Song Han, PhD
Associate Research Scientist
Research Profile
Areas of Interest
- Tumor Signaling
- Cancer Genetics
- Cancer Immunotherapy
- Extracellular vesicles
- Pancreatic Cancer Biology
- biomarker discovery
Open Researcher and Contributor ID (ORCID)
0000-0002-6542-335X
Publications
2024
Fibroblasts in the aged pancreas drive pancreatic cancer progression
Cancer Research.
[DOI] 10.1158/0008-5472.can-24-0086.
2024
Heterogeneity of weight loss and transcriptomic signatures in pancreatic ductal adenocarcinoma.
Journal of cachexia, sarcopenia and muscle.
15(1):149-158
[DOI] 10.1002/jcsm.13390.
[PMID] 38123146.
2024
Infiltration of CD3+ and CD8+ lymphocytes in association with inflammation and survival in pancreatic cancer.
PloS one.
19(2)
[DOI] 10.1371/journal.pone.0297325.
[PMID] 38346068.
2024
Peptide-based capture-and-release purification of extracellular vesicles and statistical algorithm enabled quality assessment.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.02.06.578050.
[PMID] 38370748.
2023
A one-pot isothermal Cas12-based assay for the sensitive detection of microRNAs.
Nature biomedical engineering.
7(12):1583-1601
[DOI] 10.1038/s41551-023-01033-1.
[PMID] 37106152.
2023
A peek at the other side of the coin: Tumor‐suppressor role of microRNAs expressed by pancreatic cancer‐associated fibroblasts
Clinical and Translational Medicine.
13(8)
[DOI] 10.1002/ctm2.1357.
[PMID] 37539872.
2023
A protein-based machine learning approach to the identification of inflammatory subtypes in pancreatic ductal adenocarcinoma.
Pancreatology : official journal of the International Association of Pancreatology (IAP) … [et al.].
23(6):615-621
[DOI] 10.1016/j.pan.2023.06.007.
[PMID] 37391359.
2023
Extraction-free, one-pot CRISPR/Cas12a detection of microRNAs directly from extracellular vesicles.
Chemical communications (Cambridge, England).
59(67):10165-10168
[DOI] 10.1039/d3cc02982d.
[PMID] 37531174.
2022
Single-cell profiling of microenvironment components by spatial localization in pancreatic ductal adenocarcinoma.
Theranostics.
12(11):4980-4992
[DOI] 10.7150/thno.73222.
[PMID] 35836806.
2022
The interleukin-1 axis and the tumor immune microenvironment in pancreatic ductal adenocarcinoma
Neoplasia.
28
[DOI] 10.1016/j.neo.2022.100789.
[PMID] 35395492.
2020
From tumor microenvironment communicants to biomarker discovery: Selectively packaged extracellular vesicular cargoes in pancreatic cancer.
Cytokine & growth factor reviews.
51:61-68
[DOI] 10.1016/j.cytogfr.2020.01.001.
[PMID] 32005635.
2020
Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia.
Cancers.
12(2)
[DOI] 10.3390/cancers12020329.
[PMID] 32024069.
2020
Protein Signatures and Tissue Diagnosis of Pancreatic Cancer.
Journal of the American College of Surgeons.
230(1):26-36.e1
[DOI] 10.1016/j.jamcollsurg.2019.10.002.
[PMID] 31672677.
2019
The Proteome of Pancreatic Cancer-Derived Exosomes Reveals Signatures Rich in Key Signaling Pathways.
Proteomics.
19(13)
[DOI] 10.1002/pmic.201800394.
[PMID] 31070281.
2018
Stroma-derived extracellular vesicles deliver tumor-suppressive miRNAs to pancreatic cancer cells.
Oncotarget.
9(5):5764-5777
[DOI] 10.18632/oncotarget.23532.
[PMID] 29464032.
2018
Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties.
Acta biomaterialia.
67:331-340
[DOI] 10.1016/j.actbio.2017.11.037.
[PMID] 29191507.
2017
Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.
Cancer research.
77(3):672-683
[DOI] 10.1158/0008-5472.CAN-16-1765.
[PMID] 27864347.
2017
Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia.
Oncotarget.
8(1):1177-1189
[DOI] 10.18632/oncotarget.13593.
[PMID] 27901481.
2017
The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma.
Oncotarget.
8(33):54054-54067
[DOI] 10.18632/oncotarget.10722.
[PMID] 28903323.
2016
Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research.
22(7):1787-99
[DOI] 10.1158/1078-0432.CCR-15-1256.
[PMID] 26667487.
2015
Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer.
Cancer immunology, immunotherapy : CII.
64(12):1553-63
[DOI] 10.1007/s00262-015-1760-y.
[PMID] 26423423.
2015
Primary outgrowth cultures are a reliable source of human pancreatic stellate cells.
Laboratory investigation; a journal of technical methods and pathology.
95(11):1331-40
[DOI] 10.1038/labinvest.2015.117.
[PMID] 26322418.
2014
Discovery of structure-based small molecular inhibitor of αB-crystallin against basal-like/triple-negative breast cancer development in vitro and in vivo.
Breast cancer research and treatment.
145(1):45-59
[DOI] 10.1007/s10549-014-2940-8.
[PMID] 24710637.
2013
Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinoma.
PloS one.
8(10)
[DOI] 10.1371/journal.pone.0076667.
[PMID] 24146905.
2013
Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature development.
Cancer letters.
332(1):120-9
[DOI] 10.1016/j.canlet.2012.11.016.
[PMID] 23196055.
2012
Connection of pericyte-angiopoietin-Tie-2 system in diabetic retinopathy: friend or foe?
Future medicinal chemistry.
4(17):2163-76
[DOI] 10.4155/fmc.12.170.
[PMID] 23190105.
2012
β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
EMBO molecular medicine.
4(9):980-91
[DOI] 10.1002/emmm.201101084.
[PMID] 22903875.
2011
In pursuit of new anti-angiogenic therapies for cancer treatment.
Frontiers in bioscience (Landmark edition).
16(3):803-14
[PMID] 21196204.
2011
αB-crystallin, an effector of unfolded protein response, confers anti-VEGF resistance to breast cancer via maintenance of intracrine VEGF in endothelial cells.
Molecular cancer research : MCR.
9(12):1632-43
[DOI] 10.1158/1541-7786.MCR-11-0327.
[PMID] 21984182.
2011
γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.
The Journal of biological chemistry.
286(49):42514-42523
[DOI] 10.1074/jbc.M111.296590.
[PMID] 22016384.
1975
[Natural control of blood-sucking mosquito population densities (review of literature)].
Meditsinskaia parazitologiia i parazitarnye bolezni.
44(5):603-7
[PMID] 3721.
Grants
Jul 2017
– Dec 2019
Protein Signatures Improve the Diagnostic Yield of Fine Needle Aspiration
Role: Other
Funding: Pancreatic Cancer Action Network
Apr 2015
– Jun 2016
the function of mir-200 family members and mir-205 in
Role: Principal Investigator
Funding: FL CLINICAL PRACTICE ASSO
Education
Ph.D. (Microbiology and Immunology)
1996
·
Shanghai Jiaotong University School of Medicine: Shanghai, CN
M.Sc. (Biochemistry)
1990
·
Shanghai Jiaotong University School of Medicine: Shanghai, CN
M.D. (Medicine)
1987
·
Shanghai Jiaotong University School of Medicine : Shanghai, CN
Contact Details
Phones:
- Business:
- (352) 273-7758
Emails:
- Business:
- songhan@ufl.edu
Addresses:
- Business Mailing:
-
DEPT.OF SURGERY, ARB, R4-175
GAINESVILLE FL 326100001