Karen S Thompson

Karen S Thompson, DO

UFHealth Physician

Business Phone: (352) 787-9838
Business Email: karenthompson@ufl.edu

About Karen S Thompson

Hello, my name is Dr. Karen Thompson, and I am a board-certified cardiothoracic surgeon at UF Health Heart and Vascular Surgery in Leesburg, Florida. Cardiac surgery is my main focus with professional expertise in coronary artery bypass grafting, valvular surgery and surgical treatment of atrial fibrillation. Additionally, I am actively involved in the structural heart program which includes the Transcatheter Aortic Valve Replacement (TAVR) and Transcatheter Mitral Valve Repair (Mitral Clip) procedures.

I graduated with honors, earning my osteopathic medical degree from Midwestern University of Chicago and was the recipient of the Dean’s Commendation Award. After medical school, I completed my osteopathic internship at Illinois Masonic Medical Center in Chicago, Illinois. My postdoctoral training included a five-year general surgery residency at Jewish Hospital in Cincinnati, Ohio. Following the completion of my residency in cardiothoracic surgery at the University of Mississippi, I continued to pursue a two-year adult cardiothoracic surgery fellowship at Emory University in Atlanta, Georgia.

In addition to my clinical and surgical expertise, I have spent time as a clinical faculty member at Northwestern University in Chicago, Illinois, where I received specialty training in mitral valve surgery, working with nationally renowned valve experts.

I am board-certified by the American Board of Thoracic Surgery and have active memberships in the Society of Thoracic Surgeons, the Southern Thoracic Surgical Association, the Florida Medical Association and the Florida Society of Thoracic Surgeons and Cardiovascular Surgeons.

I have a passion for cardiac surgery but also embrace the philosophy that the best treatment for heart disease is prevention. I believe that healthy relationships, nutrition, exercise and stress reduction are important components of good cardiac health. My interests include quality time with my family and friends, travel, CrossFit, tennis and my faith.


Chief Resident in Cardiothoracic Surgery
2005-2006 · University Hospital of Mississippi
Chief Resident in General Surgery
2003-2004 · Jewish Hospital Kenwood

Board Certifications

  • Thoracic Surgery
    American Board of Thoracic Surgery

Clinical Profile

  • Cardiothoracic Surgery
Areas of Interest
  • Aortic dissection
  • Aortic regurgitation
  • Aortic valve surgery – open
  • Atrial fibrillation or flutter
  • Heart bypass surgery
  • Heart disease
  • Mitral valve surgery – minimally invasive
  • Transcatheter aortic valve replacement (TAVR)


A Rare Etiology for Ascending Paralysis in an Infant.
Journal of the Pediatric Infectious Diseases Society. 11(10):448-451 [DOI] 10.1093/jpids/piac048. [PMID] 35802023.
T-cell Lymphoblastic Lymphoma in a Patient With Chromosome 8q21.11 Microdeletion.
Journal of pediatric hematology/oncology. 44(3):e756-e759 [DOI] 10.1097/MPH.0000000000002309. [PMID] 34486555.
Subcutaneous panniculitis-like T-cell lymphoma: redefinition of diagnostic criteria in the recent World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas.
Archives of pathology & laboratory medicine. 133(2):303-8 [PMID] 19195975.


Fellowship in Cardiothoracic Surgery
2006-2008 · Emory University School of Medicine
Residency in Cardiothoracic Surgery
2004-2006 · University Hospital of Mississippi
Residency in General Surgery
1999-2003 · Jewish Hospital of Kenwood
Internship in Osteopathic (Rotating Internship)
1998-1999 · Illinois Masonic Medical Center
Internship in Surgery
1998-1999 · Advocate Illinois Masonic Medical Center
Medical Degree in Osteopathic Medicine
1994-1998 · Midwestern University of Chicago
Bachelor of Arts
1991-1994 · Saint Louis University
1986-1989 · Spokane Community College

Contact Details

(352) 787-9838
Business Mailing: