Shawn D Larson, MD, FACS
Professor, Tenure Track
Department:
MD-SURGERY-PEDIATRIC
Business Phone:
(352) 273-8761
Business Email:
shawn.larson@surgery.ufl.edu
About Shawn D Larson
Hello, my name is Dr. Shawn Larson and I am a professor, tenure track, and interim chief of the division of pediatric surgery within the University of Florida College of Medicine department of surgery. I focus on all aspects of the field of pediatric surgery and have special interests in pediatric trauma, pediatric burn care, neonatal surgery and gastrointestinal surgery (including minimally invasive pediatric surgery). I also serve as the medical director for the UF Health Shands Children’s Hospital Pediatric Trauma & Burn Program.
My research interests include gastrointestinal physiology and immunology focusing on necrotizing enterocolitis (NEC), neonatal and pediatric response to sepsis, pediatric trauma and pediatric burn care.
I joined the UF College of Medicine in 2011, and completed my Pediatric Surgical fellowship at St. Louis Children’s Hospital/Washington University. I completed my general surgery residency at the University of South Florida, and a surgical research fellowship at the University of Texas Medical Branch. I earned my medical degree from the University of Sheffield School of Medicine in Sheffield, England and also have a Bachelor of Science in Zoology from the University of Florida.
Accomplishments
Research Career Development Award
2013
·
University of Florida Department of Surgery
Scholar
2013
·
American Pediatric Surgery Foundation
Resident of the Month
2008
·
Tampa General Hospital
Best Clinical Paper
2007
·
Singleton Surgical Society
Poster of Distinction
2007
·
American Pediatric Surgical Association
Teaching Profile
Courses Taught
2018
MDC7600 Surgery Clerkship
2018
MDT7600 Elect Top/Surgery
Board Certifications
-
Pediatric SurgeryAmerican Board of Surgery
-
SurgeryAmerican Board of Surgery
Clinical Profile
Subspecialties
- Pediatric Surgery
Areas of Interest
- Appendicitis
- Burns
- Cellulitis
- Constipation in infants and children
- Crohn disease
- Esophageal atresia
- Esophageal stricture – benign
- Failure to thrive
- Fistula
- Gastroesophageal reflux disease
- Gastroesophageal reflux in infants
- Gastroschisis repair
- Hirschsprung disease
- Imperforate anus repair
- Inguinal hernia repair
- Neonatal hypothyroidism
- Neonatal sepsis
- Neuroblastoma
- Pectus excavatum repair
- Peritonitis
- Pyloric stenosis in infants
- Spleen removal
- Testicular torsion
- Thyroid diseases
- Ulcerative colitis
- Umbilical hernia
- Umbilical hernia repair
- Volvulus – childhood
Research Profile
Dr. Larson is a Fellow of the American College of Surgeons (FACS) and the American Academy of Pediatrics (FAAP). Additionally, he is a member of the following organizations: American Pediatric Surgical Association (APSA), Society of University Surgeons (SUS; elected), Association for Academic Surgery (AAS), Pediatric Trauma Society (PTS), The Shock Society, and the Florida Chapters of the American College of Surgeons & American Academy of Pediatrics
Areas of Interest
- Gastrointestinal physiology and immunology (necrotizing enterocolitis)
- Neonatal Sepsis
- Pediatric Trauma
- Thyroid Tumors
Open Researcher and Contributor ID (ORCID)
0000-0002-8564-0140
Publications
2024
Charting the course for improved outcomes in chronic critical illness: therapeutic strategies for persistent inflammation, immunosuppression, and catabolism syndrome (PICS)
British Journal of Anaesthesia.
133(2):260-263
[DOI] 10.1016/j.bja.2024.05.005.
2024
Disparities in insurance status negatively affect patients with infantile hypertrophic pyloric stenosis.
Pediatric surgery international.
40(1)
[DOI] 10.1007/s00383-024-05645-9.
[PMID] 38717712.
2024
Firearm Injuries in Young Children: Surgical Resource Utilization and Implications for Prevention.
The Journal of surgical research.
302:64-70
[DOI] 10.1016/j.jss.2024.07.038.
[PMID] 39094258.
2024
Golf cart injuries have similar severity to all-terrain vehicle injuries in children: a multicenter comparison over a 5-year period.
Trauma surgery & acute care open.
9(1)
[DOI] 10.1136/tsaco-2023-001286.
[PMID] 38737814.
2024
Social determinants of health in pediatric trauma: Associations with injury mechanisms and outcomes in the context of the COVID-19 pandemic
The American Journal of Surgery.
228:107-112
[DOI] 10.1016/j.amjsurg.2023.08.019.
2024
The post-septic peripheral myeloid compartment reveals unexpected diversity in myeloid-derived suppressor cells.
Frontiers in immunology.
15
[DOI] 10.3389/fimmu.2024.1355405.
[PMID] 38720891.
2024
The unnecessary workups and admissions of adolescents and young adults with spontaneous pneumomediastinum.
Scientific reports.
14(1)
[DOI] 10.1038/s41598-024-55134-1.
[PMID] 38402248.
2024
TRANSCRIPTOMIC DIFFERENCES IN PERIPHERAL MONOCYTE POPULATIONS IN SEPTIC PATIENTS BASED ON OUTCOME.
Shock (Augusta, Ga.).
62(2):208-216
[DOI] 10.1097/SHK.0000000000002379.
[PMID] 38713581.
2023
Exploring Limited English Proficiency in the Clinical Outcomes of Pediatric Burn Patients.
The Journal of surgical research.
284:54-61
[DOI] 10.1016/j.jss.2022.10.041.
[PMID] 36535119.
2023
Monocyte anisocytosis corresponds with increasing severity of COVID-19 in children.
Frontiers in pediatrics.
11
[DOI] 10.3389/fped.2023.1177048.
[PMID] 37425266.
2023
Structural evaluation of child physical abuse in trauma: Social determinants of health at the population level.
Journal of pediatric surgery.
58(1):106-110
[DOI] 10.1016/j.jpedsurg.2022.09.033.
[PMID] 36335011.
2023
TRAINED IMMUNITY: A POTENTIAL APPROACH FOR IMPROVING HOST IMMUNITY IN NEONATAL SEPSIS.
Shock (Augusta, Ga.).
59(2):125-134
[DOI] 10.1097/SHK.0000000000002054.
[PMID] 36383390.
2023
VARIABLES INFLUENCING THE DIFFERENTIAL HOST RESPONSE TO BURNS IN PEDIATRIC AND ADULT PATIENTS.
Shock (Augusta, Ga.).
59(2):145-154
[DOI] 10.1097/SHK.0000000000002042.
[PMID] 36730790.
2022
48 Metformin Rescues the Aging-induced Failure of Post-burn White Adipose Browning
Journal of Burn Care & Research.
43(Supplement_1):S33-S33
[DOI] 10.1093/jbcr/irac012.051.
2022
49 Bromelain Based Enzymatic Debridement of Pediatric Deep Burns: Top Line Results of a Multicenter RCT
Journal of Burn Care & Research.
43(Supplement_1):S33-S34
[DOI] 10.1093/jbcr/irac012.052.
2022
Correction to: Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications.
BMC infectious diseases.
22(1)
[DOI] 10.1186/s12879-022-07563-4.
[PMID] 35799137.
2022
Decision Making Surrounding Mode of Initial Enteral Feeding in Critically Ill Pediatric Patients
International Journal of Pediatric Research.
8(1)
[DOI] 10.23937/2469-5769/1510086.
2022
Enterobius vermicularis-associated appendicitis: A 22-year case series and comprehensive review of the literature.
Journal of pediatric surgery.
57(8):1494-1498
[DOI] 10.1016/j.jpedsurg.2021.09.038.
[PMID] 34756582.
2022
Heterogeneity in the evaluation of suspected MIS-C: a cross-sectional vignette-based survey.
BMC pediatrics.
22(1)
[DOI] 10.1186/s12887-022-03446-4.
[PMID] 35787254.
2022
Medical Student Career Choice: Who Is the Influencer?
The Journal of surgical research.
272:9-16
[DOI] 10.1016/j.jss.2021.11.007.
[PMID] 34922268.
2022
Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications.
BMC infectious diseases.
22(1)
[DOI] 10.1186/s12879-022-07526-9.
[PMID] 35725405.
2022
Social determinants of health in pediatric scald burns: Is food access an issue?
Surgery.
172(5):1510-1515
[DOI] 10.1016/j.surg.2022.06.039.
2022
T-Cell Activation and LPS: A Dangerous Duo for Organ Dysfunction.
Journal of leukocyte biology.
112(2):219-220
[DOI] 10.1002/JLB.3CE0122-019R.
[PMID] 35481682.
2021
Aluminum Adjuvant Improves Survival Via NLRP3 Inflammasome and Myeloid Non-Granulocytic Cells in a Murine Model of Neonatal Sepsis.
Shock (Augusta, Ga.).
55(2):274-282
[DOI] 10.1097/SHK.0000000000001623.
[PMID] 32769820.
2021
Analysis of Outcomes in Adolescents and Young Adults With Pilonidal Disease.
Frontiers in surgery.
8
[DOI] 10.3389/fsurg.2021.613605.
[PMID] 33718427.
2021
Cecal Slurry Injection in Neonatal and Adult Mice.
Methods in molecular biology (Clifton, N.J.).
2321:27-41
[DOI] 10.1007/978-1-0716-1488-4_4.
[PMID] 34048005.
2021
Chronic “sepsis brain” and regulatory T cells – A promising therapeutic target
Brain, Behavior, and Immunity.
93:10-11
[DOI] 10.1016/j.bbi.2021.01.017.
[PMID] 33516922.
2021
Hepatitis B Vaccination Is Associated with Reduced Infectious Complications in Preterm Neonates
Journal of the American College of Surgeons.
233(5)
[DOI] 10.1016/j.jamcollsurg.2021.08.400.
2021
Prehospital personnel discretion pediatric trauma team activations: Too much of a good thing?
Journal of pediatric surgery.
56(11):2052-2057
[DOI] 10.1016/j.jpedsurg.2021.03.002.
[PMID] 33814181.
2020
Are Race, Ethnicity, and Immigration Status Associated with Clinical Outcomes in Pediatric Trauma and Burn Patients
Journal of the National Medical Association.
112(5)
[DOI] 10.1016/j.jnma.2020.09.043.
2020
Commentary: Letter to the Editor “Austere Environments Consortium for Enhanced Sepsis Outcomes (ACESO)”.
Shock (Augusta, Ga.).
53(3)
[DOI] 10.1097/SHK.0000000000001455.
[PMID] 32044850.
2020
Immunological Endotyping of Chronic Critical Illness After Severe Sepsis.
Frontiers in medicine.
7
[DOI] 10.3389/fmed.2020.616694.
[PMID] 33659259.
2020
Outcomes After Prehospital Endotracheal Intubation in Suburban/Rural Pediatric Trauma.
The Journal of surgical research.
249:138-144
[DOI] 10.1016/j.jss.2019.11.034.
[PMID] 31954974.
2020
Pediatric earlobe keloids: Outcomes and patterns of recurrence.
Journal of pediatric surgery.
55(3):461-464
[DOI] 10.1016/j.jpedsurg.2019.07.006.
[PMID] 31383580.
2020
The Clinical Presentation and Immunology of Viral Pneumonia and Implications for Management of Coronavirus Disease 2019.
Critical care explorations.
2(4)
[DOI] 10.1097/CCE.0000000000000109.
[PMID] 32426751.
