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Director: Lyle Moldawer, PhD

Professor and vice chairman of research

UF Business: (352) 265-0494

UF Business Mailing
PO Box 100019
Gainesville, FL 32610-0001

Education

1986 Ph.D. (Dr. Med. Sci.), University of Gothenberg,Gothenburg, Sweden, in Experimental Medicine

Academic Appointments

2004- present Vice Chairman of Research, University of Florida, College of Medicine, Gainesville, Florida
1996 – present Professor of Surgery, University of Florida College of Medicine, Gainesville, Florida
1994 – 1996 Associate Professor of Surgery (with tenure)University of Florida College of Medicine,Gainesville, Florida
1993 – 1996 Associate Professor of Surgery, University of Florida College of Medicine, Gainesville, Florida
1991 – 1993 Associate Professor of Cell Biology and Anatomy,Cornell University Medical College, New York, New York
1991 – 1993 Associate Professor of Surgery, Cornell University Medical College, New York, New York
1988 – 1991 Assistant Professor of Cell Biology and Anatomy,Cornell University Medical College, New York, New York
1987 – 1991 Assistant Professor of Surgery,Cornell University Medical College, New York, New York
1985 – 1987 Visiting Scientist, Department of Surgery I, Sahlgrenska sjukhuset,S-41345 Goteborg, Sweden

Publications:
Selected peer-reviewed publications from a total of 367 (in chronological order). Web of Knowledge, h-factor=73, total citations=18,432.

1.    Efron, P. A., A. Martins, D. Minnich, K. Tinsley, R. Ungaro, F. R. Bahjat, R. Hotchkiss, M. Clare-Salzler, and L. L. Moldawer. 2004. Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. J Immunol 173:3035-3043. PMID: 15322163

2.    Scumpia, P. O., P. F. McAuliffe, K. A. O’Malley, R. Ungaro, T. Uchida, T. Matsumoto, D. G. Remick, M. J. Clare-Salzler, L. L. Moldawer, and P. A. Efron. 2005. CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis. J Immunol 175:3282-3286. PMID: 16116220

3.    Scumpia, P. O., M. J. Delano, K. M. Kelly, K. A. O’Malley, P. A. Efron, P. F. McAuliffe, T. Brusko, R. Ungaro, T. Barker, J. L. Wynn, M. A. Atkinson, W. H. Reeves, M. J. Salzler, and L. L. Moldawer. 2006. Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol 177:7943-7949. PMID:17114466

4.    Laudanski, K., C. Miller-Graziano, W. Xiao, M. N. Mindrinos, D. R. Richards, A. De, L. L. Moldawer, R. V. Maier, P. Bankey, H. V. Baker, B. H. Brownstein, J. P. Cobb, S. E. Calvano, R. W. Davis, and R. G. Tompkins. 2006. Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc Natl Acad Sci 103:15564-15569. PMID: 17032758, PMC1592643

5.    Scumpia, P. O., M. J. Delano, K. M. Kelly-Scumpia, J. S. Weinstein, J. L. Wynn, R. D. Winfield, C. Xia, C. S. Chung, A. Ayala, M. A. Atkinson, W. H. Reeves, M. J. Clare-Salzler, and L. L. Moldawer. 2007. Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis. Blood 110:3673-3681. PMID: 17690255, PMC2077315

6.    Delano, M. J., P. O. Scumpia, J. S. Weinstein, D. Coco, S. Nagaraj, K. M. Kelly-Scumpia, K. A. O’Malley, J. L. Wynn, S. Antonenko, S. Z. Al-Quran, R. Swan, C. S. Chung, M. A. Atkinson, R. Ramphal, D. I. Gabrilovich, W. H. Reeves, A. Ayala, J. Phillips, D. Laface, P. G. Heyworth, M. Clare-Salzler, and L. L. Moldawer. 2007. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med 204:1463-1474. PMID: 17548519, PMC2118626

7.    Uchida, T., P. O. Scumpia, D. M. Murasko, S. Seki, S. Woulfe, M. J. Clare-Salzler, and L. L. Moldawer. 2007. Variable requirement of dendritic cells for recruitment of NK and T cells to different TLR agonists. J Immunol 178:3886-3892. PMID: 17339488

