Patrick W Underwood, MD
University of Michigan Medical School
About Patrick W Underwood
Hometown: Pinckney, MI
Clinical and Research Interests: Surgical Oncology
What were you looking for in a residency program?
I was looking for a residency program with a strong clinical experience in all of general surgery and its specialties as well as the guaranteed opportunity for two years of academic development time.
What are the strengths of the UF program?
UF Surgery will prepare you to practice as a general surgeon immediately after graduation but also set you up to pursue fellowship in whichever specialty you are interested. The academic development time is an outstanding opportunity to begin to develop your career as an academic surgeon.
What do you like best about living in Gainesville?
I love living in a mid-size college town that has everything you could need or want to do and provides the ability to afford a nice house on a resident salary. The weather allows for outdoor recreation all year long and the ocean is a short drive away.
List of hobbies/interests: Fishing, hunting, football
Publications
Academic Articles
2025
Guiding Surgical Trainee Supervision Through Competency-Based Assessment: In Reply to Kapoor and Ray.
Journal of the American College of Surgeons.
240(5):839-840
[DOI] 10.1097/XCS.0000000000001262.
[PMID] 39774630.
2025
Textbook Neoadjuvant Experience: Defining a Novel Composite Outcomes Measure for Patients with Pancreatic Cancer Undergoing Neoadjuvant Therapy.
Journal of the American College of Surgeons.
240(4):539-548
[DOI] 10.1097/XCS.0000000000001277.
[PMID] 39803957.
2024
Comment on: Predictive value of baseline serum carbohydrate antigen 19-9 level on treatment effect of neoadjuvant chemoradiotherapy in patients with resectable and borderline resectable pancreatic cancer in two randomized trials.
The British journal of surgery.
111(4)
[DOI] 10.1093/bjs/znae085.
[PMID] 38568860.
2024
Hepatic adenoma: evolution of a more individualized treatment approach.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
28(6):975-982
[DOI] 10.1016/j.gassur.2024.03.010.
[PMID] 38521190.
2024
Infiltration of CD3+ and CD8+ lymphocytes in association with inflammation and survival in pancreatic cancer.
PloS one.
19(2)
[DOI] 10.1371/journal.pone.0297325.
[PMID] 38346068.
2024
Precision Medicine for Metastatic Colorectal Cancer: Where Do We Stand?
Cancers.
16(22)
[DOI] 10.3390/cancers16223870.
[PMID] 39594824.
2024
Resident and Fellow Performance and Supervision in Surgical Oncology Procedures.
Journal of the American College of Surgeons.
239(6):528-537
[DOI] 10.1097/XCS.0000000000001131.
[PMID] 38895939.
2024
Update on Targeted Therapy and Immunotherapy for Metastatic Colorectal Cancer.
Cells.
13(3)
[DOI] 10.3390/cells13030245.
[PMID] 38334637.
2023
A protein-based machine learning approach to the identification of inflammatory subtypes in pancreatic ductal adenocarcinoma.
Pancreatology : official journal of the International Association of Pancreatology (IAP) … [et al.].
23(6):615-621
[DOI] 10.1016/j.pan.2023.06.007.
[PMID] 37391359.
2023
A simulation curriculum for laparoscopic common bile duct exploration, balloon sphincterotomy, and endobiliary stenting: Associations with resident performance and autonomy in the operating room.
Surgery.
173(4):950-956
[DOI] 10.1016/j.surg.2022.11.007.
[PMID] 36517292.
2023
Changing Practice Patterns and Improving Survival for Patients with Pancreatic Ductal Adenocarcinoma.
Cancers.
15(18)
[DOI] 10.3390/cancers15184464.
[PMID] 37760433.
2023
Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors.
Cancer research communications.
3(12):2623-2639
[DOI] 10.1158/2767-9764.CRC-23-0222.
[PMID] 38051103.
2023
Resource use for cholecystectomy with versus without cholangiography: A multicenter, propensity-matched analysis.
Surgery.
174(2):152-158
[DOI] 10.1016/j.surg.2023.04.027.
[PMID] 37188579.
2023
Surgical resident experience with common bile duct exploration and assessment of performance and autonomy with formative feedback.
World journal of emergency surgery : WJES.
18(1)
[DOI] 10.1186/s13017-023-00480-0.
[PMID] 36747289.
2023
Transcriptomic analysis of pancreatic adenocarcinoma specimens obtained from Black and White patients.
PloS one.
18(2)
[DOI] 10.1371/journal.pone.0281182.
[PMID] 36812168.
2022
Calcium channel blockers potentiate gemcitabine chemotherapy  in pancreatic cancer.
Proceedings of the National Academy of Sciences of the United States of America.
119(18)
[DOI] 10.1073/pnas.2200143119.
[PMID] 35476525.
2022
Loss of SMAD4 Is Associated With Poor Tumor Immunogenicity and Reduced PD-L1 Expression in Pancreatic Cancer.
Frontiers in oncology.
12
[DOI] 10.3389/fonc.2022.806963.
[PMID] 35155243.
2022
Osteopenia is associated with wasting in pancreatic adenocarcinoma and predicts survival after surgery.
Cancer medicine.
11(1):50-60
[DOI] 10.1002/cam4.4416.
[PMID] 34791809.
2022
Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL-Specific Degrader DT2216.
Molecular cancer therapeutics.
21(1):184-192
[DOI] 10.1158/1535-7163.MCT-21-0474.
[PMID] 34667112.
2022
The interleukin-1 axis and the tumor immune microenvironment in pancreatic ductal adenocarcinoma.
Neoplasia (New York, N.Y.).
28
[DOI] 10.1016/j.neo.2022.100789.
[PMID] 35395492.
2022
XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer.
Proceedings of the National Academy of Sciences of the United States of America.
119(4)
[DOI] 10.1073/pnas.2116764119.
[PMID] 35064087.
2021
Biliary intervention rates during neoadjuvant therapy for adenocarcinoma of the pancreatic head.
HPB : the official journal of the International Hepato Pancreato Biliary Association.
23(8):1196-1200
[DOI] 10.1016/j.hpb.2020.11.1147.
[PMID] 33388244.
2021
Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
27(14):4012-4024
[DOI] 10.1158/1078-0432.CCR-20-4781.
[PMID] 33879459.
2021
It’s more than just cancer biology: Health disparities in patients with pancreatic neuroendocrine tumors.
Journal of surgical oncology.
124(8):1390-1401
[DOI] 10.1002/jso.26667.
[PMID] 34499741.
2021
Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies.
Cancers.
13(3)
[DOI] 10.3390/cancers13030440.
[PMID] 33503832.
2021
The Current Treatment Paradigm for Pancreatic Ductal Adenocarcinoma and Barriers to Therapeutic Efficacy.
Frontiers in oncology.
11
[DOI] 10.3389/fonc.2021.688377.
[PMID] 34336673.
2020
Disparities in Pancreatic Ductal Adenocarcinoma-The Significance of Hispanic Ethnicity, Subgroup Analysis, and Treatment Facility on Clinical Outcomes.
Cancer medicine.
9(12):4069-4082
[DOI] 10.1002/cam4.3042.
[PMID] 32285629.
2020
From tumor microenvironment communicants to biomarker discovery: Selectively packaged extracellular vesicular cargoes in pancreatic cancer.
Cytokine & growth factor reviews.
51:61-68
[DOI] 10.1016/j.cytogfr.2020.01.001.
[PMID] 32005635.
2020
Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy.
Cancer research.
80(15):3101-3115
[DOI] 10.1158/0008-5472.CAN-19-2959.
[PMID] 32238357.
2020
MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer.
Cancer research.
80(9):1861-1874
[DOI] 10.1158/0008-5472.CAN-19-1558.
[PMID] 32132110.
2020
Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia.
Cancers.
12(2)
[DOI] 10.3390/cancers12020329.
[PMID] 32024069.
2020
Protein Signatures and Tissue Diagnosis of Pancreatic Cancer.
Journal of the American College of Surgeons.
230(1):26-36.e1
[DOI] 10.1016/j.jamcollsurg.2019.10.002.
[PMID] 31672677.
2019
A deeper understanding of the tumor microenvironment in pancreatic cancer: the key to developing effective immunotherapies.
Annals of translational medicine.
7(8)
[DOI] 10.21037/atm.2019.03.14.
[PMID] 31168443.
2019
Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research.
25(19):5984-5996
[DOI] 10.1158/1078-0432.CCR-18-3399.
[PMID] 31227505.
2019
Pitfalls of minimally invasive pancreatoduodenectomy.
Annals of pancreatic cancer.
2
[DOI] 10.21037/apc.2018.12.02.
[PMID] 32055795.
2019
Postoperative surgical trainee opioid prescribing practices (POST-OPP): A national survey.
Journal of opioid management.
15(4):307-322
[DOI] 10.5055/jom.2019.0516.
[PMID] 31637683.
2019
The Proteome of Pancreatic Cancer-Derived Exosomes Reveals Signatures Rich in Key Signaling Pathways.
Proteomics.
19(13)
[DOI] 10.1002/pmic.201800394.
[PMID] 31070281.
2018
Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine.
International journal of molecular sciences.
19(12)
[DOI] 10.3390/ijms19123836.
[PMID] 30513792.
2018
Postoperative surgical trainee opioid prescribing practices (POST OPP): an institutional study.
The Journal of surgical research.
229:58-65
[DOI] 10.1016/j.jss.2018.03.011.
[PMID] 29937017.
2017
Morphometric age and survival following kidney transplantation.
Clinical transplantation.
31(10)
[DOI] 10.1111/ctr.13066.
[PMID] 28758236.
2015
Sarcopenia and failure to rescue following liver transplantation.
Clinical transplantation.
29(12):1076-80
[DOI] 10.1111/ctr.12629.
[PMID] 26358578.
2014
Cigarette smoking in living kidney donors: donor and recipient outcomes.
Clinical transplantation.
28(4):419-22
[DOI] 10.1111/ctr.12330.
[PMID] 24617506.
2014
Dorsal muscle group area and surgical outcomes in liver transplantation.
Clinical transplantation.
28(10):1092-8
[DOI] 10.1111/ctr.12422.
[PMID] 25040933.
Grants
Nov 2019
– Dec 2021
Immunologic and molecular profiling of endoscopic ultrasound-guided fine needle aspiration samples for precision medicine in pancreatic ductal adenocarcinoma
Role: Principal Investigator
Funding: FREDERICK A COLLER SURGICAL SOCIETY
Contact Details
Phones:
- Business:
- (352) 265-0169
Emails:
- Business:
- p.underwood@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100287
GAINESVILLE FL 32610 - Business Street:
-
1600 SW ARCHER RD
GAINESVILLE FL 32610