Steven J Hughes, MD
Edward M. Copeland, III MD Professor And Chief, Surgical Oncology
Department:
MD-SURGERY-SURGONC-PBS
Business Phone:
(352) 265-0535
Business Email:
steven.hughes@surgery.ufl.edu
About Steven J Hughes
Steven J. Hughes, MD, is a professor and chief of surgical oncology at the UF College of Medicine. He also serves as vice chair for the department of surgery.
He obtained his bachelor’s degree from the University of Minnesota and graduated from Mayo Medical School. Dr. Hughes then completed a general surgery residency as well as a NIH-Surgical Oncology research fellowship and a surgical critical care residency at the University of Michigan.
His clinical expertise is minimally invasive approaches to hepato-pancreato-biliary diseases including the performance of laparoscopic radical pancreatoduodenectomy (Whipple’s procedure).
Dr. Hughes is a past Counselor-at-Large and Chair of the Membership Committee of the Society of University Surgeons. His NIH-funded research focuses on improving our understanding of the biology of pancreatic cancer aiming to discover new methods for the diagnosis and personalized treatment of this terrible cancer.
Accomplishments
Invited Mentor
2023
·
National Pancreas Foundation Fellows Symposium
President Elect
2023
·
Collaborative Alliance for Pancreatic Education and Research (CAPER)
Edward M. Copeland III, MD Lifetime Mentorship Award
2021
·
UF Department of Surgery Chief Residents
President
2021
·
Frederick A Coller Surgical Society
Lester R. Dragstedt Physician-Scientist Award
2016
·
Department of Surgery, University of Florida
Cracchiolo Family Professorship
2010
·
Cracchiolo Foundation
Faculty Research Fellowship
2001
·
American College of Surgeons
Robert V. Danto Memorial Cancer Research Award
1998
·
American College of Surgeons
Resident Research Award
1997
·
Frederick A. Coller Surgical Society
Teaching Profile
Courses Taught
2018
MDC7600 Surgery Clerkship
2018
MDC7602 Senior Surgery Clerk
2018
MDT7600 Elect Top/Surgery
Board Certifications
-
Critical Care SurgeryAmerican Board of Surgery
-
SurgeryAmerican Board of Surgery
Clinical Profile
Specialties
- Cancer
- Surgical Oncology
Areas of Interest
- Bile duct obstruction
- Cancer – resources
- Gallstones
- Gastrointestinal cancer
- Laparoscopic gallbladder removal
- Liver cancer – hepatocellular carcinoma
- Liver disease
- Open gallbladder removal
- Pancreatic abscess
- Pancreatic cancer
- Pancreatitis
Research Profile
Dr. Hughes’ research interests center on improving the understanding of gastrointestinal tumor biology through genetic analysis and assessing the response of these historically stubborn tumors to a new class of medications called tyrosine kinase inhibitors.
Open Researcher and Contributor ID (ORCID)
0000-0002-5688-6942
Publications
2024
Fibroblasts in the aged pancreas drive pancreatic cancer progression
Cancer Research.
84(8):1221-1236
[DOI] 10.1158/0008-5472.can-24-0086.
2024
Infiltration of CD3+ and CD8+ lymphocytes in association with inflammation and survival in pancreatic cancer
PLOS ONE.
19(2)
[DOI] 10.1371/journal.pone.0297325.
[PMID] 38346068.
2024
Interventions for Pancreatitis-New Approaches, Knowledge Gaps, and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
Pancreas.
53(4):e368-e377
[DOI] 10.1097/MPA.0000000000002333.
[PMID] 38518063.
2024
Peptide-based capture-and-release purification of extracellular vesicles and statistical algorithm enabled quality assessment.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.02.06.578050.
[PMID] 38370748.
2024
Utilization of Pancreatic Endotherapy in Patients with Chronic Pancreatitis: Results From a Multicenter Cohort Study in the United States.
Gastrointestinal endoscopy.
[DOI] 10.1016/j.gie.2024.04.002.
[PMID] 38583544.
2023
A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs.
Nature biomedical engineering.
7(12):1583-1601
[DOI] 10.1038/s41551-023-01033-1.
[PMID] 37106152.
2023
A peek at the other side of the coin: Tumor-suppressor role of microRNAs expressed by pancreatic cancer-associated fibroblasts.
Clinical and translational medicine.
13(8)
[DOI] 10.1002/ctm2.1357.
[PMID] 37539872.
2023
A phase II study of neoadjuvant liposomal irinotecan with 5-FU and oxaliplatin (NALIRIFOX) in pancreatic adenocarcinoma.
Future oncology (London, England).
19(27):1841-1851
[DOI] 10.2217/fon-2023-0256.
[PMID] 37753702.
2023
A protein-based machine learning approach to the identification of inflammatory subtypes in pancreatic ductal adenocarcinoma
Pancreatology.
23(6):615-621
[DOI] 10.1016/j.pan.2023.06.007.
[PMID] 37391359.
2023
Addendum: Importance of carbohydrate antigen (CA 19-9) and carcinoembrionic antigen (CEA) in the prognosis of patients with duodenal adenocarcinoma: a retrospective single-institution cohort study.
Oncotarget.
14
[DOI] 10.18632/oncotarget.28491.
[PMID] 38085073.
2023
Changing Practice Patterns and Improving Survival for Patients with Pancreatic Ductal Adenocarcinoma.
Cancers.
15(18)
[DOI] 10.3390/cancers15184464.
[PMID] 37760433.
2023
Ethical Considerations of Biopsies in Early-Stage Pancreatic Cancer.
JCO oncology practice.
19(10):882-887
[DOI] 10.1200/OP.23.00044.
[PMID] 37647578.
2023
Extraction-free, one-pot CRISPR/Cas12a detection of microRNAs directly from extracellular vesicles.
Chemical communications (Cambridge, England).
59(67):10165-10168
[DOI] 10.1039/d3cc02982d.
[PMID] 37531174.
2023
Impact of Biopsy Attempts, Race, and Access on Time to Initiation of Treatment for Pancreatic Cancer
Journal of Gastrointestinal Surgery.
27(11):2474-2483
[DOI] 10.1007/s11605-022-05531-6.
2023
Importance of carbohydrate antigen (CA 19-9) and carcinoembrionic antigen (CEA) in the prognosis of patients with duodenal adenocarcinoma: a retrospective single-institution cohort study.
Oncotarget.
14:351-357
[DOI] 10.18632/oncotarget.28406.
[PMID] 37068159.
2023
Low vs Standard-Dose Indocyanine Green in the Identification of Biliary Anatomy Using Near-Infrared Fluorescence Imaging: A Multicenter Randomized Controlled Trial.
Journal of the American College of Surgeons.
236(4):711-717
[DOI] 10.1097/XCS.0000000000000553.
[PMID] 36728303.
2023
National adoption of neoadjuvant chemotherapy: paradigm shift in the treatment of pancreatic cancer
HPB (Oxford).
25(11):1323-1328
[DOI] 10.1016/j.hpb.2023.06.018.
[PMID] 37453814.
2023
Prognosis and Treatment Outcomes of Bone Metastasis in Gallbladder Adenocarcinoma: A SEER-Based Study.
Cancers.
15(20)
[DOI] 10.3390/cancers15205055.
[PMID] 37894422.
2023
The Impact of a Narcotic-Sparing Enhanced Recovery Protocol on Postoperative Narcotic Use Following Colectomy.
Diseases of the colon and rectum.
66(8):1102-1109
[DOI] 10.1097/DCR.0000000000002292.
[PMID] 35316244.
2023
Translocation of Oral Microbiota into the Pancreatic Ductal Adenocarcinoma Tumor Microenvironment.
Microorganisms.
11(6)
[DOI] 10.3390/microorganisms11061466.
[PMID] 37374966.
2023
Validation of a pelvic surgery difficulty risk model to predict difficult pelvic dissection and poor outcomes.
Surgery.
173(5):1199-1204
[DOI] 10.1016/j.surg.2022.12.023.
[PMID] 36801077.
2022
A risk-adjusted analysis of drain use in pancreaticoduodenectomy: Some is good, but more may not be better.
Surgery.
171(4):1058-1066
[DOI] 10.1016/j.surg.2021.07.026.
[PMID] 34433515.
2022
Chemotherapy is associated with improved survival in a national cohort of stage IV pancreatic adenosquamous carcinoma.
Journal of gastrointestinal oncology.
13(6):3207-3215
[DOI] 10.21037/jgo-22-434.
[PMID] 36636088.
2022
Correction to: Laparoscopic‑assisted ERCP following RYGB: a 12‑year assessment of outcomes and learning curve at a high‑volume pancreatobiliary center.
Surgical endoscopy.
36(1)
[DOI] 10.1007/s00464-021-08396-z.
[PMID] 33598813.
2022
From bench to bedside: Pursuing equity in precision medicine approaches to pancreatic cancer care.
Frontiers in oncology.
12
[DOI] 10.3389/fonc.2022.1086779.
[PMID] 36568255.
2022
Laparoscopic-assisted ERCP following RYGB: a 12-year assessment of outcomes and learning curve at a high-volume pancreatobiliary center.
Surgical endoscopy.
36(1):621-630
[DOI] 10.1007/s00464-021-08328-x.
[PMID] 33543349.
2022
Novel Calculator to Estimate the Risk of Clinically Relevant Postoperative Pancreatic Fistula Following Distal Pancreatectomy.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
26(7):1436-1444
[DOI] 10.1007/s11605-022-05275-3.
[PMID] 35352209.
2022
Single-cell profiling of microenvironment components by spatial localization in pancreatic ductal adenocarcinoma.
Theranostics.
12(11):4980-4992
[DOI] 10.7150/thno.73222.
[PMID] 35836806.
2022
The Fistula Risk Score Catalog: Toward Precision Medicine for Pancreatic Fistula After Pancreatoduodenectomy.
Annals of surgery.
275(2):e463-e472
[DOI] 10.1097/SLA.0000000000004068.
[PMID] 32541227.
2022
The Influence of Intraoperative Blood Loss on Fistula Development Following Pancreatoduodenectomy.
Annals of surgery.
276(5):e527-e535
[DOI] 10.1097/SLA.0000000000004549.
[PMID] 33201132.
2022
The interleukin-1 axis and the tumor immune microenvironment in pancreatic ductal adenocarcinoma
Neoplasia.
28
[DOI] 10.1016/j.neo.2022.100789.
[PMID] 35395492.
2022
The oral microbiome, pancreatic cancer and human diversity in the age of precision medicine.
Microbiome.
10(1)
[DOI] 10.1186/s40168-022-01262-7.
[PMID] 35701831.
2021
Biliary intervention rates during neoadjuvant therapy for adenocarcinoma of the pancreatic head.
HPB : the official journal of the International Hepato Pancreato Biliary Association.
23(8):1196-1200
[DOI] 10.1016/j.hpb.2020.11.1147.
[PMID] 33388244.
2021
Diversification of Academic Surgery, Its Leadership, and the Importance of Intersectionality.
JAMA surgery.
156(8):748-756
[DOI] 10.1001/jamasurg.2021.1546.
[PMID] 33950242.
2021
It’s more than just cancer biology: Health disparities in patients with pancreatic neuroendocrine tumors.
Journal of surgical oncology.
124(8):1390-1401
[DOI] 10.1002/jso.26667.
[PMID] 34499741.
2021
Mixed acinar-neuroendocrine carcinoma with amphicrine features of the pancreas: Two rare cases with diffuse co-expression of acinar and neuroendocrine markers.
Pathology international.
71(7):485-487
[DOI] 10.1111/pin.13105.
[PMID] 34000758.
2021
Patient and Procedural Determinants of Postoperative Pain Trajectories.
Anesthesiology.
134(3):421-434
[DOI] 10.1097/ALN.0000000000003681.
[PMID] 33449996.
2021
Phase II Study of 5-Fluorouracil, Oxaliplatin plus Dasatinib (FOLFOX-D) in First-Line Metastatic Pancreatic Adenocarcinoma.
The oncologist.
26(10):825-e1674
[DOI] 10.1002/onco.13853.
[PMID] 34101295.
2021
Predicting long-term postsurgical pain by examining the evolution of acute pain.
European journal of pain (London, England).
25(3):624-636
[DOI] 10.1002/ejp.1698.
[PMID] 33171546.
2021
Slow Dynamics of Acute Postoperative Pain Intensity Time Series Determined via Wavelet Analysis Are Associated With the Risk of Severe Postoperative Day 30 Pain.
Anesthesia and analgesia.
132(5):1465-1474
[DOI] 10.1213/ANE.0000000000005385.
[PMID] 33591118.
2021
Surgeon experience contributes to improved outcomes in pancreatoduodenectomies at high risk for fistula development.
Surgery.
169(4):708-720
[DOI] 10.1016/j.surg.2020.11.022.
[PMID] 33386129.
2021
The effect of high intraoperative blood loss on pancreatic fistula development after pancreatoduodenectomy: An international, multi-institutional propensity score matched analysis.
Surgery.
170(4):1195-1204
[DOI] 10.1016/j.surg.2021.03.044.
[PMID] 33931208.
2020
From tumor microenvironment communicants to biomarker discovery: Selectively packaged extracellular vesicular cargoes in pancreatic cancer.
Cytokine & growth factor reviews.
51:61-68
[DOI] 10.1016/j.cytogfr.2020.01.001.
[PMID] 32005635.
2020
Impact of hospital volume on patient safety indicators and failure to rescue following open aortic aneurysm repair.
Journal of vascular surgery.
71(4):1135-1146.e4
[DOI] 10.1016/j.jvs.2019.06.194.
[PMID] 31515178.
2020
Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia
Cancers.
12(2)
[DOI] 10.3390/cancers12020329.
[PMID] 32024069.
2020
Protein Signatures and Tissue Diagnosis of Pancreatic Cancer.
Journal of the American College of Surgeons.
230(1):26-36.e1
[DOI] 10.1016/j.jamcollsurg.2019.10.002.
[PMID] 31672677.
2020
Relapsing Acute Pancreatitis Caused by a Mucinous Cystic Neoplasm.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
24(5):1215-1216
[DOI] 10.1007/s11605-019-04429-0.
[PMID] 31754988.
2020
The use of pancreatic enzyme replacement therapy in patients with a diagnosis of chronic pancreatitis and pancreatic cancer in the US is infrequent and inconsistent.
Alimentary pharmacology & therapeutics.
51(10):958-967
[DOI] 10.1111/apt.15698.
[PMID] 32249970.
2020
Unique circulating immune signatures for recurrent acute pancreatitis, chronic pancreatitis and pancreatic cancer: A pilot study of these conditions with and without diabetes.
Pancreatology : official journal of the International Association of Pancreatology (IAP) … [et al.].
20(1):51-59
[DOI] 10.1016/j.pan.2019.11.008.
[PMID] 31791885.
2019
Pitfalls of minimally invasive pancreatoduodenectomy.
Annals of pancreatic cancer.
2
[DOI] 10.21037/apc.2018.12.02.
[PMID] 32055795.
2019
The Proteome of Pancreatic Cancer-Derived Exosomes Reveals Signatures Rich in Key Signaling Pathways.
Proteomics.
19(13)
[DOI] 10.1002/pmic.201800394.
[PMID] 31070281.
2019
Thermal ablation versus wedge or segmental resection in patients with early stage hepatocellular carcinoma: a population survival analysis.
HPB : the official journal of the International Hepato Pancreato Biliary Association.
21(2):249-257
[DOI] 10.1016/j.hpb.2018.07.004.
[PMID] 30057124.
2018
A Prospective Study to Establish a New-Onset Diabetes Cohort: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.
Pancreas.
47(10):1244-1248
[DOI] 10.1097/MPA.0000000000001169.
[PMID] 30325864.
2018
Break Scrub to Take That Phone Call?
Journal of the American College of Surgeons.
226(6):1117-1121
[DOI] 10.1016/j.jamcollsurg.2018.03.002.
[PMID] 29524662.
2018
Characterization and Optimal Management of High-risk Pancreatic Anastomoses During Pancreatoduodenectomy.
Annals of surgery.
267(4):608-616
[DOI] 10.1097/SLA.0000000000002327.
[PMID] 28594741.
2018
Clinical Factors as a Component of the Personalized Treatment Approach to Advanced Pancreatic Cancer: a Systematic Literature Review.
Journal of gastrointestinal cancer.
49(1):1-8
[DOI] 10.1007/s12029-017-0021-z.
[PMID] 29110227.
2018
Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models.
Carcinogenesis.
39(8):1068-1078
[DOI] 10.1093/carcin/bgy073.
[PMID] 29846515.
2018
Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine.
International journal of molecular sciences.
19(12)
[DOI] 10.3390/ijms19123836.
[PMID] 30513792.
2018
Non-surgical management of patients with intrahepatic cholangiocarcinoma in the United States, 2004-2015: an NCDB analysis.
Journal of gastrointestinal oncology.
9(3):536-545
[DOI] 10.21037/jgo.2018.02.04.
[PMID] 29998019.
2018
Objective Preoperative Parameters Predict Difficult Pelvic Dissections and Clinical Outcomes.
The Journal of surgical research.
232:15-25
[DOI] 10.1016/j.jss.2018.05.042.
[PMID] 30463711.
2018
Pancreatogastrostomy Vs. Pancreatojejunostomy: a Risk-Stratified Analysis of 5316 Pancreatoduodenectomies.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
22(1):68-76
[DOI] 10.1007/s11605-017-3547-2.
[PMID] 28840459.
2018
Prognostic Value of Clinical vs Pathologic Stage in Rectal Cancer Patients Receiving Neoadjuvant Therapy.
Journal of the National Cancer Institute.
110(5):460-466
[DOI] 10.1093/jnci/djx228.
[PMID] 29165692.
2018
PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies: Rationale and Study Design for PROCEED From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.
Pancreas.
47(10):1229-1238
[DOI] 10.1097/MPA.0000000000001170.
[PMID] 30325862.
2018
Readmission After Elective Ileostomy in Colorectal Surgery Is Predictable.
JSLS : Journal of the Society of Laparoendoscopic Surgeons.
22(3)
[DOI] 10.4293/JSLS.2018.00008.
[PMID] 30275672.
2018
Rectal cancer patients younger than 50 years lack a survival benefit from NCCN guideline-directed treatment for stage II and III disease.
Cancer.
124(17):3510-3519
[DOI] 10.1002/cncr.31527.
[PMID] 29984547.
2018
Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.
Pancreas.
47(10):1213-1221
[DOI] 10.1097/MPA.0000000000001171.
[PMID] 30325860.
2018
Stroma-derived extracellular vesicles deliver tumor-suppressive miRNAs to pancreatic cancer cells.
Oncotarget.
9(5):5764-5777
[DOI] 10.18632/oncotarget.23532.
[PMID] 29464032.
2018
Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties.
Acta biomaterialia.
67:331-340
[DOI] 10.1016/j.actbio.2017.11.037.
[PMID] 29191507.
2017
A clinically applicable muscular index predicts long-term survival in resectable pancreatic cancer.
Surgery.
161(4):930-938
[DOI] 10.1016/j.surg.2016.09.038.
[PMID] 27932030.
2017
A Prospective Randomized Multicenter Trial of Distal Pancreatectomy With and Without Routine Intraperitoneal Drainage.
Annals of surgery.
266(3):421-431
[DOI] 10.1097/SLA.0000000000002375.
[PMID] 28692468.
2017
Analysis of the Cost Effectiveness of Laparoscopic Pancreatoduodenectomy.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
21(9):1404-1410
[DOI] 10.1007/s11605-017-3466-2.
[PMID] 28567575.
2017
Cost Effectiveness of a Novel Attempt to Reduce Readmission after Ileostomy Creation.
JSLS : Journal of the Society of Laparoendoscopic Surgeons.
21(1)
[DOI] 10.4293/JSLS.2016.00082.
[PMID] 28144122.
2017
Eosinophilic Pancreatitis: A Rare Cause of Recurrent Acute Pancreatitis.
Case reports in gastroenterology.
11(1):120-126
[DOI] 10.1159/000457788.
[PMID] 28611564.
2017
Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer.
World journal of gastrointestinal surgery.
9(4):103-108
[DOI] 10.4240/wjgs.v9.i4.103.
[PMID] 28503258.
2017
Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.
Cancer research.
77(3):672-683
[DOI] 10.1158/0008-5472.CAN-16-1765.
[PMID] 27864347.
2017
Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia.
Oncotarget.
8(1):1177-1189
[DOI] 10.18632/oncotarget.13593.
[PMID] 27901481.
2017
Improved outcomes following implementation of an acute gastrointestinal bleeding multidisciplinary protocol.
The journal of trauma and acute care surgery.
83(1):41-46
[DOI] 10.1097/TA.0000000000001295.
[PMID] 27779592.
2017
Improvement in Resident Robotic Surgical Perception with a Cadaver Training Lab: A Pilot Study.
The American surgeon.
83(11):e414-e420
[PMID] 30454223.
2017
Incorporation of Procedure-specific Risk Into the ACS-NSQIP Surgical Risk Calculator Improves the Prediction of Morbidity and Mortality After Pancreatoduodenectomy.
Annals of surgery.
265(5):978-986
[DOI] 10.1097/SLA.0000000000001796.
[PMID] 27232260.
2017
Minimally invasive pancreatoduodenectomy.
HPB : the official journal of the International Hepato Pancreato Biliary Association.
19(3):215-224
[DOI] 10.1016/j.hpb.2017.01.023.
[PMID] 28317658.
2017
Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease.
Pancreas.
46(6):813-819
[DOI] 10.1097/MPA.0000000000000843.
[PMID] 28609371.
2017
The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma.
Oncotarget.
8(33):54054-54067
[DOI] 10.18632/oncotarget.10722.
[PMID] 28903323.
2016
Discordant HER2 expression and response to neoadjuvant chemoradiotherapy in esophagogastric adenocarcinoma.
Journal of gastrointestinal oncology.
7(2):173-80
[DOI] 10.3978/j.issn.2078-6891.2015.071.
[PMID] 27034783.
2016
EGFR family and cMet expression profiles and prognostic significance in esophagogastric adenocarcinoma.
Journal of gastrointestinal oncology.
7(6):838-847
[DOI] 10.21037/jgo.2016.06.09.
[PMID] 28078108.
2016
Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture.
The American journal of pathology.
186(6):1537-46
[DOI] 10.1016/j.ajpath.2016.02.009.
[PMID] 27102771.
2016
Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research.
22(7):1787-99
[DOI] 10.1158/1078-0432.CCR-15-1256.
[PMID] 26667487.
2016
Oncologic and Perioperative Outcomes Following Selective Application of Laparoscopic Pancreaticoduodenectomy for Periampullary Malignancies.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
20(7):1343-9
[DOI] 10.1007/s11605-016-3136-9.
[PMID] 27142633.
2016
Risk-adjusted Outcomes of Clinically Relevant Pancreatic Fistula Following Pancreatoduodenectomy: A Model for Performance Evaluation.
Annals of surgery.
264(2):344-52
[DOI] 10.1097/SLA.0000000000001537.
[PMID] 26727086.
2016
Standardization of surgical care in a high-volume center improves survival in resected pancreatic head cancer.
American journal of surgery.
212(2):195-201.e1
[DOI] 10.1016/j.amjsurg.2016.03.001.
[PMID] 27260793.
2016
Targeting tumor tolerance: A new hope for pancreatic cancer therapy?
Pharmacology & therapeutics.
166:9-29
[DOI] 10.1016/j.pharmthera.2016.06.008.
[PMID] 27343757.
2016
The Characterization and Prediction of ISGPF Grade C Fistulas Following Pancreatoduodenectomy.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
20(2):262-76
[DOI] 10.1007/s11605-015-2884-2.
[PMID] 26162925.
2015
An unusual case of colonic hemorrhage.
Gastroenterology.
149(6):e4-5
[DOI] 10.1053/j.gastro.2015.02.025.
[PMID] 26433102.
2015
Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer.
Cancer immunology, immunotherapy : CII.
64(12):1553-63
[DOI] 10.1007/s00262-015-1760-y.
[PMID] 26423423.
2015
Local pancreatic head resection: the search for optimal indications through quality of life assessments.
American journal of surgery.
210(3):417-23
[DOI] 10.1016/j.amjsurg.2014.12.049.
[PMID] 26003202.
2015
Multidisciplinary neoadjuvant management for potentially curable pancreatic cancer.
Cancer medicine.
4(8):1224-39
[DOI] 10.1002/cam4.444.
[PMID] 25766842.
2015
Patient-derived xenograft models for pancreatic adenocarcinoma demonstrate retention of tumor morphology through incorporation of murine stromal elements.
The American journal of pathology.
185(5):1297-303
[DOI] 10.1016/j.ajpath.2015.01.016.
[PMID] 25770474.
2015
Primary outgrowth cultures are a reliable source of human pancreatic stellate cells.
Laboratory investigation; a journal of technical methods and pathology.
95(11):1331-40
[DOI] 10.1038/labinvest.2015.117.
[PMID] 26322418.
2015
The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival.
BMC cancer.
15
[DOI] 10.1186/s12885-015-1820-x.
[PMID] 26498838.
2015
The value of drains as a fistula mitigation strategy for pancreatoduodenectomy: something for everyone? Results of a randomized prospective multi-institutional study.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
19(1):21-30; discussion 30
[DOI] 10.1007/s11605-014-2640-z.
[PMID] 25183409.
2015
Using siRNA to define functional interactions between melanopsin and multiple G Protein partners.
Cellular and molecular life sciences : CMLS.
72(1):165-79
[DOI] 10.1007/s00018-014-1664-6.
[PMID] 24958088.
2014
A randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage.
Annals of surgery.
259(4):605-12
[DOI] 10.1097/SLA.0000000000000460.
[PMID] 24374513.
2014
c-Met signaling in the development of tumorigenesis and chemoresistance: potential applications in pancreatic cancer.
World journal of gastroenterology.
20(26):8458-70
[DOI] 10.3748/wjg.v20.i26.8458.
[PMID] 25024602.
2014
Disconnected pancreatic duct syndrome: disease classification and management strategies.
Journal of the American College of Surgeons.
219(4):704-12
[DOI] 10.1016/j.jamcollsurg.2014.03.055.
[PMID] 25065360.
2014
Esophageal perforation management using a multidisciplinary minimally invasive treatment algorithm.
Journal of the American College of Surgeons.
218(4):768-74
[DOI] 10.1016/j.jamcollsurg.2013.12.033.
[PMID] 24529810.
2014
IgG4-related cholecystitis presenting as biliary malignancy: report of three cases.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
18(9):1710-5
[DOI] 10.1007/s11605-014-2568-3.
[PMID] 24944152.
2014
Laparoscopic intussuscepting pancreaticojejunostomy.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
18(1):208-12
[DOI] 10.1007/s11605-013-2308-0.
[PMID] 23929187.
2014
Photoacoustic and fluorescence image-guided surgery using a multifunctional targeted nanoprobe.
Annals of surgical oncology.
21(5):1602-9
[DOI] 10.1245/s10434-014-3541-9.
[PMID] 24554061.
2014
The impact of interhospital transfers on surgical quality metrics for academic medical centers.
The American surgeon.
80(7):690-5
[PMID] 24987902.
2013
Abdominal compartment syndrome is an early, lethal complication of acute pancreatitis.
The American surgeon.
79(6):601-7
[PMID] 23711270.
2013
Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinoma.
PloS one.
8(10)
[DOI] 10.1371/journal.pone.0076667.
[PMID] 24146905.
2013
Comparative effectiveness of minimally invasive and open distal pancreatectomy for ductal adenocarcinoma.
JAMA surgery.
148(6):525-31
[DOI] 10.1001/jamasurg.2013.1673.
[PMID] 23426503.
2013
Failure to follow evidence-based best practice guidelines in the treatment of severe acute pancreatitis.
HPB : the official journal of the International Hepato Pancreato Biliary Association.
15(10):822-7
[DOI] 10.1111/hpb.12140.
[PMID] 24028271.
2013
Robot-assisted minimally invasive distal pancreatectomy is superior to the laparoscopic technique.
Annals of surgery.
257(1):128-32
[DOI] 10.1097/SLA.0b013e31825fff08.
[PMID] 22868357.
2012
Faculty clinical quality goals drive improvement in University HealthSystem Consortium outcome measures.
The American surgeon.
78(7):749-54
[PMID] 22748532.
2012
Minimally invasive treatment of pancreatic disease.
Current gastroenterology reports.
14(2):125-30
[DOI] 10.1007/s11894-012-0242-z.
[PMID] 22362246.
2012
Outcomes of operative management of appendicitis.
Surgical infections.
13(3):141-6
[DOI] 10.1089/sur.2011.104.
[PMID] 22568920.
2012
Port-site recurrence of pancreatic adenocarcinoma following laparoscopic pancreaticoduodenectomy.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
16(12):2294-6
[DOI] 10.1007/s11605-012-2050-z.
[PMID] 23093448.
2011
Bile salts differentially sensitize esophageal squamous cells to CD95 (Fas/Apo-1 receptor) mediated apoptosis.
The Journal of surgical research.
171(2):504-9
[DOI] 10.1016/j.jss.2010.05.001.
[PMID] 20934723.
2011
Can laparoscopic pancreaticoduodenectomy be safely implemented?
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
15(7):1151-7
[DOI] 10.1007/s11605-011-1530-x.
[PMID] 21538192.
2011
Cytoplasmic overexpression of CD95L in esophageal adenocarcinoma cells overcomes resistance to CD95-mediated apoptosis.
Neoplasia (New York, N.Y.).
13(3):198-205
[PMID] 21390183.
2011
Delayed operating room availability significantly impacts the total hospital costs of an urgent surgical procedure.
Surgery.
150(2):299-305
[DOI] 10.1016/j.surg.2011.05.005.
[PMID] 21801967.
2011
Phase II study of gemcitabine and erlotinib as adjuvant therapy for patients with resected pancreatic cancer.
Annals of surgical oncology.
18(4):1122-9
[DOI] 10.1245/s10434-010-1401-9.
[PMID] 21104328.
2010
Clinical, immunophenotypic, and genetic characterization of small lymphocyte-like plasma cell myeloma: a potential mimic of mature B-cell lymphoma.
American journal of clinical pathology.
133(2):265-70
[DOI] 10.1309/AJCPUS3PRRT5ZXVS.
[PMID] 20093236.
2010
Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia.
Blood.
115(3):489-95
[DOI] 10.1182/blood-2009-08-237727.
[PMID] 19843887.
2010
Short- and long-term costs of laparoscopic colectomy are significantly less than open colectomy.
Surgical endoscopy.
24(9):2128-34
[DOI] 10.1007/s00464-010-0909-1.
[PMID] 20174941.
2009
A quantitative reverse transcription-PCR assay for rapid, automated analysis of breast cancer sentinel lymph nodes.
The Journal of molecular diagnostics : JMD.
11(6):576-82
[DOI] 10.2353/jmoldx.2009.090037.
[PMID] 19797614.
2009
Inhibition of HGF/MET as therapy for malignancy.
Expert opinion on therapeutic targets.
13(5):569-81
[DOI] 10.1517/14728220902853917.
[PMID] 19397476.
2009
Minimal-access technique for distal catheter insertion during ventricular peritoneal shunt procedures: a review of 100 cases.
Journal of neurosurgery.
111(3):623-7
[DOI] 10.3171/2009.2.JNS08454.
[PMID] 19284229.
2009
Molecular staging of pathologically negative sentinel lymph nodes from melanoma patients using multimarker, quantitative real-time rt-PCR.
Annals of surgical oncology.
16(1):177-85
[DOI] 10.1245/s10434-008-0183-9.
[PMID] 18982394.
2009
Validation of a prediction rule to maximize curative (R0) resection of early-stage pancreatic adenocarcinoma.
HPB : the official journal of the International Hepato Pancreato Biliary Association.
11(7):606-11
[DOI] 10.1111/j.1477-2574.2009.00110.x.
[PMID] 20495714.
2008
Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinoma.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
12(10):1664-72; discussion 1672
[DOI] 10.1007/s11605-008-0577-9.
[PMID] 18677542.
2008
The Color Object Association Test (COAT): the development of a new measure of declarative memory for 18- to 36-month-old toddlers.
Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence.
14(1):21-41
[PMID] 18097800.
2007
Clinical challenges and images in GI. Endometriosis of the sigmoid colon with endometriotic features within mesenteric lymph nodes.
Gastroenterology.
133(6)
[PMID] 18054548.
2007
Increased interactive format for Morbidity & Mortality conference improves educational value and enhances confidence.
Journal of surgical education.
64(5):266-72
[PMID] 17961883.
2007
Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature.
The Journal of molecular diagnostics : JMD.
9(5):563-71
[PMID] 17916603.
2007
Laparoscopic colorectal surgery is safe in the high-risk patient: a NSQIP risk-adjusted analysis.
Surgery.
142(4):594-7; discussion 597.e1
[PMID] 17950353.
2007
Minimally invasive treatment of pancreatic disease.
Gastroenterology clinics of North America.
36(2):441-54, xi
[PMID] 17533089.
2007
Necrotizing pancreatitis.
Gastroenterology clinics of North America.
36(2):313-23, viii
[PMID] 17533081.
2007
Optimal markers for real-time quantitative reverse transcription PCR detection of circulating tumor cells from melanoma, breast, colon, esophageal, head and neck, and lung cancers.
Clinical chemistry.
53(7):1206-15
[PMID] 17525108.
2007
Update for surgeons: recent and noteworthy changes in therapeutic regimens for cancer of the colon and rectum.
Journal of the American College of Surgeons.
205(3):468-78 (Quiz 524)
[PMID] 17765164.
2006
A rapid, fully automated, molecular-based assay accurately analyzes sentinel lymph nodes for the presence of metastatic breast cancer.
Annals of surgery.
243(3):389-98
[PMID] 16495705.
2006
Ad-IRF-1 induces apoptosis in esophageal adenocarcinoma.
Neoplasia (New York, N.Y.).
8(1):31-7
[PMID] 16533423.
2006
Identification of mRNA markers for molecular staging of lymph nodes in colorectal cancer.
Clinical chemistry.
52(3):520-3
[PMID] 16510433.
2006
Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma.
Neoplasia (New York, N.Y.).
8(11):949-55
[PMID] 17132227.
2006
Laparoscopic repair of umbilical hernias in conjunction with other laparoscopic procedures.
JSLS : Journal of the Society of Laparoendoscopic Surgeons.
10(1):63-5
[PMID] 16709360.
2005
Altered trafficking of Fas and subsequent resistance to Fas-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma.
The Journal of surgical research.
123(2):302-11
[PMID] 15680394.
2005
IL-21 enhances tumor rejection through a NKG2D-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950).
175(4):2167-73
[PMID] 16081783.
2005
Molecular staging of lymph nodes from patients with esophageal adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
11(3):1099-109
[PMID] 15709177.
2005
Student attendance during college-based lectures: a pilot study.
Nursing standard (Royal College of Nursing (Great Britain) : 1987).
19(47):41-9
[PMID] 16101085.
2005
Technology for automated, rapid, and quantitative PCR or reverse transcription-PCR clinical testing.
Clinical chemistry.
51(5):882-90
[PMID] 15746302.
2005
The HGF receptor c-Met is overexpressed in esophageal adenocarcinoma.
Neoplasia (New York, N.Y.).
7(1):75-84
[PMID] 15720819.
2003
Fondaparinux requires further study before firm recommendation.
Archives of internal medicine.
163(4)
[PMID] 12588215.
1999
Cytochromes P450 are expressed in proliferating cells in Barrett’s metaplasia.
Neoplasia (New York, N.Y.).
1(2):145-53
[PMID] 10933049.
1999
Differential expression of Hsp27 in normal oesophagus, Barrett’s metaplasia and oesophageal adenocarcinomas.
British journal of cancer.
79(3-4):595-603
[PMID] 10027336.
1998
A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma.
Proceedings of the National Academy of Sciences of the United States of America.
95(21):12410-5
[PMID] 9770500.
1998
Impaired glucose-stimulated insulin release in islets from adult rats malnourished during foetal-neonatal life.
Molecular and cellular endocrinology.
142(1-2):41-8
[PMID] 9783901.
1998
Lack of cell surface Fas/APO-1 expression in pulmonary adenocarcinomas.
The Journal of clinical investigation.
101(5):1102-10
[PMID] 9486981.
1997
Fas/APO-1 (CD95) is not translocated to the cell membrane in esophageal adenocarcinoma.
Cancer research.
57(24):5571-8
[PMID] 9407969.
1997
The effect of maternal protein deficiency during pregnancy and lactation on glucose tolerance and pancreatic islet function in adult rat offspring.
The Journal of endocrinology.
154(1):177-85
[PMID] 9246952.
1996
Impaired glucose tolerance and mild hyperglycemia in sucrose-fed rats does not impair insulin secretion.
Acta diabetologica.
33(3):211-5
[PMID] 8904927.
1993
Chronic bile diversion does not alter canine interdigestive myoelectric activity.
Digestive diseases and sciences.
38(6):1055-61
[PMID] 8508700.
1974
A randomized controlled trial of acetyl salicylic acid in the secondary prevention of mortality from myocardial infarction.
British medical journal.
1(5905):436-40
[PMID] 4593555.
In Press
A phase II, open-label pilot study evaluating neoadjuvant Nal-IRI with 5-FU and oxaliplatin in pancreatic adenocarcinoma.
Futures Onc..
In Press
Heterogeneity of cachexia and transcriptomic signatures in pancreatic ductal adenocarcinoma based on primary tumor anatomic location.
J Cachexia Sarcopenia and Muscle .
15(1):149-158
[DOI] 10.1002/jcsm.13390.
[PMID] 38123146.
Grants
Oct 2023
ACTIVE
ExoLuminate. Observational Registry Study to Assess Exo-PDAC Assay Performance for Detection of Pancreatic Adenocarcinoma (PDAC) in High-Risk or Clinically Suspicious Patients
Role: Principal Investigator
Funding: BIOLOGICAL DYNAMICS
Sep 2023
ACTIVE
2/3 Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity Center
Role: Other
Funding: NATL INST OF HLTH NCI
May 2023
ACTIVE
Characterizing the Role of Immunosenescence in Differentiated Thyroid Cancer in the Older Adult
Role: Co-Investigator
Funding: AMERICAN ASSOC OF ENDOCRINE SURGEONS
Sep 2021
ACTIVE
UF Health Cancer Center PDX Core
Role: Co-Project Director/Principal Investigator
Funding: UF HEALTH SHANDS HOSPITAL
Dec 2020
– May 2022
The role of the IL-1/IL-1R/IL-1RA axis in the pancreatic ductal adenocarcinoma (PDAC) immune tumor microenvironment
Role: Other
Funding: FREDERICK A COLLER SURGICAL SOCIETY
Sep 2020
ACTIVE
Type 1 Diabetes in Acute Pancreatitis Consortium – Clinical Centers
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2020
ACTIVE
U-01 CONSORTIUM FOR THE STUDY OF CHRONIC PANCREATITIS,DIABETES AND PANCREATIC CANCER CLINICAL CENTERS
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Nov 2019
– Dec 2021
Immunologic and molecular profiling of endoscopic ultrasound-guided fine needle aspiration samples for precision medicine in pancreatic ductal adenocarcinoma
Role: Other
Funding: FREDERICK A COLLER SURGICAL SOCIETY
Feb 2019
– Sep 2021
The Florida Pancreas Collaborative Next-Generation Biobank: Reducing Health Disparities and Improving Survival for Pancreatic Cancer
Role: Principal Investigator
Funding: H LEE MOFFITT CANCER CTR & RES INST
Sep 2018
– Jul 2022
UFF Copeland Professorship – research project
Role: Principal Investigator
Funding: UF FOUNDATION
Sep 2018
– Aug 2020
Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer: Coordinating and Data Management Center (CSCPDPC-CDMC) NOD Study
Role: Principal Investigator
Funding: UNIV OF TEXAS MD ANDERSON CANCER CENTER
via NATL INST OF HLTH NIDDK
May 2018
ACTIVE
High throughput 3D printing
Role: Project Manager
Funding: MERCK SHARP & DOHME
Jul 2017
– Dec 2019
Protein Signatures Improve the Diagnostic Yield of Fine Needle Aspiration
Role: Principal Investigator
Funding: Pancreatic Cancer Action Network
Sep 2016
– Aug 2020
Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer: Coordinating and Data Management Center (CSCPDPC-CDMC)
Role: Principal Investigator
Funding: UNIV OF TEXAS MD ANDERSON CANCER CENTER
via NATL INST OF HLTH NIDDK
Jul 2016
– Apr 2023
Divalent Metal-ion Transporter 1 as a Therapeutic Target to Optimize Intestinal Iron Transport
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
Sep 2015
– Aug 2020
U-01 CONSORTIUM FOR THE STUDY OF CHRONIC PANCREATITIS,DIABETES AND PANCREATIC CANCER CLINICAL CENTERS
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
May 2014
– Aug 2019
Alexander Breast Cancer Research Fund
Role: Principal Investigator
Funding: UF FOUNDATION
Jul 2013
– Jun 2018
Novel therapeutic targets and approaches in pancreatic cancer
Role: Principal Investigator
Funding: UF FOUNDATION
Jan 2011
– Oct 2019
UFF Cracchiolo Professorship
Role: Principal Investigator
Funding: UF FOUNDATION
Education
Residency – Surgery
2000
·
University of Michigan
Fellowship – Surgical Critical Care
1998
·
University of Michigan
Fellowship – Surgical Oncology Research
1997
·
National Institute of Health
Residency – Surgery
1996
·
University of Michigan
Internship – Surgery
1994
·
University of Michigan
Medical Degree
1993
·
Mayo Medical School
Bachelor's Degree – Chemistry
1988
·
University of Minnesota
Contact Details
Phones:
- Business:
- (352) 265-0535
Emails:
- Business:
- steven.hughes@surgery.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100109
GAINESVILLE FL 32610