Assistant professor, division of general surgery
Education
- Bachelor of science degree: Biomedical Engineering, School of Engineering and Applied Sciences, Columbia University, New York, NY
- Master of science degree: Neuroscience and Physiology, New York University, Sackler Institute of Biomedical Sciences, New York, NY
- Doctorate degree: Neuroscience and Physiology, New York University, Sackler Institute of Biomedical Sciences, New York, NY. Advisor: Dr. Ralph Nixon. Dissertation: AD-related lysosomal proteolysis inhibition selectively disrupts axonal transport of autophagic vacuoles and lysosomes causing axonal dystrophy
Academic and Professional Honors
- National Honors Society (1995-1998)
- National Merit Scholar (1997)
- Columbia University, Dean’s List (2001, 2002)
- Columbia University, Summer Undergraduate Research Fellowship (2002)
- New York University Sackler Institute travel award (2009, 2010)
- American Society for Neurochemistry, Young Investigator Educational Enhancement Award (2011)
- Society for Neuroscience, Julius Axelrod Lecture Poster Award (2012)
- North Central Florida Chapter, Society for Neuroscience Conference, Best Poster Award (2013, 2014)
- McKnight Brain Institute, University of Florida, Young Investigator Travel Award (2013)
- Experimental Gerontology, Outstanding Paper Prize (2013)
- Basic Science Young Investigator Award, American Association for the Study of Liver Diseases (2015)
- Department of Surgery Research Career Development Award (2016)
Recent Publications
- Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA. Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer’s disease. J Neurosci. 2008 Jul 2;28(27):6926-37. doi: 10.1523/JNEUROSCI.0800-08.2008. PMID: 18596167; PMCID: PMC2676733.
- Gaisler-Salomon I, Miller GM, Chuhma N, Lee S, Zhang H, Ghoddoussi F, Lewandowski N, Fairhurst S, Wang Y, Conjard-Duplany A, Masson J, Balsam P, Hen R, Arancio O, Galloway MP, Moore HM, Small SA, Rayport S. Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia. 2009 Sep;34(10):2305-22. doi: 10.1038/npp.2009.58. Epub 2009 Jun 10. PMID: 19516252; PMCID: PMC2811085.
- Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. 2010 Jun 25;141(7):1146-58. doi: 10.1016/j.cell.2010.05.008. Epub 2010 Jun 10. PMID: 20541250; PMCID: PMC3647462.
- Lee S, Sato Y, Nixon RA. Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer’s-like axonal dystrophy. J Neurosci. 2011 May 25;31(21):7817-30. doi: 10.1523/JNEUROSCI.6412-10.2011. PMID: 21613495; PMCID: PMC3351137.
- Lee S, Sato Y, Nixon RA. Primary lysosomal dysfunction causes cargo-specific deficits of axonal transport leading to Alzheimer-like neuritic dystrophy. 2011 Dec;7(12):1562-3. PMID: 22024748; PMCID: PMC3327621