.
Annals of surgery. 258(4):638-44; discussion 644 [DOI] 10.1097/SLA.0b013e3182a53c49. [PMID] 23989050.
2009
Development and characterization of a novel in vivo model of carcinoid syndrome.
Clinical cancer research : an official journal of the American Association for Cancer Research. 15(8):2747-55 [DOI] 10.1158/1078-0432.CCR-08-2346. [PMID] 19336516.
2008
PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy.
American journal of physiology. Gastrointestinal and liver physiology. 294(6):G1401-10 [DOI] 10.1152/ajpgi.00062.2008. [PMID] 18388186.
2006
Meconium pseudocyst in a newborn.
Journal of the American College of Surgeons. 203(3) [PMID] 16931313.
View on: PubMed

Grants

Nov 2020 ACTIVE
Blood-analysis & technologies for identifying MIS-C in the context of SARS-CoV-2 exposure
Role: Principal Investigator
Funding: MASS GENERAL BRIGHAM via BIOMEDICAL ADVANCED RES & DEVLPMT AUTHOR
Oct 2018 ACTIVE
Medical Guild for Pediatric Burn Clinic Virtual Reality Therapy Headset
Role: Other
Funding: UF MEDICAL GUILD
Sep 2017 – Sep 2018
Burn Clinic Care Supplies
Role: Other
Funding: UF MEDICAL GUILD
Jul 2017 – Jun 2018
Novel Mechanisms and Approaches to Treat Neonatal Sepsis – Fellowship
Role: Other
Funding: SURGICAL INFECTION SOCIETY
Jul 2015 – Jun 2020
Novel Mechanisms and Approaches to Treat Neonatal Sepsis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS

Education

Residency – Pediatric Surgery
2011 · St. Louis Children's Hospital
Residency – Surgery
2009 · University of South Florida
Masters of Science
2007 · University of Texas
Residency – Surgery
2005 · University of South Florida
Bachelor of Medicine, Bachelor of Surgery
1999 · University of Sheffield
Bachelor of Science
1992 · University of Florida

Teaching Profile

Courses Taught
2018
MDC7600 Surgery Clerkship
2018
MDT7600 Elect Top/Surgery

Contact Details

Phones:
Business:
(352) 273-8761
Emails: