Tyler J Loftus, MD, PhD
Associate Professor, Program Director of the General Surgery Residency Program
About Tyler J Loftus
As an associate professor with tenure and an acute care surgeon in the University of Florida Department of Surgery, I treat patients for traumatic injury and those needing emergency general surgery.
I graduated magna cum laude from Clemson University, receiving my Bachelor of Science in health science in 2008. Staying in South Carolina, I obtained my medical degree at the Medical University of South Carolina in Charleston. Then, I relocated to Florida to pursue a general surgery residency and NIH-sponsored research fellowship at the Sepsis and Critical Illness Research center at UF. Subsequently, I completed a surgical critical care fellowship and a PhD in biomedical informatics at UF.
I am passionate about resident education and professional development as program director for the general surgery residency. My NIH-funded research pursuits have evolved from translational science, focusing on bone marrow failure and anemia after traumatic injury, to data science, focusing on machine learning to augment personalized, patient-centered decision-making.
Accomplishments
Lester R. Dragstedt Physician-Scientist Award
2024
·
University of Florida Department of Surgery
Rising Star Clinical Faculty Award
2024
·
University of Florida College of Medicine
Rising Start Research Award
2024
·
University of Florida College of Medicine
Outstanding Faculty Award
2022-2023
·
University of Florida Department of Surgery
Exemplary Teacher
2022
·
University of Florida College of Medicine
Hugh A. Walters Humanitarian Award
2019
·
University of Florida Department of Surgery
Quality Hero Award
2019
·
University of Florida College of Medicine
Surgical Resident's Award
2019
·
University of Florida Department of Surgery
First Place in the Surgical Skills Competition
2017
·
American College of Surgeons
Hugh M. Hill Outstanding Resident Teacher Award
2016
·
University of Florida
Alpha Omega Alpha Honor Medical Society Inductee
2015
·
University of Florida
Ray Bierstedt Memorial Award in Recognition of the Outstanding Surgical Intern
2013
·
University of Florida
Gold Humanism Honor Society Inductee
2012
·
Medical University of South Carolina
Board Certifications
-
Clinical InformaticsAmerican Board of Preventative Medicine
-
Licensed PhysicianState of Florida
-
SurgeryAmerican Board of Surgery
-
Surgical Critical CareAmerican Board of Surgery
Clinical Profile
Subspecialties
- Surgical Critical Care
Areas of Interest
- Abdominal Exploration
- Bile Duct Obstruction
- Bleeding
- Cardiac Arrest
- Cholangitis
- Endoscopy
- Gastrointestinal Bleeding
- Gastrointestinal Perforation
- Inguinal Hernia Repair
- Neck Dissection
- Peptic Ulcer
- Peritonitis
- Robotic Surgery
- Traumatic Injury
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0001-5354-443X
Areas of Interest
- augmented surgical decision-making
- machine learning for predictive analytics
- patient phenotyping
Publications
Academic Articles
2025
Antibiotic Prophylaxis for Elective Pediatric Laparoscopic Cholecystectomies
Journal of Pediatric Surgery.
60(3)
[DOI] 10.1016/j.jpedsurg.2024.162055.
2025
Determining potential immunomodulatory drug efficacy in sepsis using ELISpot.
Scientific reports.
15(1)
[DOI] 10.1038/s41598-025-92016-6.
[PMID] 40251188.
2025
Guiding Surgical Trainee Supervision Through Competency-Based Assessment: In Reply to Kapoor and Ray.
Journal of the American College of Surgeons.
240(5):839-840
[DOI] 10.1097/XCS.0000000000001262.
[PMID] 39774630.
2025
Honoring Advance Directives: A Scoping Review of Adherence and Impact on Value of Care.
Journal of palliative medicine.
[DOI] 10.1089/jpm.2024.0328.
[PMID] 40197904.
2025
Indocyanine green fluorescent cholangiography in laparoscopic cholecystectomy: A systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.
Surgery.
181
[DOI] 10.1016/j.surg.2025.109149.
[PMID] 39891966.
2025
Methods for phenotyping adult patients with acute kidney injury: a systematic review.
Journal of nephrology.
38(1):75-85
[DOI] 10.1007/s40620-024-02080-w.
[PMID] 39283471.
2025
Practical Guide to Artificial Intelligence, Chatbots, and Large Language Models in Conducting and Reporting Research.
JAMA surgery.
160(5):588-589
[DOI] 10.1001/jamasurg.2024.6025.
[PMID] 39774809.
2025
Temporal Analysis of Nationwide Emergency Department Utilization and Appendectomy Trends
Emergency Care and Medicine.
2(2)
[DOI] 10.3390/ecm2020022.
2025
The Predictive Value of Basic Laparoscopic Evaluations on Complex Cases Using the Society for Improving Medical Procedural Learning Database
Journal of Surgical Research.
311:164-171
[DOI] 10.1016/j.jss.2025.04.041.
2024
A Tribute to Dr Kevin E. Behrns, Editor-in-Chief of SURGERY
Surgery.
176(6):1558-1559
[DOI] 10.1016/j.surg.2024.08.041.
2024
Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot.
JCI insight.
9(2)
[DOI] 10.1172/jci.insight.175785.
[PMID] 38100268.
2024
APRICOT-Mamba: Acuity Prediction in Intensive Care Unit (ICU): Development and Validation of a Stability, Transitions, and Life-Sustaining Therapies Prediction Model.
Research square.
[DOI] 10.21203/rs.3.rs-4790824/v1.
[PMID] 39149454.
2024
Are we ready for “green surgery” to promote environmental sustainability in the operating room? Results from the WSES STAR investigation.
World journal of emergency surgery : WJES.
19(1)
[DOI] 10.1186/s13017-024-00533-y.
[PMID] 38267949.
2024
Artificial intelligence in surgery: a global balancing act.
The British journal of surgery.
111(3)
[DOI] 10.1093/bjs/znae062.
[PMID] 38525930.
2024
Association of Sociodemographic Factors With Overtriage, Undertriage, and Value of Care After Major Surgery.
Annals of surgery open : perspectives of surgical history, education, and clinical approaches.
5(2)
[DOI] 10.1097/AS9.0000000000000429.
[PMID] 38911666.
2024
Community-engaged artificial intelligence research: A scoping review
PLOS Digital Health.
3(8)
[DOI] 10.1371/journal.pdig.0000561.
[PMID] 39178307.
2024
Critical appraisal of artificial intelligence in robotic surgery
Surgery.
176(3):558-559
[DOI] 10.1016/j.surg.2024.03.022.
2024
Development and validation of a race-agnostic computable phenotype for kidney health in adult hospitalized patients
PLOS ONE.
19(4)
[DOI] 10.1371/journal.pone.0299332.
[PMID] 38652731.
2024
Electronic Health Record Data Quality and Performance Assessments: Scoping Review
JMIR Medical Informatics.
12:e58130-e58130
[DOI] 10.2196/58130.
[PMID] 39504136.
2024
Gender differences in autonomy and performance assessments in a national cohort of vascular surgery trainees
Journal of Vascular Surgery.
80(1):260-267.e2
[DOI] 10.1016/j.jvs.2024.03.019.
2024
Identifying acute illness phenotypes via deep temporal interpolation and clustering network on physiologic signatures.
Scientific reports.
14(1)
[DOI] 10.1038/s41598-024-59047-x.
[PMID] 38600110.
2024
Incorporating Patient Values in Large Language Model Recommendations for Surrogate and Proxy Decisions
Critical Care Explorations.
6(8)
[DOI] 10.1097/cce.0000000000001131.
2024
Integration of AI in surgical decision support: improving clinical judgment
Global Surgical Education – Journal of the Association for Surgical Education.
3(1)
[DOI] 10.1007/s44186-024-00257-2.
2024
Intraoperative hypotension and postoperative acute kidney injury: A systematic review.
American journal of surgery.
232:45-53
[DOI] 10.1016/j.amjsurg.2024.02.001.
[PMID] 38383166.
2024
Longitudinal clinical decision support for assessing decisions over time: State-of-the-art and future directions
DIGITAL HEALTH.
10
[DOI] 10.1177/20552076241249925.
[PMID] 38708184.
2024
Operating Room Supply Cost and Value of Care after Implementing a Sustainable Quality Intervention.
Journal of the American College of Surgeons.
238(4):404-413
[DOI] 10.1097/XCS.0000000000000972.
[PMID] 38224109.
2024
Predicting patient reported outcome measures: a scoping review for the artificial intelligence-guided patient preference predictor.
Frontiers in artificial intelligence.
7
[DOI] 10.3389/frai.2024.1477447.
[PMID] 39564457.
2024
Resident and Fellow Performance and Supervision in Surgical Oncology Procedures.
Journal of the American College of Surgeons.
239(6):528-537
[DOI] 10.1097/XCS.0000000000001131.
[PMID] 38895939.
2024
Risk-Specific Training Cohorts to Address Class Imbalance in Surgical Risk Prediction.
JAMA surgery.
159(12):1424-1431
[DOI] 10.1001/jamasurg.2024.4299.
[PMID] 39382865.
2024
Severe trauma leads to sustained muscle loss, induced frailty, and distinct temporal changes in myokine and chemokine profiles of older patients
Surgery.
176(5):1516-1524
[DOI] 10.1016/j.surg.2024.07.031.
[PMID] 39179433.
2024
Surgical leadership: Ensuring financial stability through growth
Surgery.
175(4):1218-1223
[DOI] 10.1016/j.surg.2023.09.020.
2024
Surviving septic patients endotyped with a functional assay demonstrate active immune responses.
Frontiers in immunology.
15
[DOI] 10.3389/fimmu.2024.1418613.
[PMID] 39469706.
2024
The dilemma of consent for AI in healthcare
Surgery.
175(5):1456-1457
[DOI] 10.1016/j.surg.2024.01.019.
2024
The post-septic peripheral myeloid compartment reveals unexpected diversity in myeloid-derived suppressor cells.
Frontiers in immunology.
15
[DOI] 10.3389/fimmu.2024.1355405.
[PMID] 38720891.
2024
TRANSCRIPTOMIC DIFFERENCES IN PERIPHERAL MONOCYTE POPULATIONS IN SEPTIC PATIENTS BASED ON OUTCOME.
Shock (Augusta, Ga.).
62(2):208-216
[DOI] 10.1097/SHK.0000000000002379.
[PMID] 38713581.
2024
Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness.
Frontiers in immunology.
15
[DOI] 10.3389/fimmu.2024.1478471.
[PMID] 39691721.
2024
Use of an electronic documentation module to improve surgical debriefing effectiveness
Surgery.
176(4):1155-1161
[DOI] 10.1016/j.surg.2024.07.003.
2024
Using AI to bridge global surgical gaps: high tech, high impact.
Lancet (London, England).
403(10438):1746-1747
[DOI] 10.1016/S0140-6736(23)02753-8.
[PMID] 38704161.
2023
A narrative review of ergonomic problems, principles, and potential solutions in surgical operations
Surgery.
174(2):214-221
[DOI] 10.1016/j.surg.2023.04.003.
2023
A simulation curriculum for laparoscopic common bile duct exploration, balloon sphincterotomy, and endobiliary stenting: Associations with resident performance and autonomy in the operating room
Surgery.
173(4):950-956
[DOI] 10.1016/j.surg.2022.11.007.
2023
Actionable artificial intelligence: Overcoming barriers to adoption of prediction tools
Surgery.
174(3):730-732
[DOI] 10.1016/j.surg.2023.03.019.
2023
Adverse Long-Term Outcomes and an Immune Suppressed Endotype in Sepsis Patients with Reduced Interferon-γELISpot: A Multicenter, Prospective Observational Study.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2023.09.13.23295360.
[PMID] 37745385.
2023
Artificial Intelligence-enabled Decision Support in Surgery: State-of-the-art and Future Directions.
Annals of surgery.
278(1):51-58
[DOI] 10.1097/SLA.0000000000005853.
[PMID] 36942574.
2023
Building an automated, machine learning-enabled platform for predicting post-operative complications.
Physiological measurement.
44(2)
[DOI] 10.1088/1361-6579/acb4db.
[PMID] 36657179.
2023
Commentary: Machine learning in clinical decision-making.
Frontiers in digital health.
5
[DOI] 10.3389/fdgth.2023.1214111.
[PMID] 37588023.
2023
Computable Phenotypes to Characterize Changing Patient Brain Dysfunction in the Intensive Care Unit.
ArXiv.
[PMID] 36945691.
2023
Continuous ECG monitoring should be the heart of bedside AI-based predictive analytics monitoring for early detection of clinical deterioration.
Journal of electrocardiology.
76:35-38
[DOI] 10.1016/j.jelectrocard.2022.10.011.
[PMID] 36434848.
2023
Correction: Surgeons’ perspectives on artificial intelligence to support clinical decision-making in trauma and emergency contexts: results from an international survey.
World journal of emergency surgery : WJES.
18(1)
[DOI] 10.1186/s13017-023-00493-9.
[PMID] 36959605.
2023
Defining critical illness using immunological endotypes in patients with and without of sepsis: A cohort study.
Research square.
[DOI] 10.21203/rs.3.rs-2874506/v1.
[PMID] 37214996.
2023
Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study.
Critical care (London, England).
27(1)
[DOI] 10.1186/s13054-023-04571-x.
[PMID] 37474944.
2023
Digital Health Transformers and Opportunities for Artificial Intelligence–Enabled Nephrology
Clinical Journal of the American Society of Nephrology.
18(4):527-529
[DOI] 10.2215/cjn.0000000000000085.
2023
Dynamic predictions of postoperative complications from explainable, uncertainty-aware, and multi-task deep neural networks
Scientific Reports.
13(1)
[DOI] 10.1038/s41598-023-27418-5.
[PMID] 36681755.
2023
Low vs Standard-Dose Indocyanine Green in the Identification of Biliary Anatomy Using Near-Infrared Fluorescence Imaging: A Multicenter Randomized Controlled Trial.
Journal of the American College of Surgeons.
236(4):711-717
[DOI] 10.1097/XCS.0000000000000553.
[PMID] 36728303.
2023
Machine learning-based prediction models for home discharge in patients with COVID-19: Development and evaluation using electronic health records
PLOS ONE.
18(10)
[DOI] 10.1371/journal.pone.0292888.
[PMID] 37862334.
2023
Machine Learning–Enabled Clinical Information Systems Using Fast Healthcare Interoperability Resources Data Standards: Scoping Review
JMIR Medical Informatics.
11:e48297-e48297
[DOI] 10.2196/48297.
[PMID] 37646309.
2023
Methods and evaluation metrics for reducing material waste in the operating room: a scoping review
Surgery.
174(2):252-258
[DOI] 10.1016/j.surg.2023.04.051.
2023
Outcomes From a Level 1 Trauma and Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program Center of Excellence
The American Surgeonâ„¢.
89(6):2920-2922
[DOI] 10.1177/00031348221084091.
2023
Overtriage, Undertriage, and Value of Care after Major Surgery: An Automated, Explainable Deep Learning-Enabled Classification System.
Journal of the American College of Surgeons.
236(2):279-291
[DOI] 10.1097/XCS.0000000000000471.
[PMID] 36648256.
2023
Postoperative Overtriage to an Intensive Care Unit Is Associated With Low Value of Care.
Annals of surgery.
277(2):179-185
[DOI] 10.1097/SLA.0000000000005460.
[PMID] 35797553.
2023
Postoperative Triage Hybrid Model: In Reply to Bellini and Bignami.
Journal of the American College of Surgeons.
237(2)
[DOI] 10.1097/XCS.0000000000000747.
[PMID] 37184098.
2023
Predictive Modeling for Readmission to Intensive Care: A Systematic Review.
Critical care explorations.
5(1)
[DOI] 10.1097/CCE.0000000000000848.
[PMID] 36699252.
2023
Re-Aiming Equity Evaluation in Clinical Decision Support: A Scoping Review of Equity Assessments in Surgical Decision Support Systems.
Annals of surgery.
277(3):359-364
[DOI] 10.1097/SLA.0000000000005661.
[PMID] 35943199.
2023
Resident Operative Autonomy and Attending Verbal Feedback Differ by Resident and Attending Gender.
Annals of surgery open : perspectives of surgical history, education, and clinical approaches.
4(1)
[DOI] 10.1097/AS9.0000000000000256.
[PMID] 37600892.
2023
Resource use for cholecystectomy with versus without cholangiography: A multicenter, propensity-matched analysis
Surgery.
174(2):152-158
[DOI] 10.1016/j.surg.2023.04.027.
2023
Retrospective value assessment of a dedicated, trauma hybrid operating room.
The journal of trauma and acute care surgery.
94(6):814-822
[DOI] 10.1097/TA.0000000000003873.
[PMID] 36727772.
2023
Surgeons’ perspectives on artificial intelligence to support clinical decision-making in trauma and emergency contexts: results from an international survey.
World journal of emergency surgery : WJES.
18(1)
[DOI] 10.1186/s13017-022-00467-3.
[PMID] 36597105.
2023
Surgical resident experience with common bile duct exploration and assessment of performance and autonomy with formative feedback
World Journal of Emergency Surgery.
18(1)
[DOI] 10.1186/s13017-023-00480-0.
[PMID] 36747289.
2023
Survival and neurologic outcomes following aortic occlusion for trauma and hemorrhagic shock in a hybrid operating room.
World journal of emergency surgery : WJES.
18(1)
[DOI] 10.1186/s13017-023-00484-w.
[PMID] 36959585.
2023
Survival and neurologic outcomes following aortic occlusion for trauma and hemorrhagic shock in a hybrid operating room.
Research square.
[DOI] 10.21203/rs.3.rs-2459030/v1.
[PMID] 36711502.
2023
The persistent inflammation, immunosuppression, and catabolism syndrome 10 years later.
The journal of trauma and acute care surgery.
95(5):790-799
[DOI] 10.1097/TA.0000000000004087.
[PMID] 37561664.
2023
Time for a paradigm shift in shared decision-making in trauma and emergency surgery? Results from an international survey.
World journal of emergency surgery : WJES.
18(1)
[DOI] 10.1186/s13017-022-00464-6.
[PMID] 36803568.
2022
A core outcome set for damage control laparotomy via modified Delphi method.
Trauma surgery & acute care open.
7(1)
[DOI] 10.1136/tsaco-2021-000821.
[PMID] 35047673.
2022
Aligning Patient Acuity With Resource Intensity After Major Surgery: A Scoping Review.
Annals of surgery.
275(2):332-339
[DOI] 10.1097/SLA.0000000000005079.
[PMID] 34261886.
2022
Artificial Intelligence and Surgery: Ethical Dilemmas and Open Issues.
Journal of the American College of Surgeons.
235(2):268-275
[DOI] 10.1097/XCS.0000000000000242.
[PMID] 35839401.
2022
Artificial intelligence in surgery: the emergency surgeon’s perspective (the ARIES project).
Discover health systems.
1(1)
[DOI] 10.1007/s44250-022-00014-6.
[PMID] 37521114.
2022
Artificial intelligence-enabled decision support in nephrology
Nature Reviews Nephrology.
18(7):452-465
[DOI] 10.1038/s41581-022-00562-3.
[PMID] 35459850.
2022
Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study.
Annals of surgery.
275(6):1184-1193
[DOI] 10.1097/SLA.0000000000004360.
[PMID] 33196489.
2022
Early Biomarker Signatures in Surgical Sepsis
Journal of Surgical Research.
277:372-383
[DOI] 10.1016/j.jss.2022.04.052.
[PMID] 35569215.
2022
EARLY DIFFERENTIATION BETWEEN SEPSIS AND STERILE INFLAMMATION VIA URINARY GENE SIGNATURES OF METABOLIC DYSREGULATION.
Shock (Augusta, Ga.).
58(1):20-27
[DOI] 10.1097/SHK.0000000000001952.
[PMID] 35904146.
2022
Evaluation of a Multivalent Transcriptomic Metric for Diagnosing Surgical Sepsis and Estimating Mortality Among Critically Ill Patients.
JAMA network open.
5(7)
[DOI] 10.1001/jamanetworkopen.2022.21520.
[PMID] 35819783.
2022
Evaluation of federated learning variations for COVID-19 diagnosis using chest radiographs from 42 US and European hospitals.
Journal of the American Medical Informatics Association : JAMIA.
30(1):54-63
[DOI] 10.1093/jamia/ocac188.
[PMID] 36214629.
2022
Executive summary of the artificial intelligence in surgery series
Surgery.
171(5):1435-1439
[DOI] 10.1016/j.surg.2021.10.047.
[PMID] 34815097.
2022
Federated learning for preserving data privacy in collaborative healthcare research
DIGITAL HEALTH.
8
[DOI] 10.1177/20552076221134455.
[PMID] 36325438.
2022
From bench to bedside: Pursuing equity in precision medicine approaches to pancreatic cancer care.
Frontiers in oncology.
12
[DOI] 10.3389/fonc.2022.1086779.
[PMID] 36568255.
2022
Gamification for Machine Learning in Surgical Patient Engagement.
Frontiers in surgery.
9
[DOI] 10.3389/fsurg.2022.896351.
[PMID] 35656082.
2022
Ideal algorithms in healthcare: Explainable, dynamic, precise, autonomous, fair, and reproducible
PLOS Digital Health.
1(1)
[DOI] 10.1371/journal.pdig.0000006.
[PMID] 36532301.
2022
Impact of Empiric Linezolid for Necrotizing Soft Tissue Infections on Duration of Methicillin-Resistant Staphylococcus aureus-Active Therapy.
Surgical infections.
23(3):313-317
[DOI] 10.1089/sur.2021.329.
[PMID] 35133888.
2022
Methods for Phenotyping Adult Patients in Sepsis and Septic Shock: A Scoping Review.
Critical care explorations.
4(4)
[DOI] 10.1097/CCE.0000000000000672.
[PMID] 35372844.
2022
Nutritional impact of omega 3 fatty acids and metabolites in acute and chronic critical illness.
Current opinion in clinical nutrition and metabolic care.
25(2):75-80
[DOI] 10.1097/MCO.0000000000000818.
[PMID] 35115447.
2022
Performance of a Machine Learning Algorithm Using Electronic Health Record Data to Predict Postoperative Complications and Report on a Mobile Platform.
JAMA network open.
5(5)
[DOI] 10.1001/jamanetworkopen.2022.11973.
[PMID] 35576007.
2022
Personalized decision-making for acute cholecystitis: Understanding surgeon judgment.
Frontiers in digital health.
4
[DOI] 10.3389/fdgth.2022.845453.
[PMID] 36339515.
2022
Phenotype clustering in health care: A narrative review for clinicians.
Frontiers in artificial intelligence.
5
[DOI] 10.3389/frai.2022.842306.
[PMID] 36034597.
2022
Physiologic signatures within six hours of hospitalization identify acute illness phenotypes
PLOS Digital Health.
1(10)
[DOI] 10.1371/journal.pdig.0000110.
[PMID] 36590701.
2022
Preoperative computed tomography for acutely incarcerated ventral or inguinal hernia
Surgery.
172(1):193-197
[DOI] 10.1016/j.surg.2022.01.014.
[PMID] 35304009.
2022
Safety of laparoscopic inguinal hernia repair in the setting of antithrombotic therapy.
Surgical endoscopy.
36(12):9011-9018
[DOI] 10.1007/s00464-022-09360-1.
[PMID] 35674797.
2022
Sepsis-Induced Myopathy and Gut Microbiome Dysbiosis: Mechanistic Links and Therapeutic Targets.
Shock (Augusta, Ga.).
57(1):15-23
[DOI] 10.1097/SHK.0000000000001843.
[PMID] 34726875.
2022
Uncertainty-aware deep learning in healthcare: A scoping review
PLOS Digital Health.
1(8)
[DOI] 10.1371/journal.pdig.0000085.
[PMID] 36590140.
2021
A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.696536.
[PMID] 34484194.
2021
Advances in artificial intelligence and deep learning systems in ICU-related acute kidney injury.
Current opinion in critical care.
27(6):560-572
[DOI] 10.1097/MCC.0000000000000887.
[PMID] 34757993.
2021
Artificial intelligence and gender bias in hiring surgeons and beyond.
American journal of surgery.
222(6)
[DOI] 10.1016/j.amjsurg.2021.10.009.
[PMID] 34657722.
2021
Association of persistent acute kidney injury and renal recovery with mortality in hospitalised patients.
BMJ health & care informatics.
28(1)
[DOI] 10.1136/bmjhci-2021-100458.
[PMID] 34876451.
2021
Association of Postoperative Undertriage to Hospital Wards With Mortality and Morbidity.
JAMA network open.
4(11)
[DOI] 10.1001/jamanetworkopen.2021.31669.
[PMID] 34757412.
2021
Bridging the artificial intelligence valley of death in surgical decision-making.
Surgery.
169(4):746-748
[DOI] 10.1016/j.surg.2021.01.008.
[PMID] 33608148.
2021
Building an Artificial Intelligence-Competent Surgical Workforce.
JAMA surgery.
156(6):511-512
[DOI] 10.1001/jamasurg.2021.0045.
[PMID] 33688933.
2021
Cardiovascular and Renal Disease in Chronic Critical Illness
Journal of Clinical Medicine.
10(8)
[DOI] 10.3390/jcm10081601.
[PMID] 33918938.
2021
Chronic Critical Illness Elicits a Unique Circulating Leukocyte Transcriptome in Sepsis Survivors
Journal of Clinical Medicine.
10(15)
[DOI] 10.3390/jcm10153211.
[PMID] 34361995.
2021
Clinical Impact of a Dedicated Trauma Hybrid Operating Room.
Journal of the American College of Surgeons.
232(4):560-570
[DOI] 10.1016/j.jamcollsurg.2020.11.008.
[PMID] 33227422.
2021
Editorial: Machine Learning in Clinical Decision-Making.
Frontiers in digital health.
3
[DOI] 10.3389/fdgth.2021.784495.
[PMID] 34870273.
2021
Effects of a Single Rapid Infusion System on Platelet Function in Stored Whole Blood: An Ex Vivo Study.
Cureus.
13(7)
[DOI] 10.7759/cureus.16518.
[PMID] 34430129.
2021
Equity and Artificial Intelligence in Surgical Care.
JAMA surgery.
156(6):509-510
[DOI] 10.1001/jamasurg.2020.7208.
[PMID] 33625504.
2021
Identification of unique microRNA expression patterns in bone marrow hematopoietic stem and progenitor cells after hemorrhagic shock and multiple injuries in young and old adult mice.
The journal of trauma and acute care surgery.
91(4):692-699
[DOI] 10.1097/TA.0000000000003350.
[PMID] 34252063.
2021
Intraoperative hypotension and complications after vascular surgery: A scoping review.
Surgery.
170(1):311-317
[DOI] 10.1016/j.surg.2021.03.054.
[PMID] 33972092.
2021
Introduction to the artificial intelligence in surgery series.
Surgery.
169(4):744-745
[DOI] 10.1016/j.surg.2020.09.021.
[PMID] 33759780.
2021
Machine Learning Applications in Solid Organ Transplantation and Related Complications.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.739728.
[PMID] 34603324.
2021
Mediators of Prolonged Hematopoietic Progenitor Cell Mobilization After Severe Trauma.
The Journal of surgical research.
260:315-324
[DOI] 10.1016/j.jss.2020.11.084.
[PMID] 33373851.
2021
Metabolomic Profiling for Diagnosis and Prognostication in Surgery: A Scoping Review.
Annals of surgery.
273(2):258-268
[DOI] 10.1097/SLA.0000000000003935.
[PMID] 32482979.
2021
Multiobjective optimization challenges in perioperative anesthesia: A review.
Surgery.
170(1):320-324
[DOI] 10.1016/j.surg.2020.11.005.
[PMID] 33334583.
2021
Objective predictors of intern performance.
BMC medical education.
21(1)
[DOI] 10.1186/s12909-021-02487-0.
[PMID] 33499857.
2021
Optimal Antibiotic Duration for Bloodstream Infections Secondary to Intraabdominal Infection.
The Journal of surgical research.
260:82-87
[DOI] 10.1016/j.jss.2020.10.029.
[PMID] 33326932.
2021
Optimizing predictive strategies for acute kidney injury after major vascular surgery.
Surgery.
170(1):298-303
[DOI] 10.1016/j.surg.2021.01.030.
[PMID] 33648766.
2021
Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course Analysis.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.792448.
[PMID] 34956225.
2021
Performance Improvement With Implementation of a Surgical Skills Curriculum
Journal of Surgical Education.
78(2):561-569
[DOI] 10.1016/j.jsurg.2020.08.030.
[PMID] 32888847.
2021
The Morbidity and Mortality Assessment Tool (MMAT): Design and Proof of Concept
Journal of Surgical Research.
267:260-266
[DOI] 10.1016/j.jss.2021.04.025.
2021
The role of bone marrow microRNA (miR) in erythropoietic dysfunction after severe trauma.
Surgery.
169(5):1206-1212
[DOI] 10.1016/j.surg.2020.11.029.
[PMID] 33413921.
2020
Added Value of Intraoperative Data for Predicting Postoperative Complications: The MySurgeryRisk PostOp Extension.
The Journal of surgical research.
254:350-363
[DOI] 10.1016/j.jss.2020.05.007.
[PMID] 32531520.
2020
Artificial Intelligence and Surgical Decision-making.
JAMA surgery.
155(2):148-158
[DOI] 10.1001/jamasurg.2019.4917.
[PMID] 31825465.
2020
Audiovisual Modules to Enhance Informed Consent in the ICU: A Pilot Study.
Critical care explorations.
2(12)
[DOI] 10.1097/CCE.0000000000000278.
[PMID] 33251517.
2020
Cardiovascular death and progression to end-stage renal disease after major surgery in elderly patients.
BJS open.
4(1):145-156
[DOI] 10.1002/bjs5.50232.
[PMID] 32011817.
2020
Chronic Critical Illness Patients Fail to Respond to Current Evidence-Based Intensive Care Nutrition Secondarily to Persistent Inflammation, Immunosuppression, and Catabolic Syndrome.
JPEN. Journal of parenteral and enteral nutrition.
44(7):1237-1249
[DOI] 10.1002/jpen.1794.
[PMID] 32026502.
2020
Decision analysis and reinforcement learning in surgical decision-making.
Surgery.
168(2):253-266
[DOI] 10.1016/j.surg.2020.04.049.
[PMID] 32540036.
2020
Delayed interhospital transfer of critically ill patients with surgical sepsis.
The journal of trauma and acute care surgery.
88(1):169-175
[DOI] 10.1097/TA.0000000000002476.
[PMID] 31856021.
2020
Effect of Beta-Blockade on the Expression of Regulatory MicroRNA after Severe Trauma and Chronic Stress.
Journal of the American College of Surgeons.
230(1):121-129
[DOI] 10.1016/j.jamcollsurg.2019.09.011.
[PMID] 31672639.
2020
ICU Delirium-Prediction Models: A Systematic Review.
Critical care explorations.
2(12)
[DOI] 10.1097/CCE.0000000000000296.
[PMID] 33354672.
2020
Impact of Injury Severity on the Inflammatory State and Severe Anemia.
The Journal of surgical research.
248:109-116
[DOI] 10.1016/j.jss.2019.10.046.
[PMID] 31881381.
2020
Intelligent, Autonomous Machines in Surgery.
The Journal of surgical research.
253:92-99
[DOI] 10.1016/j.jss.2020.03.046.
[PMID] 32339787.
2020
Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress.
Shock (Augusta, Ga.).
54(4):482-487
[DOI] 10.1097/SHK.0000000000001506.
[PMID] 31904616.
2020
Mysteries, Epistemological Modesty, and Artificial Intelligence in Surgery.
Frontiers in artificial intelligence.
2
[DOI] 10.3389/frai.2019.00032.
[PMID] 33117989.
2020
Opportunities for machine learning to improve surgical ward safety.
American journal of surgery.
220(4):905-913
[DOI] 10.1016/j.amjsurg.2020.02.037.
[PMID] 32127174.
2020
Performance advantages for grit and optimism.
American journal of surgery.
220(1):10-18
[DOI] 10.1016/j.amjsurg.2020.01.057.
[PMID] 32098653.
2020
Reactive Artificial Intelligence Using Big Data in the Era of Precision Medicine-Reply.
JAMA surgery.
155(7):671-672
[DOI] 10.1001/jamasurg.2020.0856.
[PMID] 32374380.
2020
Vitamin D status is associated with hepcidin and hemoglobin concentrations in patients with severe traumatic injury.
The journal of trauma and acute care surgery.
89(6):1124-1130
[DOI] 10.1097/TA.0000000000002895.
[PMID] 32769953.
2019
Age-dependent response to multimodal therapy for stage II-III rectal cancer.
Oncotarget.
10(45)
[DOI] 10.18632/oncotarget.27084.
[PMID] 31384389.
2019
Associations Between National Board Exam Performance and Residency Program Emphasis on Patient Safety and Interprofessional Teamwork.
Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry.
43(6):581-584
[DOI] 10.1007/s40596-019-01106-x.
[PMID] 31456123.
2019
Cardiac pseudoaneurysm following non-operative management after penetrating thoracoabdominal trauma and pericardial window.
The journal of trauma and acute care surgery.
86(4):755-757
[DOI] 10.1097/TA.0000000000002189.
[PMID] 30629012.
2019
DeepSOFA: A Continuous Acuity Score for Critically Ill Patients using Clinically Interpretable Deep Learning
Scientific Reports.
9(1)
[DOI] 10.1038/s41598-019-38491-0.
[PMID] 30755689.
2019
Gender differences among surgical fellowship program directors.
Surgery.
166(5):735-737
[DOI] 10.1016/j.surg.2019.05.017.
[PMID] 31256855.
2019
Occult bowel injury after blunt abdominal trauma
The American Journal of Surgery.
218(2):266-270
[DOI] 10.1016/j.amjsurg.2018.11.018.
[PMID] 30509454.
2019
Packed red blood cell donor age affects overall survival in transfused patients undergoing hepatectomy for non-hepatocellular malignancy
The American Journal of Surgery.
217(1):71-77
[DOI] 10.1016/j.amjsurg.2018.08.011.
2019
Patient-Specific and Hospital Resource-Specific Considerations in Operative Versus Nonoperative Management of Acute Appendicitis.
The Journal of surgical research.
237:110-111
[DOI] 10.1016/j.jss.2018.03.005.
[PMID] 29622400.
2019
Persistent inflammation and anemia among critically ill septic patients.
The journal of trauma and acute care surgery.
86(2):260-267
[DOI] 10.1097/TA.0000000000002147.
[PMID] 30489504.
2019
Serum Levels of Prealbumin and Albumin for Preoperative Risk Stratification.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.
34(3):340-348
[DOI] 10.1002/ncp.10271.
[PMID] 30908744.
2019
Sigmoido-rectal intussusception
SAGE Open Medical Case Reports.
7
[DOI] 10.1177/2050313×19856242.
2019
Systemic Regulation of Bone Marrow Stromal Cytokines After Severe Trauma
Journal of Surgical Research.
243:220-228
[DOI] 10.1016/j.jss.2019.05.033.
[PMID] 31207479.
2019
The effects of propranolol and clonidine on bone marrow expression of hematopoietic cytokines following trauma and chronic stress.
American journal of surgery.
218(5):858-863
[DOI] 10.1016/j.amjsurg.2019.02.023.
[PMID] 30827533.
2019
The Impact of Prior Laparotomy and Intra-abdominal Adhesions on Bowel and Mesenteric Injury Following Blunt Abdominal Trauma.
World journal of surgery.
43(2):457-465
[DOI] 10.1007/s00268-018-4792-6.
[PMID] 30225563.
2019
The impact of standardized protocol implementation for surgical damage control and temporary abdominal closure after emergent laparotomy.
The journal of trauma and acute care surgery.
86(4):670-678
[DOI] 10.1097/TA.0000000000002170.
[PMID] 30562327.
2019
Use of Artificial Intelligence to Represent Emergent Systems and Augment Surgical Decision-making.
JAMA surgery.
154(9):791-792
[DOI] 10.1001/jamasurg.2019.1510.
[PMID] 31215974.
2018
A protocol for non-operative management of uncomplicated appendicitis.
The journal of trauma and acute care surgery.
84(2):358-364
[DOI] 10.1097/TA.0000000000001709.
[PMID] 29370051.
2018
Anemia and blood transfusion in elderly trauma patients.
The Journal of surgical research.
229:288-293
[DOI] 10.1016/j.jss.2018.04.021.
[PMID] 29937004.
2018
Angiographic embolization followed by piecemeal resection of giant posterior mediastinal schwannoma: Case report and concise review
International Journal of Surgery Case Reports.
53:250-253
[DOI] 10.1016/j.ijscr.2018.10.055.
[PMID] 30439671.
2018
Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.
The journal of trauma and acute care surgery.
84(2):342-349
[DOI] 10.1097/TA.0000000000001758.
[PMID] 29251709.
2018
Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult.
Current opinion in hematology.
25(1):37-43
[DOI] 10.1097/MOH.0000000000000395.
[PMID] 29035909.
2018
Effect of Time to Operation on Value of Care in Acute Care Surgery.
World journal of surgery.
42(8):2356-2363
[DOI] 10.1007/s00268-018-4476-2.
[PMID] 29352339.
2018
Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis.
Shock (Augusta, Ga.).
49(3):249-258
[DOI] 10.1097/SHK.0000000000000981.
[PMID] 28885387.
2018
Hypertonic saline resuscitation after emergent laparotomy and temporary abdominal closure.
The journal of trauma and acute care surgery.
84(2):350-357
[DOI] 10.1097/TA.0000000000001730.
[PMID] 29140948.
2018
Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.
Frontiers in immunology.
9
[DOI] 10.3389/fimmu.2018.00595.
[PMID] 29670613.
2018
Mouse Injury Model of Polytrauma and Shock.
Methods in molecular biology (Clifton, N.J.).
1717:1-15
[DOI] 10.1007/978-1-4939-7526-6_1.
[PMID] 29468579.
2018
Pathologic stage dictates survival after neoadjuvant radiation for rectal cancer.
Oncotarget.
9(84):35474-35475
[DOI] 10.18632/oncotarget.26262.
[PMID] 30464801.
2018
Persistent injury-associated anemia and aging: Novel insights.
The journal of trauma and acute care surgery.
84(3):490-496
[DOI] 10.1097/TA.0000000000001766.
[PMID] 29466280.
2018
Persistent injury-associated anemia in aged rats.
Experimental gerontology.
103:63-68
[DOI] 10.1016/j.exger.2018.01.001.
[PMID] 29307734.
2018
Prognostic Value of Clinical vs Pathologic Stage in Rectal Cancer Patients Receiving Neoadjuvant Therapy.
Journal of the National Cancer Institute.
110(5):460-466
[DOI] 10.1093/jnci/djx228.
[PMID] 29165692.
2018
Response to Er and Tez: the use of artificial neural networks in medical prognostication.
The Journal of surgical research.
222
[DOI] 10.1016/j.jss.2017.10.005.
[PMID] 29110965.
2018
Successful nonoperative management of uncomplicated appendicitis: predictors and outcomes.
The Journal of surgical research.
222:212-218.e2
[DOI] 10.1016/j.jss.2017.10.006.
[PMID] 29146455.
2018
The effects of beta blockade and clonidine on persistent injury-associated anemia.
The Journal of surgical research.
230:175-180
[DOI] 10.1016/j.jss.2018.06.001.
[PMID] 29960715.
2018
The Postinjury Inflammatory State and the Bone Marrow Response to Anemia.
American journal of respiratory and critical care medicine.
198(5):629-638
[DOI] 10.1164/rccm.201712-2536OC.
[PMID] 29768025.
2017
Acute Kidney Injury Following Exploratory Laparotomy and Temporary Abdominal Closure.
Shock (Augusta, Ga.).
48(1):5-10
[DOI] 10.1097/SHK.0000000000000825.
[PMID] 28009772.
2017
Antibiotics May be Safely Discontinued Within One Week of Percutaneous Cholecystostomy.
World journal of surgery.
41(5):1239-1245
[DOI] 10.1007/s00268-016-3861-y.
[PMID] 28050668.
2017
Characterization of hypoalbuminemia following temporary abdominal closure.
The journal of trauma and acute care surgery.
83(4):650-656
[DOI] 10.1097/TA.0000000000001553.
[PMID] 28837537.
2017
Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress.
Surgery.
161(3):795-802
[DOI] 10.1016/j.surg.2016.08.043.
[PMID] 27742030.
2017
Clonidine restores vascular endothelial growth factor expression and improves tissue repair following severe trauma.
American journal of surgery.
214(4):610-615
[DOI] 10.1016/j.amjsurg.2017.06.019.
[PMID] 28666582.
2017
Computed tomography evidence of fluid in the hernia sac predicts surgical site infection following mesh repair of acutely incarcerated ventral and groin hernias.
The journal of trauma and acute care surgery.
83(1):170-174
[DOI] 10.1097/TA.0000000000001503.
[PMID] 28426559.
2017
Daily propranolol administration reduces persistent injury-associated anemia after severe trauma and chronic stress.
The journal of trauma and acute care surgery.
82(4):714-721
[DOI] 10.1097/TA.0000000000001374.
[PMID] 28099381.
2017
Early bronchoalveolar lavage for intubated trauma patients with TBI or chest trauma.
Journal of critical care.
39:78-82
[DOI] 10.1016/j.jcrc.2017.02.010.
[PMID] 28231518.
2017
Effects of trauma, hemorrhagic shock, and chronic stress on lung vascular endothelial growth factor.
The Journal of surgical research.
210:15-21
[DOI] 10.1016/j.jss.2016.10.023.
[PMID] 28457321.
2017
Emergent laparotomy and temporary abdominal closure for the cirrhotic patient
Journal of Surgical Research.
210:108-114
[DOI] 10.1016/j.jss.2016.11.013.
[PMID] 28457316.
2017
ICU-Acquired Weakness, Chronic Critical Illness, and the Persistent Inflammation-Immunosuppression and Catabolism Syndrome.
Critical care medicine.
45(11)
[DOI] 10.1097/CCM.0000000000002576.
[PMID] 29028707.
2017
Improved outcomes following implementation of an acute gastrointestinal bleeding multidisciplinary protocol.
The journal of trauma and acute care surgery.
83(1):41-46
[DOI] 10.1097/TA.0000000000001295.
[PMID] 27779592.
2017
Microbial recognition and danger signals in sepsis and trauma.
Biochimica et biophysica acta. Molecular basis of disease.
1863(10 Pt B):2564-2573
[DOI] 10.1016/j.bbadis.2017.01.013.
[PMID] 28115287.
2017
Neural network prediction of severe lower intestinal bleeding and the need for surgical intervention
Journal of Surgical Research.
212:42-47
[DOI] 10.1016/j.jss.2016.12.032.
[PMID] 28550920.
2017
Percutaneous cholecystostomy: prognostic factors and comparison to cholecystectomy
Surgical Endoscopy.
31(11):4568-4575
[DOI] 10.1007/s00464-017-5517-x.
[PMID] 28409378.
2017
Persistent injury-associated anemia: the role of the bone marrow microenvironment.
The Journal of surgical research.
214:240-246
[DOI] 10.1016/j.jss.2017.03.018.
[PMID] 28624051.
2017
Predicting appendiceal tumors among patients with appendicitis.
The journal of trauma and acute care surgery.
82(4):771-775
[DOI] 10.1097/TA.0000000000001378.
[PMID] 28099380.
2017
Routine surveillance cholangiography after percutaneous cholecystostomy delays drain removal and cholecystectomy.
The journal of trauma and acute care surgery.
82(2):351-355
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[PMID] 27893641.
2017
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.
BMJ open.
7(7)
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[PMID] 28765125.
2017
Severe trauma and chronic stress activates extramedullary erythropoiesis.
The journal of trauma and acute care surgery.
83(1):144-150
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[PMID] 28452894.
2017
Temporary abdominal closure for trauma and intra-abdominal sepsis: Different patients, different outcomes.
The journal of trauma and acute care surgery.
82(2):345-350
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2017
The effects of red cell transfusion donor age on nosocomial infection among trauma patients.
American journal of surgery.
214(4):672-676
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[PMID] 28720216.
2017
The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two Level-One Trauma Centers.
Critical care medicine.
45(12):1989-1996
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2016
Intubated Trauma Patients Receiving Prolonged Antibiotics for Pneumonia despite Negative Cultures: Predictors and Outcomes.
Surgical infections.
17(6):766-772
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2016
β-Blockade use for Traumatic Injuries and Immunomodulation: A Review of Proposed Mechanisms and Clinical Evidence.
Shock (Augusta, Ga.).
46(4):341-51
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[PMID] 27172161.
2015
A protocol for the management of adhesive small bowel obstruction.
The journal of trauma and acute care surgery.
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2015
Duodenal gangliocytic paraganglioma: A case report and literature review.
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Refractory abdominal-cutaneous fistulas or leaks: percutaneous management with a collagen plug.
Journal of the American College of Surgeons.
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Outcomes evaluation for operative and nonoperative management of the abnormal mammogram.
American journal of surgery.
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Grants
Sep 2024
ACTIVE
Artificial Intelligence Passport for Biomedical Research (AIPassportBMR ): Digital Experiential Learning Community for Upskilling in Artificial Intelligence for Biomedical, Behavioral and Clinical Research
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Mar 2024
– Oct 2024
Transforming Surgical Training Using Precision Education
Role: Principal Investigator
Funding: SOC FOR IMPROVING MED PROFESSIONAL LEARN
via WELLCOME LEAP
Jul 2023
– Jun 2025
Together: Transforming and Translating Discovery to Improve Health
Role: Project Manager
Funding: NATL INST OF HLTH NCATS
Jun 2023
– Jan 2024
Transforming Surgical Training Using Precision Education
Role: Principal Investigator
Funding: SOC FOR IMPROVING MED PROFESSIONAL LEARN
via WELLCOME LEAP
Apr 2023
ACTIVE
Aligning Patient Acuity with Resource Intensity after Major Surgery
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Aug 2022
ACTIVE
Explainable, Fair, Reproducible and Collaborative Surgical Artificial Intelligence: Integrating data, algorithms and clinical reasoning for surgical risk assessment (XAI-IDEALIST)
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2022
– May 2022
Aligning Patient Acuity with Triage Destination after Major Surgery
Role: Principal Investigator
Funding: UF FOUNDATION
via MAREN FOU
Sep 2020
– Aug 2024
Aligning Patient Acuity with Intensity of Care after Surgery
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Education
Fellowship, Surgical Critical Care
2019-2020
·
University of Florida
Research Fellowship, Sepsis and Critical Illness Research Center
2015-2017
·
University of Florida
Residency, General Surgery
2012-2019
·
University of Florida
Medical Degree
2008-2012
·
Medical University of South Carolina
Bachelor of Science
2004-2008
·
Clemson University
Contact Details
Phones:
- Business:
- (352) 273-5670
Emails:
- Business:
- tloftus@ufl.edu
Res/Fellowship Program Coordinator I:
Addresses:
- Business Mailing:
-
PO Box 100108
1600 SW ARCHER RD
GAINESVILLE FL 32610 - Business Street:
-
1600 SW ARCHER RD
GAINESVILLE FL 32610