Philip A Efron

Philip A Efron, MD, FACS, FCCM

Professor And Director, Laboratory Of Inflammation Biology And Surgical Science; Medical Director, UF Health Surgical Intensive Care Units And Respiratory Therapy, Critical Care Advanced Practice Providers

Department: MD-SURGERY-TRAUMA
Business Phone: (352) 273-5670

About Philip A Efron

Dr. Efron is a professor of surgery and anesthesiology at the University Florida College of Medicine and medical director for the UF Health Shands Hospital surgical intensive care units and respiratory therapy. Dr. Efron established a surgical critical care fellowship program at UF in 2010, which he currently directs. He is an advanced trauma life support instructor and has been selected for committees and leadership positions in several medical societies, including the Shock Society, the Surgical Infection Society and the Society of Critical Care Medicine. He also is a member of the Association for Academic Surgery and the Eastern Association for the Surgery of Trauma and has applied for fellowship in the American College of Surgeons.

He co-directs the Laboratory of Inflammation Biology and Surgical Science and focuses his research on inflammation and immunology in severe injury and infection. Dr. Efron has created novel methodologies for studying trauma and further developed the laboratory’s sepsis research to include well- known factors associated with mortality, including blood product transfusion and aging. In addition, he has led the translational human studies in trauma and sepsis at UF’s surgical intensive care unit.

Dr. Efron joined UF’s acute care surgery section at the end of 2008. After receiving his medical degree from the University of Maryland with multiple honors, Dr. Efron completed his general surgery residency at UF, spending three years as a T32 research fellow in the Laboratory of Inflammation Biology and Surgical Science under the mentorship of Lyle L. Moldawer, Ph.D. During his tenure as a general surgery resident at UF, Dr. Efron received the Edward R. Woodward Surgical Resident’s Award. He completed his critical care fellowship training at Washington University in Saint Louis.

Accomplishments

Career Development Award
2010 · University of Florida Department of Surgery Research
Shock Society Fellowship
2010 · Early Career Investigators
Edward R. Woodward Surgical Resident's Award
2007 · University of Florida
Best Clinical Abstract
2005 · University of Florida Department of Surgery Research Day

Board Certifications

  • Surgery
    American Board of Surgery
  • Surgical Critical Care
    American Board of Surgery

Clinical Profile

Specialties
  • Surgery
Subspecialties
  • Critical Care Surgery
Areas of Interest
  • Acute cholecystitis
  • Appendectomy
  • Appendicitis
  • Emergency airway puncture
  • Extracorporeal membrane oxygenation
  • Hernia
  • Laparoscopic gallbladder removal
  • Necrotizing soft tissue infection
  • Open gallbladder removal
  • Sepsis

Research Profile

Dr. Efron has a professional interest in surgical critical care and trauma, both clinically as well as in the laboratory. He conducts basic science and translational research in sepsis and inflammation. He is currently one of the principal investigators for an NIH-funded P50 center grant for the UF Sepsis and Critical Illness Research Center to study the persistent inflammation, immunosuppression and catabolism syndrome (PICS) following sepsis in surgical intensive care unit patients.

Publications

2021
A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis.
Frontiers in immunology. 12 [DOI] 10.3389/fimmu.2021.696536. [PMID] 34484194.
2021
A road map from single-cell transcriptome to patient classification for the immune response to trauma.
JCI insight. 6(2) [DOI] 10.1172/jci.insight.145108. [PMID] 33320841.
2021
Aluminum Adjuvant Improves Survival Via NLRP3 Inflammasome and Myeloid Non-Granulocytic Cells in a Murine Model of Neonatal Sepsis.
Shock (Augusta, Ga.). 55(2):274-282 [DOI] 10.1097/SHK.0000000000001623. [PMID] 32769820.
2021
Biomarker Evidence of the Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) in Chronic Critical Illness (CCI) After Surgical Sepsis.
Annals of surgery. 274(4):664-673 [DOI] 10.1097/SLA.0000000000005067. [PMID] 34506322.
2021
Cecal Slurry Injection in Neonatal and Adult Mice.
Methods in molecular biology (Clifton, N.J.). 2321:27-41 [DOI] 10.1007/978-1-0716-1488-4_4. [PMID] 34048005.
2021
Chronic “sepsis brain” and regulatory T cells – A promising therapeutic target.
Brain, behavior, and immunity. 93:10-11 [DOI] 10.1016/j.bbi.2021.01.017. [PMID] 33516922.
2021
Chronic Critical Illness Elicits a Unique Circulating Leukocyte Transcriptome in Sepsis Survivors.
Journal of clinical medicine. 10(15) [DOI] 10.3390/jcm10153211. [PMID] 34361995.
2021
Clinical Impact of a Dedicated Trauma Hybrid Operating Room.
Journal of the American College of Surgeons. 232(4):560-570 [DOI] 10.1016/j.jamcollsurg.2020.11.008. [PMID] 33227422.
2021
Distinct immunologic endotypes are associated with clinical trajectory after severe blunt trauma and hemorrhagic shock.
The journal of trauma and acute care surgery. 90(2):257-267 [DOI] 10.1097/TA.0000000000003029. [PMID] 33214489.
2021
Dysregulated Immunity and Immunotherapy after Sepsis.
Journal of clinical medicine. 10(8) [DOI] 10.3390/jcm10081742. [PMID] 33920518.
2021
Enteral Nutrition Administration Record Prescribing Process Using Computerized Order Entry: A New Paradigm and Opportunities to Improve Outcomes in Critically Ill Patients.
JPEN. Journal of parenteral and enteral nutrition. 45(3):507-517 [DOI] 10.1002/jpen.1870. [PMID] 32384191.
2021
Identification of Unique microRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells after Hemorrhagic Shock and Polytrauma in Young and Old Adult Mice.
The journal of trauma and acute care surgery. [DOI] 10.1097/TA.0000000000003350. [PMID] 34252063.
2021
Lipid and lipoprotein predictors of functional outcomes and long-term mortality after surgical sepsis.
Annals of intensive care. 11(1) [DOI] 10.1186/s13613-021-00865-x. [PMID] 34018068.
2021
Mediators of Prolonged Hematopoietic Progenitor Cell Mobilization After Severe Trauma.
The Journal of surgical research. 260:315-324 [DOI] 10.1016/j.jss.2020.11.084. [PMID] 33373851.
2021
Older adults demonstrate biomarker evidence of the persistent inflammation, immunosuppression and catabolism syndrome (PICS) after sepsis.
The journals of gerontology. Series A, Biological sciences and medical sciences. [DOI] 10.1093/gerona/glab080. [PMID] 33721883.
2021
Optimizing predictive strategies for acute kidney injury after major vascular surgery.
Surgery. 170(1):298-303 [DOI] 10.1016/j.surg.2021.01.030. [PMID] 33648766.
2021
Prolonged Chronic Stress and Persistent Iron Dysregulation Prevent Anemia Recovery Following Trauma.
The Journal of surgical research. 267:320-327 [DOI] 10.1016/j.jss.2021.05.034. [PMID] 34186308.
2021
Reply to “Do Not Blame the Rodent for the Failure of Developing Sepsis Therapies”.
Shock (Augusta, Ga.). 56(1):152-153 [DOI] 10.1097/SHK.0000000000001688. [PMID] 33156239.
2021
Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice.
Shock (Augusta, Ga.). 55(4):519-525 [DOI] 10.1097/SHK.0000000000001648. [PMID] 32826817.
2021
Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study.
Shock (Augusta, Ga.). 55(5):587-595 [DOI] 10.1097/SHK.0000000000001671. [PMID] 33021571.
2021
Stress-related changes in the gut microbiome after trauma.
The journal of trauma and acute care surgery. 91(1):192-199 [DOI] 10.1097/TA.0000000000003209. [PMID] 34144563.
2021
The Effect of Aging Physiology on Critical Care.
Critical care clinics. 37(1):135-150 [DOI] 10.1016/j.ccc.2020.08.006. [PMID] 33190766.
2021
The Hematopoietic Stem/Progenitor Cell Response to Hemorrhage, Injury, and Sepsis: A Review of Pathophysiology.
Shock (Augusta, Ga.). 56(1):30-41 [DOI] 10.1097/SHK.0000000000001699. [PMID] 33234838.
2021
The impact of hindlimb disuse on sepsis-induced myopathy in mice.
Physiological reports. 9(14) [DOI] 10.14814/phy2.14979. [PMID] 34309237.
2021
The impact of sarcopenia and acute muscle mass loss on long-term outcomes in critically ill patients with intra-abdominal sepsis.
Journal of cachexia, sarcopenia and muscle. [DOI] 10.1002/jcsm.12752. [PMID] 34196134.
2021
The role of bone marrow microRNA (miR) in erythropoietic dysfunction after severe trauma.
Surgery. 169(5):1206-1212 [DOI] 10.1016/j.surg.2020.11.029. [PMID] 33413921.
2021
Transcriptomic Changes Within Human Bone Marrow After Severe Trauma.
Shock (Augusta, Ga.). [DOI] 10.1097/SHK.0000000000001826. [PMID] 34172608.
2021
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35(2) [DOI] 10.1096/fj.202002150R. [PMID] 33140449.
2020
Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes.
American journal of surgery. 220(6):1467-1474 [DOI] 10.1016/j.amjsurg.2020.07.016. [PMID] 32807383.
2020
Artificial Intelligence and Surgical Decision-making.
JAMA surgery. 155(2):148-158 [DOI] 10.1001/jamasurg.2019.4917. [PMID] 31825465.
2020
Audiovisual Modules to Enhance Informed Consent in the ICU: A Pilot Study.
Critical care explorations. 2(12) [DOI] 10.1097/CCE.0000000000000278. [PMID] 33251517.
2020
Cardiovascular death and progression to end-stage renal disease after major surgery in elderly patients.
BJS open. 4(1):145-156 [DOI] 10.1002/bjs5.50232. [PMID] 32011817.
2020
Clinical decision support recommending ventilator settings during noninvasive ventilation.
Journal of clinical monitoring and computing. 34(5):1043-1049 [DOI] 10.1007/s10877-019-00409-6. [PMID] 31673945.
2020
Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study.
Annals of surgery. [DOI] 10.1097/SLA.0000000000004360. [PMID] 33196489.
2020
Decision analysis and reinforcement learning in surgical decision-making.
Surgery. 168(2):253-266 [DOI] 10.1016/j.surg.2020.04.049. [PMID] 32540036.
2020
Delayed interhospital transfer of critically ill patients with surgical sepsis.
The journal of trauma and acute care surgery. 88(1):169-175 [DOI] 10.1097/TA.0000000000002476. [PMID] 31856021.
2020
Discovery and Validation of Urinary Molecular Signature of Early Sepsis.
Critical care explorations. 2(10) [DOI] 10.1097/CCE.0000000000000195. [PMID] 33063018.
2020
Effect of Beta-Blockade on the Expression of Regulatory MicroRNA after Severe Trauma and Chronic Stress.
Journal of the American College of Surgeons. 230(1):121-129 [DOI] 10.1016/j.jamcollsurg.2019.09.011. [PMID] 31672639.
2020
Identification of Unique mRNA and miRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells After Trauma in Older Adults.
Frontiers in immunology. 11 [DOI] 10.3389/fimmu.2020.01289. [PMID] 32670283.
2020
Immunological Endotyping of Chronic Critical Illness After Severe Sepsis.
Frontiers in medicine. 7 [DOI] 10.3389/fmed.2020.616694. [PMID] 33659259.
2020
Impact of Injury Severity on the Inflammatory State and Severe Anemia.
The Journal of surgical research. 248:109-116 [DOI] 10.1016/j.jss.2019.10.046. [PMID] 31881381.
2020
Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress.
Shock (Augusta, Ga.). 54(4):482-487 [DOI] 10.1097/SHK.0000000000001506. [PMID] 31904616.
2020
Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.
Journal of the American Geriatrics Society. 68(9):1962-1969 [DOI] 10.1111/jgs.16435. [PMID] 32294254.
2020
Persistently increased cell-free DNA concentrations only modestly contribute to outcome and host response in sepsis survivors with chronic critical illness.
Surgery. 167(3):646-652 [DOI] 10.1016/j.surg.2019.11.018. [PMID] 31898953.
2020
Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study.
Critical care (London, England). 24(1) [DOI] 10.1186/s13054-020-02917-3. [PMID] 32381107.
2020
Prospective Validation of a Transcriptomic Metric in Severe Trauma.
Annals of surgery. 271(5):802-810 [DOI] 10.1097/SLA.0000000000003204. [PMID] 30688688.
2020
The Clinical Presentation and Immunology of Viral Pneumonia and Implications for Management of Coronavirus Disease 2019.
Critical care explorations. 2(4) [DOI] 10.1097/CCE.0000000000000109. [PMID] 32426751.
2020
The effects of selective beta-adrenergic blockade on bone marrow dysfunction following severe trauma and chronic stress.
American journal of surgery. 220(5):1312-1318 [DOI] 10.1016/j.amjsurg.2020.06.058. [PMID] 32741547.
2020
Vitamin D status is associated with hepcidin and hemoglobin concentrations in patients with severe traumatic injury.
The journal of trauma and acute care surgery. 89(6):1124-1130 [DOI] 10.1097/TA.0000000000002895. [PMID] 32769953.
2020
What’s New in Shock, September 2020?
Shock (Augusta, Ga.). 54(3):277-279 [DOI] 10.1097/SHK.0000000000001588. [PMID] 32796495.
2019
Age and Sex Influence the Hippocampal Response and Recovery Following Sepsis.
Molecular neurobiology. 56(12):8557-8572 [DOI] 10.1007/s12035-019-01681-y. [PMID] 31278440.
2019
Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma.
Scientific reports. 9(1) [DOI] 10.1038/s41598-019-50044-z. [PMID] 31541163.
2019
Chronic stress induces persistent low-grade inflammation.
American journal of surgery. 218(4):677-683 [DOI] 10.1016/j.amjsurg.2019.07.006. [PMID] 31378316.
2019
Current Epidemiology of Surgical Sepsis: Discordance Between Inpatient Mortality and 1-year Outcomes.
Annals of surgery. 270(3):502-510 [DOI] 10.1097/SLA.0000000000003458. [PMID] 31356275.
2019
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.
Critical care (London, England). 23(1) [DOI] 10.1186/s13054-019-2628-x. [PMID] 31722736.
2019
Occult bowel injury after blunt abdominal trauma.
American journal of surgery. 218(2):266-270 [DOI] 10.1016/j.amjsurg.2018.11.018. [PMID] 30509454.
2019
Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.
Critical care medicine. 47(11):e919-e929 [DOI] 10.1097/CCM.0000000000003926. [PMID] 31389840.
2019
Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints.
Shock (Augusta, Ga.). 51(1):10-22 [DOI] 10.1097/SHK.0000000000001243. [PMID] 30106874.
2019
Persistent inflammation and anemia among critically ill septic patients.
The journal of trauma and acute care surgery. 86(2):260-267 [DOI] 10.1097/TA.0000000000002147. [PMID] 30489504.
2019
Persistently Elevated Glucagon-Like Peptide-1 Levels among Critically Ill Surgical Patients after Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes.
Journal of the American College of Surgeons. 229(1):58-67.e1 [DOI] 10.1016/j.jamcollsurg.2019.04.014. [PMID] 30991107.
2019
Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors.
Critical care (London, England). 23(1) [DOI] 10.1186/s13054-019-2505-7. [PMID] 31234943.
2019
Prophylactic antibiotics in head and neck free flap surgery: A novel protocol put to the test.
American journal of otolaryngology. 40(6) [DOI] 10.1016/j.amjoto.2019.102276. [PMID] 31447185.
2019
Systemic Regulation of Bone Marrow Stromal Cytokines After Severe Trauma.
The Journal of surgical research. 243:220-228 [DOI] 10.1016/j.jss.2019.05.033. [PMID] 31207479.
2019
The authors reply.
Critical care medicine. 47(5) [DOI] 10.1097/CCM.0000000000003691. [PMID] 30985464.
2019
The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs.
Critical care medicine. 47(4):566-573 [DOI] 10.1097/CCM.0000000000003655. [PMID] 30664526.
2019
The effects of propranolol and clonidine on bone marrow expression of hematopoietic cytokines following trauma and chronic stress.
American journal of surgery. 218(5):858-863 [DOI] 10.1016/j.amjsurg.2019.02.023. [PMID] 30827533.
2019
The Impact of Prior Laparotomy and Intra-abdominal Adhesions on Bowel and Mesenteric Injury Following Blunt Abdominal Trauma.
World journal of surgery. 43(2):457-465 [DOI] 10.1007/s00268-018-4792-6. [PMID] 30225563.
2019
The impact of standardized protocol implementation for surgical damage control and temporary abdominal closure after emergent laparotomy.
The journal of trauma and acute care surgery. 86(4):670-678 [DOI] 10.1097/TA.0000000000002170. [PMID] 30562327.
2019
What’s New in Shock, December 2019?
Shock (Augusta, Ga.). 52(6):566-567 [DOI] 10.1097/SHK.0000000000001438. [PMID] 31725108.
2018
A Case for Change in Adult Critical Care Training for Physicians in the United States: A White Paper Developed by the Critical Care as a Specialty Task Force of the Society of Critical Care Medicine.
Critical care medicine. 46(10):1577-1584 [DOI] 10.1097/CCM.0000000000003266. [PMID] 30015669.
2018
A protocol for non-operative management of uncomplicated appendicitis.
The journal of trauma and acute care surgery. 84(2):358-364 [DOI] 10.1097/TA.0000000000001709. [PMID] 29370051.
2018
Adjuvant pretreatment with alum protects neonatal mice in sepsis through myeloid cell activation.
Clinical and experimental immunology. 191(3):268-278 [DOI] 10.1111/cei.13072. [PMID] 29052227.
2018
Anemia and blood transfusion in elderly trauma patients.
The Journal of surgical research. 229:288-293 [DOI] 10.1016/j.jss.2018.04.021. [PMID] 29937004.
2018
Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.
The journal of trauma and acute care surgery. 84(2):342-349 [DOI] 10.1097/TA.0000000000001758. [PMID] 29251709.
2018
Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.01511. [PMID] 30013565.
2018
Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.
Infection. 46(5):745-747 [DOI] 10.1007/s15010-018-1197-2. [PMID] 30225655.
2018
Effect of Time to Operation on Value of Care in Acute Care Surgery.
World journal of surgery. 42(8):2356-2363 [DOI] 10.1007/s00268-018-4476-2. [PMID] 29352339.
2018
Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis.
Shock (Augusta, Ga.). 49(3):249-258 [DOI] 10.1097/SHK.0000000000000981. [PMID] 28885387.
2018
Geriatric traumatic brain injury-What we know and what we don’t.
The journal of trauma and acute care surgery. 85(4):788-798 [DOI] 10.1097/TA.0000000000001910. [PMID] 30256343.
2018
Hypertonic saline resuscitation after emergent laparotomy and temporary abdominal closure.
The journal of trauma and acute care surgery. 84(2):350-357 [DOI] 10.1097/TA.0000000000001730. [PMID] 29140948.
2018
Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.00595. [PMID] 29670613.
2018
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis.
Shock (Augusta, Ga.). 50(4):377-380 [DOI] 10.1097/SHK.0000000000001212. [PMID] 30106875.
2018
Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.
Intensive care medicine experimental. 6(1) [DOI] 10.1186/s40635-018-0189-y. [PMID] 30112605.
2018
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.
Infection. 46(5):687-691 [DOI] 10.1007/s15010-018-1183-8. [PMID] 30105433.
2018
Mouse Injury Model of Polytrauma and Shock.
Methods in molecular biology (Clifton, N.J.). 1717:1-15 [DOI] 10.1007/978-1-4939-7526-6_1. [PMID] 29468579.
2018
Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.
Surgery. 164(2):178-184 [DOI] 10.1016/j.surg.2018.04.011. [PMID] 29807651.
2018
Persistent injury-associated anemia and aging: Novel insights.
The journal of trauma and acute care surgery. 84(3):490-496 [DOI] 10.1097/TA.0000000000001766. [PMID] 29466280.
2018
Persistent injury-associated anemia in aged rats.
Experimental gerontology. 103:63-68 [DOI] 10.1016/j.exger.2018.01.001. [PMID] 29307734.
2018
Review: The Perioperative Use of Thromboelastography for Liver Transplant Patients.
Transplantation proceedings. 50(10):3552-3558 [DOI] 10.1016/j.transproceed.2018.07.032. [PMID] 30577236.
2018
Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults.
PloS one. 13(10) [DOI] 10.1371/journal.pone.0205327. [PMID] 30300408.
2018
Successful nonoperative management of uncomplicated appendicitis: predictors and outcomes.
The Journal of surgical research. 222:212-218.e2 [DOI] 10.1016/j.jss.2017.10.006. [PMID] 29146455.
2018
The effects of beta blockade and clonidine on persistent injury-associated anemia.
The Journal of surgical research. 230:175-180 [DOI] 10.1016/j.jss.2018.06.001. [PMID] 29960715.
2018
The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients.
The journal of trauma and acute care surgery. 85(2):247-255 [DOI] 10.1097/TA.0000000000001921. [PMID] 29613958.
2018
The Post-injury Inflammatory State and the Bone Marrow Response to Anemia.
American Journal of Respiratory and Critical Care Medicine. 198(5):629-638 [DOI] 10.1164/rccm.201712-2536OC. [PMID] 29768025.
2018
What’s New in Shock, April 2018?
Shock (Augusta, Ga.). 49(4):355-357 [DOI] 10.1097/SHK.0000000000001101. [PMID] 29528951.
2017
Acute Kidney Injury Following Exploratory Laparotomy and Temporary Abdominal Closure.
Shock (Augusta, Ga.). 48(1):5-10 [DOI] 10.1097/SHK.0000000000000825. [PMID] 28009772.
2017
Characterization of hypoalbuminemia following temporary abdominal closure.
The journal of trauma and acute care surgery. 83(4):650-656 [DOI] 10.1097/TA.0000000000001553. [PMID] 28837537.
2017
Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress.
Surgery. 161(3):795-802 [DOI] 10.1016/j.surg.2016.08.043. [PMID] 27742030.
2017
Clonidine restores vascular endothelial growth factor expression and improves tissue repair following severe trauma.
American journal of surgery. 214(4):610-615 [DOI] 10.1016/j.amjsurg.2017.06.019. [PMID] 28666582.
2017
Computed tomography evidence of fluid in the hernia sac predicts surgical site infection following mesh repair of acutely incarcerated ventral and groin hernias.
The journal of trauma and acute care surgery. 83(1):170-174 [DOI] 10.1097/TA.0000000000001503. [PMID] 28426559.
2017
Daily propranolol administration reduces persistent injury-associated anemia after severe trauma and chronic stress.
The journal of trauma and acute care surgery. 82(4):714-721 [DOI] 10.1097/TA.0000000000001374. [PMID] 28099381.
2017
Early bronchoalveolar lavage for intubated trauma patients with TBI or chest trauma.
Journal of critical care. 39:78-82 [DOI] 10.1016/j.jcrc.2017.02.010. [PMID] 28231518.
2017
Editorial: Myeloid-derived suppressor cells: a new therapeutic target in sepsis patients.
Journal of leukocyte biology. 102(2):185-187 [DOI] 10.1189/jlb.5CE0317-080R. [PMID] 28765508.
2017
Effects of trauma, hemorrhagic shock, and chronic stress on lung vascular endothelial growth factor.
The Journal of surgical research. 210:15-21 [DOI] 10.1016/j.jss.2016.10.023. [PMID] 28457321.
2017
Emergent laparotomy and temporary abdominal closure for the cirrhotic patient.
The Journal of surgical research. 210:108-114 [DOI] 10.1016/j.jss.2016.11.013. [PMID] 28457316.
2017
Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock.
Annals of surgery. 265(4):827-834 [DOI] 10.1097/SLA.0000000000001783. [PMID] 27163951.
2017
Improved outcomes following implementation of an acute gastrointestinal bleeding multidisciplinary protocol.
The journal of trauma and acute care surgery. 83(1):41-46 [DOI] 10.1097/TA.0000000000001295. [PMID] 27779592.
2017
Improved survival after induction of sepsis by cecal slurry in PD-1 knockout murine neonates.
Surgery. 161(5):1387-1393 [DOI] 10.1016/j.surg.2016.11.008. [PMID] 28012568.
2017
Microbial recognition and danger signals in sepsis and trauma.
Biochimica et biophysica acta. Molecular basis of disease. 1863(10 Pt B):2564-2573 [DOI] 10.1016/j.bbadis.2017.01.013. [PMID] 28115287.
2017
Murine Models of Sepsis and Trauma: Can We Bridge the Gap?
ILAR journal. 58(1):90-105 [DOI] 10.1093/ilar/ilx007. [PMID] 28444204.
2017
Neural network prediction of severe lower intestinal bleeding and the need for surgical intervention.
The Journal of surgical research. 212:42-47 [DOI] 10.1016/j.jss.2016.12.032. [PMID] 28550920.
2017
Persistent injury-associated anemia: the role of the bone marrow microenvironment.
The Journal of surgical research. 214:240-246 [DOI] 10.1016/j.jss.2017.03.018. [PMID] 28624051.
2017
Predicting appendiceal tumors among patients with appendicitis.
The journal of trauma and acute care surgery. 82(4):771-775 [DOI] 10.1097/TA.0000000000001378. [PMID] 28099380.
2017
Routine surveillance cholangiography after percutaneous cholecystostomy delays drain removal and cholecystectomy.
The journal of trauma and acute care surgery. 82(2):351-355 [DOI] 10.1097/TA.0000000000001315. [PMID] 27893641.
2017
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.
BMJ open. 7(7) [DOI] 10.1136/bmjopen-2016-015136. [PMID] 28765125.
2017
Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome.
Critical care medicine. 45(2):253-262 [DOI] 10.1097/CCM.0000000000002074. [PMID] 27632674.
2017
Severe trauma and chronic stress activates extramedullary erythropoiesis.
The journal of trauma and acute care surgery. 83(1):144-150 [DOI] 10.1097/TA.0000000000001537. [PMID] 28452894.
2017
Temporary abdominal closure for trauma and intra-abdominal sepsis: Different patients, different outcomes.
The journal of trauma and acute care surgery. 82(2):345-350 [DOI] 10.1097/TA.0000000000001283. [PMID] 27787442.
2017
The authors reply.
Critical care medicine. 45(7):e740-e741 [DOI] 10.1097/CCM.0000000000002469. [PMID] 28622238.
2017
The effects of red cell transfusion donor age on nosocomial infection among trauma patients.
American journal of surgery. 214(4):672-676 [DOI] 10.1016/j.amjsurg.2017.07.004. [PMID] 28720216.
2017
The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two Level-One Trauma Centers.
Critical care medicine. 45(12):1989-1996 [DOI] 10.1097/CCM.0000000000002697. [PMID] 28837430.
2017
Unique transcriptomic response to sepsis is observed among patients of different age groups.
PloS one. 12(9) [DOI] 10.1371/journal.pone.0184159. [PMID] 28886074.
2016
Characterization of erythropoietin and hepcidin in the regulation of persistent injury-associated anemia.
The journal of trauma and acute care surgery. 81(4):705-12 [DOI] 10.1097/TA.0000000000001163. [PMID] 27398985.
2016
Integrating “big data” into surgical practice.
Surgery. 159(2):371-4 [DOI] 10.1016/j.surg.2015.08.043. [PMID] 26603852.
2016
Mortality and Cost of Acute and Chronic Kidney Disease after Vascular Surgery.
Annals of vascular surgery. 30:72-81.e1 [DOI] 10.1016/j.avsg.2015.04.092. [PMID] 26187703.
2016
Patterns of gene expression among murine models of hemorrhagic shock/trauma and sepsis.
Physiological genomics. 48(2):135-44 [DOI] 10.1152/physiolgenomics.00072.2015. [PMID] 26578697.
2016
Preoperative assessment of the risk for multiple complications after surgery.
Surgery. 160(2):463-72 [DOI] 10.1016/j.surg.2016.04.013. [PMID] 27238354.
2016
Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock.
The journal of trauma and acute care surgery. 81(3):478-85 [DOI] 10.1097/TA.0000000000001113. [PMID] 27306446.
2016
What’s New in Shock, November 2016?
Shock (Augusta, Ga.). 46(5):465-467 [PMID] 27755473.
View on: PubMed
2016
β-Blockade use for Traumatic Injuries and Immunomodulation: A Review of Proposed Mechanisms and Clinical Evidence.
Shock (Augusta, Ga.). 46(4):341-51 [DOI] 10.1097/SHK.0000000000000636. [PMID] 27172161.
2015
A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged.
Journal of immunology (Baltimore, Md. : 1950). 195(5):2396-407 [DOI] 10.4049/jimmunol.1500984. [PMID] 26246141.
2015
A Review of GM-CSF Therapy in Sepsis.
Medicine. 94(50) [DOI] 10.1097/MD.0000000000002044. [PMID] 26683913.
2015
Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.
Critical care (London, England). 19 [DOI] 10.1186/s13054-015-0788-x. [PMID] 25880307.
2015
Alum as a Preventative Therapy Abolishes Mortality in Murine Neonatal Sepsis By Improving Effector Cell Function and Bacterial Clearance
Shock. 43(6, 1)
2015
Blunt Trauma Releases Cell Free Nucleic Acids, But Its Prognostic Relevance Does Not Surface Until the Following Day.
Shock. 43(6, 1)
2015
Clostridium difficile Infections after Blunt Trauma: A Different Patient Population?
Surgical infections. 16(4):421-7 [DOI] 10.1089/sur.2013.141. [PMID] 26207402.
2015
Cost and Mortality Associated With Postoperative Acute Kidney Injury.
Annals of surgery. 261(6):1207-14 [DOI] 10.1097/SLA.0000000000000732. [PMID] 24887982.
2015
Delayed emergency myelopoiesis following polymicrobial sepsis in neonates.
Innate immunity. 21(4):386-91 [DOI] 10.1177/1753425914542445. [PMID] 25106654.
2015
Early Angiogenic Balance and Adverse Long-Term Outcomes in Sepsis
Shock. 43(6, 1)
2015
Human Myeloid Derived Suppressor Cells Induce Immune Suppression After Severe Sepsis
Shock. 43(6, 1)
2015
Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation.
Immunology. 145(2):300-11 [DOI] 10.1111/imm.12450. [PMID] 25684123.
2015
Patterns of Gene Expression Among Murine Models of Hemorrhagic Shock Trauma and Sepsis
Shock. 43(6, 1):111-112
2015
Sepsis Enhances Myeloid Cell Function and Immune Protection From Secondary Listeria Infection Through Tnf Alpha Signaling
Shock. 43(6, 1)
2015
Sphingosine-1-Phospate/S1P Receptors Modulate Hematopoietic Progenitor Cell Mobilization Following Trauma/Hemorrhagic Shock
Shock. 43(6, 1)
2015
Successful aging: Advancing the science of physical independence in older adults.
Ageing research reviews. 24(Pt B):304-27 [DOI] 10.1016/j.arr.2015.09.005. [PMID] 26462882.
2015
Successful implementation of a packed red blood cell and fresh frozen plasma transfusion protocol in the surgical intensive care unit.
PloS one. 10(5) [DOI] 10.1371/journal.pone.0126895. [PMID] 26010247.
2015
Successful Rescue Therapy for Severe Acute Anemia: Managing the Critically Ill Jehovah’s Witness.
The American surgeon. 81(6):E263-5 [PMID] 26031262.
View on: PubMed
2015
The future of murine sepsis and trauma research models.
Journal of leukocyte biology. 98(6):945-52 [DOI] 10.1189/jlb.5MR0315-127R. [PMID] 26034205.
2015
The Genomic Response After Burn Injury Predicts Organ Dysfunction and Mortality
Shock. 43(6, 1)
2015
The Monocyte That Wasn’t.
Critical care medicine. 43(7):1532-4 [DOI] 10.1097/CCM.0000000000001046. [PMID] 26079230.
2015
TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis.
Journal of immunology (Baltimore, Md. : 1950). 194(3):1169-77 [DOI] 10.4049/jimmunol.1302676. [PMID] 25548220.
2014
A better understanding of why murine models of trauma do not recapitulate the human syndrome.
Critical care medicine. 42(6):1406-13 [DOI] 10.1097/CCM.0000000000000222. [PMID] 24413577.
2014
A Comparison of the Leukocyte Genomic Responses To Sterile Or Infectious Inflammation
Shock. 41(2)
2014
Advanced Age Is An Independent Predictor of Complicated Outcomes and Mortality Among Severely Injured Pateints in Hemorrhagic Shock
Shock. 41(2)
2014
Aged mice are unable to mount an effective myeloid response to sepsis.
