Rob Maile, Ph.D.
Associate Professor
Teaching Profile
Courses Taught
2024-2025
GMS6140 Principles of Immunology
Research Profile
Areas of Interest
- Burn and Wound Care
- Extracellular vesicles
- Inhalation Injury
- Ionizing radiation injury
- Sepsis
Publications
Academic Articles
2024
Current updates in precision and personalized medicine in sepsis and trauma.
Surgery.
176(2):541-543
[DOI] 10.1016/j.surg.2024.03.048.
[PMID] 38760231.
2024
Exosomal microRNA following severe trauma: Role in bone marrow dysfunction.
The journal of trauma and acute care surgery.
96(4):548-556
[DOI] 10.1097/TA.0000000000004225.
[PMID] 38151766.
2024
Gut mycobiome dysbiosis after sepsis and trauma.
Critical care (London, England).
28(1)
[DOI] 10.1186/s13054-023-04780-4.
[PMID] 38212826.
2024
MULTIMODAL NUCLEAR FACTOR-ERYTHROID-2-RELATED FACTOR (NRF2) THERAPY IN THE CONTEXT OF MAMMALIAN TARGET OF RAPAMYCIN (MTOR) INHIBITION REPROGRAMS THE ACUTE SYSTEMIC AND PULMONARY IMMUNE RESPONSE AFTER COMBINED BURN AND INHALATION INJURY.
Shock (Augusta, Ga.).
62(6):772-782
[DOI] 10.1097/SHK.0000000000002466.
[PMID] 39178221.
2024
Persistence and Sexual Dimorphism of Gut Dysbiosis and Pathobiome after Sepsis and Trauma.
Annals of surgery.
280(3):491-503
[DOI] 10.1097/SLA.0000000000006385.
[PMID] 38864230.
2024
Resolvin D2/GPR18 signaling enhances monocytic myeloid‐derived suppressor cell function to mitigate abdominal aortic aneurysm formation
The FASEB Journal.
38(18)
[DOI] 10.1096/fj.202400414rrr.
2024
The post-septic peripheral myeloid compartment reveals unexpected diversity in myeloid-derived suppressor cells.
Frontiers in immunology.
15
[DOI] 10.3389/fimmu.2024.1355405.
[PMID] 38720891.
2024
TRANSCRIPTOMIC DIFFERENCES IN PERIPHERAL MONOCYTE POPULATIONS IN SEPTIC PATIENTS BASED ON OUTCOME.
Shock (Augusta, Ga.).
62(2):208-216
[DOI] 10.1097/SHK.0000000000002379.
[PMID] 38713581.
2024
Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness.
Frontiers in immunology.
15
[DOI] 10.3389/fimmu.2024.1478471.
[PMID] 39691721.
2023
EXTRACELLULAR VESICLES AS REGULATORS OF IMMUNE FUNCTION IN TRAUMATIC INJURIES AND SEPSIS.
Shock (Augusta, Ga.).
59(2):180-189
[DOI] 10.1097/SHK.0000000000002023.
[PMID] 36516458.
2023
Extracellular vesicles: secret agents of inflammation and the importance of their identification
Journal of Leukocyte Biology.
114(5):384-386
[DOI] 10.1093/jleuko/qiad100.
2023
Involvement of extracellular vesicles in the progression, diagnosis, treatment, and prevention of whole-body ionizing radiation-induced immune dysfunction.
Frontiers in immunology.
14
[DOI] 10.3389/fimmu.2023.1188830.
[PMID] 37404812.
2023
NUCLEAR FACTOR-ERYTHROID-2-RELATED FACTOR REGULATES SYSTEMIC AND PULMONARY BARRIER FUNCTION AND IMMUNE PROGRAMMING AFTER BURN AND INHALATION INJURY.
Shock (Augusta, Ga.).
59(2):300-310
[DOI] 10.1097/SHK.0000000000002022.
[PMID] 36730842.
2022
A prospective study of asymptomatic SARS-CoV-2 infection among individuals involved in academic research under limited operations during the COVID-19 pandemic.
PloS one.
17(4)
[DOI] 10.1371/journal.pone.0267353.
[PMID] 35468150.
2022
Characterization of the Basal and mTOR-Dependent Acute Pulmonary and Systemic Immune Response in a Murine Model of Combined Burn and Inhalation Injury
International Journal of Molecular Sciences.
23(15)
[DOI] 10.3390/ijms23158779.
[PMID] 35955914.
2022
Early expression of IL-10, IL-12, ARG1, and NOS2 genes in peripheral blood mononuclear cells synergistically correlate with patient outcome after burn injury.
The journal of trauma and acute care surgery.
93(5):702-711
[DOI] 10.1097/TA.0000000000003602.
[PMID] 35363228.
2022
Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release.
International journal of molecular sciences.
23(19)
[DOI] 10.3390/ijms231911635.
[PMID] 36232937.
2022
Multiplexed Human Gene Expression Analysis Reveals a Central Role of the TLR/mTOR/PPARγ and NFkB Axes in Burn and Inhalation Injury-Induced Changes in Systemic Immunometabolism and Long-Term Patient Outcomes
International Journal of Molecular Sciences.
23(16)
[DOI] 10.3390/ijms23169418.
[PMID] 36012680.
2022
Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection.
Journal of visualized experiments : JoVE.
(186)
[DOI] 10.3791/64345.
[PMID] 36094269.
2022
Role of Nitric Oxide-Releasing Glycosaminoglycans in Wound Healing.
ACS biomaterials science & engineering.
8(6):2537-2552
[DOI] 10.1021/acsbiomaterials.2c00392.
[PMID] 35580341.
2021
Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.
International journal of molecular sciences.
22(18)
[DOI] 10.3390/ijms221810083.
[PMID] 34576246.
2021
Characterization of extracellular vesicle miRNA identified in peripheral blood of chronic pancreatitis patients.
Molecular and cellular biochemistry.
476(12):4331-4341
[DOI] 10.1007/s11010-021-04248-5.
[PMID] 34448998.
2021
Development of novel nanofibers targeted to smoke-injured lungs.
Biomaterials.
274
[DOI] 10.1016/j.biomaterials.2021.120862.
[PMID] 33975274.
2021
Improving the Sensitivity for Quantifying Heparan Sulfate from Biological Samples.
Analytical chemistry.
93(32):11191-11199
[DOI] 10.1021/acs.analchem.1c01761.
[PMID] 34355888.
2021
Nitric Oxide-Releasing Hyaluronic Acid as an Antibacterial Agent for Wound Therapy.
Biomacromolecules.
22(2):867-879
[DOI] 10.1021/acs.biomac.0c01583.
[PMID] 33372774.
2021
Plasma extracellular vesicles released after severe burn injury modulate macrophage phenotype and function
Journal of Leukocyte Biology.
111(1):33-49
[DOI] 10.1002/jlb.3mia0321-150rr.
2021
Role of miR-2392 in driving SARS-CoV-2 infection.
Cell reports.
37(3)
[DOI] 10.1016/j.celrep.2021.109839.
[PMID] 34624208.
2021
SARS-CoV-2 infection of the oral cavity and saliva.
Nature medicine.
27(5):892-903
[DOI] 10.1038/s41591-021-01296-8.
[PMID] 33767405.
2020
A comparative study of a preclinical survival model of smoke inhalation injury in mice and rats.
American journal of physiology. Lung cellular and molecular physiology.
319(3):L471-L480
[DOI] 10.1152/ajplung.00241.2020.
[PMID] 32697601.
2020
Emerging therapies for smoke inhalation injury: a review.
Journal of translational medicine.
18(1)
[DOI] 10.1186/s12967-020-02300-4.
[PMID] 32228626.
2020
Integrated Single-Cell Atlases Reveal an Oral SARS-CoV-2 Infection and Transmission Axis.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2020.10.26.20219089.
[PMID] 33140061.
2019
One-hit wonder: Late after burn injury, granulocytes can clear one bacterial infection but cannot control a subsequent infection.
Burns : journal of the International Society for Burn Injuries.
45(3):627-640
[DOI] 10.1016/j.burns.2018.08.019.
[PMID] 30833100.
2018
Blocking CXCL1-dependent neutrophil recruitment prevents immune damage and reduces pulmonary bacterial infection after inhalation injury
American Journal of Physiology-Lung Cellular and Molecular Physiology.
314(5):L822-L834
[DOI] 10.1152/ajplung.00272.2017.
[PMID] 29368547.
2018
HMGB1/IL-1β complexes in plasma microvesicles modulate immune responses to burn injury.
PloS one.
13(3)
[DOI] 10.1371/journal.pone.0195335.
[PMID] 29601597.
2018
Mammalian target of rapamycin regulates a hyperresponsive state in pulmonary neutrophils late after burn injury.
Journal of leukocyte biology.
103(5):909-918
[DOI] 10.1002/JLB.3AB0616-251RRR.
[PMID] 29393976.
2017
Correction: Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes.
PloS one.
12(11)
[DOI] 10.1371/journal.pone.0187785.
[PMID] 29095909.
2017
Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes.
PloS one.
12(9)
[DOI] 10.1371/journal.pone.0184164.
[PMID] 28886135.
2017
Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis
The Journal of Immunology.
198(6):2426-2433
[DOI] 10.4049/jimmunol.1601048.
[PMID] 28159904.
2017
Pseudomonas aeruginosa exoproducts determine antibiotic efficacy against Staphylococcus aureus.
PLoS biology.
15(11)
[DOI] 10.1371/journal.pbio.2003981.
[PMID] 29176757.
2016
Direct detection of blood nitric oxide reveals a burn-dependent decrease of nitric oxide in response to Pseudomonas aeruginosa infection.
Burns : journal of the International Society for Burn Injuries.
42(7):1522-1527
[DOI] 10.1016/j.burns.2016.05.005.
[PMID] 27268107.
2016
Timeline of health care-associated infections and pathogens after burn injuries.
American journal of infection control.
44(12):1511-1516
[DOI] 10.1016/j.ajic.2016.07.027.
[PMID] 27742146.
2015
Association between early airway damage-associated molecular patterns and subsequent bacterial infection in patients with inhalational and burn injury
American Journal of Physiology-Lung Cellular and Molecular Physiology.
308(9):L855-L860
[DOI] 10.1152/ajplung.00321.2014.
[PMID] 25770180.
2014
Flagellin treatment prevents increased susceptibility to systemic bacterial infection after injury by inhibiting anti-inflammatory IL-10+ IL-12- neutrophil polarization.
PloS one.
9(1)
[DOI] 10.1371/journal.pone.0085623.
[PMID] 24454904.
2013
Bronchoscopy-derived correlates of lung injury following inhalational injuries: a prospective observational study.
PloS one.
8(5)
[DOI] 10.1371/journal.pone.0064250.
[PMID] 23691180.
2013
Burn injury induces high levels of phosphorylated insulin-like growth factor binding protein-1.
International journal of burns and trauma.
3(4):180-9
[PMID] 24273693.
2013
Functional modularity of the arginine catabolic mobile element contributes to the success of USA300 methicillin-resistant Staphylococcus aureus.
Cell host & microbe.
13(1):100-7
[DOI] 10.1016/j.chom.2012.11.012.
[PMID] 23332159.
2012
Radiation combined with thermal injury induces immature myeloid cells.
Shock (Augusta, Ga.).
38(5):532-42
[DOI] 10.1097/SHK.0b013e31826c5b19.
[PMID] 23042190.
2011
Th17 (IFNγ- IL17+) CD4+ T cells generated after burn injury may be a novel cellular mechanism for postburn immunosuppression.
The Journal of trauma.
70(3):681-90
[DOI] 10.1097/TA.0b013e31820d18a6.
[PMID] 21610359.
2008
Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II.
European journal of immunology.
38(6):1511-21
[DOI] 10.1002/eji.200737710.
[PMID] 18465769.
2008
Toll-like receptor 2 and 4 ligation results in complex altered cytokine profiles early and late after burn injury.
The Journal of trauma.
64(4):1069-77; discussion 1077
[DOI] 10.1097/TA.0b013e318166b7d9.
[PMID] 18404077.
2007
CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate.
Journal of immunology (Baltimore, Md. : 1950).
179(5):2952-60
[PMID] 17709510.
2007
Downregulation of immune signaling genes in patients with large surface burn injury.
Journal of burn care & research : official publication of the American Burn Association.
28(6):879-87
[PMID] 17925653.
2007
Transgene expression levels and kinetics determine risk of humoral immune response modeled in factor IX knockout and missense mutant mice.
Gene therapy.
14(5):429-40
[PMID] 17066096.
2006
Increased Toll-like receptor 4 expression on T cells may be a mechanism for enhanced T cell response late after burn injury.
The Journal of trauma.
61(2):293-8; discussion 298
[PMID] 16917441.
2006
Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen.
European journal of immunology.
36(2):397-410
[PMID] 16402405.
2006
Lymphopenia-induced homeostatic proliferation of CD8+ T cells is a mechanism for effective allogeneic skin graft rejection following burn injury.
Journal of immunology (Baltimore, Md. : 1950).
176(11):6717-26
[PMID] 16709831.
2006
The effect of burn injury on CD8+ and CD4+ T cells in an irradiation model of homeostatic proliferation.
The Journal of trauma.
61(5):1062-8
[PMID] 17099510.
2005
Memory CD8 T cells require CD8 coreceptor engagement for calcium mobilization and proliferation, but not cytokine production.
Immunology.
114(1):44-52
[PMID] 15606794.
2005
Peripheral “CD8 tuning” dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo.
Journal of immunology (Baltimore, Md. : 1950).
174(2):619-27
[PMID] 15634879.
2003
Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement.
Journal of immunology (Baltimore, Md. : 1950).
171(9):4493-503
[PMID] 14568922.
2002
Peptidic termini play a significant role in TCR recognition.
Journal of immunology (Baltimore, Md. : 1950).
169(6):3137-45
[PMID] 12218131.
2001
Antigen-specific modulation of an immune response by in vivo administration of soluble MHC class I tetramers.
Journal of immunology (Baltimore, Md. : 1950).
167(7):3708-14
[PMID] 11564786.
2001
CD8(+) T cells express a T-helper 1–like phenotype after burn injury.
Surgery.
130(2):210-6
[PMID] 11490351.
2000
Effective formation of major histocompatibility complex class II-peptide complexes from endogenous antigen by thyroid epithelial cells.
Immunology.
99(3):367-74
[PMID] 10712666.
2000
Modulation of immune response with MHC class i allotetramers
Journal of the American College of Surgeons.
191(4)
[DOI] 10.1016/s1072-7515(00)00524-x.
2000
Naive CD8+ T cells do not require costimulation for proliferation and differentiation into cytotoxic effector cells.
Journal of immunology (Baltimore, Md. : 1950).
164(3):1216-22
[PMID] 10640733.
1998
The steady state distribution of humTGN46 is not significantly altered in cells defective in clathrin-mediated endocytosis.
Journal of cell science.
111 ( Pt 23):3451-8
[PMID] 9811560.
1997
FasL expression on epithelial cells: the Bottazzo-Feldman hypothesis revisited.
Immunology today.
18(5)
[PMID] 9153948.
1997
Functionality of inducible major histocompatibility class II expression by specialised non-lymphoid cells.
Biochemical Society transactions.
25(2)
[PMID] 9191362.
1996
BCL-6 expression during B-cell activation.
Blood.
87(12):5257-68
[PMID] 8652841.
Grants
Nov 2024
ACTIVE
Developability Assessment and in Vivo Pharmacology Studies of AQP9 Inhibitors in the Treatment of Systemic Inflammation Caused by Burn Wounds
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Jul 2024
ACTIVE
Molecular Biology in Burns and Trauma
Role: Other
Funding: NATL INST OF HLTH NIGMS
Apr 2024
ACTIVE
Renewal: Short-Term Training for Medical Students in Cardiovascular and Pulmonary Research
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Sep 2023
ACTIVE
BA220315: Extracellular vesicles as Biomarkers, Mediators Of Immune Dysfunction and Universal Countermeasures against Radiation Syndrome and Associated Polytrauma
Role: Principal Investigator
Funding: US ARMY MED RES AND DEVELOPMENT COMMAND
May 2023
ACTIVE
Nitric oxide-releasing hyaluronic acid therapeutics for treating periodontal disease
Role: Co-Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via NATL INST OF HLTH NIDCR
Jan 2023
ACTIVE
Nitric oxide-releasing Glycosaminoglycans for treating complex wounds
Role: Co-Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via NATL INST OF HLTH NIDDK
Dec 2022
– Nov 2023
Damage-Induced Activation of the TLR/mTOR/PPARg Axis Regulates the Immune Response After Burn and Inhalation Injury
Role: Principal Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via NATL INST OF HLTH NIGMS
Sep 2022
ACTIVE
Multi-modal rescue of pulmonary NRF2-insufficiency after burn and burn + inhalation injury to regulate innate immune dysfunction
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Sep 2020
ACTIVE
Stratifying Patient Immune Endotypes in Sepsis (SPIES Study)
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Contact Details
Phones:
- Business:
- (352) 273-5670
Emails:
- Business:
- robertmaile@ufl.edu
Addresses: