Ryan M Thomas

Ryan M Thomas, MD

Assistant Professor-VA Faculty

Department: MD-SURGERY-SURGONC-PBS
Business Phone: (352) 265-0535
Business Email: ryan.thomas.md@ufl.edu

Publications

2021
Bacteria and Sepsis: Microbiome to the Rescue?
Journal of clinical medicine. 10(16) [DOI] 10.3390/jcm10163578. [PMID] 34441874.
2021
Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut.
Neoplasia (New York, N.Y.). 23(2):246-256 [DOI] 10.1016/j.neo.2020.12.008. [PMID] 33418277.
2021
Intraductal Oncocytic Papillary Neoplasm of the Pancreas.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 25(1):319-321 [DOI] 10.1007/s11605-020-04638-y. [PMID] 32394127.
2021
Invited Commentary.
Journal of the American College of Surgeons. 232(4):514-516 [DOI] 10.1016/j.jamcollsurg.2020.12.042. [PMID] 33771308.
2021
Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice.
Shock (Augusta, Ga.). 55(4):519-525 [DOI] 10.1097/SHK.0000000000001648. [PMID] 32826817.
2021
SSAT State-of-the-Art Conference: Advancements in the Microbiome.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 25(7):1885-1895 [DOI] 10.1007/s11605-020-04551-4. [PMID] 32989690.
2021
Stress-related changes in the gut microbiome after trauma.
The journal of trauma and acute care surgery. 91(1):192-199 [DOI] 10.1097/TA.0000000000003209. [PMID] 34144563.
2020
Fungating Anal Mass: Extrapulmonary Small Cell Carcinoma Masquerading as a Hemorrhoid.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 24(6):1441-1443 [DOI] 10.1007/s11605-019-04498-1. [PMID] 31848872.
2020
Microbiota in pancreatic health and disease: the next frontier in microbiome research.
Nature reviews. Gastroenterology & hepatology. 17(1):53-64 [DOI] 10.1038/s41575-019-0242-7. [PMID] 31811279.
2020
Minimally Invasive Ivor Lewis Esophagectomy with Linear Stapled Anastomosis Associated with Low Leak and Stricture Rates.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 24(8):1729-1735 [DOI] 10.1007/s11605-019-04320-y. [PMID] 31317458.
2020
Patient-derived xenografts in surgical oncology: A short research review.
Surgery. 168(6):1021-1025 [DOI] 10.1016/j.surg.2020.07.031. [PMID] 33010939.
2020
Protein Signatures and Tissue Diagnosis of Pancreatic Cancer.
Journal of the American College of Surgeons. 230(1):26-36.e1 [DOI] 10.1016/j.jamcollsurg.2019.10.002. [PMID] 31672677.
2020
Proton Pump Inhibitor Use After Hiatal Hernia Repair: Inhibitor of Recurrent Symptoms and Potential Revisional Surgery.
The Journal of surgical research. 256:570-576 [DOI] 10.1016/j.jss.2020.07.033. [PMID] 32805579.
2019
Extrahepatic Neuroendocrine Tumor Causing Biliary Obstruction.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 23(6):1266-1268 [DOI] 10.1007/s11605-018-4048-7. [PMID] 30465186.
2019
Packed red blood cell donor age affects overall survival in transfused patients undergoing hepatectomy for non-hepatocellular malignancy.
American journal of surgery. 217(1):71-77 [DOI] 10.1016/j.amjsurg.2018.08.011. [PMID] 30172359.
2019
Reply to: Preoperative enteral access is not necessary prior to multimodality treatment of esophageal cancer.
Surgery. 166(1) [DOI] 10.1016/j.surg.2019.01.029. [PMID] 30876668.
2018
Impact of Palliative Chemotherapy and Travel Distance on Hospice Referral in Patients With Stage IV Pancreatic Cancer: A Retrospective Analysis Within a Veterans Administration Medical Center.
The American journal of hospice & palliative care. 35(6):875-881 [DOI] 10.1177/1049909117746390. [PMID] 29216749.
2018
Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models.
Carcinogenesis. 39(8):1068-1078 [DOI] 10.1093/carcin/bgy073. [PMID] 29846515.
2018
Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine.
International journal of molecular sciences. 19(12) [DOI] 10.3390/ijms19123836. [PMID] 30513792.
2018
Microbial marauders: pancreatic microbiota and its impact on carcinogenesis.
Annals of translational medicine. 6(Suppl 1) [DOI] 10.21037/atm.2018.10.34. [PMID] 30613638.
2018
Patient-derived xenograft cryopreservation and reanimation outcomes are dependent on cryoprotectant type.
Laboratory investigation; a journal of technical methods and pathology. 98(7):947-956 [DOI] 10.1038/s41374-018-0042-7. [PMID] 29520054.
2018
Preoperative enteral access is not necessary prior to multimodality treatment of esophageal cancer.
Surgery. 163(4):770-776 [DOI] 10.1016/j.surg.2017.09.046. [PMID] 29198770.
2018
Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties.
Acta biomaterialia. 67:331-340 [DOI] 10.1016/j.actbio.2017.11.037. [PMID] 29191507.
2017
A clinically applicable muscular index predicts long-term survival in resectable pancreatic cancer.
Surgery. 161(4):930-938 [DOI] 10.1016/j.surg.2016.09.038. [PMID] 27932030.
2017
Comparative Effectiveness of Preoperative Treatment Regimens in Patients With Potentially Resectable Esophageal Cancer.
JAMA surgery. 152(1):103-105 [DOI] 10.1001/jamasurg.2016.2821. [PMID] 27627680.
2017
Delayed Imaging Presentation of a Symptomatic Insulinoma After Bariatric Surgery.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 21(2):412-414 [DOI] 10.1007/s11605-016-3219-7. [PMID] 27561632.
2017
Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.
Cancer research. 77(3):672-683 [DOI] 10.1158/0008-5472.CAN-16-1765. [PMID] 27864347.
2017
Percutaneous cholecystostomy: prognostic factors and comparison to cholecystectomy.
Surgical endoscopy. 31(11):4568-4575 [DOI] 10.1007/s00464-017-5517-x. [PMID] 28409378.
2017
The effects of red cell transfusion donor age on nosocomial infection among trauma patients.
American journal of surgery. 214(4):672-676 [DOI] 10.1016/j.amjsurg.2017.07.004. [PMID] 28720216.
2017
The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma.
Oncotarget. 8(33):54054-54067 [DOI] 10.18632/oncotarget.10722. [PMID] 28903323.
2016
Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture.
The American journal of pathology. 186(6):1537-46 [DOI] 10.1016/j.ajpath.2016.02.009. [PMID] 27102771.
2016
Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research. 22(7):1787-99 [DOI] 10.1158/1078-0432.CCR-15-1256. [PMID] 26667487.
2016
Oncologic and Perioperative Outcomes Following Selective Application of Laparoscopic Pancreaticoduodenectomy for Periampullary Malignancies.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 20(7):1343-9 [DOI] 10.1007/s11605-016-3136-9. [PMID] 27142633.
2016
Standardization of surgical care in a high-volume center improves survival in resected pancreatic head cancer.
American journal of surgery. 212(2):195-201.e1 [DOI] 10.1016/j.amjsurg.2016.03.001. [PMID] 27260793.
2016
Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research. 22(19):4934-4946 [PMID] 27126993.
View on: PubMed
2015
Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer.
Cancer immunology, immunotherapy : CII. 64(12):1553-63 [DOI] 10.1007/s00262-015-1760-y. [PMID] 26423423.
2015
Patient-derived xenograft models for pancreatic adenocarcinoma demonstrate retention of tumor morphology through incorporation of murine stromal elements.
The American journal of pathology. 185(5):1297-303 [DOI] 10.1016/j.ajpath.2015.01.016. [PMID] 25770474.
2015
Primary outgrowth cultures are a reliable source of human pancreatic stellate cells.
Laboratory investigation; a journal of technical methods and pathology. 95(11):1331-40 [DOI] 10.1038/labinvest.2015.117. [PMID] 26322418.
2015
Prospective Comprehensive Swallowing Evaluation of Minimally Invasive Esophagectomies with Cervical Anastomosis: Silent Versus Vocal Aspiration
Journal of Gastrointestinal Surgery. 19(10):1748-52 [DOI] 10.1007/s11605-015-2889-x. [PMID] 26202151.
2015
The canary in the coal mine: the growth of patient-derived tumorgrafts in mice predicts clinical recurrence after surgical resection of pancreatic ductal adenocarcinoma.
Annals of surgical oncology. 22(6):1884-92 [DOI] 10.1245/s10434-014-4241-1. [PMID] 25404477.
2015
The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival.
BMC cancer. 15 [DOI] 10.1186/s12885-015-1820-x. [PMID] 26498838.
2015
The Microbiome and Cancer: Is the ‘Oncobiome’ Mirage Real?
Trends in cancer. 1(1):24-35 [PMID] 26568984.
View on: PubMed
2015
Two-dimensional culture of human pancreatic adenocarcinoma cells results in an irreversible transition from epithelial to mesenchymal phenotype.
Laboratory investigation; a journal of technical methods and pathology. 95(2):207-22 [DOI] 10.1038/labinvest.2014.143. [PMID] 25485535.
2014
Extracellular lumican inhibits pancreatic cancer cell growth and is associated with prolonged survival after surgery.
Clinical cancer research : an official journal of the American Association for Cancer Research. 20(24):6529-40 [DOI] 10.1158/1078-0432.CCR-14-0970. [PMID] 25336691.
2014
Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer.
Physical biology. 11(6) [DOI] 10.1088/1478-3975/11/6/065002. [PMID] 25427073.
2014
SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium.
PloS one. 9(9) [DOI] 10.1371/journal.pone.0107948. [PMID] 25264609.
2014
Transport properties of pancreatic cancer describe gemcitabine delivery and response.
The Journal of clinical investigation. 124(4):1525-36 [DOI] 10.1172/JCI73455. [PMID] 24614108.
2014
Treatment sequencing strategy for hepatic epithelioid haemangioendothelioma.
HPB : the official journal of the International Hepato Pancreato Biliary Association. 16(7):677-85 [DOI] 10.1111/hpb.12202. [PMID] 24308564.
2012
MicroRNA dissects out dangerous pancreatic cysts from all the rest.
Clinical cancer research : an official journal of the American Association for Cancer Research. 18(17):4482-4 [DOI] 10.1158/1078-0432.CCR-12-2089. [PMID] 22919002.
2012
Multimodality therapy offers a chance for cure in patients with pancreatic adenocarcinoma deemed unresectable at first operative exploration.
Journal of the American College of Surgeons. 215(1):41-51; discussion 51 [DOI] 10.1016/j.jamcollsurg.2012.03.024. [PMID] 22608401.
2012
Selective reoperation for locally recurrent or metastatic pancreatic ductal adenocarcinoma following primary pancreatic resection.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 16(9):1696-704 [DOI] 10.1007/s11605-012-1912-8. [PMID] 22644446.
2010
Chemokine receptor CXCR4 enhances proliferation in pancreatic cancer cells through AKT and ERK dependent pathways.
Pancreas. 39(1):81-7 [DOI] 10.1097/MPA.0b013e3181bb2ab7. [PMID] 19820417.
2010
Current concepts in the surgical management of pancreatic cancer.
Surgical oncology clinics of North America. 19(2):335-58 [DOI] 10.1016/j.soc.2009.11.001. [PMID] 20159518.
2010
Management of acute post-operative portal venous thrombosis.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 14(3):570-7 [DOI] 10.1007/s11605-009-0967-7. [PMID] 19582513.
2010
Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers.
Cancer research. 70(3):1130-40 [DOI] 10.1158/0008-5472.CAN-09-0761. [PMID] 20103639.
2010
The RON tyrosine kinase receptor regulates vascular endothelial growth factor production in pancreatic cancer cells.
Pancreas. 39(3):301-7 [PMID] 20358644.
View on: PubMed
2007
The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression.
Cancer research. 67(13):6075-82 [PMID] 17616662.
View on: PubMed
2003
Infection with chronic hepatitis C virus and liver transplantation: a role for interferon therapy before transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 9(9):905-15 [PMID] 12942451.
View on: PubMed
2002
Minimal access closure of patent foramen ovale: is it also recommended for patients with paradoxical emboli?
The Annals of thoracic surgery. 74(4):S1326-9 [PMID] 12400810.
View on: PubMed

Grants

Jan 2018 ACTIVE
The role of the microbiome on pancreatic carcinogenesis in a murine model
Role: Principal Investigator
Funding: AMER CANCER SOC
Oct 2016 – Sep 2018
Role of Gram negative bacterial lipopolysaccharide in CXCR4-mediated pancreatic carcinogenesis
Role: Principal Investigator
Funding: ASSOC OF VA SURGEONS FOU
Feb 2015 ACTIVE
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2015 ACTIVE
UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Apr 2014 – Jun 2018
Research Startup
Role: Principal Investigator
Funding: FL CLINICAL PRACTICE ASSO

Teaching Profile

Courses Taught
2018
MDC7600 Surgery Clerkship
2018
MDC7602 Senior Surgery Clerk
2018
MDC6001 Intro Clin Practice

Contact Details

Phones:
Business:
(352) 265-0535
Emails: