Philip A Efron, MD, FACS, FCCM
Professor; Director Of Sepsis And Critical Illness Research Center (SCIRC); Executive Director, Surgery, UF Health Critical Care Organization
Department:
MD-SURGERY-TRAUMA
Business Phone:
(352) 273-5670
Business Email:
philip.efron@surgery.ufl.edu
About Philip A Efron
I come from a family of surgeons and as the youngest, I was inspired to follow suit. Now, I am a professor of surgery in the University of Florida while serving as the medical director for the UF Health Shands Hospital Surgical Intensive Care Units (SICUs). I aim to establish the best critical care in the nation, so that patients and loved ones can feel assured of the highest quality of medical care and expertise. My goal is to create and ensure the success of UF Health’s first Critical Care Organization (CCO), further enabling world-class critical care. Most of all, I love what I do every day — providing surgical critical care to those in need.
I received my medical degree from the University of Maryland with multiple honors, and then completed my general surgery residency at UF. My residency included a three-year period as a T32 research fellow in the Laboratory of Inflammation Biology and Surgical Science under the mentorship of Lyle L. Moldawer, PhD. During my tenure as a general surgery resident, I received the Edward R. Woodward Surgical Resident’s Award. Subsequently, I completed my critical care fellowship training at Washington University in St. Louis, Missouri.
I am a member and leader of multiple national societies related to surgery and critical care, as well as being on the editorial board of journals related to these fields. Importantly, I now direct the Laboratory of Inflammation Biology and Surgical Science, and I assist in leading the UF Sepsis and Critical Illness Research Center (SCIRC). My research focuses on inflammation and immunology in severe injury and infection, and their contribution to poor long-term outcomes in ICU patients. This has led to multiple successful collaborations with UF and other institution researchers. Of note, I am a physician-scientist independently funded by the National Institutes of Health (NIH), and my work ranges from basic research to clinical outcomes.
Outside of practice, I enjoy being with family: my wife, two daughters, son and dog. My wife and I revel in anything science fiction. As a family, we watch anime and support local, national and international sports meets and events. My hobbies include grilling/smoking food for friends and exercising.
Accomplishments
Career Development Award
2010
·
University of Florida Department of Surgery Research
Shock Society Fellowship
2010
·
Early Career Investigators
Edward R. Woodward Surgical Resident's Award
2007
·
University of Florida
Best Clinical Abstract
2005
·
University of Florida Department of Surgery Research Day
Teaching Profile
Courses Taught
2018
PAS5701L Critical Care Medicin
2018
PAS5702L Intensive Care Med 2
2015
GMS6029 Brain Journal Club
Board Certifications
-
SurgeryAmerican Board of Surgery
-
Surgical Critical CareAmerican Board of Surgery
Clinical Profile
Subspecialties
- Critical Care Surgery
Areas of Interest
- Acute cholecystitis
- Appendectomy
- Appendicitis
- Emergency airway puncture
- Extracorporeal membrane oxygenation
- Hernias
- Laparoscopic gallbladder removal
- Necrotizing soft tissue infection
- Open gallbladder removal
- Sepsis
Research Profile
Dr. Efron has a professional interest in surgical critical care and trauma, both clinically as well as in the laboratory. He conducts basic science and translational research in sepsis and inflammation. He is currently one of the principal investigators for an NIH-funded P50 center grant for the UF Sepsis and Critical Illness Research Center to study the persistent inflammation, immunosuppression and catabolism syndrome (PICS) following sepsis in surgical intensive care unit patients.
Open Researcher and Contributor ID (ORCID)
0000-0002-3931-650X
Publications
2024
A modified Mediterranean-style diet enhances brain function via specific gut-microbiome-brain mechanisms.
Gut microbes.
16(1)
[DOI] 10.1080/19490976.2024.2323752.
[PMID] 38444392.
2024
Acute Emergence of the Intestinal Pathobiome after Postinjury Pneumonia
Journal of Trauma and Acute Care Surgery.
[DOI] 10.1097/ta.0000000000004300.
2024
Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot.
JCI insight.
9(2)
[DOI] 10.1172/jci.insight.175785.
[PMID] 38100268.
2024
Exosomal microRNA following severe trauma: Role in bone marrow dysfunction.
The journal of trauma and acute care surgery.
96(4):548-556
[DOI] 10.1097/TA.0000000000004225.
[PMID] 38151766.
2024
Gut mycobiome dysbiosis after sepsis and trauma.
Critical care (London, England).
28(1)
[DOI] 10.1186/s13054-023-04780-4.
[PMID] 38212826.
2024
MerTK-dependent efferocytosis by monocytic-MDSCs mediates resolution of post-lung transplant injury.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.01.18.576261.
[PMID] 38328174.
2024
Multicompartmental Trauma Induces Persistent Inflammation and Organ Injury.
The Journal of surgical research.
293:266-273
[DOI] 10.1016/j.jss.2023.08.033.
[PMID] 37804796.
2024
Operating Room Supply Cost and Value of Care after Implementing a Sustainable Quality Intervention.
Journal of the American College of Surgeons.
238(4):404-413
[DOI] 10.1097/XCS.0000000000000972.
[PMID] 38224109.
2024
Posttraumatic pneumonia exacerbates bone marrow erythropoietic dysfunction.
The journal of trauma and acute care surgery.
96(1):17-25
[DOI] 10.1097/TA.0000000000004157.
[PMID] 37853556.
2023
A narrative review of ergonomic problems, principles, and potential solutions in surgical operations.
Surgery.
174(2):214-221
[DOI] 10.1016/j.surg.2023.04.003.
[PMID] 37202309.
2023
A simulation curriculum for laparoscopic common bile duct exploration, balloon sphincterotomy, and endobiliary stenting: Associations with resident performance and autonomy in the operating room.
Surgery.
173(4):950-956
[DOI] 10.1016/j.surg.2022.11.007.
[PMID] 36517292.
2023
Adverse Long-Term Outcomes and an Immune Suppressed Endotype in Sepsis Patients with Reduced Interferon-γELISpot: A Multicenter, Prospective Observational Study.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2023.09.13.23295360.
[PMID] 37745385.
2023
Anemia Recovery After Lung Contusion, Hemorrhagic Shock, and Chronic Stress Is Gender-Specific in a Rat Model.
Surgical infections.
24(9):773-781
[DOI] 10.1089/sur.2023.154.
[PMID] 37903014.
2023
Anemia Recovery after Trauma: A Longitudinal Study.
Surgical infections.
24(1):39-45
[DOI] 10.1089/sur.2022.299.
[PMID] 36579920.
2023
Bone Marrow Adipokine Expression Was Associated With Decreased Erythroid Colony Growth After Trauma.
The American surgeon.
89(4):558-565
[DOI] 10.1177/00031348221135772.
[PMID] 36282510.
2023
Building an automated, machine learning-enabled platform for predicting post-operative complications.
Physiological measurement.
44(2)
[DOI] 10.1088/1361-6579/acb4db.
[PMID] 36657179.
2023
Chronic Critical Illness in Patients With Sepsis is Associated With Persistent Anemia, Inflammation, and Impaired Functional Outcomes.
The American surgeon.
89(6):2563-2571
[DOI] 10.1177/00031348221104252.
[PMID] 35593749.
2023
Chronic mesenteric ischemia-induced intestinal dysbiosis resolved after revascularization.
Journal of vascular surgery cases and innovative techniques.
9(2)
[DOI] 10.1016/j.jvscit.2022.101084.
[PMID] 36970136.
2023
Defining critical illness using immunological endotypes in patients with and without of sepsis: A cohort study.
Research square.
[DOI] 10.21203/rs.3.rs-2874506/v1.
[PMID] 37214996.
2023
Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study.
Critical care (London, England).
27(1)
[DOI] 10.1186/s13054-023-04571-x.
[PMID] 37474944.
2023
EFFECTS OF TRAUMA PLASMA-DERIVED EXOSOMES ON HEMATOPOIETIC PROGENITOR CELLS.
Shock (Augusta, Ga.).
59(4):591-598
[DOI] 10.1097/SHK.0000000000002094.
[PMID] 36772985.
2023
Factors Affecting Turnover of Advanced Practice Providers: A University Teaching Hospital Review.
Journal of healthcare management / American College of Healthcare Executives.
68(1):15-24
[DOI] 10.1097/JHM-D-21-00279.
[PMID] 36602452.
2023
Multicompartmental trauma alters bone marrow erythroblastic islands.
The journal of trauma and acute care surgery.
94(2):197-204
[DOI] 10.1097/TA.0000000000003821.
[PMID] 36652391.
2023
Multicompartmental traumatic injury and the microbiome: Shift to a pathobiome.
The journal of trauma and acute care surgery.
94(1):15-22
[DOI] 10.1097/TA.0000000000003803.
[PMID] 36203239.
2023
Multicompartmental traumatic injury induces sex-specific alterations in the gut microbiome.
The journal of trauma and acute care surgery.
95(1):30-38
[DOI] 10.1097/TA.0000000000003939.
[PMID] 36872509.
2023
NARROWING THE GAP: PRECLINICAL TRAUMA WITH POSTINJURY SEPSIS MODEL WITH INCREASED CLINICAL RELEVANCE.
Shock (Augusta, Ga.).
60(2):272-279
[DOI] 10.1097/SHK.0000000000002161.
[PMID] 37310788.
2023
NEW INSIGHTS INTO THE PATHOPHYSIOLOGY OF TRAUMA AND HEMORRHAGE.
Shock (Augusta, Ga.).
59(3S Suppl 1):6-9
[DOI] 10.1097/SHK.0000000000001954.
[PMID] 36867756.
2023
Overtriage, Undertriage, and Value of Care after Major Surgery: An Automated, Explainable Deep Learning-Enabled Classification System.
Journal of the American College of Surgeons.
236(2):279-291
[DOI] 10.1097/XCS.0000000000000471.
[PMID] 36648256.
2023
Postoperative Overtriage to an Intensive Care Unit Is Associated With Low Value of Care.
Annals of surgery.
277(2):179-185
[DOI] 10.1097/SLA.0000000000005460.
[PMID] 35797553.
2023
Predictive Modeling for Readmission to Intensive Care: A Systematic Review.
Critical care explorations.
5(1)
[DOI] 10.1097/CCE.0000000000000848.
[PMID] 36699252.
2023
Resource use for cholecystectomy with versus without cholangiography: A multicenter, propensity-matched analysis.
Surgery.
174(2):152-158
[DOI] 10.1016/j.surg.2023.04.027.
[PMID] 37188579.
2023
Retrospective value assessment of a dedicated, trauma hybrid operating room.
The journal of trauma and acute care surgery.
94(6):814-822
[DOI] 10.1097/TA.0000000000003873.
[PMID] 36727772.
2023
Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection.
Clinical science (London, England : 1979).
137(12):963-978
[DOI] 10.1042/CS20220555.
[PMID] 37337946.
2023
Sex-specific intestinal dysbiosis persists after multicompartmental injury.
Surgery.
174(6):1453-1462
[DOI] 10.1016/j.surg.2023.08.023.
[PMID] 37833155.
2023
Surgical resident experience with common bile duct exploration and assessment of performance and autonomy with formative feedback.
World journal of emergency surgery : WJES.
18(1)
[DOI] 10.1186/s13017-023-00480-0.
[PMID] 36747289.
2023
Surgical Science and the Evolution of Critical Care Medicine.
Critical care medicine.
51(2):182-211
[DOI] 10.1097/CCM.0000000000005708.
[PMID] 36661448.
2023
Survival and neurologic outcomes following aortic occlusion for trauma and hemorrhagic shock in a hybrid operating room.
Research square.
[DOI] 10.21203/rs.3.rs-2459030/v1.
[PMID] 36711502.
2023
Survival and neurologic outcomes following aortic occlusion for trauma and hemorrhagic shock in a hybrid operating room.
World journal of emergency surgery : WJES.
18(1)
[DOI] 10.1186/s13017-023-00484-w.
[PMID] 36959585.
2023
Temporal Changes in Innate and Adaptive Immunity During Sepsis as Determined by ELISpot.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.12.14.571668.
[PMID] 38168302.
2023
The Intestinal Microbiome after Traumatic Injury.
Microorganisms.
11(8)
[DOI] 10.3390/microorganisms11081990.
[PMID] 37630549.
2023
The persistent inflammation, immunosuppression, and catabolism syndrome 10 years later.
The journal of trauma and acute care surgery.
95(5):790-799
[DOI] 10.1097/TA.0000000000004087.
[PMID] 37561664.
2023
TRAINED IMMUNITY: A POTENTIAL APPROACH FOR IMPROVING HOST IMMUNITY IN NEONATAL SEPSIS.
Shock (Augusta, Ga.).
59(2):125-134
[DOI] 10.1097/SHK.0000000000002054.
[PMID] 36383390.
2023
VARIABLES INFLUENCING THE DIFFERENTIAL HOST RESPONSE TO BURNS IN PEDIATRIC AND ADULT PATIENTS.
Shock (Augusta, Ga.).
59(2):145-154
[DOI] 10.1097/SHK.0000000000002042.
[PMID] 36730790.
2022
Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study.
Annals of surgery.
275(6):1184-1193
[DOI] 10.1097/SLA.0000000000004360.
[PMID] 33196489.
2022
Early Biomarker Signatures in Surgical Sepsis.
The Journal of surgical research.
277:372-383
[DOI] 10.1016/j.jss.2022.04.052.
[PMID] 35569215.
2022
Estimated vs measured energy expenditure in ventilated surgical-trauma critically ill patients.
JPEN. Journal of parenteral and enteral nutrition.
46(6):1431-1440
[DOI] 10.1002/jpen.2314.
[PMID] 34921708.
2022
Evaluation of a Multivalent Transcriptomic Metric for Diagnosing Surgical Sepsis and Estimating Mortality Among Critically Ill Patients.
JAMA network open.
5(7)
[DOI] 10.1001/jamanetworkopen.2022.21520.
[PMID] 35819783.
2022
Federated learning for preserving data privacy in collaborative healthcare research.
Digital health.
8
[DOI] 10.1177/20552076221134455.
[PMID] 36325438.
2022
Gamification for Machine Learning in Surgical Patient Engagement.
Frontiers in surgery.
9
[DOI] 10.3389/fsurg.2022.896351.
[PMID] 35656082.
2022
Immunopathology of chronic critical illness in sepsis survivors: Role of abnormal myelopoiesis.
Journal of leukocyte biology.
112(6):1525-1534
[DOI] 10.1002/JLB.4MR0922-690RR.
[PMID] 36193662.
2022
Ineffective Erythropoietin Response to Anemia in Sepsis.
Surgical infections.
23(2):142-149
[DOI] 10.1089/sur.2021.152.
[PMID] 34958257.
2022
Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis.
Aging.
14(2):728-746
[DOI] 10.18632/aging.203868.
[PMID] 35094981.
2022
Mechanisms of improved erythroid progenitor growth with removal of chronic stress after trauma.
Surgery.
172(2):759-765
[DOI] 10.1016/j.surg.2022.04.056.
[PMID] 35672167.
2022
Methods for Phenotyping Adult Patients in Sepsis and Septic Shock: A Scoping Review.
Critical care explorations.
4(4)
[DOI] 10.1097/CCE.0000000000000672.
[PMID] 35372844.
2022
Older Adults Demonstrate Biomarker Evidence of the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) After Sepsis.
The journals of gerontology. Series A, Biological sciences and medical sciences.
77(1):188-196
[DOI] 10.1093/gerona/glab080.
[PMID] 33721883.
2022
Personalized decision-making for acute cholecystitis: Understanding surgeon judgment.
Frontiers in digital health.
4
[DOI] 10.3389/fdgth.2022.845453.
[PMID] 36339515.
2022
Phenotype clustering in health care: A narrative review for clinicians.
Frontiers in artificial intelligence.
5
[DOI] 10.3389/frai.2022.842306.
[PMID] 36034597.
2022
Preoperative computed tomography for acutely incarcerated ventral or inguinal hernia.
Surgery.
172(1):193-197
[DOI] 10.1016/j.surg.2022.01.014.
[PMID] 35304009.
2022
Sepsis-Induced Myopathy and Gut Microbiome Dysbiosis: Mechanistic Links and Therapeutic Targets.
Shock (Augusta, Ga.).
57(1):15-23
[DOI] 10.1097/SHK.0000000000001843.
[PMID] 34726875.
2022
Sex differences associate with late microbiome alterations after murine surgical sepsis.
The journal of trauma and acute care surgery.
93(2):137-146
[DOI] 10.1097/TA.0000000000003599.
[PMID] 35324554.
2022
T-Cell Activation and LPS: A Dangerous Duo for Organ Dysfunction.
Journal of leukocyte biology.
112(2):219-220
[DOI] 10.1002/JLB.3CE0122-019R.
[PMID] 35481682.
2022
Transcriptomic Changes Within Human Bone Marrow After Severe Trauma.
Shock (Augusta, Ga.).
57(1):24-30
[DOI] 10.1097/SHK.0000000000001826.
[PMID] 34172608.
2022
Uncertainty-aware deep learning in healthcare: A scoping review.
PLOS digital health.
1(8)
[DOI] 10.1371/journal.pdig.0000085.
[PMID] 36590140.
2021
A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.696536.
[PMID] 34484194.
2021
A road map from single-cell transcriptome to patient classification for the immune response to trauma.
JCI insight.
6(2)
[DOI] 10.1172/jci.insight.145108.
[PMID] 33320841.
2021
A Transcriptomic Severity Metric That Predicts Clinical Outcomes in Critically Ill Surgical Sepsis Patients.
Critical care explorations.
3(10)
[DOI] 10.1097/CCE.0000000000000554.
[PMID] 34671746.
2021
Aluminum Adjuvant Improves Survival Via NLRP3 Inflammasome and Myeloid Non-Granulocytic Cells in a Murine Model of Neonatal Sepsis.
Shock (Augusta, Ga.).
55(2):274-282
[DOI] 10.1097/SHK.0000000000001623.
[PMID] 32769820.
2021
Association of Postoperative Undertriage to Hospital Wards With Mortality and Morbidity.
JAMA network open.
4(11)
[DOI] 10.1001/jamanetworkopen.2021.31669.
[PMID] 34757412.
2021
Biomarker Evidence of the Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) in Chronic Critical Illness (CCI) After Surgical Sepsis.
Annals of surgery.
274(4):664-673
[DOI] 10.1097/SLA.0000000000005067.
[PMID] 34506322.
2021
Cecal Slurry Injection in Neonatal and Adult Mice.
Methods in molecular biology (Clifton, N.J.).
2321:27-41
[DOI] 10.1007/978-1-0716-1488-4_4.
[PMID] 34048005.
2021
Chronic Critical Illness Elicits a Unique Circulating Leukocyte Transcriptome in Sepsis Survivors.
Journal of clinical medicine.
10(15)
[DOI] 10.3390/jcm10153211.
[PMID] 34361995.
2021
Chronic “sepsis brain” and regulatory T cells – A promising therapeutic target
Brain, Behavior, and Immunity.
93:10-11
[DOI] 10.1016/j.bbi.2021.01.017.
[PMID] 33516922.
2021
Clinical Impact of a Dedicated Trauma Hybrid Operating Room.
Journal of the American College of Surgeons.
232(4):560-570
[DOI] 10.1016/j.jamcollsurg.2020.11.008.
[PMID] 33227422.
2021
Distinct immunologic endotypes are associated with clinical trajectory after severe blunt trauma and hemorrhagic shock.
The journal of trauma and acute care surgery.
90(2):257-267
[DOI] 10.1097/TA.0000000000003029.
[PMID] 33214489.
2021
Dysregulated Immunity and Immunotherapy after Sepsis.
Journal of clinical medicine.
10(8)
[DOI] 10.3390/jcm10081742.
[PMID] 33920518.
2021
Enteral Nutrition Administration Record Prescribing Process Using Computerized Order Entry: A New Paradigm and Opportunities to Improve Outcomes in Critically Ill Patients.
JPEN. Journal of parenteral and enteral nutrition.
45(3):507-517
[DOI] 10.1002/jpen.1870.
[PMID] 32384191.
2021
Identification of unique microRNA expression patterns in bone marrow hematopoietic stem and progenitor cells after hemorrhagic shock and multiple injuries in young and old adult mice.
The journal of trauma and acute care surgery.
91(4):692-699
[DOI] 10.1097/TA.0000000000003350.
[PMID] 34252063.
2021
Lipid and lipoprotein predictors of functional outcomes and long-term mortality after surgical sepsis.
Annals of intensive care.
11(1)
[DOI] 10.1186/s13613-021-00865-x.
[PMID] 34018068.
2021
Machine Learning Applications in Solid Organ Transplantation and Related Complications.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.739728.
[PMID] 34603324.
2021
Mediators of Prolonged Hematopoietic Progenitor Cell Mobilization After Severe Trauma.
The Journal of surgical research.
260:315-324
[DOI] 10.1016/j.jss.2020.11.084.
[PMID] 33373851.
2021
Optimizing predictive strategies for acute kidney injury after major vascular surgery.
Surgery.
170(1):298-303
[DOI] 10.1016/j.surg.2021.01.030.
[PMID] 33648766.
2021
Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course Analysis.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.792448.
[PMID] 34956225.
2021
Prolonged Chronic Stress and Persistent Iron Dysregulation Prevent Anemia Recovery Following Trauma.
The Journal of surgical research.
267:320-327
[DOI] 10.1016/j.jss.2021.05.034.
[PMID] 34186308.
2021
Reply to “Do Not Blame the Rodent for the Failure of Developing Sepsis Therapies”.
Shock (Augusta, Ga.).
56(1):152-153
[DOI] 10.1097/SHK.0000000000001688.
[PMID] 33156239.
2021
Sepsis and Cognitive Assessment.
Journal of clinical medicine.
10(18)
[DOI] 10.3390/jcm10184269.
[PMID] 34575380.
2021
Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice.
Shock (Augusta, Ga.).
55(4):519-525
[DOI] 10.1097/SHK.0000000000001648.
[PMID] 32826817.
2021
Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study.
Shock (Augusta, Ga.).
55(5):587-595
[DOI] 10.1097/SHK.0000000000001671.
[PMID] 33021571.
2021
Stress-related changes in the gut microbiome after trauma.
The journal of trauma and acute care surgery.
91(1):192-199
[DOI] 10.1097/TA.0000000000003209.
[PMID] 34144563.
2021
The Effect of Aging Physiology on Critical Care.
Critical care clinics.
37(1):135-150
[DOI] 10.1016/j.ccc.2020.08.006.
[PMID] 33190766.
2021
The Hematopoietic Stem/Progenitor Cell Response to Hemorrhage, Injury, and Sepsis: A Review of Pathophysiology.
Shock (Augusta, Ga.).
56(1):30-41
[DOI] 10.1097/SHK.0000000000001699.
[PMID] 33234838.
2021
The impact of hindlimb disuse on sepsis-induced myopathy in mice.
Physiological reports.
9(14)
[DOI] 10.14814/phy2.14979.
[PMID] 34309237.
2021
The impact of sarcopenia and acute muscle mass loss on long-term outcomes in critically ill patients with intra-abdominal sepsis.
Journal of cachexia, sarcopenia and muscle.
12(5):1203-1213
[DOI] 10.1002/jcsm.12752.
[PMID] 34196134.
2021
The role of bone marrow microRNA (miR) in erythropoietic dysfunction after severe trauma.
Surgery.
169(5):1206-1212
[DOI] 10.1016/j.surg.2020.11.029.
[PMID] 33413921.
2021
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
35(2)
[DOI] 10.1096/fj.202002150R.
[PMID] 33140449.
2020
Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes.
American journal of surgery.
220(6):1467-1474
[DOI] 10.1016/j.amjsurg.2020.07.016.
[PMID] 32807383.
2020
Artificial Intelligence and Surgical Decision-making.
JAMA surgery.
155(2):148-158
[DOI] 10.1001/jamasurg.2019.4917.
[PMID] 31825465.
2020
Audiovisual Modules to Enhance Informed Consent in the ICU: A Pilot Study.
Critical care explorations.
2(12)
[DOI] 10.1097/CCE.0000000000000278.
[PMID] 33251517.
2020
Cardiovascular death and progression to end-stage renal disease after major surgery in elderly patients.
BJS open.
4(1):145-156
[DOI] 10.1002/bjs5.50232.
[PMID] 32011817.
2020
Clinical decision support recommending ventilator settings during noninvasive ventilation.
Journal of clinical monitoring and computing.
34(5):1043-1049
[DOI] 10.1007/s10877-019-00409-6.
[PMID] 31673945.
2020
Decision analysis and reinforcement learning in surgical decision-making.
Surgery.
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41(2)
2014
Advanced Age Is An Independent Predictor of Complicated Outcomes and Mortality Among Severely Injured Pateints in Hemorrhagic Shock
Shock.
41(2)
2014
Aged mice are unable to mount an effective myeloid response to sepsis.
Journal of immunology (Baltimore, Md. : 1950).
192(2):612-22
[DOI] 10.4049/jimmunol.1302109.
[PMID] 24337739.
2014
Computer versus paper system for recognition and management of sepsis in surgical intensive care.
The journal of trauma and acute care surgery.
76(2):311-7; discussion 318
[DOI] 10.1097/TA.0000000000000121.
[PMID] 24458039.
2014
Enhanced Protective Immunity and Extramedullary Myelopoiesis in Neonatal Sepsis By Ablation of Caspase-1 Signaling
Shock.
41(2)
2014
Genomic Analysis of Individual Leukocyte Populations After Severe Trauma
Shock.
41(2)
2014
Gram stain can be used to safely discontinue vancomycin therapy for early pneumonia in the trauma intensive care unit.
The American surgeon.
80(12):1277-9
[PMID] 25513932.
2014
Host responses to sepsis vary in different low-lethality murine models.
PloS one.
9(5)
[DOI] 10.1371/journal.pone.0094404.
[PMID] 24788351.
2014
Inadequate Pmn Chemokine Receptor Expression After Polymicrobial Abdominal Sepsis Contributes To Defective Pmn Chemotaxis in the Aged
Shock.
41(2)
2014
Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia.
Journal of immunology (Baltimore, Md. : 1950).
192(12):6111-9
[DOI] 10.4049/jimmunol.1302895.
[PMID] 24829407.
2014
Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma.
The journal of trauma and acute care surgery.
76(1):21-9; discussion 29
[DOI] 10.1097/TA.0b013e3182ab1ab5.
[PMID] 24368353.
2014
Protective immunity and defects in the neonatal and elderly immune response to sepsis.
Journal of immunology (Baltimore, Md. : 1950).
192(7):3156-65
[DOI] 10.4049/jimmunol.1301726.
[PMID] 24591376.
2014
The Female Transcriptomic Response After Severe Trauma Is Different From That of Males
Shock.
41(2)
2014
The Lung Neutrophil Transcriptome After Trauma Influences the Worse Outcomes of the Old To Pneumonia
Critical Care Medicine.
42(12, S)
2014
Use of Alum as An Innate Immune Adjuvant in Neonatal Sepsis: What Is the Role of Caspase 1?
Shock.
41(2):29-30
2013
A genomic analysis of Clostridium difficile infections in blunt trauma patients.
The journal of trauma and acute care surgery.
74(1):334-8
[DOI] 10.1097/TA.0b013e3182789426.
[PMID] 23271108.
2013
Acute kidney injury is associated with early cytokine changes after trauma.
The journal of trauma and acute care surgery.
74(4):1005-13
[DOI] 10.1097/TA.0b013e31828586ec.
[PMID] 23511138.
2013
Candida albicans necrotizing soft tissue infection: a case report and literature review of fungal necrotizing soft tissue infections.
Annals of plastic surgery.
70(6):739-41
[DOI] 10.1097/SAP.0b013e31823fac60.
[PMID] 23123606.
2013
Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients.
Critical care medicine.
41(5):1175-85
[DOI] 10.1097/CCM.0b013e318277131c.
[PMID] 23388514.
2013
Excessive nitric oxide impairs wound collagen accumulation.
The Journal of surgical research.
183(1):487-92
[DOI] 10.1016/j.jss.2012.11.056.
[PMID] 23290597.
2013
Identification and description of a novel murine model for polytrauma and shock.
Critical care medicine.
41(4):1075-85
[DOI] 10.1097/CCM.0b013e318275d1f9.
[PMID] 23399937.
2013
Improbable survival after prolonged traumatic cardiopulmonary arrest: revisiting the 15-minute rule.
The American surgeon.
79(6):649-50
[PMID] 23711279.
2013
Is there value in plasma cytokine measurements in patients with severe trauma and sepsis?
Methods (San Diego, Calif.).
61(1):3-9
[DOI] 10.1016/j.ymeth.2013.04.024.
[PMID] 23669589.
2013
National surgical quality improvement program underestimates the risk associated with mild and moderate postoperative acute kidney injury.
Critical care medicine.
41(11):2570-83
[DOI] 10.1097/CCM.0b013e31829860fc.
[PMID] 23928835.
2013
Soybean oil: a potentially new intravascular perfusate.
Perfusion.
28(2):160-6
[DOI] 10.1177/0267659112469643.
[PMID] 23257679.
2012
A Novel Role for Tumor-Induced Expansion of Myeloid Derived Cells in Host Resistance and Cancer Cachexia
Shock.
37
2012
A regionalised strategy for improving motor vehicle-related highway driver deaths using a weighted averages method.
Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention.
18(1):16-21
[DOI] 10.1136/ip.2010.030759.
[PMID] 21685144.
2012
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures.
Annals of surgery.
255(5):993-9
[DOI] 10.1097/SLA.0b013e31824f1ebc.
[PMID] 22470077.
2012
Effect of Postoperative Acute Kidney Injury On Hospital Cost
Critical Care Medicine.
40
2012
Gram Stain Can Be Used To Safely Discontinue Vancomycin Therapy for Early Pneumonia in the Trauma Icu
Critical Care Medicine.
40:U114-U115
2012
Hypdxia-Induced Angiogenic Factors, Progenitor Endothelial Cells and Urinary Hypdxic Markers as Early Markers of Endothelial Injury in Hemorrhagic Shock (Hypper)
Shock.
37:59-60
2012
Identification and Description of a Novel Murine Model for Polytrauma and Shock
Shock.
37
2012
Incidence and Timing of Space Respiratory Isolates in Patients Admitted To a Trauma-Orthopedics-Vascular Intensive Care Unit
Critical Care Medicine.
40
2012
Loss of Myd88 Or Trif Does Not Impact Survival To Neonatal Polymicrobial Sepsis
Shock.
37:29-30
2012
Obese patients show a depressed cytokine profile following severe blunt injury.
Shock (Augusta, Ga.).
37(3):253-6
[DOI] 10.1097/SHK.0b013e3182449c0e.
[PMID] 22266966.
2012
Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care.
The journal of trauma and acute care surgery.
72(6):1491-501
[DOI] 10.1097/TA.0b013e318256e000.
[PMID] 22695412.
2012
Successful Implementation of a Packed Red Blood Cell and Fresh Frozen Plasma Transfusion Protocol in the Surgical Intensive Care Unit
Critical Care Medicine.
40
2012
The acute immunological response to blood transfusion is influenced by polymicrobial sepsis.
Shock (Augusta, Ga.).
38(6):598-606
[DOI] 10.1097/SHK.0b013e318273621a.
[PMID] 23143057.
2011
A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma.
Molecular medicine (Cambridge, Mass.).
17(3-4):281-92
[DOI] 10.2119/molmed.2010.00178.
[PMID] 21085745.
2011
A pilot study on the randomization of inferior vena cava filter placement for venous thromboembolism prophylaxis in high-risk trauma patients.
The Journal of trauma.
71(2):323-8; discussion 328
[DOI] 10.1097/TA.0b013e318226ece1.
[PMID] 21825934.
2011
B cells enhance early innate immune responses during bacterial sepsis.
The Journal of experimental medicine.
208(8):1673-82
[DOI] 10.1084/jem.20101715.
[PMID] 21746813.
2011
Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.
Infection and immunity.
79(7):2746-54
[DOI] 10.1128/IAI.01291-10.
[PMID] 21518789.
2011
Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage.
Laboratory investigation; a journal of technical methods and pathology.
91(12):1787-95
[DOI] 10.1038/labinvest.2011.94.
[PMID] 21931299.
2011
Mopeds and scooters: crash outcomes in a high traffic state.
The Journal of trauma.
71(1):217-22
[DOI] 10.1097/TA.0b013e318208f874.
[PMID] 21399547.
2011
Murine Blood Transfusion Induces Immune Dysregulation During Sepsis
Shock.
35
2011
Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling.
Journal of immunology (Baltimore, Md. : 1950).
187(2):911-8
[DOI] 10.4049/jimmunol.1100588.
[PMID] 21690321.
2011
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.
Journal of immunology (Baltimore, Md. : 1950).
186(1):195-202
[DOI] 10.4049/jimmunol.1002104.
[PMID] 21106855.
2011
The potential influence of common viral infections diagnosed during hospitalization among critically ill patients in the United States.
PloS one.
6(4)
[DOI] 10.1371/journal.pone.0018890.
[PMID] 21573031.
2010
Alternative Modes of Transportation and Their Crash Oucomes
Shock.
33
2010
Analysis of factorial time-course microarrays with application to a clinical study of burn injury.
Proceedings of the National Academy of Sciences of the United States of America.
107(22):9923-8
[DOI] 10.1073/pnas.1002757107.
[PMID] 20479259.
2010
Cecal ligation and puncture.
Current protocols in immunology.
Chapter 19
[DOI] 10.1002/0471142735.im1913s91.
[PMID] 21053304.
2010
The Role of Ip-10/Cxcr3 in the Neonatal Immune Response To a Septic Insult
Shock.
33
2010
Transfusion-Induced Immunosuppression Varies With Blood Age
Shock.
33
2009
Clostridium difficile colitis.
The Surgical clinics of North America.
89(2):483-500, x
[DOI] 10.1016/j.suc.2008.09.014.
[PMID] 19281896.
2009
Major hepatectomy induces phenotypic changes in circulating dendritic cells and monocytes.
Journal of clinical immunology.
29(5):568-81
[DOI] 10.1007/s10875-009-9291-y.
[PMID] 19387804.
2009
Myeloid-Derived Suppressor Cell Expansion Requires Cxcl12-Induced Progenitor Cell Development and Is Necessary for Survival
Shock.
31
2009
Polymicrobial Sepsis Activates Th1 and Protects Against Listeria Infection
Shock.
31
2009
Pseudomonas Eradication After Sepsis Depends On Adequate Neutrophil Function
Shock.
31
2008
Mesenteric lipoblastoma: a rare location in children.
Journal of pediatric surgery.
43(12):e5-7
[DOI] 10.1016/j.jpedsurg.2008.08.019.
[PMID] 19040920.
2008
Pediatric basal cell carcinoma: case reports and literature review.
Journal of pediatric surgery.
43(12):2277-80
[DOI] 10.1016/j.jpedsurg.2008.08.035.
[PMID] 19040953.
2008
Role of Toll-like receptors in the development of sepsis.
Shock (Augusta, Ga.).
29(3):315-21
[DOI] 10.1097/SHK.0b013e318157ee55.
[PMID] 18277854.
2006
Differential response of neuroblastoma cells to TRAIL is independent of PI3K/AKT.
Journal of pediatric surgery.
41(6):1072-80
[PMID] 16769337.
2006
Differential toll-like receptor expression after ex vivo lipopolysaccharide exposure in patients with sepsis and following surgical stress.
Clinical immunology (Orlando, Fla.).
119(2):180-7
[PMID] 16517212.
2006
Dose-dependent improvements in outcome with adenoviral expression of interleukin-10 in a murine model of multisystem organ failure.
Gene therapy.
13(3):276-82
[PMID] 16251998.
2006
Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950).
177(11):7943-9
[PMID] 17114466.
2006
Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning.
Surgery.
140(5):793-802
[PMID] 17084723.
2006
Maturation of murine bone marrow-derived dendritic cells with poly(I:C) produces altered TLR-9 expression and response to CpG DNA.
Immunology letters.
107(2):155-62
[PMID] 17011046.
2006
Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis.
Analytical chemistry.
78(15):5453-61
[PMID] 16878882.
2005
Adenoviral gene transfer of an NF-kappaB super-repressor increases collagen deposition in rodent cutaneous wound healing.
Surgery.
138(5):940-6
[PMID] 16291396.
2005
CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950).
175(5):3282-6
[PMID] 16116220.
2005
Delayed neutralization of interferon-gamma prevents lethality in primate Gram-negative bacteremic shock.
Critical care medicine.
33(4):797-805
[PMID] 15818108.
2005
Differential maturation of murine bone-marrow derived dendritic cells with lipopolysaccharide and tumor necrosis factor-alpha.
Journal of endotoxin research.
11(3):145-60
[PMID] 15949143.
2005
Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions.
Journal of leukocyte biology.
78(4):888-97
[PMID] 16033815.
2005
Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis.
Shock (Augusta, Ga.).
23(6):507-15
[PMID] 15897802.
2005
Splenic transposition is superior to caudal shunt as a model of murine total hepatic ischemia.
Laboratory investigation; a journal of technical methods and pathology.
85(1):90-8
[PMID] 15558060.
2005
The effects of renal transplantation on circulating precursor dendritic cells.
Transplantation proceedings.
37(1):3-6
[PMID] 15808527.
2005
The effects of renal transplantation on peripheral blood dendritic cells.
Clinical Transplantation.
19(5):659-67
[DOI] 10.1111/j.1399-0012.2005.00405.x.
[PMID] 16146559.
2005
Varying blood monocyte and dendritic cell responses after laparoscopic versus open gastric bypass surgery.
Obesity surgery.
15(10):1424-31
[PMID] 16354522.
2004
Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950).
173(5):3035-43
[PMID] 15322163.
2004
Cytokines and wound healing: the role of cytokine and anticytokine therapy in the repair response.
The Journal of burn care & rehabilitation.
25(2):149-60
[PMID] 15091141.
2004
Increased lymphoid tissue apoptosis in baboons with bacteremic shock.
Shock (Augusta, Ga.).
21(6):566-71
[PMID] 15167687.
2003
Blocking interleukin-18: a tumor necrosis factor-alpha lesson already learned.
Critical care medicine.
31(8):2241-2
[PMID] 12973187.
2003
Pediatric sand aspiration: case report and literature review.
Pediatric surgery international.
19(5):409-12
[PMID] 12802608.
2003
Sepsis and the dendritic cell.
Shock (Augusta, Ga.).
20(5):386-401
[PMID] 14560102.
1997
Diabetes-impaired healing and reduced wound nitric oxide synthesis: a possible pathophysiologic correlation.
Surgery.
121(5):513-9
[PMID] 9142149.
1997
Nitric oxide, an autocrine regulator of wound fibroblast synthetic function.
Journal of immunology (Baltimore, Md. : 1950).
158(5):2375-81
[PMID] 9036987.
Grants
Sep 2023
ACTIVE
Cytoskeletal Regulation of Lung Endothelial Pathobiology in ARDS
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Dec 2022
ACTIVE
Sepsis-induced myopathy in aging: influence of disuse on skeletal muscle regeneration
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Aug 2022
ACTIVE
Sepsis and the Systemic Cytokine Storm in Aging and Alzheimer Disease Models
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Jun 2022
– Jun 2022
Phase II: RT Assistant handheld patient safety tool for mechanical ventilation aim 2
Role: Principal Investigator
Funding: CONVERGENT ENGINEERING INC.
via NATL INST OF HLTH NHLBI
Apr 2022
ACTIVE
Affinity Reagents and Sensor Platform Development for Blood Biochemical Monitoring
Role: Other
Funding: NATL INST OF HLTH NIBIB
Jul 2021
ACTIVE
Together: Transforming and Translating Discovery to Improve Health
Role: Project Manager
Funding: NATL INST OF HLTH NCATS
Jun 2021
– May 2022
Phase II: RT Assistant handheld patient safety tool for mechanical ventilation
Role: Principal Investigator
Funding: CONVERGENT ENGINEERING INC.
via NATL INST OF HLTH NHLBI
Jun 2021
ACTIVE
Pathological Myeloid Activation After Sepsis and Trauma
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Jun 2021
– Aug 2022
Sepsis-induced Myopathy in Aging: Influence of disuse on skeletal muscle regeneration
Role: Principal Investigator
Funding: FL STATE UNIV
via NATL INST OF HLTH NIA
May 2021
ACTIVE
Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Feb 2021
– May 2022
Cytokine and Inflammatory Mediator Measurements A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of Intravenous FDY-5301 for the Prevention and Treatment of ICU Acquired Weakness in Major Trauma Patients
Role: Co-Investigator
Funding: FARADAY PHARMACEUTICALS
Sep 2020
ACTIVE
Recombinant InterLeukin-7 (CYT107) to Improve clinical outcomes in lymphopenic pAtients with COVID-19 infection ILIAD 7 trial
Role: Principal Investigator
Funding: REVIMMUNE
Jun 2020
ACTIVE
1Florida Alzheimers Disease Research Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Jun 2020
– Nov 2023
Role of myeloid-derived suppressor cells in aortic aneurysms and rupture
Role: Other
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
May 2020
– Apr 2022
Development of a Designer Proline-rich antimicrobial peptide Chaperone protein inhibitor (DPC) for treating sepsis
Role: Principal Investigator
Funding: ARREVUS
via NATL INST OF HLTH NIAID
Mar 2020
– Jun 2022
Clinical Validation of HostDx Sepsis on NanoString; a prospective observational validation trial
Role: Principal Investigator
Funding: INFLAMMATIX
Jul 2019
ACTIVE
Molecular Biology in Burns and Trauma
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Feb 2019
– Jul 2022
International, multicenter, randomized, double-blinded, placebo-controlled study of Recombinant Interleukin-7 (CYT107) to restore absolute lymphocyte counts (ALC) in patients with Sepsis (IRIS-7 C & D Bridge Studies)
Role: Principal Investigator
Funding: REVIMMUNE
Aug 2018
– Jul 2023
Chronic Stress and Anemia Recovery following Major Trauma
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Jun 2018
– May 2020
PICS: A New Horizon for Surgical Critical Care
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Mar 2018
ACTIVE
Sepsis/Critical Illness Center CT Operating Account
Role: Principal Investigator
Funding: UNIV OF FLORIDA
Jun 2017
– May 2018
PICS: A New Horizon for Surgical Critical Care
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2017
– Mar 2022
University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Jun 2016
– May 2017
PICS: A New Horizon for Surgical Critical Care
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Apr 2016
– Mar 2017
Claude D Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Jun 2015
– May 2016
PICS: A New Horizon for Surgical Critical Care
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Apr 2015
– Jan 2021
Hematopoietic Stem Cell Dysfunction in the Elderly after Severe Injury
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2015
– Mar 2016
Claude D. Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Feb 2015
– Oct 2023
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jul 2007
– Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU
Contact Details
Phones:
- Business:
- (352) 273-5670
Emails:
- Business:
- philip.efron@surgery.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100108
GAINESVILLE FL 32610 - Business Street:
-
HEALTH SCIENCE CNETER
1600 SW ARCHER RD
M-609
GAINESVILLE FL 326103003