Journal of immunology (Baltimore, Md. : 1950). 192(2):612-22 [DOI] 10.4049/jimmunol.1302109. [PMID] 24337739.
2014
Computer versus paper system for recognition and management of sepsis in surgical intensive care.
The journal of trauma and acute care surgery. 76(2):311-7; discussion 318 [DOI] 10.1097/TA.0000000000000121. [PMID] 24458039.
2014
Enhanced Protective Immunity and Extramedullary Myelopoiesis in Neonatal Sepsis By Ablation of Caspase-1 Signaling
Shock. 41(2)
2014
Genomic Analysis of Individual Leukocyte Populations After Severe Trauma
Shock. 41(2)
2014
Gram stain can be used to safely discontinue vancomycin therapy for early pneumonia in the trauma intensive care unit.
The American surgeon. 80(12):1277-9 [PMID] 25513932.
View on: PubMed
2014
Host responses to sepsis vary in different low-lethality murine models.
PloS one. 9(5) [DOI] 10.1371/journal.pone.0094404. [PMID] 24788351.
2014
Inadequate Pmn Chemokine Receptor Expression After Polymicrobial Abdominal Sepsis Contributes To Defective Pmn Chemotaxis in the Aged
Shock. 41(2)
2014
Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia.
Journal of immunology (Baltimore, Md. : 1950). 192(12):6111-9 [DOI] 10.4049/jimmunol.1302895. [PMID] 24829407.
2014
Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma.
The journal of trauma and acute care surgery. 76(1):21-9; discussion 29 [DOI] 10.1097/TA.0b013e3182ab1ab5. [PMID] 24368353.
2014
Protective immunity and defects in the neonatal and elderly immune response to sepsis.
Journal of immunology (Baltimore, Md. : 1950). 192(7):3156-65 [DOI] 10.4049/jimmunol.1301726. [PMID] 24591376.
2014
The Female Transcriptomic Response After Severe Trauma Is Different From That of Males
Shock. 41(2)
2014
The Lung Neutrophil Transcriptome After Trauma Influences the Worse Outcomes of the Old To Pneumonia
Critical Care Medicine. 42(12, S)
2014
Use of Alum as An Innate Immune Adjuvant in Neonatal Sepsis: What Is the Role of Caspase 1?
Shock. 41(2):29-30
2013
A genomic analysis of Clostridium difficile infections in blunt trauma patients.
The journal of trauma and acute care surgery. 74(1):334-8 [DOI] 10.1097/TA.0b013e3182789426. [PMID] 23271108.
2013
Acute kidney injury is associated with early cytokine changes after trauma.
The journal of trauma and acute care surgery. 74(4):1005-13 [DOI] 10.1097/TA.0b013e31828586ec. [PMID] 23511138.
2013
Candida albicans necrotizing soft tissue infection: a case report and literature review of fungal necrotizing soft tissue infections.
Annals of plastic surgery. 70(6):739-41 [DOI] 10.1097/SAP.0b013e31823fac60. [PMID] 23123606.
2013
Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients.
Critical care medicine. 41(5):1175-85 [DOI] 10.1097/CCM.0b013e318277131c. [PMID] 23388514.
2013
Excessive nitric oxide impairs wound collagen accumulation.
The Journal of surgical research. 183(1):487-92 [DOI] 10.1016/j.jss.2012.11.056. [PMID] 23290597.
2013
Identification and description of a novel murine model for polytrauma and shock.
Critical care medicine. 41(4):1075-85 [DOI] 10.1097/CCM.0b013e318275d1f9. [PMID] 23399937.
2013
Improbable survival after prolonged traumatic cardiopulmonary arrest: revisiting the 15-minute rule.
The American surgeon. 79(6):649-50 [PMID] 23711279.
View on: PubMed
2013
Is there value in plasma cytokine measurements in patients with severe trauma and sepsis?
Methods (San Diego, Calif.). 61(1):3-9 [DOI] 10.1016/j.ymeth.2013.04.024. [PMID] 23669589.
2013
Soybean oil: a potentially new intravascular perfusate.
Perfusion. 28(2):160-6 [DOI] 10.1177/0267659112469643. [PMID] 23257679.
2012
A Novel Role for Tumor-Induced Expansion of Myeloid Derived Cells in Host Resistance and Cancer Cachexia
Shock. 37
2012
A regionalised strategy for improving motor vehicle-related highway driver deaths using a weighted averages method.
Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention. 18(1):16-21 [DOI] 10.1136/ip.2010.030759. [PMID] 21685144.
2012
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures.
Annals of surgery. 255(5):993-9 [DOI] 10.1097/SLA.0b013e31824f1ebc. [PMID] 22470077.
2012
Effect of Postoperative Acute Kidney Injury On Hospital Cost
Critical Care Medicine. 40
2012
Gram Stain Can Be Used To Safely Discontinue Vancomycin Therapy for Early Pneumonia in the Trauma Icu
Critical Care Medicine. 40:U114-U115
2012
Hypdxia-Induced Angiogenic Factors, Progenitor Endothelial Cells and Urinary Hypdxic Markers as Early Markers of Endothelial Injury in Hemorrhagic Shock (Hypper)
Shock. 37:59-60
2012
Identification and Description of a Novel Murine Model for Polytrauma and Shock
Shock. 37
2012
Incidence and Timing of Space Respiratory Isolates in Patients Admitted To a Trauma-Orthopedics-Vascular Intensive Care Unit
Critical Care Medicine. 40
2012
Loss of Myd88 Or Trif Does Not Impact Survival To Neonatal Polymicrobial Sepsis
Shock. 37:29-30
2012
Obese patients show a depressed cytokine profile following severe blunt injury.
Shock (Augusta, Ga.). 37(3):253-6 [DOI] 10.1097/SHK.0b013e3182449c0e. [PMID] 22266966.
2012
Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care.
The journal of trauma and acute care surgery. 72(6):1491-501 [DOI] 10.1097/TA.0b013e318256e000. [PMID] 22695412.
2012
Successful Implementation of a Packed Red Blood Cell and Fresh Frozen Plasma Transfusion Protocol in the Surgical Intensive Care Unit
Critical Care Medicine. 40
2012
The acute immunological response to blood transfusion is influenced by polymicrobial sepsis.
Shock (Augusta, Ga.). 38(6):598-606 [DOI] 10.1097/SHK.0b013e318273621a. [PMID] 23143057.
2011
A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma.
Molecular medicine (Cambridge, Mass.). 17(3-4):281-92 [DOI] 10.2119/molmed.2010.00178. [PMID] 21085745.
2011
A pilot study on the randomization of inferior vena cava filter placement for venous thromboembolism prophylaxis in high-risk trauma patients.
The Journal of trauma. 71(2):323-8; discussion 328 [DOI] 10.1097/TA.0b013e318226ece1. [PMID] 21825934.
2011
B cells enhance early innate immune responses during bacterial sepsis.
The Journal of experimental medicine. 208(8):1673-82 [DOI] 10.1084/jem.20101715. [PMID] 21746813.
2011
Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.
Infection and immunity. 79(7):2746-54 [DOI] 10.1128/IAI.01291-10. [PMID] 21518789.
2011
Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage.
Laboratory investigation; a journal of technical methods and pathology. 91(12):1787-95 [DOI] 10.1038/labinvest.2011.94. [PMID] 21931299.
2011
Mopeds and scooters: crash outcomes in a high traffic state.
The Journal of trauma. 71(1):217-22 [DOI] 10.1097/TA.0b013e318208f874. [PMID] 21399547.
2011
Murine Blood Transfusion Induces Immune Dysregulation During Sepsis
Shock. 35
2011
Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling.
Journal of immunology (Baltimore, Md. : 1950). 187(2):911-8 [DOI] 10.4049/jimmunol.1100588. [PMID] 21690321.
2011
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.
Journal of immunology (Baltimore, Md. : 1950). 186(1):195-202 [DOI] 10.4049/jimmunol.1002104. [PMID] 21106855.
2011
The potential influence of common viral infections diagnosed during hospitalization among critically ill patients in the United States.
PloS one. 6(4) [DOI] 10.1371/journal.pone.0018890. [PMID] 21573031.
2010
Alternative Modes of Transportation and Their Crash Oucomes
Shock. 33
2010
Analysis of factorial time-course microarrays with application to a clinical study of burn injury.
Proceedings of the National Academy of Sciences of the United States of America. 107(22):9923-8 [DOI] 10.1073/pnas.1002757107. [PMID] 20479259.
2010
Cecal ligation and puncture.
Current protocols in immunology. Chapter 19 [DOI] 10.1002/0471142735.im1913s91. [PMID] 21053304.
2010
National surgical quality improvement program underestimates the risk associated with mild and moderate postoperative acute kidney injury.
Critical care medicine. 38:14-83
2010
The Role of Ip-10/Cxcr3 in the Neonatal Immune Response To a Septic Insult
Shock. 33
2010
Transfusion-Induced Immunosuppression Varies With Blood Age
Shock. 33
2009
Clostridium difficile colitis.
The Surgical clinics of North America. 89(2):483-500, x [DOI] 10.1016/j.suc.2008.09.014. [PMID] 19281896.
2009
Major hepatectomy induces phenotypic changes in circulating dendritic cells and monocytes.
Journal of clinical immunology. 29(5):568-81 [DOI] 10.1007/s10875-009-9291-y. [PMID] 19387804.
2009
Myeloid-Derived Suppressor Cell Expansion Requires Cxcl12-Induced Progenitor Cell Development and Is Necessary for Survival
Shock. 31
2009
Polymicrobial Sepsis Activates Th1 and Protects Against Listeria Infection
Shock. 31
2009
Pseudomonas Eradication After Sepsis Depends On Adequate Neutrophil Function
Shock. 31
2008
Mesenteric lipoblastoma: a rare location in children.
Journal of pediatric surgery. 43(12):e5-7 [DOI] 10.1016/j.jpedsurg.2008.08.019. [PMID] 19040920.
2008
Pediatric basal cell carcinoma: case reports and literature review.
Journal of pediatric surgery. 43(12):2277-80 [DOI] 10.1016/j.jpedsurg.2008.08.035. [PMID] 19040953.
2008
Role of Toll-like receptors in the development of sepsis.
Shock (Augusta, Ga.). 29(3):315-21 [DOI] 10.1097/SHK.0b013e318157ee55. [PMID] 18277854.
2006
Differential response of neuroblastoma cells to TRAIL is independent of PI3K/AKT.
Journal of pediatric surgery. 41(6):1072-80 [PMID] 16769337.
View on: PubMed
2006
Differential toll-like receptor expression after ex vivo lipopolysaccharide exposure in patients with sepsis and following surgical stress.
Clinical immunology (Orlando, Fla.). 119(2):180-7 [PMID] 16517212.
View on: PubMed
2006
Dose-dependent improvements in outcome with adenoviral expression of interleukin-10 in a murine model of multisystem organ failure.
Gene therapy. 13(3):276-82 [PMID] 16251998.
View on: PubMed
2006
Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950). 177(11):7943-9 [PMID] 17114466.
View on: PubMed
2006
Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning.
Surgery. 140(5):793-802 [PMID] 17084723.
View on: PubMed
2006
Maturation of murine bone marrow-derived dendritic cells with poly(I:C) produces altered TLR-9 expression and response to CpG DNA.
Immunology letters. 107(2):155-62 [PMID] 17011046.
View on: PubMed
2006
Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis.
Analytical chemistry. 78(15):5453-61 [PMID] 16878882.
View on: PubMed
2005
Adenoviral gene transfer of an NF-kappaB super-repressor increases collagen deposition in rodent cutaneous wound healing.
Surgery. 138(5):940-6 [PMID] 16291396.
View on: PubMed
2005
CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950). 175(5):3282-6 [PMID] 16116220.
View on: PubMed
2005
Delayed neutralization of interferon-gamma prevents lethality in primate Gram-negative bacteremic shock.
Critical care medicine. 33(4):797-805 [PMID] 15818108.
View on: PubMed
2005
Differential maturation of murine bone-marrow derived dendritic cells with lipopolysaccharide and tumor necrosis factor-alpha.
Journal of endotoxin research. 11(3):145-60 [PMID] 15949143.
View on: PubMed
2005
Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions.
Journal of leukocyte biology. 78(4):888-97 [PMID] 16033815.
View on: PubMed
2005
Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis.
Shock (Augusta, Ga.). 23(6):507-15 [PMID] 15897802.
View on: PubMed
2005
Splenic transposition is superior to caudal shunt as a model of murine total hepatic ischemia.
Laboratory investigation; a journal of technical methods and pathology. 85(1):90-8 [PMID] 15558060.
View on: PubMed
2005
The effects of renal transplantation on circulating precursor dendritic cells.
Transplantation proceedings. 37(1):3-6 [PMID] 15808527.
View on: PubMed
2005
The effects of renal transplantation on peripheral blood dendritic cells.
Clinical Transplantation. 19(5):659-67 [DOI] 10.1111/j.1399-0012.2005.00405.x. [PMID] 16146559.
2005
Varying blood monocyte and dendritic cell responses after laparoscopic versus open gastric bypass surgery.
Obesity surgery. 15(10):1424-31 [PMID] 16354522.
View on: PubMed
2004
Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950). 173(5):3035-43 [PMID] 15322163.
View on: PubMed
2004
Cytokines and wound healing: the role of cytokine and anticytokine therapy in the repair response.
The Journal of burn care & rehabilitation. 25(2):149-60 [PMID] 15091141.
View on: PubMed
2004
Increased lymphoid tissue apoptosis in baboons with bacteremic shock.
Shock (Augusta, Ga.). 21(6):566-71 [PMID] 15167687.
View on: PubMed
2003
Blocking interleukin-18: a tumor necrosis factor-alpha lesson already learned.
Critical care medicine. 31(8):2241-2 [PMID] 12973187.
View on: PubMed
2003
Pediatric sand aspiration: case report and literature review.
Pediatric surgery international. 19(5):409-12 [PMID] 12802608.
View on: PubMed
2003
Sepsis and the dendritic cell.
Shock (Augusta, Ga.). 20(5):386-401 [PMID] 14560102.
View on: PubMed
2002
Anaphylactic reaction to isosulfan blue used for sentinel node biopsy: case report and literature review.
The breast journal. 8(6):396-9 [PMID] 12390368.
View on: PubMed
1997
Diabetes-impaired healing and reduced wound nitric oxide synthesis: a possible pathophysiologic correlation.
Surgery. 121(5):513-9 [PMID] 9142149.
View on: PubMed
1997
Nitric oxide, an autocrine regulator of wound fibroblast synthetic function.
Journal of immunology (Baltimore, Md. : 1950). 158(5):2375-81 [PMID] 9036987.
View on: PubMed

Grants

Jul 2021 ACTIVE
Together: Transforming and Translating Discovery to Improve Health
Role: Project Manager
Funding: NATL INST OF HLTH NCATS
Jun 2021 ACTIVE
Phase II: RT Assistant handheld patient safety tool for mechanical ventilation
Role: Principal Investigator
Funding: CONVERGENT ENGINEERING INC. via NATL INST OF HLTH NHLBI
Jun 2021 ACTIVE
Pathological Myeloid Activation After Sepsis and Trauma
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Jun 2021 ACTIVE
Sepsis-induced Myopathy in Aging: Influence of disuse on skeletal muscle regeneration
Role: Principal Investigator
Funding: FL STATE UNIV via NATL INST OF HLTH NIA
May 2021 ACTIVE
Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Jun 2020 ACTIVE
Role of myeloid-derived suppressor cells in aortic aneurysms and rupture
Role: Other
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
May 2020 ACTIVE
Development of a Designer Proline-rich antimicrobial peptide Chaperone protein inhibitor (DPC) for treating sepsis
Role: Principal Investigator
Funding: ARREVUS via NATL INST OF HLTH NIAID
Aug 2018 ACTIVE
Chronic Stress and Anemia Recovery following Major Trauma
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Jun 2018 – May 2020
PICS: A New Horizon for Surgical Critical Care
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Jun 2017 – May 2018
PICS: A New Horizon for Surgical Critical Care
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2017 ACTIVE
University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Jun 2016 – May 2017
PICS: A New Horizon for Surgical Critical Care
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Apr 2016 – Mar 2017
Claude D Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Jun 2015 – May 2016
PICS: A New Horizon for Surgical Critical Care
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Apr 2015 – Jan 2021
Hematopoietic Stem Cell Dysfunction in the Elderly after Severe Injury
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2015 – Mar 2016
Claude D. Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Feb 2015 ACTIVE
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jul 2007 – Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU

Teaching Profile

Courses Taught
2018
PAS5701L Critical Care Medicin
2018
PAS5702L Intensive Care Med 2
2015
GMS6029 Brain Journal Club

Contact Details

Phones:
Business:
(352) 273-5670
Emails: