Rob Maile, Ph.D.
Associate Professor
Teaching Profile
Courses Taught
2024
GMS6140 Principles of Immunology
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-9126-4188
Publications
2023
EXTRACELLULAR VESICLES AS REGULATORS OF IMMUNE FUNCTION IN TRAUMATIC INJURIES AND SEPSIS.
Shock (Augusta, Ga.).
59(2):180-189
[DOI] 10.1097/SHK.0000000000002023.
[PMID] 36516458.
2023
Extracellular vesicles: secret agents of inflammation and the importance of their identification
Journal of Leukocyte Biology.
114(5):384-386
[DOI] 10.1093/jleuko/qiad100.
2023
Involvement of extracellular vesicles in the progression, diagnosis, treatment, and prevention of whole-body ionizing radiation-induced immune dysfunction.
Frontiers in immunology.
14
[DOI] 10.3389/fimmu.2023.1188830.
[PMID] 37404812.
2023
NUCLEAR FACTOR-ERYTHROID-2-RELATED FACTOR REGULATES SYSTEMIC AND PULMONARY BARRIER FUNCTION AND IMMUNE PROGRAMMING AFTER BURN AND INHALATION INJURY.
Shock (Augusta, Ga.).
59(2):300-310
[DOI] 10.1097/SHK.0000000000002022.
[PMID] 36730842.
2022
A prospective study of asymptomatic SARS-CoV-2 infection among individuals involved in academic research under limited operations during the COVID-19 pandemic
PLOS ONE.
17(4)
[DOI] 10.1371/journal.pone.0267353.
[PMID] 35468150.
2022
Characterization of the Basal and mTOR-Dependent Acute Pulmonary and Systemic Immune Response in a Murine Model of Combined Burn and Inhalation Injury
International Journal of Molecular Sciences.
23(15)
[DOI] 10.3390/ijms23158779.
[PMID] 35955914.
2022
Early expression of IL-10, IL-12, ARG1, and NOS2 genes in peripheral blood mononuclear cells synergistically correlate with patient outcome after burn injury.
The journal of trauma and acute care surgery.
93(5):702-711
[DOI] 10.1097/TA.0000000000003602.
[PMID] 35363228.
2022
Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release.
International journal of molecular sciences.
23(19)
[DOI] 10.3390/ijms231911635.
[PMID] 36232937.
2022
Multiplexed Human Gene Expression Analysis Reveals a Central Role of the TLR/mTOR/PPARγ and NFkB Axes in Burn and Inhalation Injury-Induced Changes in Systemic Immunometabolism and Long-Term Patient Outcomes
International Journal of Molecular Sciences.
23(16)
[DOI] 10.3390/ijms23169418.
[PMID] 36012680.
2022
Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection.
Journal of visualized experiments : JoVE.
(186)
[DOI] 10.3791/64345.
[PMID] 36094269.
2022
Role of Nitric Oxide-Releasing Glycosaminoglycans in Wound Healing.
ACS biomaterials science & engineering.
8(6):2537-2552
[DOI] 10.1021/acsbiomaterials.2c00392.
[PMID] 35580341.
2021
Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.
International journal of molecular sciences.
22(18)
[DOI] 10.3390/ijms221810083.
[PMID] 34576246.
2021
Characterization of extracellular vesicle miRNA identified in peripheral blood of chronic pancreatitis patients.
Molecular and cellular biochemistry.
476(12):4331-4341
[DOI] 10.1007/s11010-021-04248-5.
[PMID] 34448998.
2021
Development of novel nanofibers targeted to smoke-injured lungs.
Biomaterials.
274
[DOI] 10.1016/j.biomaterials.2021.120862.
[PMID] 33975274.
2021
Improving the Sensitivity for Quantifying Heparan Sulfate from Biological Samples.
Analytical chemistry.
93(32):11191-11199
[DOI] 10.1021/acs.analchem.1c01761.
[PMID] 34355888.
2021
Nitric Oxide-Releasing Hyaluronic Acid as an Antibacterial Agent for Wound Therapy.
Biomacromolecules.
22(2):867-879
[DOI] 10.1021/acs.biomac.0c01583.
[PMID] 33372774.
2021
Plasma extracellular vesicles released after severe burn injury modulate macrophage phenotype and function
Journal of Leukocyte Biology.
111(1):33-49
[DOI] 10.1002/jlb.3mia0321-150rr.
2021
Role of miR-2392 in driving SARS-CoV-2 infection.
Cell reports.
37(3)
[DOI] 10.1016/j.celrep.2021.109839.
[PMID] 34624208.
2021
SARS-CoV-2 infection of the oral cavity and saliva.
Nature medicine.
27(5):892-903
[DOI] 10.1038/s41591-021-01296-8.
[PMID] 33767405.
2020
A comparative study of a preclinical survival model of smoke inhalation injury in mice and rats.
American journal of physiology. Lung cellular and molecular physiology.
319(3):L471-L480
[DOI] 10.1152/ajplung.00241.2020.
[PMID] 32697601.
2020
Emerging therapies for smoke inhalation injury: a review.
Journal of translational medicine.
18(1)
[DOI] 10.1186/s12967-020-02300-4.
[PMID] 32228626.
2020
Integrated Single-Cell Atlases Reveal an Oral SARS-CoV-2 Infection and Transmission Axis.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2020.10.26.20219089.
[PMID] 33140061.
2019
One-hit wonder: Late after burn injury, granulocytes can clear one bacterial infection but cannot control a subsequent infection
Burns.
45(3):627-640
[DOI] 10.1016/j.burns.2018.08.019.
[PMID] 30833100.
2018
Blocking CXCL1-dependent neutrophil recruitment prevents immune damage and reduces pulmonary bacterial infection after inhalation injury
American Journal of Physiology-Lung Cellular and Molecular Physiology.
314(5):L822-L834
[DOI] 10.1152/ajplung.00272.2017.
[PMID] 29368547.
2018
HMGB1/IL-1β complexes in plasma microvesicles modulate immune responses to burn injury.
PloS one.
13(3)
[DOI] 10.1371/journal.pone.0195335.
[PMID] 29601597.
2018
Mammalian target of rapamycin regulates a hyperresponsive state in pulmonary neutrophils late after burn injury.
Journal of leukocyte biology.
103(5):909-918
[DOI] 10.1002/JLB.3AB0616-251RRR.
[PMID] 29393976.
2017
Correction: Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes.
PloS one.
12(11)
[DOI] 10.1371/journal.pone.0187785.
[PMID] 29095909.
2017
Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes.
PloS one.
12(9)
[DOI] 10.1371/journal.pone.0184164.
[PMID] 28886135.
2017
Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis
The Journal of Immunology.
198(6):2426-2433
[DOI] 10.4049/jimmunol.1601048.
[PMID] 28159904.
2017
Pseudomonas aeruginosa exoproducts determine antibiotic efficacy against Staphylococcus aureus.
PLoS biology.
15(11)
[DOI] 10.1371/journal.pbio.2003981.
[PMID] 29176757.
2016
Direct detection of blood nitric oxide reveals a burn-dependent decrease of nitric oxide in response to Pseudomonas aeruginosa infection.
Burns : journal of the International Society for Burn Injuries.
42(7):1522-1527
[DOI] 10.1016/j.burns.2016.05.005.
[PMID] 27268107.
2016
Timeline of health care-associated infections and pathogens after burn injuries.
American journal of infection control.
44(12):1511-1516
[DOI] 10.1016/j.ajic.2016.07.027.
[PMID] 27742146.
2015
Association between early airway damage-associated molecular patterns and subsequent bacterial infection in patients with inhalational and burn injury
American Journal of Physiology-Lung Cellular and Molecular Physiology.
308(9):L855-L860
[DOI] 10.1152/ajplung.00321.2014.
[PMID] 25770180.
2014
Flagellin treatment prevents increased susceptibility to systemic bacterial infection after injury by inhibiting anti-inflammatory IL-10+ IL-12- neutrophil polarization.
PloS one.
9(1)
[DOI] 10.1371/journal.pone.0085623.
[PMID] 24454904.
2013
Bronchoscopy-derived correlates of lung injury following inhalational injuries: a prospective observational study.
PloS one.
8(5)
[DOI] 10.1371/journal.pone.0064250.
[PMID] 23691180.
2013
Burn injury induces high levels of phosphorylated insulin-like growth factor binding protein-1.
International journal of burns and trauma.
3(4):180-9
[PMID] 24273693.
2013
Functional modularity of the arginine catabolic mobile element contributes to the success of USA300 methicillin-resistant Staphylococcus aureus.
Cell host & microbe.
13(1):100-7
[DOI] 10.1016/j.chom.2012.11.012.
[PMID] 23332159.
2012
Radiation combined with thermal injury induces immature myeloid cells.
Shock (Augusta, Ga.).
38(5):532-42
[DOI] 10.1097/SHK.0b013e31826c5b19.
[PMID] 23042190.
2011
Th17 (IFNγ- IL17+) CD4+ T cells generated after burn injury may be a novel cellular mechanism for postburn immunosuppression.
The Journal of trauma.
70(3):681-90
[DOI] 10.1097/TA.0b013e31820d18a6.
[PMID] 21610359.
2008
Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II.
European journal of immunology.
38(6):1511-21
[DOI] 10.1002/eji.200737710.
[PMID] 18465769.
2008
Toll-like receptor 2 and 4 ligation results in complex altered cytokine profiles early and late after burn injury.
The Journal of trauma.
64(4):1069-77; discussion 1077
[DOI] 10.1097/TA.0b013e318166b7d9.
[PMID] 18404077.
2007
CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate.
Journal of immunology (Baltimore, Md. : 1950).
179(5):2952-60
[PMID] 17709510.
2007
Downregulation of immune signaling genes in patients with large surface burn injury.
Journal of burn care & research : official publication of the American Burn Association.
28(6):879-87
[PMID] 17925653.
2007
Transgene expression levels and kinetics determine risk of humoral immune response modeled in factor IX knockout and missense mutant mice.
Gene therapy.
14(5):429-40
[PMID] 17066096.
2006
Increased Toll-like receptor 4 expression on T cells may be a mechanism for enhanced T cell response late after burn injury.
The Journal of trauma.
61(2):293-8; discussion 298
[PMID] 16917441.
2006
Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen.
European journal of immunology.
36(2):397-410
[PMID] 16402405.
2006
Lymphopenia-induced homeostatic proliferation of CD8+ T cells is a mechanism for effective allogeneic skin graft rejection following burn injury.
Journal of immunology (Baltimore, Md. : 1950).
176(11):6717-26
[PMID] 16709831.
2006
The effect of burn injury on CD8+ and CD4+ T cells in an irradiation model of homeostatic proliferation.
The Journal of trauma.
61(5):1062-8
[PMID] 17099510.
2005
Memory CD8 T cells require CD8 coreceptor engagement for calcium mobilization and proliferation, but not cytokine production.
Immunology.
114(1):44-52
[PMID] 15606794.
2005
Peripheral “CD8 tuning” dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo.
Journal of immunology (Baltimore, Md. : 1950).
174(2):619-27
[PMID] 15634879.
2003
Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement.
Journal of immunology (Baltimore, Md. : 1950).
171(9):4493-503
[PMID] 14568922.
2002
Peptidic termini play a significant role in TCR recognition.
Journal of immunology (Baltimore, Md. : 1950).
169(6):3137-45
[PMID] 12218131.
2001
Antigen-specific modulation of an immune response by in vivo administration of soluble MHC class I tetramers.
Journal of immunology (Baltimore, Md. : 1950).
167(7):3708-14
[PMID] 11564786.
2001
CD8(+) T cells express a T-helper 1–like phenotype after burn injury.
Surgery.
130(2):210-6
[PMID] 11490351.
2000
Effective formation of major histocompatibility complex class II-peptide complexes from endogenous antigen by thyroid epithelial cells.
Immunology.
99(3):367-74
[PMID] 10712666.
2000
Modulation of immune response with MHC class i allotetramers
Journal of the American College of Surgeons.
191(4)
[DOI] 10.1016/s1072-7515(00)00524-x.
2000
Naive CD8+ T cells do not require costimulation for proliferation and differentiation into cytotoxic effector cells.
Journal of immunology (Baltimore, Md. : 1950).
164(3):1216-22
[PMID] 10640733.
1998
The steady state distribution of humTGN46 is not significantly altered in cells defective in clathrin-mediated endocytosis.
Journal of cell science.
111 ( Pt 23):3451-8
[PMID] 9811560.
1997
FasL expression on epithelial cells: the Bottazzo-Feldman hypothesis revisited.
Immunology today.
18(5)
[PMID] 9153948.
1997
Functionality of inducible major histocompatibility class II expression by specialised non-lymphoid cells.
Biochemical Society transactions.
25(2)
[PMID] 9191362.
1996
BCL-6 expression during B-cell activation.
Blood.
87(12):5257-68
[PMID] 8652841.
Grants
Sep 2023
ACTIVE
BA220315: Extracellular vesicles as Biomarkers, Mediators Of Immune Dysfunction and Universal Countermeasures against Radiation Syndrome and Associated Polytrauma
Role: Principal Investigator
Funding: US ARMY MED RES AND DEVELOPMENT COMMAND
May 2023
ACTIVE
Nitric oxide-releasing hyaluronic acid therapeutics for treating periodontal disease
Role: Co-Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via NATL INST OF HLTH NIDCR
Jan 2023
ACTIVE
Nitric oxide-releasing Glycosaminoglycans for treating complex wounds
Role: Co-Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via NATL INST OF HLTH NIDDK
Dec 2022
– Nov 2023
Damage-Induced Activation of the TLR/mTOR/PPARg Axis Regulates the Immune Response After Burn and Inhalation Injury
Role: Principal Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL
via NATL INST OF HLTH NIGMS
Sep 2022
ACTIVE
Multi-modal rescue of pulmonary NRF2-insufficiency after burn and burn + inhalation injury to regulate innate immune dysfunction
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Contact Details
Phones:
- Business:
- (352) 273-5670
Emails:
- Business:
- robertmaile@ufl.edu
Addresses: