About Ashish K Sharma
Dr. Sharma is a basic and translational medical scientist with a background in immunology, cell biology, molecular biology and pulmonary physiology. He joined UF in June 2018 as an Associate Professor in the Department of Surgery. Prior to joining UF, Dr. Sharma was a faculty member in Department of Surgery at University of Virginia since 2004. He received his PhD from University of Virginia and completed his medical graduation from MR Medical College, Gulbarga, India.
The research in Dr. Sharma’s laboratory focuses on defining the molecular and signal transduction mechanisms of acute lung injury (i.e. ischemia-reperfusion injury or primary graft dysfunction) after lung transplantation as well as investigating the pathophysiology of aortic aneurysms. The main focus of his research is to decipher the contribution of purinergic signaling via pannexin and transient receptor potential channels as well as to implement mesenchymal stem cell-derived extracellular vesicles as a therapeutic strategy in aortic aneurysms and primary graft dysfunction after lung transplantation.
He has served as a peer-reviewer for numerous scientific journals. He is an active member of the American Thoracic Society and the American Heart Association and has been invited to give guest lectures at various academic institutions and to serve as a guest editor on peer-reviewed scientific journals. Dr. Sharma has a strong history in the research training of surgery residents, postdoctoral fellows, graduate students, medical students and undergraduates.
Dr. Sharma’s research laboratory focuses on the role of pannexin and transient receptor channel signaling in aortic aneurysms and lung transplant immunology. Furthermore, he is also investigating the role of mesenchymal stem cells and its derivatives i.e. extracellular vesicles, as a therapeutic modality in the treatment of lung injury and aortic aneurysms. In addition, Dr. Sharma has extensive expertise in the role of innate immune cells, cytokines, HMGB1/RAGE axis, purinergic signaling and oxidative stress during inflammation and vascular remodeling in acute lung injury as well as aortic aneurysms. He has extensively published manuscripts, book chapters and abstracts on these topics.
Another area of research is the rehabilitation of non-heart beating donor lungs (i.e. DCD or donation after cardiac death) via ex vivo lung perfusion (EVLP) which has the potential to increase the donor lung pool size. Dr. Sharma’s research focuses on the use of stem cells and extracellular vesicles to supplement EVLP as a strategy to rescue marginal donor lungs and to prevent primary graft dysfunction. These projects utilize mouse and pig models of lung transplant & ischemia-reperfusion injury, mouse/pig/human EVLP models and in vitro models.