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UF Health University of Florida
Department of Surgery College of Medicine
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Rob Maile

Rob Maile, Ph.D.

Associate Professor

Department: MD-SURGERY-TRAUMA
Business Phone: (352) 273-5670
Business Email: robertmaile@ufl.edu

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About Rob Maile

My initial interest in burn in 2001 was sparked by the concept that patients suffering burn injury have profound immune suppression leading to bacterial susceptibility, but a paradoxical ability to reject allografted skin very efficiently.

Teaching Profile

Courses Taught

  1. GMS6140 – Principles of Immunology

    College of Medicine

Teaching Philosophy

I consider the explanation and discussion of scientific concepts a crucial aspect of a scientific career, whether organized in the classroom or less formally in the lab. I have a particular interest in mentoring trainees interested in translational research, and igniting the passion of clinicians to undertake academic research.

Research Profile

My overarching personal research interest is in innate and adaptive immune regulation during health and in disease, using models of burn, bacterial and viral infection, transplantation and autoimmunity. My research projects have examined regulation of adaptive and innate immune responses against autoimmune, allograft, viral and bacterial elements. My focus at the NC Jaycee Burn Center for 20 years, and now at the UF Burn Center and SCIRC, is to develop a translational and collaborative Immunology research program to tease apart the mechanisms of the acute and chronic immune effects of burn injury and resultant sepsis.

I use an established mouse model of burn injury and have developed NIH and DoD-funded animal models of burn injury combined with radiation or inhalation injury to test potential countermeasures. I have developed various methodologies to test bacterial susceptibility in these models. I also have the unique ability to translate my findings with a large number of banked burn patient blood, skin and pulmonary samples within a central Burn Biorepository (currently comprising ~2,000 longitudinal samples from ~300 patients, and, pertinent to this Proposal, actively recruiting further samples). My goal is to provide meaningful immunotherapeutics, changes in clinical strategy and clinical diagnostics which will reduce the overall mortality, and length of hospital stay of burn and other trauma patients.

Areas of Interest

  • Burn and Wound Care
  • Extracellular vesicles
  • Inhalation Injury
  • Ionizing radiation injury
  • Sepsis

Publications

Academic Articles

Grants

  1. Developability Assessment and in Vivo Pharmacology Studies of AQP9 Inhibitors in the Treatment of Systemic Inflammation Caused by Burn Wounds

    Active

    Role:
    Principal Investigator
    Funding:
    US ARMY MED RES ACQUISITION

  2. Molecular Biology in Burns and Trauma

    Active

    Role:
    Other
    Funding:
    NATL INST OF HLTH NIGMS

  3. Renewal: Short-Term Training for Medical Students in Cardiovascular and Pulmonary Research

    Active

    Role:
    Principal Investigator
    Funding:
    NATL INST OF HLTH NHLBI

  4. BA220315: Extracellular vesicles as Biomarkers, Mediators Of Immune Dysfunction and Universal Countermeasures against Radiation Syndrome and Associated Polytrauma

    Active

    Role:
    Principal Investigator
    Funding:
    US ARMY MED RES AND DEVELOPMENT COMMAND

  5. Nitric oxide-releasing hyaluronic acid therapeutics for treating periodontal disease

    Active

    Role:
    Co-Investigator
    Funding:
    UNIV OF NORTH CAROLINA CHAPEL HILL via NATL INST OF HLTH NIDCR

  6. Nitric oxide-releasing Glycosaminoglycans for treating complex wounds

    Active

    Role:
    Co-Investigator
    Funding:
    UNIV OF NORTH CAROLINA CHAPEL HILL via NATL INST OF HLTH NIDDK

  7. Damage-Induced Activation of the TLR/mTOR/PPARg Axis Regulates the Immune Response After Burn and Inhalation Injury

    Role:
    Principal Investigator
    Funding:
    UNIV OF NORTH CAROLINA CHAPEL HILL via NATL INST OF HLTH NIGMS

  8. Multi-modal rescue of pulmonary NRF2-insufficiency after burn and burn + inhalation injury to regulate innate immune dysfunction

    Active

    Role:
    Principal Investigator
    Funding:
    NATL INST OF HLTH NIGMS

  9. Stratifying Patient Immune Endotypes in Sepsis (SPIES Study)

    Active

    Role:
    Principal Investigator
    Funding:
    NATL INST OF HLTH NIGMS

Education

  1. PhD

    University of Bristol, United Kingdom

Contact Details

Phones:
Business:
(352) 273-5670
Emails:
Business:
robertmaile@ufl.edu
Addresses: