Song Han

Song Han, PhD

Assistant Scientist

Department: MD-SURGERY-SURGONC-PBS
Business Phone: (352) 265-0169
Business Email: songhan@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-6542-335X

Areas of Interest
  • Tumor Signaling
  • Cancer Genetics
  • Cancer Immunotherapy
  • Extracellular vesicles
  • Pancreatic Cancer Biology
  • biomarker discovery

Publications

2020
From tumor microenvironment communicants to biomarker discovery: Selectively packaged extracellular vesicular cargoes in pancreatic cancer.
Cytokine & growth factor reviews. 51:61-68 [DOI] 10.1016/j.cytogfr.2020.01.001. [PMID] 32005635.
2020
Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia.
Cancers. 12(2) [DOI] 10.3390/cancers12020329. [PMID] 32024069.
2020
Protein Signatures and Tissue Diagnosis of Pancreatic Cancer.
Journal of the American College of Surgeons. 230(1):26-36.e1 [DOI] 10.1016/j.jamcollsurg.2019.10.002. [PMID] 31672677.
2019
The Proteome of Pancreatic Cancer-Derived Exosomes Reveals Signatures Rich in Key Signaling Pathways.
Proteomics. 19(13) [DOI] 10.1002/pmic.201800394. [PMID] 31070281.
2018
Stroma-derived extracellular vesicles deliver tumor-suppressive miRNAs to pancreatic cancer cells.
Oncotarget. 9(5):5764-5777 [DOI] 10.18632/oncotarget.23532. [PMID] 29464032.
2018
Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties.
Acta biomaterialia. 67:331-340 [DOI] 10.1016/j.actbio.2017.11.037. [PMID] 29191507.
2017
Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.
Cancer research. 77(3):672-683 [DOI] 10.1158/0008-5472.CAN-16-1765. [PMID] 27864347.
2017
Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia.
Oncotarget. 8(1):1177-1189 [DOI] 10.18632/oncotarget.13593. [PMID] 27901481.
2017
The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma.
Oncotarget. 8(33):54054-54067 [DOI] 10.18632/oncotarget.10722. [PMID] 28903323.
2016
Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research. 22(7):1787-99 [DOI] 10.1158/1078-0432.CCR-15-1256. [PMID] 26667487.
2015
Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer.
Cancer immunology, immunotherapy : CII. 64(12):1553-63 [DOI] 10.1007/s00262-015-1760-y. [PMID] 26423423.
2015
Primary outgrowth cultures are a reliable source of human pancreatic stellate cells.
Laboratory investigation; a journal of technical methods and pathology. 95(11):1331-40 [DOI] 10.1038/labinvest.2015.117. [PMID] 26322418.
2014
Discovery of structure-based small molecular inhibitor of αB-crystallin against basal-like/triple-negative breast cancer development in vitro and in vivo.
Breast cancer research and treatment. 145(1):45-59 [DOI] 10.1007/s10549-014-2940-8. [PMID] 24710637.
2013
Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinoma.
PloS one. 8(10) [DOI] 10.1371/journal.pone.0076667. [PMID] 24146905.
2013
Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature development.
Cancer letters. 332(1):120-9 [DOI] 10.1016/j.canlet.2012.11.016. [PMID] 23196055.
2012
Connection of pericyte-angiopoietin-Tie-2 system in diabetic retinopathy: friend or foe?
Future medicinal chemistry. 4(17):2163-76 [DOI] 10.4155/fmc.12.170. [PMID] 23190105.
2012
β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
EMBO molecular medicine. 4(9):980-91 [DOI] 10.1002/emmm.201101084. [PMID] 22903875.
2011
In Pursuit of New Anti-Angiogenic Therapies for Cancer Treatment
Meditsinskaia parazitologiia i parazitarnye bolezni. 16(5):803-814 [DOI] 10.2741/3721. [PMID] 3721.
2011
In pursuit of new anti-angiogenic therapies for cancer treatment.
Frontiers in bioscience (Landmark edition). 16:803-14 [PMID] 21196204.
View on: PubMed
2011
αB-crystallin, an effector of unfolded protein response, confers anti-VEGF resistance to breast cancer via maintenance of intracrine VEGF in endothelial cells.
Molecular cancer research : MCR. 9(12):1632-43 [DOI] 10.1158/1541-7786.MCR-11-0327. [PMID] 21984182.
2011
γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.
The Journal of biological chemistry. 286(49):42514-42523 [DOI] 10.1074/jbc.M111.296590. [PMID] 22016384.

Grants

Jul 2017 – Dec 2019
Protein Signatures Improve the Diagnostic Yield of Fine Needle Aspiration
Role: Other
Funding: Pancreatic Cancer Action Network
Apr 2015 – Jun 2016
the function of mir-200 family members and mir-205 in
Role: Principal Investigator
Funding: FL CLINICAL PRACTICE ASSO

Education

Ph.D. (Microbiology and Immunology)
1996 · Shanghai Jiaotong University School of Medicine: Shanghai, CN
M.Sc. (Biochemistry)
1990 · Shanghai Jiaotong University School of Medicine: Shanghai, CN
M.D. (Medicine)
1987 · Shanghai Jiaotong University School of Medicine : Shanghai, CN

Contact Details

Phones:
Business:
(352) 265-0169
Emails:
Business:
songhan@ufl.edu