8.    Wynn, J. L., P. O. Scumpia, R. D. Winfield, M. J. Delano, K. Kelly-Scumpia, T. Barker, R. Ungaro, O. Levy, and L. L. Moldawer. 2008. Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood 112:1750-1758. PMID:18591384, PMC2518883

9.    Wynn, J. L., J. Neu, L. L. Moldawer, and O. Levy. 2009. Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis. J Perinatol 29:79-88. PMID: 18769381

10.  Kelly-Scumpia, K. M., P. O. Scumpia, M. J. Delano, J. S. Weinstein, A. G. Cuenca, J. L. Wynn, and L. L. Moldawer.  2011.Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10.  J. Exp Med 207(2):319-26. PMID: 20071504, PMC2822595

11.  Scumpia, P. O., K. M. Kelly-Scumpia, M. J. Delano, J. S. Weinstein, A. G. Cuenca, S. Al-Quran, I. Bovio, S. Akira, Y. Kumagai, and L. L. Moldawer. 2010. Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling. J Immunol 184:2247-2251. PMID:20130216

12.  Delano, M.J., Thayer, T., Gabrilovich, S., Kelly-Scumpia, K.M., Winfield, R.D., Scumpia, P.O., Cuenca, A.G., Warner, E., Wallet, S.M., Wallet, M.A., O’Malley, K.A., Ramphal, R., Clare-Salzer, M., Efron, P.A., Mathews, C.E., Moldawer, L.L.  2011. Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.  J Immunol. 186(1):195-202. PMID: 21106855

13.  Cuenca, A.G., Delano, M.J., Kelly-Scumpia, K.M., Moreno, C., Scumpia, P.O., Laface, D.M., Heyworth, P.G., Efron, P.A., Moldawer, L.L. 2011. A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Mol Med. 17(3-4):281-92. PMID: 21085745, PMC3060988

14.  Delano, M.J., Kelly-Scumpia, K.M., Thayer, T.C., Winfield, R.D., Scumpia, P.O., Cuenca, A.G., Harrington, P.B., O’Malley, K.A., Warner, E., Gabrilovich, S., Mathews, C.E., LaFace, D., Heyworth, P.G., Ramphal, R., Strieter, R.M., Moldawer, L.L., Efron, P.A. 2011. Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol. 187(2):911-8. PMID: 21690321

15.  Kelly-Scumpia, K.M., Scumpia, P.O., Weinstein, J.S., Delano, M.J., Cuenca, A.G., Nacionales, D.C., Wynn, J.L., Lee, P.Y., Kumagai, Y., Efron, P.A., Akira, S., Wasserfall, C., Atkinson, M.A., Moldawer, L.L. 2011. B cells enhance early innate immune responses during bacterial sepsis. J Ex Med 208(8):1673-82. PMID:21746813, PMC3149216

Research:

Dr. Moldawer has received independent funding from the National Institutes of Health (NIH) continuously since 1988. In 1998, Dr. Moldawer received the prestigious Merit Award from the National Institute of General Medical Sciences, extending his current NIH support through the year 2006. Dr. Moldawer is the principal investigator on a training grant from the NIH to prepare surgical residents in training with a two year research experience in molecular biology and gene therapy. Dr. Moldawer is one of only a small number of Ph.D.’s in the country who holds the academic rank of Full Professor in a Department of Surgery. Since 1988, Dr. Moldawer has trained 28 surgical residents in research methodologies (19 at the University of Florida). Sixteen of these surgical residents have continued in academic training programs, and eight are currently on the faculty of colleges of medicine.

General info:

Dr. Moldawer serves on numerous federal government public advisory groups, including:

  • Ad Hoc Member, several Special Emphasis Panels CSR, NIAID, NIGMS, NIDDK and NHLBI 2009-2012
  • Ad Hoc Member, Integrative Clinical Endocrinology and Reproductive Sciences Study Section, 2010, 2011
  • Ad Hoc Member, NIGMS Program Project and Center Grant Special Emphasis Panel, 2010, 2011
  • Regular Member, Surgery Anesthesiology and Trauma Study Section, 2004-2009, Chairperson, 2007-2009
  • Ad Hoc Member, Surgery B Study Section, Veterans Affairs Scientific Review Group, 2004-2005
  • Regular Member, Metabolic Pathology Study Section, DRG, 1995-1999