Zhihua Jiang, Ph.D.

Assistant professor, division of vascular surgery and endovascular therapy

Education

  • Medical degree: Hengyang Medical College, China (not board certified in U.S.)
  • General surgery resident: Huaihua People’s First Hospital, China
  • Chief resident: Guangxi Medical University, China
  • Doctorate degree: Tongji Medical University, China
  • Postdoctoral fellow: Vascular Biology, University of Florida College of Medicine
Professional Societies
  • American Heart Association
  • American Physiological Society
  • Council member, Peripheral Vascular Diseases
  • Council member, Basic Cardiovascular Sciences
  • Member, BCVS early career committee

Research Funding 

  1. NIH/NHLBI 1 R01 HL105764-01A1 2011-2016
    Zhihua Jiang (Principal Investigator)
    The Dichotomy of Alk1 and Alk5 Signaling Pathways in Vascular Response to Injury
    This project aims to determine the effects of Alk1 and Alk5 mediated TGF-β signaling in specific cell populations (e.g. smooth muscule cells and endothelial cells) on neointimal hyperplasia development in vein grafts and explore the underlying regulatory mechanisms.
  1. James & Esther King Biomedical Research Program – NIR (08KN-05), 2008-2011
    Zhihua Jiang (Principal Investigator)
    Mechanisms of MCP-1/CCR2 Regulated Vein Graft Neointimal Hyperplasia
    The overall goal of this award is to explore the role of graft intrinsic MCP-1/CCR2 signaling in vein graft neointimal thickening and the modulation of neointimal smooth muscle cell phenotype during vein graft adaptations.
  1. Research Career Development Award (00075067) 2008-2009
    Zhihua Jiang (Principal Investigator)
    Role of Graft Intrinsic and Extrinsic CCR2 Signaling in Vein Graft Remodeling
    This project seeks to evaluate the relative contribution of graft wall intrinsic and extrinsic CCR2 signaling in vein graft neointimal hyperplasia and outward remodeling.
  1. NIH R21 Submitted
    Zhihua Jiang (Principal Investigator)
    TGF-b Signaling Determinants of Stem Cell Differentiation to a Vascular Smooth Muscle Cell Phenotype
    This project proposes experiments to determine the role of Smad2 and Smad3 mediated TGF-β activity in the acquisition of a smooth muscle cell phenotype for the mesenchymal stem cells in the vein graft wall during neointimal hyperplasia.
  1. AHA Scientist Development Grant (0635354N) 07/01/2006-06/31/2010
    Zhihua Jiang (Principal Investigator)
    TGF-β signaling mechanisms in vein graft adaptations
    This project is to evaluate the contribution of TGF-β binding to its type II receptor in matrix metabolism and neointimal hyperplasia in vein grafts.
  1. Research Foundation, Guangxi Medical University, China 07/01/1999-06/31/2002
    Zhihua Jiang (Principal Investigator)
    Myocardial protection of persistent cardiac perfusion of oxygenated blood with no cardioplegia during open heart surgery
    The major goal of this project is to examine the protective effects of persistent cardiac perfusion of oxygenated blood with no cardioplegia on myocardial function in patients receiving mitral valve replacement: Phase I clinical trial.