Rob Maile

Rob Maile, Ph.D.

Associate Professor

Department: MD-SURGERY-TRAUMA
Business Phone: (352) 273-5670
Business Email: robertmaile@ufl.edu

Teaching Profile

Courses Taught
2024-2025
GMS6140 Principles of Immunology

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9126-4188

Publications

2024
Exosomal microRNA following severe trauma: Role in bone marrow dysfunction.
The journal of trauma and acute care surgery. 96(4):548-556 [DOI] 10.1097/TA.0000000000004225. [PMID] 38151766.
2023
EXTRACELLULAR VESICLES AS REGULATORS OF IMMUNE FUNCTION IN TRAUMATIC INJURIES AND SEPSIS.
Shock (Augusta, Ga.). 59(2):180-189 [DOI] 10.1097/SHK.0000000000002023. [PMID] 36516458.
2023
Extracellular vesicles: secret agents of inflammation and the importance of their identification
Journal of Leukocyte Biology. 114(5):384-386 [DOI] 10.1093/jleuko/qiad100.
2023
Involvement of extracellular vesicles in the progression, diagnosis, treatment, and prevention of whole-body ionizing radiation-induced immune dysfunction.
Frontiers in immunology. 14 [DOI] 10.3389/fimmu.2023.1188830. [PMID] 37404812.
2023
NUCLEAR FACTOR-ERYTHROID-2-RELATED FACTOR REGULATES SYSTEMIC AND PULMONARY BARRIER FUNCTION AND IMMUNE PROGRAMMING AFTER BURN AND INHALATION INJURY.
Shock (Augusta, Ga.). 59(2):300-310 [DOI] 10.1097/SHK.0000000000002022. [PMID] 36730842.
2022
A prospective study of asymptomatic SARS-CoV-2 infection among individuals involved in academic research under limited operations during the COVID-19 pandemic
PLOS ONE. 17(4) [DOI] 10.1371/journal.pone.0267353. [PMID] 35468150.
2022
Characterization of the Basal and mTOR-Dependent Acute Pulmonary and Systemic Immune Response in a Murine Model of Combined Burn and Inhalation Injury
International Journal of Molecular Sciences. 23(15) [DOI] 10.3390/ijms23158779. [PMID] 35955914.
2022
Early expression of IL-10, IL-12, ARG1, and NOS2 genes in peripheral blood mononuclear cells synergistically correlate with patient outcome after burn injury.
The journal of trauma and acute care surgery. 93(5):702-711 [DOI] 10.1097/TA.0000000000003602. [PMID] 35363228.
2022
Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release.
International journal of molecular sciences. 23(19) [DOI] 10.3390/ijms231911635. [PMID] 36232937.
2022
Multiplexed Human Gene Expression Analysis Reveals a Central Role of the TLR/mTOR/PPARγ and NFkB Axes in Burn and Inhalation Injury-Induced Changes in Systemic Immunometabolism and Long-Term Patient Outcomes
International Journal of Molecular Sciences. 23(16) [DOI] 10.3390/ijms23169418. [PMID] 36012680.
2022
Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection.
Journal of visualized experiments : JoVE. (186) [DOI] 10.3791/64345. [PMID] 36094269.
2022
Role of Nitric Oxide-Releasing Glycosaminoglycans in Wound Healing.
ACS biomaterials science & engineering. 8(6):2537-2552 [DOI] 10.1021/acsbiomaterials.2c00392. [PMID] 35580341.
2021
Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.
International journal of molecular sciences. 22(18) [DOI] 10.3390/ijms221810083. [PMID] 34576246.
2021
Characterization of extracellular vesicle miRNA identified in peripheral blood of chronic pancreatitis patients.
Molecular and cellular biochemistry. 476(12):4331-4341 [DOI] 10.1007/s11010-021-04248-5. [PMID] 34448998.
2021
Development of novel nanofibers targeted to smoke-injured lungs.
Biomaterials. 274 [DOI] 10.1016/j.biomaterials.2021.120862. [PMID] 33975274.
2021
Improving the Sensitivity for Quantifying Heparan Sulfate from Biological Samples.
Analytical chemistry. 93(32):11191-11199 [DOI] 10.1021/acs.analchem.1c01761. [PMID] 34355888.
2021
Nitric Oxide-Releasing Hyaluronic Acid as an Antibacterial Agent for Wound Therapy.
Biomacromolecules. 22(2):867-879 [DOI] 10.1021/acs.biomac.0c01583. [PMID] 33372774.
2021
Plasma extracellular vesicles released after severe burn injury modulate macrophage phenotype and function
Journal of Leukocyte Biology. 111(1):33-49 [DOI] 10.1002/jlb.3mia0321-150rr.
2021
Role of miR-2392 in driving SARS-CoV-2 infection.
Cell reports. 37(3) [DOI] 10.1016/j.celrep.2021.109839. [PMID] 34624208.
2021
SARS-CoV-2 infection of the oral cavity and saliva.
Nature medicine. 27(5):892-903 [DOI] 10.1038/s41591-021-01296-8. [PMID] 33767405.
2020
A comparative study of a preclinical survival model of smoke inhalation injury in mice and rats.
American journal of physiology. Lung cellular and molecular physiology. 319(3):L471-L480 [DOI] 10.1152/ajplung.00241.2020. [PMID] 32697601.
2020
Emerging therapies for smoke inhalation injury: a review.
Journal of translational medicine. 18(1) [DOI] 10.1186/s12967-020-02300-4. [PMID] 32228626.
2020
Integrated Single-Cell Atlases Reveal an Oral SARS-CoV-2 Infection and Transmission Axis.
medRxiv : the preprint server for health sciences. [DOI] 10.1101/2020.10.26.20219089. [PMID] 33140061.
2019
One-hit wonder: Late after burn injury, granulocytes can clear one bacterial infection but cannot control a subsequent infection
Burns. 45(3):627-640 [DOI] 10.1016/j.burns.2018.08.019. [PMID] 30833100.
2018
Blocking CXCL1-dependent neutrophil recruitment prevents immune damage and reduces pulmonary bacterial infection after inhalation injury
American Journal of Physiology-Lung Cellular and Molecular Physiology. 314(5):L822-L834 [DOI] 10.1152/ajplung.00272.2017. [PMID] 29368547.
2018
HMGB1/IL-1β complexes in plasma microvesicles modulate immune responses to burn injury.
PloS one. 13(3) [DOI] 10.1371/journal.pone.0195335. [PMID] 29601597.
2018
Mammalian target of rapamycin regulates a hyperresponsive state in pulmonary neutrophils late after burn injury.
Journal of leukocyte biology. 103(5):909-918 [DOI] 10.1002/JLB.3AB0616-251RRR. [PMID] 29393976.
2017
Correction: Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes.
PloS one. 12(11) [DOI] 10.1371/journal.pone.0187785. [PMID] 29095909.
2017
Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes.
PloS one. 12(9) [DOI] 10.1371/journal.pone.0184164. [PMID] 28886135.
2017
Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis
The Journal of Immunology. 198(6):2426-2433 [DOI] 10.4049/jimmunol.1601048. [PMID] 28159904.
2017
Pseudomonas aeruginosa exoproducts determine antibiotic efficacy against Staphylococcus aureus.
PLoS biology. 15(11) [DOI] 10.1371/journal.pbio.2003981. [PMID] 29176757.
2016
Direct detection of blood nitric oxide reveals a burn-dependent decrease of nitric oxide in response to Pseudomonas aeruginosa infection.
Burns : journal of the International Society for Burn Injuries. 42(7):1522-1527 [DOI] 10.1016/j.burns.2016.05.005. [PMID] 27268107.
2016
Timeline of health care-associated infections and pathogens after burn injuries.
American journal of infection control. 44(12):1511-1516 [DOI] 10.1016/j.ajic.2016.07.027. [PMID] 27742146.
2015
Association between early airway damage-associated molecular patterns and subsequent bacterial infection in patients with inhalational and burn injury
American Journal of Physiology-Lung Cellular and Molecular Physiology. 308(9):L855-L860 [DOI] 10.1152/ajplung.00321.2014. [PMID] 25770180.
2014
Flagellin treatment prevents increased susceptibility to systemic bacterial infection after injury by inhibiting anti-inflammatory IL-10+ IL-12- neutrophil polarization.
PloS one. 9(1) [DOI] 10.1371/journal.pone.0085623. [PMID] 24454904.
2013
Bronchoscopy-derived correlates of lung injury following inhalational injuries: a prospective observational study.
PloS one. 8(5) [DOI] 10.1371/journal.pone.0064250. [PMID] 23691180.
2013
Burn injury induces high levels of phosphorylated insulin-like growth factor binding protein-1.
International journal of burns and trauma. 3(4):180-9 [PMID] 24273693.
2013
Functional modularity of the arginine catabolic mobile element contributes to the success of USA300 methicillin-resistant Staphylococcus aureus.
Cell host & microbe. 13(1):100-7 [DOI] 10.1016/j.chom.2012.11.012. [PMID] 23332159.
2012
Radiation combined with thermal injury induces immature myeloid cells.
Shock (Augusta, Ga.). 38(5):532-42 [DOI] 10.1097/SHK.0b013e31826c5b19. [PMID] 23042190.
2011
Th17 (IFNγ- IL17+) CD4+ T cells generated after burn injury may be a novel cellular mechanism for postburn immunosuppression.
The Journal of trauma. 70(3):681-90 [DOI] 10.1097/TA.0b013e31820d18a6. [PMID] 21610359.
2008
Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II.
European journal of immunology. 38(6):1511-21 [DOI] 10.1002/eji.200737710. [PMID] 18465769.
2008
Toll-like receptor 2 and 4 ligation results in complex altered cytokine profiles early and late after burn injury.
The Journal of trauma. 64(4):1069-77; discussion 1077 [DOI] 10.1097/TA.0b013e318166b7d9. [PMID] 18404077.
2007
CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate.
Journal of immunology (Baltimore, Md. : 1950). 179(5):2952-60 [PMID] 17709510.
2007
Downregulation of immune signaling genes in patients with large surface burn injury.
Journal of burn care & research : official publication of the American Burn Association. 28(6):879-87 [PMID] 17925653.
2007
Transgene expression levels and kinetics determine risk of humoral immune response modeled in factor IX knockout and missense mutant mice.
Gene therapy. 14(5):429-40 [PMID] 17066096.
2006
Increased Toll-like receptor 4 expression on T cells may be a mechanism for enhanced T cell response late after burn injury.
The Journal of trauma. 61(2):293-8; discussion 298 [PMID] 16917441.
2006
Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen.
European journal of immunology. 36(2):397-410 [PMID] 16402405.
2006
Lymphopenia-induced homeostatic proliferation of CD8+ T cells is a mechanism for effective allogeneic skin graft rejection following burn injury.
Journal of immunology (Baltimore, Md. : 1950). 176(11):6717-26 [PMID] 16709831.
2006
The effect of burn injury on CD8+ and CD4+ T cells in an irradiation model of homeostatic proliferation.
The Journal of trauma. 61(5):1062-8 [PMID] 17099510.
2005
Memory CD8 T cells require CD8 coreceptor engagement for calcium mobilization and proliferation, but not cytokine production.
Immunology. 114(1):44-52 [PMID] 15606794.
2005
Peripheral “CD8 tuning” dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo.
Journal of immunology (Baltimore, Md. : 1950). 174(2):619-27 [PMID] 15634879.
2003
Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement.
Journal of immunology (Baltimore, Md. : 1950). 171(9):4493-503 [PMID] 14568922.
2002
Peptidic termini play a significant role in TCR recognition.
Journal of immunology (Baltimore, Md. : 1950). 169(6):3137-45 [PMID] 12218131.
2001
Antigen-specific modulation of an immune response by in vivo administration of soluble MHC class I tetramers.
Journal of immunology (Baltimore, Md. : 1950). 167(7):3708-14 [PMID] 11564786.
2001
CD8(+) T cells express a T-helper 1–like phenotype after burn injury.
Surgery. 130(2):210-6 [PMID] 11490351.
2000
Effective formation of major histocompatibility complex class II-peptide complexes from endogenous antigen by thyroid epithelial cells.
Immunology. 99(3):367-74 [PMID] 10712666.
2000
Modulation of immune response with MHC class i allotetramers
Journal of the American College of Surgeons. 191(4) [DOI] 10.1016/s1072-7515(00)00524-x.
2000
Naive CD8+ T cells do not require costimulation for proliferation and differentiation into cytotoxic effector cells.
Journal of immunology (Baltimore, Md. : 1950). 164(3):1216-22 [PMID] 10640733.
1998
The steady state distribution of humTGN46 is not significantly altered in cells defective in clathrin-mediated endocytosis.
Journal of cell science. 111 ( Pt 23):3451-8 [PMID] 9811560.
1997
FasL expression on epithelial cells: the Bottazzo-Feldman hypothesis revisited.
Immunology today. 18(5) [PMID] 9153948.
1997
Functionality of inducible major histocompatibility class II expression by specialised non-lymphoid cells.
Biochemical Society transactions. 25(2) [PMID] 9191362.
1996
BCL-6 expression during B-cell activation.
Blood. 87(12):5257-68 [PMID] 8652841.

