Tyler J Loftus, MD
Assistant Professor
About Tyler J Loftus
Tyler Loftus, MD, is an assistant professor with the UF Department of Surgery and an acute care surgeon at UF Health Shands. Graduating magna cum laude from Clemson University, Dr. Loftus received his Bachelor of Science in Health Science in 2008. Continuing his education in South Carolina, he obtained his doctorate in medicine at the Medical University of South Carolina in Charleston.
In 2012, Dr. Loftus started his residency in general surgery at UF Health Department of Surgery and became the administrative chief resident in 2018. After completing an NIH-sponsored research fellowship in the Sepsis and Critical Illness Research Center, Dr. Loftus continues to further his education working toward a PhD in Biomedical Informatics through the UF College of Medicine.
His peer-reviewed publications and research presentations at national and international meetings have evolved from translational science focusing on bone marrow failure and anemia after traumatic injury to data science focusing on machine learning to augment personalized, patient-centered decision-making.
Additionally, Dr. Loftus is interested in medical student and resident education and technical skills development and advancing trauma care through the Advanced Surgical Skills for Exposure in Trauma and Advanced Trauma Operative Management curricula.
Accomplishments
Surgical Resident's Award
2019
·
University of Florida Department of Surgery
Quality Hero Award
2019
·
University of Florida College of Medicine
Hugh A. Walters Humanitarian Award
2019
·
University of Florida Department of Surgery
First Place in the Surgical Skills Competition
2017
·
American College of Surgeons
Hugh M. Hill Outstanding Resident Teacher Award
2016
·
University of Florida
Alpha Omega Alpha Honor Medical Society Inductee
2015
·
University of Florida
Ray Bierstedt Memorial Award in Recognition of the Outstanding Surgical Intern
2013
·
University of Florida
Gold Humanism Honor Society Inductee
2012
·
Medical University of South Carolina
Board Certifications
-
American Board of Surgery Certifying ExaminationAmerican Board of Surgery
-
Licensed PhysicianState of Florida
Clinical Profile
Specialties
- Surgery
Areas of Interest
- Abdominal exploration
- Bile duct obstruction
- Bleeding
- Cardiac arrest
- Cholangitis
- Endoscopy
- Gastrointestinal bleeding
- Gastrointestinal perforation
- Inguinal hernia repair
- Neck dissection
- Peptic ulcer
- Peritonitis
- Robotic surgery
- Traumatic Injury
Research Profile
Areas of Interest
- augmented surgical decision-making
- machine learning for predictive analytics
- patient phenotyping
Publications
2021
Bridging the artificial intelligence valley of death in surgical decision-making.
Surgery.
[DOI] 10.1016/j.surg.2021.01.008.
[PMID] 33608148.
2021
The role of bone marrow microRNA (miR) in erythropoietic dysfunction after severe trauma.
Surgery.
[DOI] 10.1016/j.surg.2020.11.029.
[PMID] 33413921.
2021
Metabolomic Profiling for Diagnosis and Prognostication in Surgery: A Scoping Review.
Annals of surgery.
273(2):258-268
[DOI] 10.1097/SLA.0000000000003935.
[PMID] 32482979.
2021
Objective predictors of intern performance.
BMC medical education.
21(1)
[DOI] 10.1186/s12909-021-02487-0.
[PMID] 33499857.
2020
Added Value of Intraoperative Data for Predicting Postoperative Complications: The MySurgeryRisk PostOp Extension.
The Journal of surgical research.
254:350-363
[DOI] 10.1016/j.jss.2020.05.007.
[PMID] 32531520.
2020
Vitamin D status is associated with hepcidin and hemoglobin concentrations in patients with severe traumatic injury.
The journal of trauma and acute care surgery.
89(6):1124-1130
[DOI] 10.1097/TA.0000000000002895.
[PMID] 32769953.
2020
Reactive Artificial Intelligence Using Big Data in the Era of Precision Medicine-Reply.
JAMA surgery.
155(7):671-672
[DOI] 10.1001/jamasurg.2020.0856.
[PMID] 32374380.
2020
Optimal Antibiotic Duration for Bloodstream Infections Secondary to Intraabdominal Infection.
The Journal of surgical research.
260:82-87
[DOI] 10.1016/j.jss.2020.10.029.
[PMID] 33326932.
2020
Opportunities for machine learning to improve surgical ward safety.
American journal of surgery.
220(4):905-913
[DOI] 10.1016/j.amjsurg.2020.02.037.
[PMID] 32127174.
2020
Mysteries, Epistemological Modesty, and Artificial Intelligence in Surgery.
