Ryan M Thomas, MD
Assistant Professor-VA Faculty
Department:
MD-SURGERY-SURGONC-PBS
Business Phone:
(352) 265-0535
Business Email:
ryan.thomas.md@ufl.edu
Publications
2021
Bacteria and Sepsis: Microbiome to the Rescue?
Journal of clinical medicine.
10(16)
[DOI] 10.3390/jcm10163578.
[PMID] 34441874.
2021
Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut.
Neoplasia (New York, N.Y.).
23(2):246-256
[DOI] 10.1016/j.neo.2020.12.008.
[PMID] 33418277.
2021
Intraductal Oncocytic Papillary Neoplasm of the Pancreas.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
25(1):319-321
[DOI] 10.1007/s11605-020-04638-y.
[PMID] 32394127.
2021
Invited Commentary.
Journal of the American College of Surgeons.
232(4):514-516
[DOI] 10.1016/j.jamcollsurg.2020.12.042.
[PMID] 33771308.
2021
Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice.
Shock (Augusta, Ga.).
55(4):519-525
[DOI] 10.1097/SHK.0000000000001648.
[PMID] 32826817.
2021
SSAT State-of-the-Art Conference: Advancements in the Microbiome.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
25(7):1885-1895
[DOI] 10.1007/s11605-020-04551-4.
[PMID] 32989690.
2021
Stress-related changes in the gut microbiome after trauma.
The journal of trauma and acute care surgery.
91(1):192-199
[DOI] 10.1097/TA.0000000000003209.
[PMID] 34144563.
2020
Fungating Anal Mass: Extrapulmonary Small Cell Carcinoma Masquerading as a Hemorrhoid.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
24(6):1441-1443
[DOI] 10.1007/s11605-019-04498-1.
[PMID] 31848872.
2020
Microbiota in pancreatic health and disease: the next frontier in microbiome research.
Nature reviews. Gastroenterology & hepatology.
17(1):53-64
[DOI] 10.1038/s41575-019-0242-7.
[PMID] 31811279.
2020
Minimally Invasive Ivor Lewis Esophagectomy with Linear Stapled Anastomosis Associated with Low Leak and Stricture Rates.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
24(8):1729-1735
[DOI] 10.1007/s11605-019-04320-y.
[PMID] 31317458.
2020
Patient-derived xenografts in surgical oncology: A short research review.
Surgery.
168(6):1021-1025
[DOI] 10.1016/j.surg.2020.07.031.
[PMID] 33010939.
2020
Protein Signatures and Tissue Diagnosis of Pancreatic Cancer.
Journal of the American College of Surgeons.
230(1):26-36.e1
[DOI] 10.1016/j.jamcollsurg.2019.10.002.
[PMID] 31672677.
2020
Proton Pump Inhibitor Use After Hiatal Hernia Repair: Inhibitor of Recurrent Symptoms and Potential Revisional Surgery.
The Journal of surgical research.
256:570-576
[DOI] 10.1016/j.jss.2020.07.033.
[PMID] 32805579.
2019
Extrahepatic Neuroendocrine Tumor Causing Biliary Obstruction.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
23(6):1266-1268
[DOI] 10.1007/s11605-018-4048-7.
[PMID] 30465186.
2019
Packed red blood cell donor age affects overall survival in transfused patients undergoing hepatectomy for non-hepatocellular malignancy.
American journal of surgery.
217(1):71-77
[DOI] 10.1016/j.amjsurg.2018.08.011.
[PMID] 30172359.
2019
Reply to: Preoperative enteral access is not necessary prior to multimodality treatment of esophageal cancer.
Surgery.
166(1)
[DOI] 10.1016/j.surg.2019.01.029.
[PMID] 30876668.
2018
Impact of Palliative Chemotherapy and Travel Distance on Hospice Referral in Patients With Stage IV Pancreatic Cancer: A Retrospective Analysis Within a Veterans Administration Medical Center.
The American journal of hospice & palliative care.
35(6):875-881
[DOI] 10.1177/1049909117746390.
[PMID] 29216749.
2018
Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models.
Carcinogenesis.
39(8):1068-1078
[DOI] 10.1093/carcin/bgy073.
[PMID] 29846515.
2018
Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine.
International journal of molecular sciences.
19(12)
[DOI] 10.3390/ijms19123836.
[PMID] 30513792.
2018
Microbial marauders: pancreatic microbiota and its impact on carcinogenesis.
Annals of translational medicine.
6(Suppl 1)
[DOI] 10.21037/atm.2018.10.34.
[PMID] 30613638.
2018
Patient-derived xenograft cryopreservation and reanimation outcomes are dependent on cryoprotectant type.
Laboratory investigation; a journal of technical methods and pathology.
98(7):947-956
[DOI] 10.1038/s41374-018-0042-7.
[PMID] 29520054.
2018
Preoperative enteral access is not necessary prior to multimodality treatment of esophageal cancer.
Surgery.
163(4):770-776
[DOI] 10.1016/j.surg.2017.09.046.
[PMID] 29198770.
2018
Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties.
Acta biomaterialia.
67:331-340
[DOI] 10.1016/j.actbio.2017.11.037.
[PMID] 29191507.
2017
A clinically applicable muscular index predicts long-term survival in resectable pancreatic cancer.
Surgery.
161(4):930-938
[DOI] 10.1016/j.surg.2016.09.038.
[PMID] 27932030.
2017
Comparative Effectiveness of Preoperative Treatment Regimens in Patients With Potentially Resectable Esophageal Cancer.
JAMA surgery.
152(1):103-105
[DOI] 10.1001/jamasurg.2016.2821.
[PMID] 27627680.
2017
Delayed Imaging Presentation of a Symptomatic Insulinoma After Bariatric Surgery.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
21(2):412-414
[DOI] 10.1007/s11605-016-3219-7.
[PMID] 27561632.
2017
Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.
Cancer research.
77(3):672-683
[DOI] 10.1158/0008-5472.CAN-16-1765.
[PMID] 27864347.
2017
Percutaneous cholecystostomy: prognostic factors and comparison to cholecystectomy.
Surgical endoscopy.
31(11):4568-4575
[DOI] 10.1007/s00464-017-5517-x.
[PMID] 28409378.
2017
The effects of red cell transfusion donor age on nosocomial infection among trauma patients.
American journal of surgery.
214(4):672-676
[DOI] 10.1016/j.amjsurg.2017.07.004.
[PMID] 28720216.
2017
The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma.
Oncotarget.
8(33):54054-54067
[DOI] 10.18632/oncotarget.10722.
[PMID] 28903323.
2016
Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture.
The American journal of pathology.
186(6):1537-46
[DOI] 10.1016/j.ajpath.2016.02.009.
[PMID] 27102771.
2016
Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research.
22(7):1787-99
[DOI] 10.1158/1078-0432.CCR-15-1256.
[PMID] 26667487.
2016
Oncologic and Perioperative Outcomes Following Selective Application of Laparoscopic Pancreaticoduodenectomy for Periampullary Malignancies.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
20(7):1343-9
[DOI] 10.1007/s11605-016-3136-9.
[PMID] 27142633.
2016
Standardization of surgical care in a high-volume center improves survival in resected pancreatic head cancer.
American journal of surgery.
212(2):195-201.e1
[DOI] 10.1016/j.amjsurg.2016.03.001.
[PMID] 27260793.
2016
Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research.
22(19):4934-4946
[PMID] 27126993.
View on:
PubMed
2015
Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer.
Cancer immunology, immunotherapy : CII.
64(12):1553-63
[DOI] 10.1007/s00262-015-1760-y.
[PMID] 26423423.
2015
Patient-derived xenograft models for pancreatic adenocarcinoma demonstrate retention of tumor morphology through incorporation of murine stromal elements.
The American journal of pathology.
185(5):1297-303
[DOI] 10.1016/j.ajpath.2015.01.016.
[PMID] 25770474.
2015
Primary outgrowth cultures are a reliable source of human pancreatic stellate cells.
Laboratory investigation; a journal of technical methods and pathology.
95(11):1331-40
[DOI] 10.1038/labinvest.2015.117.
[PMID] 26322418.
2015
Prospective Comprehensive Swallowing Evaluation of Minimally Invasive Esophagectomies with Cervical Anastomosis: Silent Versus Vocal Aspiration
Journal of Gastrointestinal Surgery.
19(10):1748-52
[DOI] 10.1007/s11605-015-2889-x.
[PMID] 26202151.
2015
The canary in the coal mine: the growth of patient-derived tumorgrafts in mice predicts clinical recurrence after surgical resection of pancreatic ductal adenocarcinoma.
Annals of surgical oncology.
22(6):1884-92
[DOI] 10.1245/s10434-014-4241-1.
[PMID] 25404477.
2015
The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival.
BMC cancer.
15
[DOI] 10.1186/s12885-015-1820-x.
[PMID] 26498838.
2015
The Microbiome and Cancer: Is the ‘Oncobiome’ Mirage Real?
Trends in cancer.
1(1):24-35
[PMID] 26568984.
View on:
PubMed
2015
Two-dimensional culture of human pancreatic adenocarcinoma cells results in an irreversible transition from epithelial to mesenchymal phenotype.
Laboratory investigation; a journal of technical methods and pathology.
95(2):207-22
[DOI] 10.1038/labinvest.2014.143.
[PMID] 25485535.
2014
Extracellular lumican inhibits pancreatic cancer cell growth and is associated with prolonged survival after surgery.
Clinical cancer research : an official journal of the American Association for Cancer Research.
20(24):6529-40
[DOI] 10.1158/1078-0432.CCR-14-0970.
[PMID] 25336691.
2014
Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer.
Physical biology.
11(6)
[DOI] 10.1088/1478-3975/11/6/065002.
[PMID] 25427073.
2014
SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium.
PloS one.
9(9)
[DOI] 10.1371/journal.pone.0107948.
[PMID] 25264609.
2014
Transport properties of pancreatic cancer describe gemcitabine delivery and response.
The Journal of clinical investigation.
124(4):1525-36
[DOI] 10.1172/JCI73455.
[PMID] 24614108.
2014
Treatment sequencing strategy for hepatic epithelioid haemangioendothelioma.
HPB : the official journal of the International Hepato Pancreato Biliary Association.
16(7):677-85
[DOI] 10.1111/hpb.12202.
[PMID] 24308564.
2012
MicroRNA dissects out dangerous pancreatic cysts from all the rest.
Clinical cancer research : an official journal of the American Association for Cancer Research.
18(17):4482-4
[DOI] 10.1158/1078-0432.CCR-12-2089.
[PMID] 22919002.
2012
Multimodality therapy offers a chance for cure in patients with pancreatic adenocarcinoma deemed unresectable at first operative exploration.
Journal of the American College of Surgeons.
215(1):41-51; discussion 51
[DOI] 10.1016/j.jamcollsurg.2012.03.024.
[PMID] 22608401.
2012
Selective reoperation for locally recurrent or metastatic pancreatic ductal adenocarcinoma following primary pancreatic resection.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
16(9):1696-704
[DOI] 10.1007/s11605-012-1912-8.
[PMID] 22644446.
2010
Chemokine receptor CXCR4 enhances proliferation in pancreatic cancer cells through AKT and ERK dependent pathways.
Pancreas.
39(1):81-7
[DOI] 10.1097/MPA.0b013e3181bb2ab7.
[PMID] 19820417.
2010
Current concepts in the surgical management of pancreatic cancer.
Surgical oncology clinics of North America.
19(2):335-58
[DOI] 10.1016/j.soc.2009.11.001.
[PMID] 20159518.
2010
Management of acute post-operative portal venous thrombosis.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
14(3):570-7
[DOI] 10.1007/s11605-009-0967-7.
[PMID] 19582513.
2010
Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers.
Cancer research.
70(3):1130-40
[DOI] 10.1158/0008-5472.CAN-09-0761.
[PMID] 20103639.
2010
The RON tyrosine kinase receptor regulates vascular endothelial growth factor production in pancreatic cancer cells.
Pancreas.
39(3):301-7
[PMID] 20358644.
View on:
PubMed
2007
The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression.
Cancer research.
67(13):6075-82
[PMID] 17616662.
View on:
PubMed
2003
Infection with chronic hepatitis C virus and liver transplantation: a role for interferon therapy before transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
9(9):905-15
[PMID] 12942451.
View on:
PubMed
2002
Minimal access closure of patent foramen ovale: is it also recommended for patients with paradoxical emboli?
The Annals of thoracic surgery.
74(4):S1326-9
[PMID] 12400810.
View on:
PubMed
Grants
Jan 2018
ACTIVE
The role of the microbiome on pancreatic carcinogenesis in a murine model
Role: Principal Investigator
Funding: AMER CANCER SOC
Oct 2016
– Sep 2018
Role of Gram negative bacterial lipopolysaccharide in CXCR4-mediated pancreatic carcinogenesis
Role: Principal Investigator
Funding: ASSOC OF VA SURGEONS FOU
Feb 2015
ACTIVE
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2015
ACTIVE
UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Apr 2014
– Jun 2018
Research Startup
Role: Principal Investigator
Funding: FL CLINICAL PRACTICE ASSO
Teaching Profile
Courses Taught
2018
MDC7600 Surgery Clerkship
2018
MDC7602 Senior Surgery Clerk
2018
MDC6001 Intro Clin Practice
Contact Details
Phones:
- Business:
- (352) 265-0535
Emails:
- Business:
- ryan.thomas.md@ufl.edu