2019
Long-term outcomes of antegrade continence enema in children with chronic encopresis and incontinence: what is the optimal flush to use?
Pediatric surgery international.
35(4):431-438
[DOI] 10.1007/s00383-018-4416-0.
[PMID] 30426223.
2019
What’s New in Shock, December 2019?
Shock (Augusta, Ga.).
52(6):566-567
[DOI] 10.1097/SHK.0000000000001438.
[PMID] 31725108.
2018
Adjuvant pretreatment with alum protects neonatal mice in sepsis through myeloid cell activation
Clinical and Experimental Immunology.
191(3):268-278
[DOI] 10.1111/cei.13072.
[PMID] 29052227.
2018
Delayed Healing Associated with Silver Sulfadiazine Use for Partial Thickness Scald Burns in Children.
The American surgeon.
84(6):836-840
[PMID] 29981611.
2018
Duodenal web presenting outside the neonatal period concurrently with malrotation and mid-gut volvulus
Journal of Pediatric Surgery Case Reports.
39:35-37
[DOI] 10.1016/j.epsc.2018.09.005.
2018
Impact of toll-like receptor 4 stimulation on human neonatal neutrophil spontaneous migration, transcriptomics, and cytokine production
Journal of Molecular Medicine.
96(7):673-684
[DOI] 10.1007/s00109-018-1646-5.
[PMID] 29808244.
2018
Inguinal hernias in premature neonates: exploring optimal timing for repair.
Pediatric surgery international.
34(11):1157-1161
[DOI] 10.1007/s00383-018-4356-8.
[PMID] 30255352.
2018
Initial primary spontaneous pneumothorax in children and adolescents: Operate or wait?
Journal of pediatric surgery.
53(10):1960-1963
[DOI] 10.1016/j.jpedsurg.2017.12.014.
[PMID] 29361279.
2018
Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.
Frontiers in immunology.
9
[DOI] 10.3389/fimmu.2018.00595.
[PMID] 29670613.
2018
Review: The Perioperative Use of Thromboelastography for Liver Transplant Patients.
Transplantation proceedings.
50(10):3552-3558
[DOI] 10.1016/j.transproceed.2018.07.032.
[PMID] 30577236.
2018
Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults.
PloS one.
13(10)
[DOI] 10.1371/journal.pone.0205327.
[PMID] 30300408.
2017
Immunological Defects in Neonatal Sepsis and Potential Therapeutic Approaches.
Frontiers in pediatrics.
5
[DOI] 10.3389/fped.2017.00014.
[PMID] 28224121.
2017
Impact of Early-Life Exposures to Infections, Antibiotics, and Vaccines on Perinatal and Long-term Health and Disease.
Frontiers in immunology.
8
[DOI] 10.3389/fimmu.2017.00729.
[PMID] 28690615.
2017
LPS Stimulation of Cord Blood Reveals a Newborn-Specific Neutrophil Transcriptomic Response and Cytokine Production.
Shock (Augusta, Ga.).
47(5):606-614
[DOI] 10.1097/SHK.0000000000000800.
[PMID] 28410545.
2017
Microbial recognition and danger signals in sepsis and trauma.
Biochimica et biophysica acta. Molecular basis of disease.
1863(10 Pt B):2564-2573
[DOI] 10.1016/j.bbadis.2017.01.013.
[PMID] 28115287.
2017
Neutrophil chemotaxis and transcriptomics in term and preterm neonates
Translational Research.
190:4-15
[DOI] 10.1016/j.trsl.2017.08.003.
[PMID] 28873345.
2017
Severe Neonatal Purpura Fulminans Caused By Staphylococcus Aureus
Clinical Pediatrics.
56(8):776-780
[DOI] 10.1177/0009922816660693.
2017
Unique transcriptomic response to sepsis is observed among patients of different age groups.
PloS one.
12(9)
[DOI] 10.1371/journal.pone.0184159.
[PMID] 28886074.
2016
Improved Survival in Left Liver-Up Congenital Diaphragmatic Hernia by Early Repair Before Extracorporeal Membrane Oxygenation: Optimization of Patient Selection by Multivariate Risk Modeling.
Journal of the American College of Surgeons.
222(4):459-70
[DOI] 10.1016/j.jamcollsurg.2015.12.059.
[PMID] 27016974.
2016
Patterns of gene expression among murine models of hemorrhagic shock/trauma and sepsis.
Physiological genomics.
48(2):135-44
[DOI] 10.1152/physiolgenomics.00072.2015.
[PMID] 26578697.
2016
Pediatric sepsis.
Current opinion in pediatrics.
28(3):380-7
[DOI] 10.1097/MOP.0000000000000337.
[PMID] 26983000.
2015
Alum as a Preventative Therapy Abolishes Mortality in Murine Neonatal Sepsis By Improving Effector Cell Function and Bacterial Clearance
Shock.
43(6, 1)
2015
Delayed emergency myelopoiesis following polymicrobial sepsis in neonates.
Innate immunity.
21(4):386-91
[DOI] 10.1177/1753425914542445.
[PMID] 25106654.
2015
Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation.
Immunology.
145(2):300-11
[DOI] 10.1111/imm.12450.
[PMID] 25684123.
2015
Outcomes in the physiologically most severe congenital diaphragmatic hernia (CDH) patients: Whom should we treat?
Journal of pediatric surgery.
50(6):893-7
[DOI] 10.1016/j.jpedsurg.2015.03.005.
[PMID] 25933923.
2014
Appendiceal carcinoids in children–management and outcomes.
The Journal of surgical research.
192(2):250-3
[DOI] 10.1016/j.jss.2014.06.031.
[PMID] 25039014.
2014
Enhanced Protective Immunity and Extramedullary Myelopoiesis in Neonatal Sepsis By Ablation of Caspase-1 Signaling
Shock.
41(2)
2014
Extracorporeal life support in patients with congenital diaphragmatic hernia: how long should we treat?
Journal of the American College of Surgeons.
218(4):808-17
[DOI] 10.1016/j.jamcollsurg.2013.12.047.
[PMID] 24655875.
2014
Feasibility of Laparoscopic Pyloromyotomy Under Spinal Anesthesia
Journal of Pediatric Surgery.
49(10):1485-1487
[DOI] 10.1016/j.jpedsurg.2014.02.083.
[PMID] 25280651.
2014
Ogilvie’s syndrome after pediatric spinal deformity surgery: successful treatment with neostigmine.
Journal of neurosurgery. Pediatrics.
14(3):255-8
[DOI] 10.3171/2014.6.PEDS13636.
[PMID] 25036854.
2014
Protective immunity and defects in the neonatal and elderly immune response to sepsis.
Journal of immunology (Baltimore, Md. : 1950).
192(7):3156-65
[DOI] 10.4049/jimmunol.1301726.
[PMID] 24591376.
2013
Long-term maturation of congenital diaphragmatic hernia treatment results: toward development of a severity-specific treatment algorithm.
Annals of surgery.
258(4):638-44; discussion 644
[DOI] 10.1097/SLA.0b013e3182a53c49.
[PMID] 23989050.
2009
Development and characterization of a novel in vivo model of carcinoid syndrome.
Clinical cancer research : an official journal of the American Association for Cancer Research.
15(8):2747-55
[DOI] 10.1158/1078-0432.CCR-08-2346.
[PMID] 19336516.
2008
PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy.
American journal of physiology. Gastrointestinal and liver physiology.
294(6):G1401-10
[DOI] 10.1152/ajpgi.00062.2008.
[PMID] 18388186.
2006
Meconium pseudocyst in a newborn.
Journal of the American College of Surgeons.
203(3)
[PMID] 16931313.
Grants
May 2023
– May 2023
A Phase 3 Multicenter, Single-Arm, Open-Label Study Evaluating the Safety, Tolerability and Efficacy of StrataGraft? Construct in Pediatric Subjects with Deep Partial Thickness (DPT) Thermal Burns
Role: Principal Investigator
Funding: *STRATATECH CORPORATION– Bankruptcy
via BIOMEDICAL ADVANCED RES & DEVLPMT AUTHOR
Oct 2022
– Oct 2023
Supporting Patients and Caregivers in the UF Health Pediatric Surgery G-tube Clinic
Role: Other
Funding: UF MEDICAL GUILD
Aug 2022
– Aug 2023
MotionMgix Interactive Floor Games for Pediatric Burn Clinic Waiting Room
Role: Other
Funding: UF MEDICAL GUILD
Aug 2022
ACTIVE
Pathologic Myeloid Activation in Pediatric Burn Injury
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Apr 2022
ACTIVE
Prevention of Neonatal Sepsis by Therapeutic Targeting of MDSCs
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Jan 2022
– Jun 2023
An Adaptive, Randomized, Controlled Trial Evaluating the Effectiveness of PermeaDerm as Compared To Mepilex Ag Used as Standard of Care in The Treatment of Adult and Pediatric Partial Thickness Burns
Role: Principal Investigator
Funding: *STEDICAL SCIENTIFIC
via SIMBEC-ORION GROUP
Sep 2021
– Jul 2024
Use of NexoBrid for Treatment of Acute deep partial and full thickness Burn Injuries (NCT04040660)
Role: Principal Investigator
Funding: MEDIWOUND
via BIOMEDICAL ADVANCED RES & DEVLPMT AUTHOR
Nov 2020
– Nov 2021
Blood-analysis & technologies for identifying MIS-C in the context of SARS-CoV-2 exposure
Role: Principal Investigator
Funding: MASS GENERAL BRIGHAM
via BIOMEDICAL ADVANCED RES & DEVLPMT AUTHOR
Nov 2018
– Aug 2023
A multicenter, multinational, randomized, controlled, open label study, performed in children with thermal burns, to evaluate the efficacy and safety of NexoBrid as compared to standard of care (SOC) treatment
Role: Principal Investigator
Funding: MEDIWOUND
via BIOMEDICAL ADVANCED RES & DEVLPMT AUTHOR
Nov 2018
– Jul 2022
A multicenter, multinational, randomized, controlled, open label study, performed in children with thermal burns, to evaluate the efficacy and safety of NexoBrid as compared to standard of care (SOC) treatment
Role: Principal Investigator
Funding: MEDIWOUND
Oct 2018
– Jan 2022
Medical Guild for Pediatric Burn Clinic Virtual Reality Therapy Headset
Role: Other
Funding: UF MEDICAL GUILD
Sep 2017
– Sep 2018
Burn Clinic Care Supplies
Role: Other
Funding: UF MEDICAL GUILD
Jul 2017
– Jun 2018
Novel Mechanisms and Approaches to Treat Neonatal Sepsis – Fellowship
Role: Other
Funding: SURGICAL INFECTION SOCIETY
Jul 2015
– Jun 2020
Novel Mechanisms and Approaches to Treat Neonatal Sepsis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Education
Residency – Pediatric Surgery
2011
·
St. Louis Children's Hospital
Residency – Surgery
2009
·
University of South Florida
Masters of Science
2007
·
University of Texas
Residency – Surgery
2005
·
University of South Florida
Bachelor of Medicine, Bachelor of Surgery
1999
·
University of Sheffield
Bachelor of Science
1992
·
University of Florida
Contact Details
Phones:
- Business:
- (352) 273-8761
Emails:
- Business:
- shawn.larson@surgery.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100119
GAINESVILLE FL 32610 - Business Street:
-
DIVISION OF PEDIATRIC SURGERY
DIVISION OF PEDIATRIC SURGERY
1600 SW ARCHER ROAD
GAINESVILLE FL 326100001