Frontiers in artificial intelligence.
2
[DOI] 10.3389/frai.2019.00032.
[PMID] 33117989.
2020
Multiobjective optimization challenges in perioperative anesthesia: A review.
Surgery.
[DOI] 10.1016/j.surg.2020.11.005.
[PMID] 33334583.
2020
Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress.
Shock (Augusta, Ga.).
54(4):482-487
[DOI] 10.1097/SHK.0000000000001506.
[PMID] 31904616.
2020
Mediators of Prolonged Hematopoietic Progenitor Cell Mobilization After Severe Trauma.
The Journal of surgical research.
260:315-324
[DOI] 10.1016/j.jss.2020.11.084.
[PMID] 33373851.
2020
Intelligent, Autonomous Machines in Surgery.
The Journal of surgical research.
253:92-99
[DOI] 10.1016/j.jss.2020.03.046.
[PMID] 32339787.
2020
Impact of Injury Severity on the Inflammatory State and Severe Anemia.
The Journal of surgical research.
248:109-116
[DOI] 10.1016/j.jss.2019.10.046.
[PMID] 31881381.
2020
Performance Improvement With Implementation of a Surgical Skills Curriculum.
Journal of surgical education.
[DOI] 10.1016/j.jsurg.2020.08.030.
[PMID] 32888847.
2020
Effect of Beta-Blockade on the Expression of Regulatory MicroRNA after Severe Trauma and Chronic Stress.
Journal of the American College of Surgeons.
230(1):121-129
[DOI] 10.1016/j.jamcollsurg.2019.09.011.
[PMID] 31672639.
2020
ICU Delirium-Prediction Models: A Systematic Review.
Critical care explorations.
2(12)
[DOI] 10.1097/CCE.0000000000000296.
[PMID] 33354672.
2020
Artificial Intelligence and Surgical Decision-making.
JAMA surgery.
155(2):148-158
[DOI] 10.1001/jamasurg.2019.4917.
[PMID] 31825465.
2020
Audiovisual Modules to Enhance Informed Consent in the ICU: A Pilot Study.
Critical care explorations.
2(12)
[DOI] 10.1097/CCE.0000000000000278.
[PMID] 33251517.
2020
Cardiovascular death and progression to end-stage renal disease after major surgery in elderly patients.
BJS open.
4(1):145-156
[DOI] 10.1002/bjs5.50232.
[PMID] 32011817.
2020
Chronic Critical Illness Patients Fail to Respond to Current Evidence-Based Intensive Care Nutrition Secondarily to Persistent Inflammation, Immunosuppression, and Catabolic Syndrome.
JPEN. Journal of parenteral and enteral nutrition.
44(7):1237-1249
[DOI] 10.1002/jpen.1794.
[PMID] 32026502.
2020
Performance advantages for grit and optimism.
American journal of surgery.
220(1):10-18
[DOI] 10.1016/j.amjsurg.2020.01.057.
[PMID] 32098653.
2020
Clinical Impact of a Dedicated Trauma Hybrid Operating Room.
Journal of the American College of Surgeons.
[DOI] 10.1016/j.jamcollsurg.2020.11.008.
[PMID] 33227422.
2020
Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study.
Annals of surgery.
[DOI] 10.1097/SLA.0000000000004360.
[PMID] 33196489.
2020
Decision analysis and reinforcement learning in surgical decision-making.
Surgery.
168(2):253-266
[DOI] 10.1016/j.surg.2020.04.049.
[PMID] 32540036.
2020
Delayed interhospital transfer of critically ill patients with surgical sepsis.
The journal of trauma and acute care surgery.
88(1):169-175
[DOI] 10.1097/TA.0000000000002476.
[PMID] 31856021.
2019
Use of Artificial Intelligence to Represent Emergent Systems and Augment Surgical Decision-making.
JAMA surgery.
154(9):791-792
[DOI] 10.1001/jamasurg.2019.1510.
[PMID] 31215974.
2019
The impact of standardized protocol implementation for surgical damage control and temporary abdominal closure after emergent laparotomy.
The journal of trauma and acute care surgery.
86(4):670-678
[DOI] 10.1097/TA.0000000000002170.
[PMID] 30562327.
2019
The Impact of Prior Laparotomy and Intra-abdominal Adhesions on Bowel and Mesenteric Injury Following Blunt Abdominal Trauma.
World journal of surgery.
43(2):457-465
[DOI] 10.1007/s00268-018-4792-6.
[PMID] 30225563.
2019
The effects of propranolol and clonidine on bone marrow expression of hematopoietic cytokines following trauma and chronic stress.
American journal of surgery.
218(5):858-863
[DOI] 10.1016/j.amjsurg.2019.02.023.
[PMID] 30827533.
2019
Systemic Regulation of Bone Marrow Stromal Cytokines After Severe Trauma.
The Journal of surgical research.
243:220-228
[DOI] 10.1016/j.jss.2019.05.033.
[PMID] 31207479.
2019
Sigmoido-rectal intussusception.
SAGE open medical case reports.
7
[DOI] 10.1177/2050313X19856242.
[PMID] 31217975.
2019
Serum Levels of Prealbumin and Albumin for Preoperative Risk Stratification.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.
34(3):340-348
[DOI] 10.1002/ncp.10271.
[PMID] 30908744.
2019
Persistent inflammation and anemia among critically ill septic patients.
The journal of trauma and acute care surgery.
86(2):260-267
[DOI] 10.1097/TA.0000000000002147.
[PMID] 30489504.
2019
Patient-Specific and Hospital Resource-Specific Considerations in Operative Versus Nonoperative Management of Acute Appendicitis.
The Journal of surgical research.
237:110-111
[DOI] 10.1016/j.jss.2018.03.005.
[PMID] 29622400.
2019
Packed red blood cell donor age affects overall survival in transfused patients undergoing hepatectomy for non-hepatocellular malignancy.
American journal of surgery.
217(1):71-77
[DOI] 10.1016/j.amjsurg.2018.08.011.
[PMID] 30172359.
2019
Occult bowel injury after blunt abdominal trauma.
American journal of surgery.
218(2):266-270
[DOI] 10.1016/j.amjsurg.2018.11.018.
[PMID] 30509454.
2019
DeepSOFA: A Continuous Acuity Score for Critically Ill Patients using Clinically Interpretable Deep Learning.
Scientific reports.
9(1)
[DOI] 10.1038/s41598-019-38491-0.
[PMID] 30755689.
2019
Cardiac pseudoaneurysm following non-operative management after penetrating thoracoabdominal trauma and pericardial window.
The journal of trauma and acute care surgery.
86(4):755-757
[DOI] 10.1097/TA.0000000000002189.
[PMID] 30629012.
2019
Associations Between National Board Exam Performance and Residency Program Emphasis on Patient Safety and Interprofessional Teamwork.
Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry.
43(6):581-584
[DOI] 10.1007/s40596-019-01106-x.
[PMID] 31456123.
2019
Age-dependent response to multimodal therapy for stage II-III rectal cancer.
Oncotarget.
10(45)
[DOI] 10.18632/oncotarget.27084.
[PMID] 31384389.
2019
Gender differences among surgical fellowship program directors.
Surgery.
166(5):735-737
[DOI] 10.1016/j.surg.2019.05.017.
[PMID] 31256855.
2018
A protocol for non-operative management of uncomplicated appendicitis.
The journal of trauma and acute care surgery.
84(2):358-364
[DOI] 10.1097/TA.0000000000001709.
[PMID] 29370051.
2018
Anemia and blood transfusion in elderly trauma patients.
The Journal of surgical research.
229:288-293
[DOI] 10.1016/j.jss.2018.04.021.
[PMID] 29937004.
2018
Angiographic embolization followed by piecemeal resection of giant posterior mediastinal schwannoma: Case report and concise review.
International journal of surgery case reports.
53:250-253
[DOI] 10.1016/j.ijscr.2018.10.055.
[PMID] 30439671.
2018
Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult.
Current opinion in hematology.
25(1):37-43
[DOI] 10.1097/MOH.0000000000000395.
[PMID] 29035909.
2018
Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.
The journal of trauma and acute care surgery.
84(2):342-349
[DOI] 10.1097/TA.0000000000001758.
[PMID] 29251709.
2018
The Postinjury Inflammatory State and the Bone Marrow Response to Anemia.
American journal of respiratory and critical care medicine.
198(5):629-638
[DOI] 10.1164/rccm.201712-2536OC.
[PMID] 29768025.
2018
Successful nonoperative management of uncomplicated appendicitis: predictors and outcomes.
The Journal of surgical research.
222:212-218.e2
[DOI] 10.1016/j.jss.2017.10.006.
[PMID] 29146455.
2018
Response to Er and Tez: the use of artificial neural networks in medical prognostication.
The Journal of surgical research.
222
[DOI] 10.1016/j.jss.2017.10.005.
[PMID] 29110965.
2018
Prognostic Value of Clinical vs Pathologic Stage in Rectal Cancer Patients Receiving Neoadjuvant Therapy.
Journal of the National Cancer Institute.
110(5):460-466
[DOI] 10.1093/jnci/djx228.
[PMID] 29165692.
2018
Persistent injury-associated anemia in aged rats.
Experimental gerontology.
103:63-68
[DOI] 10.1016/j.exger.2018.01.001.
[PMID] 29307734.
2018
Persistent injury-associated anemia and aging: Novel insights.
The journal of trauma and acute care surgery.
84(3):490-496
[DOI] 10.1097/TA.0000000000001766.
[PMID] 29466280.
2018
The effects of beta blockade and clonidine on persistent injury-associated anemia.
The Journal of surgical research.
230:175-180
[DOI] 10.1016/j.jss.2018.06.001.
[PMID] 29960715.
2018
Mouse Injury Model of Polytrauma and Shock.
Methods in molecular biology (Clifton, N.J.).
1717:1-15
[DOI] 10.1007/978-1-4939-7526-6_1.
[PMID] 29468579.
2018
Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.
Frontiers in immunology.
9
[DOI] 10.3389/fimmu.2018.00595.
[PMID] 29670613.
2018
Hypertonic saline resuscitation after emergent laparotomy and temporary abdominal closure.
The journal of trauma and acute care surgery.
84(2):350-357
[DOI] 10.1097/TA.0000000000001730.
[PMID] 29140948.
2018
Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis.
Shock (Augusta, Ga.).
49(3):249-258
[DOI] 10.1097/SHK.0000000000000981.
[PMID] 28885387.
2018
Effect of Time to Operation on Value of Care in Acute Care Surgery.
World journal of surgery.
42(8):2356-2363
[DOI] 10.1007/s00268-018-4476-2.
[PMID] 29352339.
2018
Pathologic stage dictates survival after neoadjuvant radiation for rectal cancer.
Oncotarget.
9(84):35474-35475
[DOI] 10.18632/oncotarget.26262.
[PMID] 30464801.
2017
Percutaneous cholecystostomy: prognostic factors and comparison to cholecystectomy.
Surgical endoscopy.
31(11):4568-4575
[DOI] 10.1007/s00464-017-5517-x.
[PMID] 28409378.
2017
Persistent injury-associated anemia: the role of the bone marrow microenvironment.
The Journal of surgical research.
214:240-246
[DOI] 10.1016/j.jss.2017.03.018.
[PMID] 28624051.
2017
Predicting appendiceal tumors among patients with appendicitis.
The journal of trauma and acute care surgery.
82(4):771-775
[DOI] 10.1097/TA.0000000000001378.
[PMID] 28099380.
2017
Routine surveillance cholangiography after percutaneous cholecystostomy delays drain removal and cholecystectomy.
The journal of trauma and acute care surgery.
82(2):351-355
[DOI] 10.1097/TA.0000000000001315.
[PMID] 27893641.
2017
Severe trauma and chronic stress activates extramedullary erythropoiesis.
The journal of trauma and acute care surgery.
83(1):144-150
[DOI] 10.1097/TA.0000000000001537.
[PMID] 28452894.
2017
Temporary abdominal closure for trauma and intra-abdominal sepsis: Different patients, different outcomes.
The journal of trauma and acute care surgery.
82(2):345-350
[DOI] 10.1097/TA.0000000000001283.
[PMID] 27787442.
2017
The effects of red cell transfusion donor age on nosocomial infection among trauma patients.
American journal of surgery.
214(4):672-676
[DOI] 10.1016/j.amjsurg.2017.07.004.
[PMID] 28720216.
2017
The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two Level-One Trauma Centers.
Critical care medicine.
45(12):1989-1996
[DOI] 10.1097/CCM.0000000000002697.
[PMID] 28837430.
2017
Neural network prediction of severe lower intestinal bleeding and the need for surgical intervention.
The Journal of surgical research.
212:42-47
[DOI] 10.1016/j.jss.2016.12.032.
[PMID] 28550920.
2017
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.
BMJ open.
7(7)
[DOI] 10.1136/bmjopen-2016-015136.
[PMID] 28765125.
2017
Microbial recognition and danger signals in sepsis and trauma.
Biochimica et biophysica acta. Molecular basis of disease.
1863(10 Pt B):2564-2573
[DOI] 10.1016/j.bbadis.2017.01.013.
[PMID] 28115287.
2017
Early bronchoalveolar lavage for intubated trauma patients with TBI or chest trauma.
Journal of critical care.
39:78-82
[DOI] 10.1016/j.jcrc.2017.02.010.
[PMID] 28231518.
2017
ICU-Acquired Weakness, Chronic Critical Illness, and the Persistent Inflammation-Immunosuppression and Catabolism Syndrome.
Critical care medicine.
45(11)
[DOI] 10.1097/CCM.0000000000002576.
[PMID] 29028707.
2017
Acute Kidney Injury Following Exploratory Laparotomy and Temporary Abdominal Closure.
Shock (Augusta, Ga.).
48(1):5-10
[DOI] 10.1097/SHK.0000000000000825.
[PMID] 28009772.
2017
Improved outcomes following implementation of an acute gastrointestinal bleeding multidisciplinary protocol.
The journal of trauma and acute care surgery.
83(1):41-46
[DOI] 10.1097/TA.0000000000001295.
[PMID] 27779592.
2017
Characterization of hypoalbuminemia following temporary abdominal closure.
The journal of trauma and acute care surgery.
83(4):650-656
[DOI] 10.1097/TA.0000000000001553.
[PMID] 28837537.
2017
Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress.
Surgery.
161(3):795-802
[DOI] 10.1016/j.surg.2016.08.043.
[PMID] 27742030.
2017
Clonidine restores vascular endothelial growth factor expression and improves tissue repair following severe trauma.
American journal of surgery.
214(4):610-615
[DOI] 10.1016/j.amjsurg.2017.06.019.
[PMID] 28666582.
2017
Antibiotics May be Safely Discontinued Within One Week of Percutaneous Cholecystostomy.
World journal of surgery.
41(5):1239-1245
[DOI] 10.1007/s00268-016-3861-y.
[PMID] 28050668.
2017
Daily propranolol administration reduces persistent injury-associated anemia after severe trauma and chronic stress.
The journal of trauma and acute care surgery.
82(4):714-721
[DOI] 10.1097/TA.0000000000001374.
[PMID] 28099381.
2017
Effects of trauma, hemorrhagic shock, and chronic stress on lung vascular endothelial growth factor.
The Journal of surgical research.
210:15-21
[DOI] 10.1016/j.jss.2016.10.023.
[PMID] 28457321.
2017
Emergent laparotomy and temporary abdominal closure for the cirrhotic patient.
The Journal of surgical research.
210:108-114
[DOI] 10.1016/j.jss.2016.11.013.
[PMID] 28457316.
2017
Computed tomography evidence of fluid in the hernia sac predicts surgical site infection following mesh repair of acutely incarcerated ventral and groin hernias.
The journal of trauma and acute care surgery.
83(1):170-174
[DOI] 10.1097/TA.0000000000001503.
[PMID] 28426559.
2016
Intubated Trauma Patients Receiving Prolonged Antibiotics for Pneumonia despite Negative Cultures: Predictors and Outcomes.
Surgical infections.
17(6):766-772
[PMID] 27635693.
View on:
PubMed
2016
β-Blockade use for Traumatic Injuries and Immunomodulation: A Review of Proposed Mechanisms and Clinical Evidence.
Shock (Augusta, Ga.).
46(4):341-51
[DOI] 10.1097/SHK.0000000000000636.
[PMID] 27172161.
2015
A protocol for the management of adhesive small bowel obstruction.
The journal of trauma and acute care surgery.
78(1):13-9; discussion 19
[DOI] 10.1097/TA.0000000000000491.
[PMID] 25539198.
2015
Duodenal gangliocytic paraganglioma: A case report and literature review.
International journal of surgery case reports.
8C:5-8
[DOI] 10.1016/j.ijscr.2015.01.003.
[PMID] 25600615.
2000
Refractory abdominal-cutaneous fistulas or leaks: percutaneous management with a collagen plug.
Journal of the American College of Surgeons.
190(5):588-92
[PMID] 10801026.
View on:
PubMed
1998
Outcomes evaluation for operative and nonoperative management of the abnormal mammogram.
American journal of surgery.
175(1):69-72
[PMID] 9445245.
View on:
PubMed
Grants
Sep 2020
ACTIVE
Aligning Patient Acuity with Intensity of Care after Surgery
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Education
Fellowship, Surgical Critical Care
2019-2020
·
University of Florida
Research Fellowship, Sepsis and Critical Illness Research Center
2015-2017
·
University of Florida
Residency, General Surgery
2012-2019
·
University of Florida
Medical Degree
2008-2012
·
Medical University of South Carolina
Bachelor of Science
2004-2008
·
Clemson University
Contact Details
Phones:
- Business:
- (352) 273-9440
Emails:
- Business:
- tloftus@ufl.edu