Eddie W Manning

Eddie W Manning, MD

Assistant Professor

Business Phone: (352) 376-1611

About Eddie W Manning

My name is Dr. Eddie W. Manning III, and I am an assistant professor of surgery in the division of cardiovascular surgery at the University of Florida College of Medicine and the North Florida/South Georgia Malcolm Randall Veterans Affairs Medical Center.

My practice is focused on adult cardiac and thoracic surgery, transcatheter aortic valve replacement and percutaneous mitral valve repair. I established the minimally invasive thoracic surgery program within the North Florida/South Georgia Malcolm Randall Veterans Affairs Medical Center, utilizing conventional video-assisted thoracoscopic techniques and the da Vinci robotic platform. This development has led to a decreased length of stay for patients, improved safety of thoracic operations and increased patient satisfaction. The minimally invasive cardiothoracic surgery program in the Gainesville VA medical center has the highest volume of all VA Medical Centers Nationally.

I earned my bachelor’s degree in science from Cornell University, a bachelor’s in nursing from the University of Pennsylvania where I graduated Magna Cum Laude and my medical degree from Temple University. My general surgery residency, postdoctoral research fellowship in cardiothoracic transplant surgery and cardiothoracic surgery fellowship were completed at the University of Miami, Jackson Memorial Hospital where I was inducted into the Alpha Omega Alpha Honor Society.

I was honored to serve as a member of the United States Army Medical Corps and retired from military service as a lieutenant colonel. I served in the U.S. Army Reserves, 348th General Hospital from 1995 to 2001, and was on active duty from 2011 to 2013 – first as the chief of general surgery at Reynolds Army Community Hospital, Fort Sill, Oklahoma and then as commander of the 14th Forward Surgical Element, Task Force Medical South during a combat deployment to Camp Dwyer, Afghanistan.

My research spans basic science research related to the modification of cellular changes secondary to ischemia-reperfusion injury and local pressure changes to selected clinical areas in adult cardiac surgery. In collaboration with colleagues from many scientific and medical disciplines I have participated in published works in Circulation, the Journal of Vascular Research, Human Gene Therapy, the Journal of the American College of Cardiology and the Journal of Cardiology and Therapy.

I am particularly committed to graduate medical education and serve as the program director of the Thoracic and Cardiovascular Fellowship programs and also serve as the educational director for the traditional three-year cardiothoracic surgery fellowship. Additionally, I have developed a six-year integrated thoracic surgery training program with a new curriculum that involves many of the surgical and non-surgical specialties within the University of Florida Health System.

Board Certifications

  • Thoracic and Cardiac Surgery
    American Board of Thoracic Surgery

Clinical Profile

  • Thoracic and Cardiovascular Surgery


Commentary: Shades of gray: The right aortic valve for the right patient in 2022.
The Journal of thoracic and cardiovascular surgery. 166(3):738-739 [DOI] 10.1016/j.jtcvs.2022.02.008. [PMID] 35249751.
Commentary: Stentless AVR in dialysis patients – another hand on the elephant.
Seminars in thoracic and cardiovascular surgery. 34(3) [DOI] 10.1053/j.semtcvs.2021.06.029. [PMID] 34242753.
Commentary: Which Aortic Valve Prosthesis to Choose in End-Stage Renal Failure.
Seminars in thoracic and cardiovascular surgery. 34(4):1195-1196 [DOI] 10.1053/j.semtcvs.2021.09.013. [PMID] 34597794.
Monitored Anesthesia Care Versus General Anesthesia for Transcatheter Aortic Valve Replacement.
Innovations (Philadelphia, Pa.). 17(5):401-408 [DOI] 10.1177/15569845221124113. [PMID] 36217748.
Outcome and Cost Comparisons Between Surgical and Transcatheter Aortic Valve Replacements.
Innovations (Philadelphia, Pa.). 17(6):482-490 [DOI] 10.1177/15569845221125474. [PMID] 36317252.
Coronary Artery Bypass: Review of Surgical Techniques and Impact on Long-Term Revascularization Outcomes.
Cardiology and therapy. 10(1):89-109 [DOI] 10.1007/s40119-021-00211-z. [PMID] 33515370.
Relationship between Invasive and Echocardiographic Transvalvular Gradients after Transcatheter Aortic Valve Replacement.
Cardiology and therapy. 9(1):201-206 [DOI] 10.1007/s40119-020-00161-y. [PMID] 31970689.
Aortoventricular Index Predicts Long-Term Mortality After Transcatheter Aortic Valve Replacement.
JACC. Cardiovascular interventions. 12(22):2327-2329 [DOI] 10.1016/j.jcin.2019.07.033. [PMID] 31753307.
Cardiac pseudoaneurysm following non-operative management after penetrating thoracoabdominal trauma and pericardial window.
The journal of trauma and acute care surgery. 86(4):755-757 [DOI] 10.1097/TA.0000000000002189. [PMID] 30629012.
Comparison of Different Invasive Hemodynamic Measurements as a Prediction Tool for Mortality after Transcatheter Aortic Valve Replacement in Men: A Retrospective Observational Study.
Cardiology and therapy. 6(2):251-259 [DOI] 10.1007/s40119-017-0095-5. [PMID] 28667514.
Late Paravalvular Aortic Regurgitation: Migration of the Valve or Late Recoil?
Cardiology and therapy. 6(1):133-138 [DOI] 10.1007/s40119-016-0077-z. [PMID] 28044267.
A new arteriovenous fistula model to study the development of neointimal hyperplasia.
Journal of vascular research. 49(2):123-31 [DOI] 10.1159/000332327. [PMID] 22249138.
Breast and lung metastasis from pancreatic neuroendocrine carcinoma.
World journal of radiology. 3(1):32-7 [DOI] 10.4329/wjr.v3.i1.32. [PMID] 21286493.
Origin of neointimal cells in arteriovenous fistulae: bone marrow, artery, or the vein itself?
Seminars in dialysis. 24(2):242-8 [DOI] 10.1111/j.1525-139X.2011.00870.x. [PMID] 21517994.
Interleukin-10 delivery via mesenchymal stem cells: a novel gene therapy approach to prevent lung ischemia-reperfusion injury.
Human gene therapy. 21(6):713-27 [DOI] 10.1089/hum.2009.147. [PMID] 20102275.
Proteasome peptidase activities parallel histomorphological and functional consequences of ischemia-reperfusion injury in the lung.
Experimental lung research. 35(4):284-95 [DOI] 10.1080/01902140802668823. [PMID] 19415546.
Ubiquitin enhances the Th2 cytokine response and attenuates ischemia-reperfusion injury in the lung.
Critical care medicine. 36(3):979-82 [DOI] 10.1097/CCM.0B013E318164E417. [PMID] 18209671.


Fellowship in Cardiothoracic Surgery
2015 · University of Miami/Jackson Memorial Hospital
Residency in General Surgery
2011 · University of Miami/Jackson Memorial Hospital
Medical Degree
2004 · Temple University
Bachelor of Science in Nursing
1999 · University of Pennsylvania
Bachelor in Biology
1993 · Cornell University

Contact Details

(352) 376-1611
Business Mailing:
PO Box 100129