Grants

Apr 2024 ACTIVE
Renewal: Short-Term Training for Medical Students in Cardiovascular and Pulmonary Research
Role: Principal Investigator
Funding: NATL INST OF HLTH
Sep 2023 ACTIVE
BA220315: Extracellular vesicles as Biomarkers, Mediators Of Immune Dysfunction and Universal Countermeasures against Radiation Syndrome and Associated Polytrauma
Role: Principal Investigator
Funding: US ARMY MED RES AND DEVELOPMENT COMMAND
May 2023 ACTIVE
Nitric oxide-releasing hyaluronic acid therapeutics for treating periodontal disease
Role: Co-Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL via NATL INST OF HLTH NIDCR
Jan 2023 ACTIVE
Nitric oxide-releasing Glycosaminoglycans for treating complex wounds
Role: Co-Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL via NATL INST OF HLTH NIDDK
Dec 2022 – Nov 2023
Damage-Induced Activation of the TLR/mTOR/PPARg Axis Regulates the Immune Response After Burn and Inhalation Injury
Role: Principal Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL via NATL INST OF HLTH NIGMS
Sep 2022 ACTIVE
Multi-modal rescue of pulmonary NRF2-insufficiency after burn and burn + inhalation injury to regulate innate immune dysfunction
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS

Contact Details

Phones:
Business:
(352) 273-5670
Emails:
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